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Entry version 59 (07 Oct 2020)
Sequence version 2 (26 Jun 2013)
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Protein

WD repeat-containing protein 35

Gene

WDR35

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradationUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat-containing protein 35UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR35Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, CiliumUniRule annotation, Cytoplasm, CytoskeletonUniRule annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000007095, Expressed in testis and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000007051

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini90 – 156ANAPC4_WD40InterPro annotationAdd BLAST67

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1059 – 1079Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2041, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155745

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004048_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KG96

Database of Orthologous Groups

More...
OrthoDBi
95796at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314076

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024977, Apc4_WD40_dom
IPR011990, TPR-like_helical_dom_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR036322, WD40_repeat_dom_sf
IPR017233, WDR35

The PANTHER Classification System

More...
PANTHERi
PTHR16517:SF1, PTHR16517:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12894, ANAPC4_WD40, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037536, WD_repeat_p35, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KG96-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFVYLSKKIT IPGNVRLRSI SWSKDQGYIA CGGEDGLLKV LKLETKTDEA
60 70 80 90 100
KLKGLAAPSN LSMNQSLEGH TGAWYEEMIN NRNKSVVRSM RWNADGQKIC
110 120 130 140 150
IIYEDGAVIV GSVDGNRIWG KDLKVQLHHV AWSPDGRTLL FGMANGEIHI
160 170 180 190 200
YDKHGTFMMK MKMNCLVNVT GAFSIAGIQW YPGTEGYVEQ DCPCLAICFD
210 220 230 240 250
NGRCQIMRHE NDQNPVLIDA ALNVVSVQWN HCGNVLAIAG LQKIATQEKD
260 270 280 290 300
INVVQFYSPF GEHLRTLKVP GKQMAALSWE GGGLKIGLVV DQCIYFANIR
310 320 330 340 350
PDYKWGYCTN TVVYAYTRPD RPEYCVVFWD IKNNEKYLKF VKSLISITTC
360 370 380 390 400
GDFCILATKA DENQMQEEHE TETLGAMYVL VLCNSIGTPL DPKYIDIVPL
410 420 430 440 450
FVTMTKTQVI AASKEAFYIW QYRVDKKLTA MEINQVARTR KEGKERIYHV
460 470 480 490 500
DDNPSGAGDG ALDYAKVLQG TRDPICAITA SDKTLIIGRE SGTIQSYRLP
510 520 530 540 550
NVGLIRKYLL NCRPYQLSLN CTSSRLAIID MLGVLVFFDL DTRVADGSGN
560 570 580 590 600
QVVGELLKLE RRDVWDMKWA KDNPDLFAMM EKTRMYVFRN LDPEEPIQTS
610 620 630 640 650
GYICNFEDLE IKSVLLDEIF KNPEHPNKDD MLNFEIRSLR DAQAILKEAG
660 670 680 690 700
IAESTQFIEE NSHPRLWRLL AETALQRLDL HTAEQAFVRY KNYQGIKFVK
710 720 730 740 750
RLQNLQSESL RQAEVAVYFG RFEEAERMYL DMDRRDLAVD LRLKLGNGFR
760 770 780 790 800
VVQLLQTGSG HGDDHLLEQA HNEIGDYFAD RQKWVNAVPY YVQGRNHERL
810 820 830 840 850
AECYYMLEDY QALEDLATSL PENNKLLPDI AHKFVTVGMC EQAVTAFLKC
860 870 880 890 900
NRPKDAVDIC VNLNQWSKAV ELAKQHNMKE IGSLLARYAS QLLEKNKPLD
910 920 930 940 950
AVELYRKANY FFDAAKLMFK ISDEESKRRT KPLRVKKLYV MSALLVEQYH
960 970 980 990 1000
EQMKNAQRGK TKGKTSEATS ALAGLLEEDV LSSDSRLIDH AWRGAEAYHF
1010 1020 1030 1040 1050
FILAQRQLYE GYVDTAMKTA LHLRDYEDII PAVEIYSLLA LCACANRAFG
1060 1070 1080 1090 1100
TCSKAFVKLE SLENLTQEQR QQYEELALQI FTKHYPKDNK KSELDGLLEE
1110 1120 1130 1140 1150
GEGKLPTCVA TGRPITEYQF WMCNICKHCV QAQEISNYNF CPLCHSSVAY
Length:1,150
Mass (Da):131,002
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CE9420D12F39D7A
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000007203; ENSACAP00000007051; ENSACAG00000007095

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000007051

Genome annotation databases

EnsembliENSACAT00000007203; ENSACAP00000007051; ENSACAG00000007095

Phylogenomic databases

eggNOGiKOG2041, Eukaryota
GeneTreeiENSGT00940000155745
HOGENOMiCLU_004048_1_0_1
InParanoidiG1KG96
OrthoDBi95796at2759
TreeFamiTF314076

Gene expression databases

BgeeiENSACAG00000007095, Expressed in testis and 14 other tissues

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR024977, Apc4_WD40_dom
IPR011990, TPR-like_helical_dom_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR036322, WD40_repeat_dom_sf
IPR017233, WDR35
PANTHERiPTHR16517:SF1, PTHR16517:SF1, 1 hit
PfamiView protein in Pfam
PF12894, ANAPC4_WD40, 1 hit
PIRSFiPIRSF037536, WD_repeat_p35, 2 hits
SMARTiView protein in SMART
SM00320, WD40, 4 hits
SUPFAMiSSF50978, SSF50978, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KG96_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KG96
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: October 7, 2020
This is version 59 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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