Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - G1KF39 (G1KF39_ANOCA)

Entry version 54 (10 Feb 2021)
Sequence version 2 (26 Jun 2013)
Previous versions | rss
Add a publicationFeedback
Protein

Non-specific serine/threonine protein kinase

Gene

RPS6KC1

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseARBA annotation, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPS6KC1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSACAG00000006181, Expressed in testis and 15 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		28377.ENSACAP00000006059

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 132PXInterPro annotationAdd BLAST125
Domaini696 – 1053Protein kinaseInterPro annotationAdd BLAST358

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni200 – 220DisorderedSequence analysisAdd BLAST21
Regioni327 – 349DisorderedSequence analysisAdd BLAST23
Regioni447 – 482DisorderedSequence analysisAdd BLAST36
Regioni496 – 526DisorderedSequence analysisAdd BLAST31
Regioni755 – 776DisorderedSequence analysisAdd BLAST22
Regioni789 – 815DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi328 – 349PolarSequence analysisAdd BLAST22
Compositional biasi451 – 466PolarSequence analysisAdd BLAST16

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0603, Eukaryota
KOG2101, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155656

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014272_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		G1KF39

Database of Orthologous Groups

More...OrthoDBi		255297at2759

TreeFam database of animal gene trees

More...TreeFami		TF323964

Family and domain databases

Conserved Domains Database

More...CDDi		cd07287, PX_RPK118_like, 1 hit
cd05576, STKc_RPK118_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR007330, MIT
IPR036181, MIT_dom_sf
IPR000719, Prot_kinase_dom
IPR001683, PX_dom
IPR036871, PX_dom_sf
IPR042132, PX_S6K-delta-1
IPR035053, STK_RPK118-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04212, MIT, 1 hit
PF00069, Pkinase, 1 hit
PF00787, PX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00745, MIT, 1 hit
SM00312, PX, 1 hit
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF116846, SSF116846, 1 hit
SSF56112, SSF56112, 1 hit
SSF64268, SSF64268, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS50195, PX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KF39-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSPRDRGGE VARFYTVTEP KRHPRGYTLY KVTARIVSRK NPEDVQEIVV 
        60         70         80         90        100
WKRYSDFKKL HKELWQIHKH LFRHTELFPP FAKAIVFGRF EESVIEERRQ 
       110        120        130        140        150
CAEDLLQFSA NIPALYNSKQ LEDFFKDGEV HDGSELIGPA EPLLDSLTDS 
       160        170        180        190        200
LSICSSEARK DVGVLDDVTL SQSEYGGFSS DSDLISLTVD VDSLAELDDG 
       210        220        230        240        250
MASNQNSPSR SLGLGFTTDP PVQASAISDH EWSKPDGERE SRGLFTGSLK 
       260        270        280        290        300
ARLGRRDYLD KAGELIKLAL KKEEEEDYEA AYSFYRKGVD LLLEGVQGES 
       310        320        330        340        350
SPTRREAVKR KTSEYLMRAE KISSLYCRPS SEDGSTSGPP GSLSSRPSWN 
       360        370        380        390        400
LRSPAEELKA FRVLGVIDKV LLVMDTRTQQ TFILKGLRKS SEYSRKRKTI 
       410        420        430        440        450
IPRCVPNMVA LHKYIISEES VFLVLHHAEG GKLWSYISKF LNRSPEESFE 
       460        470        480        490        500
VPPSRRSSST KIHLHQATPS PEDGRVSMDS RGSIDGSMLK VLPLKTSLSP 
       510        520        530        540        550
SSHDGSSNHE DGQESSPRWI DSGSSSEEEC TTSYLTLCNE YGQEKVDPGS 
       560        570        580        590        600
LNEESVMKAG DGIPKEPEGN QAHGVVVSGN LGSAFTSQEV NIFADDADPE 
       610        620        630        640        650
RASPTRISES LSKSKNSPME LFRIDSKDST TELLGLDFGD KLYSLKSESL 
       660        670        680        690        700
KQYLFMPDRD KGLDAIENKL GPACQDTISR GSNDSVPVIS FKDVAFDDVS 
       710        720        730        740        750
SVDEGRPDLL VNLPGIMEPV KEATLDGPAK QMEQNGDVLD SKLLETPDVL 
       760        770        780        790        800
QLNKSAEPST VPEQKVDHLT GEAREKRNDN QKVIRTFHMA ASDPPGSGDR 
       810        820        830        840        850
TPFPGPGTGA SSSLDTFNRE DNWLMQAGAK EYKTDINNEA VLLFSDHMDD 
       860        870        880        890        900
LRKEGTVSSL LQKAESKQSD VGVRGESEIH QIFQDLDERL ALTSRFYLPE 
       910        920        930        940        950
DCVQRWAAEM VVALDALHRE GIVCRDLNPN NILLNDRGHI QLTYFSRWSE 
       960        970        980        990       1000
VEDSCDNDAI ERMYCAPEVG VVFEETEACD WWSLGALLFE LITGRTLVEC 
      1010       1020       1030       1040       1050
HPAGINTHTC LNLPDHISEE ARSLLQQLLQ FNSGERLGAG IAGVDDIKSH 
      1060 
PFFALIDWAE LTK
Length:1,063
Mass (Da):118,241
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9A74155F71422DA3
GO

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_008124046.1, XM_008125839.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSACAT00000006193; ENSACAP00000006059; ENSACAG00000006181

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100557472

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		acs:100557472

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_008124046.1, XM_008125839.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000006059

Genome annotation databases

EnsembliENSACAT00000006193; ENSACAP00000006059; ENSACAG00000006181
GeneIDi100557472
KEGGiacs:100557472

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		26750

Phylogenomic databases

eggNOGiKOG0603, Eukaryota
KOG2101, Eukaryota
GeneTreeiENSGT00940000155656
HOGENOMiCLU_014272_0_0_1
InParanoidiG1KF39
OrthoDBi255297at2759
TreeFamiTF323964

Gene expression databases

BgeeiENSACAG00000006181, Expressed in testis and 15 other tissues

Family and domain databases

CDDicd07287, PX_RPK118_like, 1 hit
cd05576, STKc_RPK118_like, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR007330, MIT
IPR036181, MIT_dom_sf
IPR000719, Prot_kinase_dom
IPR001683, PX_dom
IPR036871, PX_dom_sf
IPR042132, PX_S6K-delta-1
IPR035053, STK_RPK118-like
PfamiView protein in Pfam
PF04212, MIT, 1 hit
PF00069, Pkinase, 1 hit
PF00787, PX, 1 hit
SMARTiView protein in SMART
SM00745, MIT, 1 hit
SM00312, PX, 1 hit
SM00220, S_TKc, 1 hit
SUPFAMiSSF116846, SSF116846, 1 hit
SSF56112, SSF56112, 1 hit
SSF64268, SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS50195, PX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KF39_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KF39
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: February 10, 2021
This is version 54 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again