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Entry version 52 (12 Aug 2020)
Sequence version 1 (19 Oct 2011)
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Protein
Submitted name:

Pericentriolar material 1

Gene

PCM1

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Pericentriolar material 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCM1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000006685, Expressed in forelimb bud and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000006610

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1363 – 1979PCM1_CInterPro annotationAdd BLAST617

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 91DisorderedSequence analysisAdd BLAST91
Regioni111 – 141DisorderedSequence analysisAdd BLAST31
Regioni150 – 169DisorderedSequence analysisAdd BLAST20
Regioni527 – 557DisorderedSequence analysisAdd BLAST31
Regioni615 – 644DisorderedSequence analysisAdd BLAST30
Regioni841 – 897DisorderedSequence analysisAdd BLAST57
Regioni905 – 924DisorderedSequence analysisAdd BLAST20
Regioni1076 – 1102DisorderedSequence analysisAdd BLAST27
Regioni1156 – 1199DisorderedSequence analysisAdd BLAST44
Regioni1226 – 1338DisorderedSequence analysisAdd BLAST113
Regioni1425 – 1460DisorderedSequence analysisAdd BLAST36
Regioni1525 – 1565DisorderedSequence analysisAdd BLAST41
Regioni1706 – 1771DisorderedSequence analysisAdd BLAST66
Regioni1799 – 1830DisorderedSequence analysisAdd BLAST32
Regioni1888 – 1944DisorderedSequence analysisAdd BLAST57
Regioni1984 – 2007DisorderedSequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili267 – 294Sequence analysisAdd BLAST28
Coiled coili480 – 517Sequence analysisAdd BLAST38
Coiled coili655 – 682Sequence analysisAdd BLAST28
Coiled coili724 – 768Sequence analysisAdd BLAST45
Coiled coili980 – 1007Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi23 – 41PolarSequence analysisAdd BLAST19
Compositional biasi853 – 884PolarSequence analysisAdd BLAST32
Compositional biasi1255 – 1283PolarSequence analysisAdd BLAST29
Compositional biasi1297 – 1317PolarSequence analysisAdd BLAST21
Compositional biasi1318 – 1338PolyampholyteSequence analysisAdd BLAST21
Compositional biasi1441 – 1458PolarSequence analysisAdd BLAST18
Compositional biasi1530 – 1550PolarSequence analysisAdd BLAST21
Compositional biasi1801 – 1830PolarSequence analysisAdd BLAST30
Compositional biasi1899 – 1938PolarSequence analysisAdd BLAST40

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QRMF, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006641

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002145_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KFP9

Identification of Orthologs from Complete Genome Data

More...
OMAi
EHMEEVC

TreeFam database of animal gene trees

More...
TreeFami
TF328740

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031446, PCM1_C
IPR024138, Pericentriolar_Pcm1

The PANTHER Classification System

More...
PANTHERi
PTHR14164, PTHR14164, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15717, PCM1_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KFP9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGGGPFEE GMDDHDLPNW SNESLDDRLN NTSWGGQPKR PNKSSEKNKK
60 70 80 90 100
KVSSESETRL TNDISPESTP GVGRRKSKTP HSFPHTRYMT QMSVPEQAEL
110 120 130 140 150
EKLKQRINFS DLDQRSIGSD SQGRATAANN KRQLNENKKP FNFLSLQINT
160 170 180 190 200
NKGKDGATSS QTHETSGSSQ YKDLITAALS KDLLQNCPVS IEEDGRGEPA
210 220 230 240 250
VDSSQIVSRL VQIRDYIAKA SSMRDDLVEK NERSANVERL SHLINHLKDQ
260 270 280 290 300
EKSYLKFLQK ILARDPQQEA TEELVNLKKQ HDLLKRMLQQ QEQLKALQGR
310 320 330 340 350
QAALLALQHK AEQAIAVMDD SVTQATLHPT PPAMTISSEI AYIILEVLLL
360 370 380 390 400
KYENFSLKCI PTNLARSQTR IELFLSCIFF NFPAAASAFI DAPVVVPTKM
410 420 430 440 450
EIKLLEGFKR YKTSIQWYQI QKHYINKMLP GSGSPQRSVD QRSATSVASA
460 470 480 490 500
PVGITAGVNE EPNSLASSVV YHPDSVTSQN ESEEDDNLNA TEKLQKLNEV
510 520 530 540 550
RKRLNELREL VHYYEQTSDM MTDAVNENTK GEEETEDSEC DSDLENPQPV
560 570 580 590 600
TNIRNPQGIS NWSEINCNSN LQCGTNNRSG SHLNTACEIN NRSANIRMLN
610 620 630 640 650
MPSTVDCHYN REDDSIEIPQ GEDDDIGPEA DRASEASLSS RRSSIVDEAP
660 670 680 690 700
VDAEFEQKIN RLIAAKQKLR QLQNLVAMVQ DDEGAPESAG RDNVDQYYLA
710 720 730 740 750
EEEKEQQQPN NVLTSANKSE KAVVLNEKAR EKFYEAKLQQ QQRELKHLQE
760 770 780 790 800
ERKKLIKIQE KIQVLQKACP DLQLSSSLDN CPGNTSAPTA NEINVGNKAV
810 820 830 840 850
DQPEEKAMVD SELWSEMRRH ELLREELRQR RKQLEALMAE HQRRRDLADT
860 870 880 890 900
TSAGAASVKS DGSETQCTPQ QSRTEKTMAT WGGSTQCALD EDEGDEDAYL
910 920 930 940 950
SDGLAQAEEE EEEEQDSSSN ELSICSNNVD QSSYCAKEDI QSWKNPRPLS
960 970 980 990 1000
ADGNYRPLAK AKQQQNISMR RQENHRWMSE LSYVEEKEQW QEQINQLKKQ
1010 1020 1030 1040 1050
LEFSVSICQT LMQDQQNLSC LLQTLLTGPY SVMPSNVASP QVHLIMHQLN
1060 1070 1080 1090 1100
QCYSQLTWQQ NNVQRLKQML NDLMHHQEQQ QAKTAKKKKS SSAPPPPSPT
1110 1120 1130 1140 1150
VFCPFSFPSQ TMNLFNMPGF TNFSSFPPGI NFSPMFPPGL GDFSQNCTAQ
1160 1170 1180 1190 1200
NNEQQPLEHN TTGKTDYMAF PKPFESSSTP GAEKPRGQRQ SEEELESRSA
1210 1220 1230 1240 1250
WLNEHQGGGK EKPLFLKTGF AVPVQNTACG SQKGQPDTGR RREFDEESLE
1260 1270 1280 1290 1300
SYSSMPDPVD PTTVTKTFKP RKASAQASLA SKDKTPKSKS KRSTSQFKNR
1310 1320 1330 1340 1350
PRTNGFESAS ASSTCEPYKR NRSRHSTRKE EATQAKVFSK KNREQLEKII
1360 1370 1380 1390 1400
KYSRSSEMSS ETGSDLSMFE ALRDTIYSEV ATLISQNESR PHFLIELFHE
1410 1420 1430 1440 1450
LQMLNTDYLR QRALYALQDI VTRHASDDNE KGECPKPLSS AAWAGSNSEL
1460 1470 1480 1490 1500
TPSESLATTD DETFEKNFDQ GACRECEKND ADNGSTMSIS SNFEPFATDD
1510 1520 1530 1540 1550
LGNTVIHLDQ ALARMREYER MKMAAESNLD SEDGCSNVRS VSSSKPEDVV
1560 1570 1580 1590 1600
ESHSAAQPTE VPAVPCPRID TQQLDRQIKA IMKEVIPFLK EHMDEVCSTQ
1610 1620 1630 1640 1650
LLTSVRRMVL TLTQQNDESK EFVKIFHKQL GSILQDSLAK FAGKKLKDCG
1660 1670 1680 1690 1700
EDLLVEISEV LFNELAFFKL MQDLDNNSLT VKQRCKRKVE ADGTMQSYAK
1710 1720 1730 1740 1750
EAKRTLEGGA CSSTEDIDED KDKDETETLK QVHESAIFNN REVPRTIRSD
1760 1770 1780 1790 1800
ASDQEEEENE SCPVSISLSK AETQALTNYG SGEDENEDEE IDEFEEGPVD
1810 1820 1830 1840 1850
VQTSLQANNE TTAENEQEQI SQPKSENSDD CITVLSEQES VAKGDLDSTV
1860 1870 1880 1890 1900
VVPQYLNIIE DTQAIPVNAA EDLNPSTVVT EEQDVTLAEN ESHALVTVHE
1910 1920 1930 1940 1950
EPKSSSGTPE SSVVDSPDTE SPVLVNEYET GSGNNSQKSD EDDFVKVEDV
1960 1970 1980 1990 2000
SLKLAVYSEE ELMKTIVEEA QTNSITSEIL ASTENHEDLV GDPQILKEPE

TLGAQSA
Length:2,007
Mass (Da):224,758
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD72398B18D42424C
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000006756; ENSACAP00000006610; ENSACAG00000006685

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000006610

Genome annotation databases

EnsembliENSACAT00000006756; ENSACAP00000006610; ENSACAG00000006685

Phylogenomic databases

eggNOGiENOG502QRMF, Eukaryota
GeneTreeiENSGT00390000006641
HOGENOMiCLU_002145_0_0_1
InParanoidiG1KFP9
OMAiEHMEEVC
TreeFamiTF328740

Gene expression databases

BgeeiENSACAG00000006685, Expressed in forelimb bud and 14 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR031446, PCM1_C
IPR024138, Pericentriolar_Pcm1
PANTHERiPTHR14164, PTHR14164, 1 hit
PfamiView protein in Pfam
PF15717, PCM1_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KFP9_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KFP9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: August 12, 2020
This is version 52 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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