UniProtKB - G1KFI5 (G1KFI5_ANOCA)
Protein
Caveolin
Gene
CAV2
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.UniRule annotation
GO - Molecular functioni
- molecular adaptor activity Source: GO_Central
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: Ensembl
- protein kinase binding Source: GO_Central
- protein-macromolecule adaptor activity Source: Ensembl
- scaffold protein binding Source: Ensembl
GO - Biological processi
- basement membrane organization Source: Ensembl
- caveola assembly Source: GO_Central
- cell differentiation Source: GO_Central
- endoplasmic reticulum organization Source: Ensembl
- insulin receptor signaling pathway Source: GO_Central
- mitochondrion organization Source: Ensembl
- negative regulation of endothelial cell proliferation Source: GO_Central
- negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
- positive regulation by host of viral release from host cell Source: Ensembl
- positive regulation of dopamine receptor signaling pathway Source: Ensembl
- positive regulation of endothelial cell proliferation Source: Ensembl
- positive regulation of GTPase activity Source: Ensembl
- positive regulation of MAPK cascade Source: GO_Central
- receptor-mediated endocytosis of virus by host cell Source: Ensembl
- regulation of cytosolic calcium ion concentration Source: GO_Central
- regulation of mitotic nuclear division Source: Ensembl
- skeletal muscle fiber development Source: Ensembl
- vesicle docking Source: Ensembl
- vesicle fusion Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: CaveolinUniRule annotation |
Gene namesi | Name:CAV2Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane UniRule annotationARBA annotation; Peripheral membrane protein UniRule annotationARBA annotation
Golgi apparatus
- Golgi apparatus membrane UniRule annotation; Peripheral membrane protein UniRule annotation
Other locations
- caveola UniRule annotationARBA annotation; Peripheral membrane protein UniRule annotationARBA annotation
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation
Golgi apparatus
- Golgi apparatus Source: GO_Central
- Golgi membrane Source: UniProtKB-SubCell
Plasma Membrane
- caveolar macromolecular signaling complex Source: Ensembl
- extrinsic component of cytoplasmic side of plasma membrane Source: Ensembl
- integral component of plasma membrane Source: GO_Central
Other locations
- acrosomal membrane Source: Ensembl
- cytoplasmic vesicle Source: GO_Central
- focal adhesion Source: Ensembl
- perinuclear region of cytoplasm Source: GO_Central
- transport vesicle Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 83 – 106 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 112 – 133 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Cell membraneUniRule annotation, Golgi apparatusUniRule annotationARBA annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSACAG00000006587, Expressed in lung and 12 other tissues |
Interactioni
GO - Molecular functioni
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: Ensembl
- protein kinase binding Source: GO_Central
- scaffold protein binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000006449 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 45 | DisorderedSequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 25 | PolyampholyteSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | ENOG502RZYX, Eukaryota |
GeneTreei | ENSGT00950000183006 |
HOGENOMi | CLU_102582_2_0_1 |
InParanoidi | G1KFI5 |
OrthoDBi | 1468974at2759 |
TreeFami | TF315736 |
Family and domain databases
InterProi | View protein in InterPro IPR033306, CAV-2 IPR001612, Caveolin IPR018361, Caveolin_CS |
PANTHERi | PTHR10844, PTHR10844, 1 hit PTHR10844:SF3, PTHR10844:SF3, 1 hit |
Pfami | View protein in Pfam PF01146, Caveolin, 1 hit |
PROSITEi | View protein in PROSITE PS01210, CAVEOLIN, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KFI5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLEKEKADT KIFMDEDDFH RSGSPALSES EKNSEKAPDR DPRGLNTHLK
60 70 80 90 100
LGFEDVIAEP ASTHSFDRIW ICSHALFELS KYLVYKVLTL VLAVPLALVA
110 120 130 140 150
GLLFALLSCL HIWFVVPFIK SCLMVLPSIQ AVWKSMTDLL VAPVCRSIGK
160
CFSGIKIRLD QE
Sequence databases
RefSeqi | XP_003221260.1, XM_003221212.3 |
Genome annotation databases
Ensembli | ENSACAT00000006594; ENSACAP00000006449; ENSACAG00000006587 |
GeneIDi | 100560849 |
KEGGi | acs:100560849 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_003221260.1, XM_003221212.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000006449 |
Genome annotation databases
Ensembli | ENSACAT00000006594; ENSACAP00000006449; ENSACAG00000006587 |
GeneIDi | 100560849 |
KEGGi | acs:100560849 |
Organism-specific databases
CTDi | 858 |
Phylogenomic databases
eggNOGi | ENOG502RZYX, Eukaryota |
GeneTreei | ENSGT00950000183006 |
HOGENOMi | CLU_102582_2_0_1 |
InParanoidi | G1KFI5 |
OrthoDBi | 1468974at2759 |
TreeFami | TF315736 |
Gene expression databases
Bgeei | ENSACAG00000006587, Expressed in lung and 12 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR033306, CAV-2 IPR001612, Caveolin IPR018361, Caveolin_CS |
PANTHERi | PTHR10844, PTHR10844, 1 hit PTHR10844:SF3, PTHR10844:SF3, 1 hit |
Pfami | View protein in Pfam PF01146, Caveolin, 1 hit |
PROSITEi | View protein in PROSITE PS01210, CAVEOLIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KFI5_ANOCA | |
Accessioni | G1KFI5Primary (citable) accession number: G1KFI5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 65 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |