UniProtKB - G1KEM2 (G1KEM2_ANOCA)
Protein
WH1 domain-containing protein
Gene
ENAH
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- profilin binding Source: GO_Central
- SH3 domain binding Source: GO_Central
GO - Biological processi
- actin polymerization-dependent cell motility Source: GO_Central
- actin polymerization or depolymerization Source: GO_Central
- axon guidance Source: GO_Central
Keywordsi
Molecular function | Actin-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: WH1 domain-containing proteinInterPro annotation |
Gene namesi | Name:ENAHImported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Cytoskeleton
- cytoskeleton ARBA annotation
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: Ensembl
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- cell projection Source: UniProtKB-KW
- focal adhesion Source: Ensembl
Keywords - Cellular componenti
Cell projectionARBA annotation, CytoplasmARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000005736, Expressed in embryonic post-anal tail and 14 other tissues |
Interactioni
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- profilin binding Source: GO_Central
- SH3 domain binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000005645 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 111 | WH1InterPro annotationAdd BLAST | 111 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 114 – 140 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 194 – 374 | DisorderedSequence analysisAdd BLAST | 181 | |
Regioni | 392 – 517 | DisorderedSequence analysisAdd BLAST | 126 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 528 – 552 | Sequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 194 – 258 | PolyampholyteSequence analysisAdd BLAST | 65 | |
Compositional biasi | 263 – 297 | PolarSequence analysisAdd BLAST | 35 | |
Compositional biasi | 298 – 366 | Pro-richSequence analysisAdd BLAST | 69 | |
Compositional biasi | 399 – 417 | PolarSequence analysisAdd BLAST | 19 | |
Compositional biasi | 437 – 465 | PolyampholyteSequence analysisAdd BLAST | 29 | |
Compositional biasi | 466 – 514 | PolarSequence analysisAdd BLAST | 49 |
Sequence similaritiesi
Belongs to the Ena/VASP family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, SH3-bindingARBA annotationPhylogenomic databases
eggNOGi | KOG4590, Eukaryota |
GeneTreei | ENSGT00940000157376 |
HOGENOMi | CLU_017790_1_1_1 |
InParanoidi | G1KEM2 |
OrthoDBi | 972128at2759 |
TreeFami | TF321411 |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR042180, IF_rod_dom_coil1B IPR011993, PH-like_dom_sf IPR038023, VASP_sf IPR014885, VASP_tetra IPR000697, WH1/EVH1_dom |
Pfami | View protein in Pfam PF08776, VASP_tetra, 1 hit PF00568, WH1, 1 hit |
SMARTi | View protein in SMART SM00461, WH1, 1 hit |
SUPFAMi | SSF118370, SSF118370, 1 hit |
PROSITEi | View protein in PROSITE PS50229, WH1, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KEM2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEQSICQAR AAVMVYDDAN KKWVPAGGST GFSRVHIYHH TGNNTFRVVG
60 70 80 90 100
RKIQDHQVVI NCAIPKGLKY NQATQTFHQW RDARQVYGLN FGSKEDANVF
110 120 130 140 150
ASAMMHALEV LNSQDSGPTL PRQNAQLPTQ VQNGPSQEDI EIQRRQLQEQ
160 170 180 190 200
QRQKELERER LERDRMERER LERERLERER LERERLEKER LERDRLEQEQ
210 220 230 240 250
LERQERERQE RDRQERLERE RQDRERQDRE QLEWERQERE RQEQLEREQL
260 270 280 290 300
EWERERKLSN AAPPASVENS LNSVLGDSSA SEPVLQTASQ PVEPPSQQGV
310 320 330 340 350
IQGPPAPPPP PPLPPGPVQS PPAVPPPPGP PPPPPLPPSG PPPPPPPPPL
360 370 380 390 400
PNQVPPPPPA PPLPVSGFPK GLMYEDHRPI TGLAAALAGA KLRKVSRNEE
410 420 430 440 450
SPNPSGGSSS ASPKTDSGRG NGPLPLGGSG LMEEMSALLA RRRRIAEKGS
460 470 480 490 500
SEAEQKEEKS EEPEPSVSKP PSTSTPELTR KPWERTNTMN GSKSPVISRP
510 520 530 540 550
KSASTGQPST NGVQAEGLDY DRLKQDILDE MRKELTKLKE ELIDAIRQEL
NKSNTT
Sequence databases
RefSeqi | XP_008124146.1, XM_008125939.2 |
Genome annotation databases
Ensembli | ENSACAT00000005768; ENSACAP00000005645; ENSACAG00000005736 |
GeneIDi | 100555779 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_008124146.1, XM_008125939.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000005645 |
Genome annotation databases
Ensembli | ENSACAT00000005768; ENSACAP00000005645; ENSACAG00000005736 |
GeneIDi | 100555779 |
Organism-specific databases
CTDi | 55740 |
Phylogenomic databases
eggNOGi | KOG4590, Eukaryota |
GeneTreei | ENSGT00940000157376 |
HOGENOMi | CLU_017790_1_1_1 |
InParanoidi | G1KEM2 |
OrthoDBi | 972128at2759 |
TreeFami | TF321411 |
Gene expression databases
Bgeei | ENSACAG00000005736, Expressed in embryonic post-anal tail and 14 other tissues |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR042180, IF_rod_dom_coil1B IPR011993, PH-like_dom_sf IPR038023, VASP_sf IPR014885, VASP_tetra IPR000697, WH1/EVH1_dom |
Pfami | View protein in Pfam PF08776, VASP_tetra, 1 hit PF00568, WH1, 1 hit |
SMARTi | View protein in SMART SM00461, WH1, 1 hit |
SUPFAMi | SSF118370, SSF118370, 1 hit |
PROSITEi | View protein in PROSITE PS50229, WH1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KEM2_ANOCA | |
Accessioni | G1KEM2Primary (citable) accession number: G1KEM2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | February 10, 2021 | |
This is version 58 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |