Uncharacterized protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cyclin binding Source: Ensembl
• MDM2/MDM4 family protein binding Source: Ensembl
• mitogen-activated protein kinase binding Source: Ensembl
• NF-kappaB binding Source: Ensembl
• ubiquitin-like protein ligase binding Source: Ensembl

GO - Biological processⁱ

• apoptotic nuclear changes Source: Ensembl
• cell population proliferation Source: Ensembl
• definitive erythrocyte differentiation Source: Ensembl
• endoplasmic reticulum unfolded protein response Source: Ensembl
• liver development Source: Ensembl
• mitotic G2 DNA damage checkpoint Source: Ensembl
• negative regulation of cellular protein catabolic process Source: Ensembl
• negative regulation of MAP kinase activity Source: Ensembl
• negative regulation of NF-kappaB transcription factor activity Source: Ensembl
• negative regulation of protein kinase activity by regulation of protein phosphorylation Source: Ensembl
• positive regulation of protein localization to nucleus Source: Ensembl
• positive regulation of protein ubiquitination Source: Ensembl
• positive regulation of signal transduction by p53 class mediator Source: Ensembl
• positive regulation of transcription by RNA polymerase II Source: Ensembl
• protein ufmylation Source: Ensembl
• regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of mitotic cell cycle Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of phosphatase activity Source: Ensembl

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• cyclin binding Source: Ensembl
• MDM2/MDM4 family protein binding Source: Ensembl
• mitogen-activated protein kinase binding Source: Ensembl
• NF-kappaB binding Source: Ensembl
• ubiquitin-like protein ligase binding Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Coiled coil

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MQDYQNLPID IQTSKLLDWL VDRRHCNLKW QGQVRTVREK IAAAIQDMPE 
        60         70         80         90        100
NEEIKQLLSG SYIHYFHCLR IVEILRGTEA STKNIFGRYS SQRMKDWQEI 
       110        120        130        140        150
VSLYEKDNTY LVELASLLVR NVNYEIPSLK KQISKCQQLQ QEYSRKEEEC 
       160        170        180        190        200
QLAATEMRER FYTSCKQYGI MGDNVHRELV ALVKDLPSQL NEIGTGASGL 
       210        220        230        240        250
SEAIDLYQAC VQFVCDNSTE QVVPLLRHMQ VRGNTTIFEW RRGVKPTSVE 
       260        270        280        290        300
RPKTEEVKEE TEDEAAIDWG DFGAEPPSAS VTDDYGISVE GTSDDIDWGI 
       310        320        330        340        350
SLESETQESS AAGIDWGDQT EEAAAQIVVM EASSDAPEGI AKGPDALTIL 
       360        370        380        390        400
ETPDTRNQFI DELMELEIFL SQRIVETSEE ADILAVSQFQ QAPPILQDQT 
       410        420        430        440        450
KEKLEAMVAT IQHLLGQLTS LKMQHLFMIL ASPRYVDRVT ELLHQKLKQA 
       460        470        480        490        500
DLLLLKKDLM IKKRQEALEE QASLEPKLDI LVQKTRELQK LIEADISKRY 
       510 
TGRPVNLMGA SL                                          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ