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Entry version 58 (07 Oct 2020)
Sequence version 2 (26 Jun 2013)
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Protein

C2H2-type domain-containing protein

Gene

PHF20

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C2H2-type domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PHF20Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000006565, Expressed in forelimb bud and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000006412

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini443 – 473C2H2-typeInterPro annotationAdd BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni139 – 364DisorderedSequence analysisAdd BLAST226
Regioni378 – 425DisorderedSequence analysisAdd BLAST48
Regioni471 – 567DisorderedSequence analysisAdd BLAST97
Regioni581 – 609DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi153 – 263PolyampholyteSequence analysisAdd BLAST111
Compositional biasi282 – 323PolyampholyteSequence analysisAdd BLAST42
Compositional biasi345 – 359PolyampholyteSequence analysisAdd BLAST15
Compositional biasi386 – 425PolarSequence analysisAdd BLAST40
Compositional biasi474 – 508PolarSequence analysisAdd BLAST35
Compositional biasi509 – 526PolyampholyteSequence analysisAdd BLAST18
Compositional biasi527 – 542BasicSequence analysisAdd BLAST16
Compositional biasi549 – 567PolarSequence analysisAdd BLAST19
Compositional biasi586 – 604PolyampholyteSequence analysisAdd BLAST19

Keywords - Domaini

RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1844, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156477

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012707_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KFH5

KEGG Orthology (KO)

More...
KOi
K18402

Database of Orthologous Groups

More...
OrthoDBi
147824at2759

TreeFam database of animal gene trees

More...
TreeFami
TF106475

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041297, Crb2_Tudor
IPR022255, DUF3776
IPR037915, PHF20
IPR043449, PHF20-like
IPR002999, Tudor
IPR019786, Zinc_finger_PHD-type_CS
IPR013087, Znf_C2H2_type
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR15856, PTHR15856, 1 hit
PTHR15856:SF27, PTHR15856:SF27, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12618, DUF3776, 1 hit
PF18115, Tudor_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00333, TUDOR, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01359, ZF_PHD_1, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit
PS50157, ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KFH5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKHPPNRRG ISFEVGAQLE ARDRLKNWYP AHIEEIDYEE GKVLIHFKRW
60 70 80 90 100
NHRYDEWFCW DSPYLRPLEK IQLRKEGLHE EERSSGFRIN DQVLACWSDC
110 120 130 140 150
RFYPAKVTSV NKDGTYTVKF YDGVIQTVKN IHVKAFSKDQ PIVNNPRPKE
160 170 180 190 200
RGNEIPSSPE RWEKFKEQRK ATENHKKDKD EKTLKIERRS KPDKEGKLIV
210 220 230 240 250
PLEKNKVSEK TLPKDGKEDK ENISENDREF SIDSQIEKKP ENDNVKTPPD
260 270 280 290 300
NLKETKRRRG RPPVLPPAEQ GSQTLQPITL ELRRRKITKG GDLPSKRPRL
310 320 330 340 350
QKNMSQDKLK TVPDNEKDSI KKQSSHSTSS NNETLDTEVI IPLPDETEPS
360 370 380 390 400
KEPDSSLKEV TEGPLEVCVE SELKLKEELP PCSEEASQPL VNNSKAEEDS
410 420 430 440 450
IAELSSTPEL QEIPETSIPV ASASKRNDGF SASKAAIEHE PKFRCKFLDC
460 470 480 490 500
SKSFRKAKLL HYHMKYFHGI EKSPEPQQSP TTRNIQTRGS LASEKTNQDI
510 520 530 540 550
SNRRRTTSGC LSTKEKEKNK EKKVRDIAKA KAKKKKKKKK KTKSELSGSE
560 570 580 590 600
ENTEFSQDLS PPRSLISTRC SSTSRSCAHL STQLHGTDSG HRKHKEKINE
610 620 630 640 650
DDTLSESSAD SLLWSDDDCS RDIDVTTNPD EDLEDDDDSG FEIVRCICEV
660 670 680 690 700
EEENDFMIQC EECLCWQHGV CMGLLEENVP EKYTCYICQD PPGKRSSLKY
710 720 730 740 750
WYEKDWLCSG HMHGLAFLGE NYSHQNAKKI VATHQLLGDV QKVIEVLHGL
760 770 780 790 800
QLKMSILQSK EHPDLKLWCQ PWKHLDVEEK SHTMRLIHVE ENCCKEETAS
810 820 830 840 850
YRTFNGTIDK SSAIPSVEES YITSEHCYQK PRAYYPAIEQ RLVVETRNSD
860 870 880 890 900
IDESVNRIRE NGDDTIVERL GWELDREICK LENESKHNYS KIREKVTAEE
910 920 930 940 950
DSDVKLLEKD KEGVVNSQLQ WQLNLLAHVE SLQDEVTHRM DLIEKELDVL
960 970 980 990
ESWLDYTGEL EPPEPLARLP QLKHCIKQLL TDLGKVQQIA LCCST
Length:995
Mass (Da):114,674
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC18A805DB8899135
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_003220526.1, XM_003220478.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000006556; ENSACAP00000006412; ENSACAG00000006565

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100564388

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
acs:100564388

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_003220526.1, XM_003220478.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000006412

Genome annotation databases

EnsembliENSACAT00000006556; ENSACAP00000006412; ENSACAG00000006565
GeneIDi100564388
KEGGiacs:100564388

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51230

Phylogenomic databases

eggNOGiKOG1844, Eukaryota
GeneTreeiENSGT00940000156477
HOGENOMiCLU_012707_0_0_1
InParanoidiG1KFH5
KOiK18402
OrthoDBi147824at2759
TreeFamiTF106475

Gene expression databases

BgeeiENSACAG00000006565, Expressed in forelimb bud and 14 other tissues

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR041297, Crb2_Tudor
IPR022255, DUF3776
IPR037915, PHF20
IPR043449, PHF20-like
IPR002999, Tudor
IPR019786, Zinc_finger_PHD-type_CS
IPR013087, Znf_C2H2_type
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR15856, PTHR15856, 1 hit
PTHR15856:SF27, PTHR15856:SF27, 1 hit
PfamiView protein in Pfam
PF12618, DUF3776, 1 hit
PF18115, Tudor_3, 1 hit
SMARTiView protein in SMART
SM00333, TUDOR, 2 hits
SUPFAMiSSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359, ZF_PHD_1, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit
PS50157, ZINC_FINGER_C2H2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KFH5_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KFH5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: October 7, 2020
This is version 58 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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