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Entry version 63 (29 Sep 2021)
Sequence version 3 (29 Sep 2021)
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Protein
Submitted name:

CASK interacting protein 2

Gene

CASKIN2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CASK interacting protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CASKIN2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000006671, Expressed in hemipenis and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000006549

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

ANK repeatPROSITE-ProRule annotationARBA annotation, Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0507, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158256

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003619_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KFM2

Identification of Orthologs from Complete Genome Data

More...
OMAi
QHLPDEC

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09497, SAM_caskin1_2_repeat1, 1 hit
cd09498, SAM_caskin1_2_repeat2, 1 hit
cd12063, SH3_Caskin2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 2 hits
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR027013, Caskin-1/2
IPR032232, Caskin1-CID
IPR035497, Caskin1/2_SAM_1
IPR035498, Caskin1/2_SAM_2
IPR035499, Caskin2_SH3
IPR032117, Caskin_C
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR24174:SF7, PTHR24174:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 2 hits
PF16632, Caskin-tail, 1 hit
PF16600, Caskin1-CID, 1 hit
PF00536, SAM_1, 2 hits
PF07653, SH3_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 6 hits
SM00454, SAM, 2 hits
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769, SSF47769, 2 hits
SSF48403, SSF48403, 1 hit
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50088, ANK_REPEAT, 5 hits
PS50105, SAM_DOMAIN, 2 hits
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

G1KFM2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMGREQELIQ AVKNGDISGV QKLVAKIKAS KSKLLGSTKR LNVNYQDVDG
60 70 80 90 100
FSALHHAALV GSLDLISLLL EAQATVDIKD VNGMRPLHYA AWQGKVEPVR
110 120 130 140 150
LLLRAAASVN MASLDGQIPL HLSAQYGHYE VSEMLLQHQS NPCLINKAKK
160 170 180 190 200
TPLDLACEFG RLKVAQLLLN SHMCVALLEG QSKDTSDPNY TTPLHLAAKN
210 220 230 240 250
GHKEIIRQLL KAGIEINKQT KTGTALHEAA LYGKTEVVRL LLQGGIDVNI
260 270 280 290 300
RNTYNQTALD IVNQFTTSHA SKDIKQLLRE ASGILKVRAL KDFWNLHDPT
310 320 330 340 350
ALNIRAGDVI TVLEQHADGR WKGHIHDSQK GTDRVGYFPP SIVEVISKRT
360 370 380 390 400
AGDRNSVGSE GSIGSIRSAG SGQSTEGTNG QVTGLLIENV KPLSPSGEDL
410 420 430 440 450
QQRLLSSNSH NGQTDPMIGT LAHLSNCNTS DMIFSHQYLR PEQLLEGKDA
460 470 480 490 500
EAIYNWLCEF QLEGYTSNFL SAGYDVPTIS RMTPEDLTAI GVTKPGHRKK
510 520 530 540 550
ISTEIGQLSI AEWLPNYIPD DLMEWLSAIG LPQYHKKLVS NGYDSINIVT
560 570 580 590 600
DLTWEDLQEI GINKLGHQKK IMLAVKKLTD LRKSVSQADT STLRRKIPGA
610 620 630 640 650
LDIVTIESVE NGECHSPNTP KMTTFQDSEL SYELQTAMSN SCQETLTIKS
660 670 680 690 700
AQGMSRSQES IGVRSRGSGH SQENMLSQSI TSSRSQESLG SGESSSGSSG
710 720 730 740 750
GHSSSTQVRL GENGAVPQGQ PGPDSYGKSI SQLSGSDGVN SYANGGGGSP
760 770 780 790 800
LRERNLPEGM DQYQRPNATP SDPASPGPIP SPCTSPHTAS KGTAPYVFMY
810 820 830 840 850
PHVSLKSQPP PSPSVPEPGN SAHFSAQRSL LQSTAQKAFS YIHSHCGPTE
860 870 880 890 900
PPLPRVSPKP GMDQQNSEGS KHKKRSHSLN RYALSDGETE EEEPPSNTVG
910 920 930 940 950
SYATLTRRPG RSQVPRAQQM PADGKVSRSQ SFAIRARKKG PPPPPPKRLS
960 970 980 990 1000
SVSSAQAVDA EYEQVLSSSS SQDGGENSHE RSCPVRTIVV DGPGADRSPT
1010 1020 1030 1040 1050
KPLHSSKLSL ELTSGAAQGE PNTIDSTNDR SQVFESNIPR RRTFSEPAVT
1060 1070 1080 1090 1100
MTEALRQSQE DVRSDTEEEG QSKGENSTKS PCSSQNSSSE CIPFAEEGNL
1110 1120 1130 1140 1150
TIKQRPKPVG QLKTDSPAPD STSTPPQPSG EEQQGTPTKE SSLLEFNLTE
1160 1170 1180 1190 1200
SDTVKRRPRC KEREPLQNVL KAFGMAAPNP APPASAPQYA QAQTVSISGP
1210 1220 1230 1240 1250
SLRGAESPQS PSGDTLSDEN VEFQIAEIEK SILSLERGIK KPPISLKPAS
1260 1270 1280 1290 1300
PAPVQMERPG GMVQLRTPAT VNDVSAKHVA STKLVFSGPK TIYQQVLQNS
1310 1320 1330 1340 1350
RTTVAPWAAT EMASEVTGPY PMKLGLSNKS NMNFGVPLSM MSLSGSPDMI
1360 1370 1380 1390 1400
QAQQRLEQTN SSLASTLEAA EKKISAEKSD SSRYGTAHTA KNILEDISNM
1410
FDDLAEQLDA MLD
Length:1,413
Mass (Da):152,511
Last modified:September 29, 2021 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06D19DD6F693EB5E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A803SRQ4A0A803SRQ4_ANOCA
CASK interacting protein 2
CASKIN2
1,458Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A803TDE5A0A803TDE5_ANOCA
CASK interacting protein 2
CASKIN2
1,481Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000006694; ENSACAP00000006549; ENSACAG00000006671

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000006549

Genome annotation databases

EnsembliENSACAT00000006694; ENSACAP00000006549; ENSACAG00000006671

Phylogenomic databases

eggNOGiKOG0507, Eukaryota
GeneTreeiENSGT00940000158256
HOGENOMiCLU_003619_1_1_1
InParanoidiG1KFM2
OMAiQHLPDEC

Gene expression databases

BgeeiENSACAG00000006671, Expressed in hemipenis and 14 other tissues

Family and domain databases

CDDicd09497, SAM_caskin1_2_repeat1, 1 hit
cd09498, SAM_caskin1_2_repeat2, 1 hit
cd12063, SH3_Caskin2, 1 hit
Gene3Di1.10.150.50, 2 hits
1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR027013, Caskin-1/2
IPR032232, Caskin1-CID
IPR035497, Caskin1/2_SAM_1
IPR035498, Caskin1/2_SAM_2
IPR035499, Caskin2_SH3
IPR032117, Caskin_C
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR24174:SF7, PTHR24174:SF7, 1 hit
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
PF16632, Caskin-tail, 1 hit
PF16600, Caskin1-CID, 1 hit
PF00536, SAM_1, 2 hits
PF07653, SH3_2, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SM00454, SAM, 2 hits
SM00326, SH3, 1 hit
SUPFAMiSSF47769, SSF47769, 2 hits
SSF48403, SSF48403, 1 hit
SSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50088, ANK_REPEAT, 5 hits
PS50105, SAM_DOMAIN, 2 hits
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KFM2_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KFM2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: September 29, 2021
Last modified: September 29, 2021
This is version 63 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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