UniProtKB - G1KG42 (G1KG42_ANOCA)
Protein
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
Gene
SAMHD1
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Catalytic activityi
- a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside + H+ + triphosphateARBA annotation
Cofactori
Zn2+ARBA annotation
GO - Molecular functioni
- dGTPase activity Source: GO_Central
- dGTP binding Source: Ensembl
- GTP binding Source: UniProtKB-KW
- identical protein binding Source: Ensembl
- ribonuclease activity Source: Ensembl
- RNA binding Source: Ensembl
- single-stranded DNA binding Source: Ensembl
- zinc ion binding Source: Ensembl
GO - Biological processi
- dATP catabolic process Source: Ensembl
- defense response to virus Source: GO_Central
- dGTP catabolic process Source: GO_Central
- DNA strand resection involved in replication fork processing Source: Ensembl
- double-strand break repair via homologous recombination Source: Ensembl
- negative regulation of type I interferon-mediated signaling pathway Source: Ensembl
- protein homotetramerization Source: Ensembl
- regulation of innate immune response Source: GO_Central
- somatic hypermutation of immunoglobulin genes Source: Ensembl
Keywordsi
Molecular function | Allosteric enzymeARBA annotation |
Biological process | Antiviral defenseARBA annotation, DNA damage, DNA repairARBA annotation, DNA replicationARBA annotation |
Ligand | GTP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1ARBA annotation |
Gene namesi | Name:SAMHD1Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Other locations
- Chromosome ARBA annotation
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: GO_Central
Plasma Membrane
- tetraspanin-enriched microdomain Source: Ensembl
Other locations
- site of double-strand break Source: Ensembl
Keywords - Cellular componenti
ChromosomeARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000007007, Expressed in lung and 14 other tissues |
Interactioni
GO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000006927 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 87 – 152 | SAMInterPro annotationAdd BLAST | 66 | |
Domaini | 206 – 358 | HDInterPro annotationAdd BLAST | 153 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 41 – 83 | DisorderedSequence analysisAdd BLAST | 43 |
Sequence similaritiesi
Belongs to the SAMHD1 family.ARBA annotation
Phylogenomic databases
eggNOGi | KOG2681, Eukaryota |
GeneTreei | ENSGT00390000013867 |
HOGENOMi | CLU_026821_1_2_1 |
InParanoidi | G1KG42 |
OrthoDBi | 835545at2759 |
TreeFami | TF316113 |
Family and domain databases
CDDi | cd00077, HDc, 1 hit |
Gene3Di | 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR003607, HD/PDEase_dom IPR006674, HD_domain IPR001660, SAM IPR013761, SAM/pointed_sf |
Pfami | View protein in Pfam PF01966, HD, 1 hit PF07647, SAM_2, 1 hit |
SMARTi | View protein in SMART SM00471, HDc, 1 hit SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS51831, HD, 1 hit PS50105, SAM_DOMAIN, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KG42-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPFPAGCPLA RGWPASVALE SPAWKVVARW LRCIPARAAM DHRHERDGAP
60 70 80 90 100
KRACPSSPTD DQDLRTPEKR VSAVPDGLPS PQHPREWDSA QLCAFLHARG
110 120 130 140 150
LGDAEELSRL RENDITGSCL LHLTESHLEK IGFRKMGMRR KILDCLHKLA
160 170 180 190 200
QSHADKMKVF NDPVHGHIEM HPLLVKIIDT PQFQRLRYIK QLGGTYYVFP
210 220 230 240 250
GASHNRFEHS LGVSHLAGCL VRALQERQPE LDINHRDILC VQIAGLCHDL
260 270 280 290 300
GHGPFSHMFD GRFIPRARPG FPWKHEDASV QMFEHMIASN NLRPEMESYG
310 320 330 340 350
LKLNKDIPFI KEQIAGPIES KKDDSSWSYQ GRTEEKSFLY EIVANKRSGI
360 370 380 390 400
DVDKWDYFAR DCHHLGIQNN FDYQRFIKFA RVCKVENKKH ICTRDKEVGN
410 420 430 440 450
LYDMFHTRNC LHRRAYQHKV GNIIETMITE AFLNADPYIS IRGSDGKEYK
460 470 480 490 500
ISTAMEDMEA YTKLTDDIFL SILHSDRPEL EAARDILCKI ERRDLYKFLG
510 520 530 540 550
QTQPPEGMEI KKELWDSLPS EIVKAKPIIT ELTPVELKAE DFIVDVINMD
560 570 580 590 600
YGMKEKNPIN NVRFYCKFDI TKAIPISKEQ VSQLLPEKFA EQLIRVYCKK
610 620 630 640 650
TDEDIIYVAK KHFYQWCIEK DFSKPQDVDV VAPEMTPLKK DWALNEDCAK
660
HGSMGTSSPS KFRQKLFK
Sequence databases
RefSeqi | XP_003220590.2, XM_003220542.3 |
Genome annotation databases
Ensembli | ENSACAT00000007078; ENSACAP00000006927; ENSACAG00000007007 |
GeneIDi | 100560254 |
KEGGi | acs:100560254 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_003220590.2, XM_003220542.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000006927 |
Genome annotation databases
Ensembli | ENSACAT00000007078; ENSACAP00000006927; ENSACAG00000007007 |
GeneIDi | 100560254 |
KEGGi | acs:100560254 |
Organism-specific databases
CTDi | 25939 |
Phylogenomic databases
eggNOGi | KOG2681, Eukaryota |
GeneTreei | ENSGT00390000013867 |
HOGENOMi | CLU_026821_1_2_1 |
InParanoidi | G1KG42 |
OrthoDBi | 835545at2759 |
TreeFami | TF316113 |
Gene expression databases
Bgeei | ENSACAG00000007007, Expressed in lung and 14 other tissues |
Family and domain databases
CDDi | cd00077, HDc, 1 hit |
Gene3Di | 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR003607, HD/PDEase_dom IPR006674, HD_domain IPR001660, SAM IPR013761, SAM/pointed_sf |
Pfami | View protein in Pfam PF01966, HD, 1 hit PF07647, SAM_2, 1 hit |
SMARTi | View protein in SMART SM00471, HDc, 1 hit SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS51831, HD, 1 hit PS50105, SAM_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KG42_ANOCA | |
Accessioni | G1KG42Primary (citable) accession number: G1KG42 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 63 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |