UniProtKB - G1KGE0 (G1KGE0_ANOCA)
Protein
Plug_translocon domain-containing protein
Gene
SEC61A1
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- calcium channel activity Source: Ensembl
- protein transmembrane transporter activity Source: GO_Central
- ribosome binding Source: GO_Central
- signal sequence binding Source: GO_Central
GO - Biological processi
- endoplasmic reticulum organization Source: Ensembl
- posttranslational protein targeting to membrane, translocation Source: GO_Central
- pronephric nephron development Source: Ensembl
- SRP-dependent cotranslational protein targeting to membrane, translocation Source: GO_Central
Keywordsi
Biological process | Protein transport, TranslocationUniRule annotationARBA annotation, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Plug_translocon domain-containing proteinInterPro annotation |
Gene namesi | Name:SEC61A1Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum membrane Source: GO_Central
- Sec61 translocon complex Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 32 – 54 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 74 – 97 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 118 – 137 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 143 – 165 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 172 – 193 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 205 – 221 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 242 – 263 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 283 – 303 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 413 – 431 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 437 – 458 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Endoplasmic reticulumARBA annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSACAG00000007248, Expressed in hindlimb bud and 14 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 74 | Plug_transloconInterPro annotationAdd BLAST | 35 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG1373, Eukaryota |
GeneTreei | ENSGT00390000003721 |
HOGENOMi | CLU_031763_2_0_1 |
InParanoidi | G1KGE0 |
OrthoDBi | 482911at2759 |
TreeFami | TF300348 |
Family and domain databases
Gene3Di | 1.10.3370.10, 1 hit |
InterProi | View protein in InterPro IPR002208, SecY/SEC61-alpha IPR030659, SecY_CS IPR023201, SecY_dom_sf IPR019561, Translocon_Sec61/SecY_plug_dom |
PANTHERi | PTHR10906, PTHR10906, 1 hit |
Pfami | View protein in Pfam PF10559, Plug_translocon, 1 hit PF00344, SecY, 1 hit |
PIRSFi | PIRSF004557, SecY, 1 hit |
SUPFAMi | SSF103491, SSF103491, 1 hit |
TIGRFAMsi | TIGR00967, 3a0501s007, 1 hit |
PROSITEi | View protein in PROSITE PS00755, SECY_1, 1 hit PS00756, SECY_2, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KGE0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGIKFLEVIK PFCVILPEIQ KPERKIQFKE KVLWTAITLF IFLVCCQIPL
60 70 80 90 100
FGIMSSDSAD PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII
110 120 130 140 150
EVGDTPKDRA LFNGAQKLFG MIITIGQSIV YVMTGMYGDP SEMGAGICLL
160 170 180 190 200
ITIQLFVAGL IVLLLDELLQ KGYGLGSGIS LFIATNICET IVWKAFSPTT
210 220 230 240 250
VNTGRGMEFE GAIIALFHLL ATRTDKVRAL REAFYRQNLP NLMNLIATIF
260 270 280 290 300
VFAVVIYFQG FRVDLPIKSA RYRGQYNTYP IKLFYTSNIP IILQSALVSN
310 320 330 340 350
LYVISQMLSA RFSGNLLVSL LGTWSDTSSG GPARSYPVGG LCYYLSPPES
360 370 380 390 400
FGSVLEDPVH AVVYIVFMLG SCAFFSKTWI EVSGSSAKDV AKQLKEQQMV
410 420 430 440 450
MRGHRETSMV HELNRYIPTA AAFGGLCIGA LSVLADFLGA IGSGTGILLA
460 470
VTIIYQYFEI FVKEQSEVGS MGALLF
Sequence databases
RefSeqi | XP_003217774.1, XM_003217726.3 |
Genome annotation databases
Ensembli | ENSACAT00000007301; ENSACAP00000007146; ENSACAG00000007248 |
GeneIDi | 100567770 |
KEGGi | acs:100567770 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_003217774.1, XM_003217726.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000007146 |
Genome annotation databases
Ensembli | ENSACAT00000007301; ENSACAP00000007146; ENSACAG00000007248 |
GeneIDi | 100567770 |
KEGGi | acs:100567770 |
Organism-specific databases
CTDi | 29927 |
Phylogenomic databases
eggNOGi | KOG1373, Eukaryota |
GeneTreei | ENSGT00390000003721 |
HOGENOMi | CLU_031763_2_0_1 |
InParanoidi | G1KGE0 |
OrthoDBi | 482911at2759 |
TreeFami | TF300348 |
Gene expression databases
Bgeei | ENSACAG00000007248, Expressed in hindlimb bud and 14 other tissues |
Family and domain databases
Gene3Di | 1.10.3370.10, 1 hit |
InterProi | View protein in InterPro IPR002208, SecY/SEC61-alpha IPR030659, SecY_CS IPR023201, SecY_dom_sf IPR019561, Translocon_Sec61/SecY_plug_dom |
PANTHERi | PTHR10906, PTHR10906, 1 hit |
Pfami | View protein in Pfam PF10559, Plug_translocon, 1 hit PF00344, SecY, 1 hit |
PIRSFi | PIRSF004557, SecY, 1 hit |
SUPFAMi | SSF103491, SSF103491, 1 hit |
TIGRFAMsi | TIGR00967, 3a0501s007, 1 hit |
PROSITEi | View protein in PROSITE PS00755, SECY_1, 1 hit PS00756, SECY_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KGE0_ANOCA | |
Accessioni | G1KGE0Primary (citable) accession number: G1KGE0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 57 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |