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Entry version 67 (07 Oct 2020)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

DOCK1

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factorARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DOCK1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000007299, Expressed in embryo and 15 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000007285

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 70SH3InterPro annotationAdd BLAST62
Domaini425 – 609C2 DOCK-typeInterPro annotationAdd BLAST185
Domaini1204 – 1614DOCKERInterPro annotationAdd BLAST411

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1616 – 1708DisorderedSequence analysisAdd BLAST93
Regioni1803 – 1859DisorderedSequence analysisAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1298 – 1318Sequence analysisAdd BLAST21
Coiled coili1487 – 1507Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1630 – 1659PolarSequence analysisAdd BLAST30
Compositional biasi1673 – 1708PolyampholyteSequence analysisAdd BLAST36
Compositional biasi1824 – 1847Pro-richSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1998, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154974

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000595_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KGL2

KEGG Orthology (KO)

More...
KOi
K13708

Database of Orthologous Groups

More...
OrthoDBi
102580at2759

TreeFam database of animal gene trees

More...
TreeFami
TF300423

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1270.350, 1 hit
1.20.58.740, 1 hit
1.25.40.410, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR035892, C2_domain_sf
IPR027007, DHR-1_domain
IPR027357, DHR-2
IPR026791, DOCK
IPR030717, DOCK1/DOCK5
IPR010703, DOCK_C
IPR043161, DOCK_C_lobe_A
IPR043162, DOCK_C_lobe_C
IPR032376, DOCK_N
IPR042455, DOCK_N_sub1
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR45653, PTHR45653, 1 hit
PTHR45653:SF3, PTHR45653:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06920, DHR-2, 1 hit
PF14429, DOCK-C2, 1 hit
PF16172, DOCK_N, 1 hit
PF14604, SH3_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51650, DHR_1, 1 hit
PS51651, DHR_2, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KGL2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRWVPTKRE EKYGVAFYNY DARGPDELSL QIGDTVHILE THEDWYRGYT
60 70 80 90 100
LRKKSKKGIF PASYVQLKEA IVEGKGQHET VIPSELPLIQ EVTTTLREWS
110 120 130 140 150
TIWRQLYIQD NREMFHSVRH MIYDLIEWRS QILSGTLPQD ELKEMKKKVT
160 170 180 190 200
AKIDYGNRIL DLDLVVRDED GNILDPEQTS TISLFRAHEI ASKQVEERLL
210 220 230 240 250
EEKSQKQNLD ITRQAKFAAT PSFALFVNLK NVVCKIGEDA EVLMSLYDPL
260 270 280 290 300
ESKFISENYL VRWSSSGLPK DIDRLHNLRA VFTDLGSKDL KREKISFVCQ
310 320 330 340 350
IVRVGRMELR DNNTRKLTSG LRRPFGVAVM DVTDIINGKV DDEDKQHFIP
360 370 380 390 400
FQPVAGENDF LQTVINKVIA AKEVNHKGQG LWVTMKLLPG DIHQIRKEFP
410 420 430 440 450
HLVDRTTAVA RKMGFPEIIM PGDVRNDIYV TLVQGDFDKG SKTTAKNVEV
460 470 480 490 500
TVSVYDEDGK KLENVIFPGA GDDALSEYKS VIYYQVKQPR WFETVKVAIP
510 520 530 540 550
IEDVNRSHLR FTFRHRSSQD SKDKSEKIFA LAFVKLMRYD GTTLRDGEHD
560 570 580 590 600
LIVYKAEAKK LEDFSTYLSL PSTKIELEEK GHSTAGKSMQ NLGSCTISKD
610 620 630 640 650
SFQISTLVCS TKLTQNVDLL GLLKWRSNTN LLQQNLRQLM KVDGGEVVKF
660 670 680 690 700
LQDTLDALFN IMMENSESET FDTLVFDALV FIIGLIADRK FQHFNPVLET
710 720 730 740 750
YIKKHFSATL AYTKLTKVLR TYVDNAGITD QLFKAMKSLE YIFKFIVRSR
760 770 780 790 800
ILFNQLYENK GEANFRESLL QLFKSINEMM SSPSEQTVIV KGAALKYLPT
810 820 830 840 850
IVNDVKLVFD PKELSKLFTD FILNVPMGRL TIQKLYCLIE IVHSDLFTQH
860 870 880 890 900
DCREILLPMM TDQLKYHLER QEDLEACCQL LSNILEVLYR KDVGPTQRHV
910 920 930 940 950
QVIMEKLLRT VNRTVISMGR DSELIGNFVA SMTAILRQME DYHYAHLIKT
960 970 980 990 1000
FGKMRSDVVD FLMETFIMFK NLIGKNVYPS DWVIMNMMQN KVFLRAINQY
1010 1020 1030 1040 1050
ADMLNKKFLD QANFELQLWN NYFHLAVAFL TQESLQLENF SSAKRCKILN
1060 1070 1080 1090 1100
KYGDMRRQIG FEIRDMWYNL GQHKIKFIPE MVGPMLEMTL IPETELRKAT
1110 1120 1130 1140 1150
IPIFFDMMQC EFHSTRSFQM FENEIITKLD HEVEGGRGDE QYKVLFEKIL
1160 1170 1180 1190 1200
LEHCRKHKYL AKNGETFVKL VVRLMERLLD YRTIMHDENK ENRMSCTVNV
1210 1220 1230 1240 1250
LNFYKEIERE EMYIRYLYKL CDLHKECDNY TEAAYTLLLH AKLLKWSEEP
1260 1270 1280 1290 1300
CAAHLTQRDG YQAATQGQLK DQLYQEIIHY FDKGKMWEEA IALGKELAEQ
1310 1320 1330 1340 1350
YENEMFDYEQ LSELLKKQAQ FYENIVKVIR PKPDYFAVGY YGHGFPTFLR
1360 1370 1380 1390 1400
NKVFIYRGKE YERREDFEAR LLTQFPNAEK MKTTSPPGED LKNSPGQYIQ
1410 1420 1430 1440 1450
CFTVKPKLDL PPKFHRPVSE QILSFYRVNE VQRFEYSRPV RKGEKNPDNE
1460 1470 1480 1490 1500
FANMWIERTV YVTGYKLPGI LRWFEVKSVF MVEISPLENA IETMQVTNDK
1510 1520 1530 1540 1550
INNMVQQHLN DPNLPINPLS MLLNGIVDPA VMGGFTNYEK AFFTEKYMYD
1560 1570 1580 1590 1600
HPEDHEKIEK LKDLIAWQIP FLAEGIRIHG DKVTEALRPF HERMEACFRQ
1610 1620 1630 1640 1650
LKEKVEKQYG VRTLPSMVDD RRGSRPRSMV RSFTMPSSSR PLSIASISSV
1660 1670 1680 1690 1700
SSDSASSRPG SDGFVLEPLL PKKMHSRSQD KLDKDDPDKD KKEKKKEKRN
1710 1720 1730 1740 1750
SKHQEIFEKE FKSTDISLQQ SEAVILSETI SPLRPQRPKS QVINAMGNEK
1760 1770 1780 1790 1800
RFSVSPSPPS QSIPPPITPR TKLSFSLQSN LDLNGMATLE MTNVPPPLPL
1810 1820 1830 1840 1850
KGSMADYGNL METHESISPA TSPPVPQRQL PPPLPSKTPP PPPPKTTRKQ

ASVDSGIVQ
Length:1,859
Mass (Da):215,328
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82DECCAF723A2942
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_003218616.1, XM_003218568.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000007441; ENSACAP00000007285; ENSACAG00000007299

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100554287

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
acs:100554287

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_003218616.1, XM_003218568.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000007285

Genome annotation databases

EnsembliENSACAT00000007441; ENSACAP00000007285; ENSACAG00000007299
GeneIDi100554287
KEGGiacs:100554287

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1793

Phylogenomic databases

eggNOGiKOG1998, Eukaryota
GeneTreeiENSGT00940000154974
HOGENOMiCLU_000595_2_1_1
InParanoidiG1KGL2
KOiK13708
OrthoDBi102580at2759
TreeFamiTF300423

Gene expression databases

BgeeiENSACAG00000007299, Expressed in embryo and 15 other tissues

Family and domain databases

Gene3Di1.20.1270.350, 1 hit
1.20.58.740, 1 hit
1.25.40.410, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR035892, C2_domain_sf
IPR027007, DHR-1_domain
IPR027357, DHR-2
IPR026791, DOCK
IPR030717, DOCK1/DOCK5
IPR010703, DOCK_C
IPR043161, DOCK_C_lobe_A
IPR043162, DOCK_C_lobe_C
IPR032376, DOCK_N
IPR042455, DOCK_N_sub1
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR45653, PTHR45653, 1 hit
PTHR45653:SF3, PTHR45653:SF3, 1 hit
PfamiView protein in Pfam
PF06920, DHR-2, 1 hit
PF14429, DOCK-C2, 1 hit
PF16172, DOCK_N, 1 hit
PF14604, SH3_9, 1 hit
SMARTiView protein in SMART
SM00326, SH3, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51650, DHR_1, 1 hit
PS51651, DHR_2, 1 hit
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KGL2_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KGL2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: October 7, 2020
This is version 67 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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