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UniProtKB - G1KGE0 (G1KGE0_ANOCA)

Entry version 57 (02 Dec 2020)
Sequence version 2 (26 Jun 2013)
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Protein

Plug_translocon domain-containing protein

Gene

SEC61A1

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, TranslocationUniRule annotationARBA annotation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plug_translocon domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEC61A1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei32 – 54HelicalSequence analysisAdd BLAST23
Transmembranei74 – 97HelicalSequence analysisAdd BLAST24
Transmembranei118 – 137HelicalSequence analysisAdd BLAST20
Transmembranei143 – 165HelicalSequence analysisAdd BLAST23
Transmembranei172 – 193HelicalSequence analysisAdd BLAST22
Transmembranei205 – 221HelicalSequence analysisAdd BLAST17
Transmembranei242 – 263HelicalSequence analysisAdd BLAST22
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Transmembranei413 – 431HelicalSequence analysisAdd BLAST19
Transmembranei437 – 458HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Endoplasmic reticulumARBA annotation, Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSACAG00000007248, Expressed in hindlimb bud and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		28377.ENSACAP00000007146

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 74Plug_transloconInterPro annotationAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.UniRule annotationARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1373, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003721

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_031763_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		G1KGE0

Database of Orthologous Groups

More...OrthoDBi		482911at2759

TreeFam database of animal gene trees

More...TreeFami		TF300348

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.3370.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002208, SecY/SEC61-alpha
IPR030659, SecY_CS
IPR023201, SecY_dom_sf
IPR019561, Translocon_Sec61/SecY_plug_dom

The PANTHER Classification System

More...PANTHERi		PTHR10906, PTHR10906, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10559, Plug_translocon, 1 hit
PF00344, SecY, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF004557, SecY, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103491, SSF103491, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00967, 3a0501s007, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00755, SECY_1, 1 hit
PS00756, SECY_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KGE0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGIKFLEVIK PFCVILPEIQ KPERKIQFKE KVLWTAITLF IFLVCCQIPL 
        60         70         80         90        100
FGIMSSDSAD PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII 
       110        120        130        140        150
EVGDTPKDRA LFNGAQKLFG MIITIGQSIV YVMTGMYGDP SEMGAGICLL 
       160        170        180        190        200
ITIQLFVAGL IVLLLDELLQ KGYGLGSGIS LFIATNICET IVWKAFSPTT 
       210        220        230        240        250
VNTGRGMEFE GAIIALFHLL ATRTDKVRAL REAFYRQNLP NLMNLIATIF 
       260        270        280        290        300
VFAVVIYFQG FRVDLPIKSA RYRGQYNTYP IKLFYTSNIP IILQSALVSN 
       310        320        330        340        350
LYVISQMLSA RFSGNLLVSL LGTWSDTSSG GPARSYPVGG LCYYLSPPES 
       360        370        380        390        400
FGSVLEDPVH AVVYIVFMLG SCAFFSKTWI EVSGSSAKDV AKQLKEQQMV 
       410        420        430        440        450
MRGHRETSMV HELNRYIPTA AAFGGLCIGA LSVLADFLGA IGSGTGILLA 
       460        470 
VTIIYQYFEI FVKEQSEVGS MGALLF
Length:476
Mass (Da):52,267
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i023C3E01E13BF58E
GO

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_003217774.1, XM_003217726.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSACAT00000007301; ENSACAP00000007146; ENSACAG00000007248

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100567770

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		acs:100567770

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_003217774.1, XM_003217726.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000007146

Genome annotation databases

EnsembliENSACAT00000007301; ENSACAP00000007146; ENSACAG00000007248
GeneIDi100567770
KEGGiacs:100567770

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		29927

Phylogenomic databases

eggNOGiKOG1373, Eukaryota
GeneTreeiENSGT00390000003721
HOGENOMiCLU_031763_2_0_1
InParanoidiG1KGE0
OrthoDBi482911at2759
TreeFamiTF300348

Gene expression databases

BgeeiENSACAG00000007248, Expressed in hindlimb bud and 14 other tissues

Family and domain databases

Gene3Di1.10.3370.10, 1 hit
InterProiView protein in InterPro
IPR002208, SecY/SEC61-alpha
IPR030659, SecY_CS
IPR023201, SecY_dom_sf
IPR019561, Translocon_Sec61/SecY_plug_dom
PANTHERiPTHR10906, PTHR10906, 1 hit
PfamiView protein in Pfam
PF10559, Plug_translocon, 1 hit
PF00344, SecY, 1 hit
PIRSFiPIRSF004557, SecY, 1 hit
SUPFAMiSSF103491, SSF103491, 1 hit
TIGRFAMsiTIGR00967, 3a0501s007, 1 hit
PROSITEiView protein in PROSITE
PS00755, SECY_1, 1 hit
PS00756, SECY_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KGE0_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KGE0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: December 2, 2020
This is version 57 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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