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UniProtKB - G1KFQ6 (G1KFQ6_ANOCA)

Entry version 70 (10 Feb 2021)
Sequence version 2 (26 Jun 2013)
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Protein

Neuropilin

Gene

NRP1

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi193CalciumUniRule annotation1
Metal bindingi207CalciumUniRule annotation1
Metal bindingi248CalciumUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental proteinUniRule annotation, Heparin-bindingARBA annotation, ReceptorUniRule annotation
Biological processAngiogenesisARBA annotation, DifferentiationUniRule annotationARBA annotation, NeurogenesisUniRule annotationARBA annotation
LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NeuropilinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei846 – 871HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500341275520 – 912NeuropilinSequence analysisAdd BLAST893

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi25 ↔ 52UniRule annotation
Disulfide bondi80 ↔ 102UniRule annotation
Disulfide bondi145 ↔ 171UniRule annotation
Disulfide bondi204 ↔ 226UniRule annotation
Disulfide bondi273 ↔ 423UniRule annotation
Disulfide bondi430 ↔ 583UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationARBA annotation, Glycoprotein, Heparan sulfateARBA annotation, Proteoglycan

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSACAG00000006518, Expressed in embryonic post-anal tail and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		28377.ENSACAP00000006623

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 139CUBInterPro annotationAdd BLAST115
Domaini145 – 263CUBInterPro annotationAdd BLAST119
Domaini273 – 423F5/8 type CInterPro annotationAdd BLAST151
Domaini430 – 583F5/8 type CInterPro annotationAdd BLAST154
Domaini641 – 803MAMInterPro annotationAdd BLAST163

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the neuropilin family.UniRule annotationARBA annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QUEH, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157169

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015228_6_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		G1KFQ6

Database of Orthologous Groups

More...OrthoDBi		124611at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd00041, CUB, 2 hits
cd00057, FA58C, 2 hits
cd06263, MAM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.260, 2 hits
2.60.120.290, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000859, CUB_dom
IPR000421, FA58C
IPR008979, Galactose-bd-like_sf
IPR000998, MAM_dom
IPR014648, Neuropilin
IPR022579, Neuropilin_C
IPR027146, NRP1
IPR035914, Sperma_CUB_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR46806:SF4, PTHR46806:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00431, CUB, 2 hits
PF11980, DUF3481, 1 hit
PF00754, F5_F8_type_C, 2 hits
PF00629, MAM, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF036960, Neuropilin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00020, MAMDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00042, CUB, 2 hits
SM00231, FA58C, 2 hits
SM00137, MAM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49785, SSF49785, 2 hits
SSF49854, SSF49854, 2 hits
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01180, CUB, 2 hits
PS01285, FA58C_1, 2 hits
PS01286, FA58C_2, 2 hits
PS50022, FA58C_3, 2 hits
PS00740, MAM_1, 1 hit
PS50060, MAM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KFQ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDWGLFLNYV ALTASLGRAL KSDKCGENIK IIEPGYLTSP GYPNTYHPSQ 
        60         70         80         90        100
KCEWLIQAPQ PYQRIMINFN PHFDLEDREC KYDYVEVIDG DNANGRVWGK 
       110        120        130        140        150
FCGKIAPPPV ISTGPHLLIK FVSDYETHGA GFSIRYEIFK RGPECSRNFT 
       160        170        180        190        200
SMSGVIRSPG FPEKYPNSLE CTYIVFAPKM SEIILEFESF ELEPDSNPPG 
       210        220        230        240        250
GVFCRYDRLE IWDGFPEVGP HIGRYCGQNT PGRIRSSTGI LSMVFYTDSA 
       260        270        280        290        300
IAKEGFSANY TALQNSVSED FQCAEPLGME SGEIHSDQIS ASSQYSTNWS 
       310        320        330        340        350
SERSRLNYPE NGWTPGEDSS REWIQVDLGL LRFVSAIGTQ GAISKETKKK 
       360        370        380        390        400
YFLKTYRVDI SSNGEDWISV KDGNNKPLVF IGNINPTDVA YRPFPKPVLT 
       410        420        430        440        450
RFVRIKPASW ETGISLRFEV YGCKITDYPC SGMLGMVSGL ITDSQITASN 
       460        470        480        490        500
EFERNWSPEN VRLITSRVGW ALPPPATHSY SKEWLQIDLG EEKIVRGIIV 
       510        520        530        540        550
QGGKHRENKV FMRKFKLGYS YNGSDWKWIM DASKKKAKVF EGNTNYDTPE 
       560        570        580        590        600
LRTFEPITTR FIRVYPERAT HGGLGLRMEL LGCEIEVPTS VPTTADSNLV 
       610        620        630        640        650
DECDDDQANC HSGTGSTTAM ITERSTAIDT TVQPELPAYG FNCGFGYSSQ 
       660        670        680        690        700
KTICRWEHDG QLDLRWAVLT SKTGPIQDHT GDGNFIYSQA DENQKGKVAR 
       710        720        730        740        750
LISPIINPQN SALCMTFWYH MSGHHVGTLR IKLRYQTPKE YDQVLWTLSG 
       760        770        780        790        800
NQGNFWKEGR VFLHKSAKHY QVMVEGEIGK GTGGIAVDDI NFDGHITQEE 
       810        820        830        840        850
CRRNEIVEVE PDINQTGFTP DYHGNGEPYD DISRKPGNVL KTLDPILITI 
       860        870        880        890        900
IAMSSLGVLL GAICGVILYC ACWHNGMSDR NLSALENYNF ELVDGVKLKK 
       910 
DKLNAQNTYS EA
Length:912
Mass (Da):102,415
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i14F5F17F5E73C292
GO

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_003222034.1, XM_003221986.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSACAT00000006769; ENSACAP00000006623; ENSACAG00000006518

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100552005

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		acs:100552005

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_003222034.1, XM_003221986.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000006623

Genome annotation databases

EnsembliENSACAT00000006769; ENSACAP00000006623; ENSACAG00000006518
GeneIDi100552005
KEGGiacs:100552005

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8829

Phylogenomic databases

eggNOGiENOG502QUEH, Eukaryota
GeneTreeiENSGT00940000157169
HOGENOMiCLU_015228_6_1_1
InParanoidiG1KFQ6
OrthoDBi124611at2759

Gene expression databases

BgeeiENSACAG00000006518, Expressed in embryonic post-anal tail and 14 other tissues

Family and domain databases

CDDicd00041, CUB, 2 hits
cd00057, FA58C, 2 hits
cd06263, MAM, 1 hit
Gene3Di2.60.120.260, 2 hits
2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000859, CUB_dom
IPR000421, FA58C
IPR008979, Galactose-bd-like_sf
IPR000998, MAM_dom
IPR014648, Neuropilin
IPR022579, Neuropilin_C
IPR027146, NRP1
IPR035914, Sperma_CUB_dom_sf
PANTHERiPTHR46806:SF4, PTHR46806:SF4, 1 hit
PfamiView protein in Pfam
PF00431, CUB, 2 hits
PF11980, DUF3481, 1 hit
PF00754, F5_F8_type_C, 2 hits
PF00629, MAM, 1 hit
PIRSFiPIRSF036960, Neuropilin, 1 hit
PRINTSiPR00020, MAMDOMAIN
SMARTiView protein in SMART
SM00042, CUB, 2 hits
SM00231, FA58C, 2 hits
SM00137, MAM, 1 hit
SUPFAMiSSF49785, SSF49785, 2 hits
SSF49854, SSF49854, 2 hits
SSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01180, CUB, 2 hits
PS01285, FA58C_1, 2 hits
PS01286, FA58C_2, 2 hits
PS50022, FA58C_3, 2 hits
PS00740, MAM_1, 1 hit
PS50060, MAM_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KFQ6_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KFQ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: February 10, 2021
This is version 70 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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