UniProtKB - G1KF19 (G1KF19_ANOCA)
Protein
Adenosine receptor A3
Gene
ADORA3
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.UniRule annotation
GO - Molecular functioni
- G protein-coupled adenosine receptor activity Source: UniProtKB-UniRule
GO - Biological processi
- negative regulation of cell migration Source: Ensembl
- negative regulation of cell population proliferation Source: Ensembl
- negative regulation of NF-kappaB transcription factor activity Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Adenosine receptor A3UniRule annotationARBA annotation |
Gene namesi | Name:ADORA3Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 6 – 29 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 41 – 65 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 71 – 99 | HelicalUniRule annotationAdd BLAST | 29 | |
Transmembranei | 120 – 142 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 165 – 187 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 221 – 241 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 253 – 275 | HelicalUniRule annotationAdd BLAST | 23 |
Keywords - Cellular componenti
Cell membraneUniRule annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSACAG00000006155, Expressed in liver and 3 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 273 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 251 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00990000203639 |
HOGENOMi | CLU_009579_11_5_1 |
InParanoidi | G1KF19 |
OrthoDBi | 550297at2759 |
TreeFami | TF325296 |
Family and domain databases
InterProi | View protein in InterPro IPR000466, Adeno_A3_rcpt IPR001634, Adenosn_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00555, ADENOSINEA3R PR00424, ADENOSINER PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KF19-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSENLRNVYI AFEVMIAVLA ILGNILVIWV LKINQGFQKT IFYFIISLAV
60 70 80 90 100
ADIAVGLVMP ATIVVSLRLQ MPYKACLFMC CLPVTFTQAS IMSLLAIAID
110 120 130 140 150
RYLRVRLLIR YKLITTERRI RVALGTTWLL SMLVGFTPMF GWGKEIPRNT
160 170 180 190 200
SNVQCLFTNV MKMEYLVYLS FFTGTLVPLV VMCVLYARLF CIIRSKLKLC
210 220 230 240 250
SCSGRGQSVF YKHEFKTAKS LSLVLFFFAI CWLPMCILNC FTLFCPSLWL
260 270 280 290 300
PDYVVYCAIV LSHSNSVMNP IIYAFRIKKF RKTCIQIFRT YFLKVDTEQD
310
ASDGHTSSDP L
Sequence databases
RefSeqi | XP_003220500.1, XM_003220452.3 |
Genome annotation databases
Ensembli | ENSACAT00000006138; ENSACAP00000006004; ENSACAG00000006155 |
GeneIDi | 100559260 |
KEGGi | acs:100559260 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_003220500.1, XM_003220452.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000006004 |
Protein family/group databases
GPCRDBi | Search... |
Genome annotation databases
Ensembli | ENSACAT00000006138; ENSACAP00000006004; ENSACAG00000006155 |
GeneIDi | 100559260 |
KEGGi | acs:100559260 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00990000203639 |
HOGENOMi | CLU_009579_11_5_1 |
InParanoidi | G1KF19 |
OrthoDBi | 550297at2759 |
TreeFami | TF325296 |
Gene expression databases
Bgeei | ENSACAG00000006155, Expressed in liver and 3 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000466, Adeno_A3_rcpt IPR001634, Adenosn_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00555, ADENOSINEA3R PR00424, ADENOSINER PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KF19_ANOCA | |
Accessioni | G1KF19Primary (citable) accession number: G1KF19 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 60 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |