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Entry version 63 (02 Dec 2020)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

CEP250

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEP250Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000005735, Expressed in forelimb bud and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000005625

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2196 – 2243DisorderedSequence analysisAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili84 – 114Sequence analysisAdd BLAST31
Coiled coili122 – 142Sequence analysisAdd BLAST21
Coiled coili280 – 331Sequence analysisAdd BLAST52
Coiled coili401 – 547Sequence analysisAdd BLAST147
Coiled coili569 – 606Sequence analysisAdd BLAST38
Coiled coili618 – 712Sequence analysisAdd BLAST95
Coiled coili723 – 757Sequence analysisAdd BLAST35
Coiled coili772 – 792Sequence analysisAdd BLAST21
Coiled coili807 – 841Sequence analysisAdd BLAST35
Coiled coili851 – 900Sequence analysisAdd BLAST50
Coiled coili923 – 943Sequence analysisAdd BLAST21
Coiled coili962 – 1035Sequence analysisAdd BLAST74
Coiled coili1047 – 1098Sequence analysisAdd BLAST52
Coiled coili1107 – 1130Sequence analysisAdd BLAST24
Coiled coili1145 – 1200Sequence analysisAdd BLAST56
Coiled coili1212 – 1274Sequence analysisAdd BLAST63
Coiled coili1278 – 1383Sequence analysisAdd BLAST106
Coiled coili1387 – 1421Sequence analysisAdd BLAST35
Coiled coili1502 – 1543Sequence analysisAdd BLAST42
Coiled coili1583 – 1617Sequence analysisAdd BLAST35
Coiled coili1632 – 1680Sequence analysisAdd BLAST49
Coiled coili1684 – 1718Sequence analysisAdd BLAST35
Coiled coili1730 – 1788Sequence analysisAdd BLAST59
Coiled coili1803 – 1823Sequence analysisAdd BLAST21
Coiled coili1874 – 1894Sequence analysisAdd BLAST21
Coiled coili1923 – 1957Sequence analysisAdd BLAST35
Coiled coili1962 – 1982Sequence analysisAdd BLAST21
Coiled coili1996 – 2017Sequence analysisAdd BLAST22
Coiled coili2023 – 2096Sequence analysisAdd BLAST74
Coiled coili2115 – 2156Sequence analysisAdd BLAST42
Coiled coili2338 – 2372Sequence analysisAdd BLAST35
Coiled coili2387 – 2414Sequence analysisAdd BLAST28
Coiled coili2422 – 2442Sequence analysisAdd BLAST21
Coiled coili2483 – 2531Sequence analysisAdd BLAST49
Coiled coili2566 – 2586Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTBY, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161056

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000920_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KEL1

Database of Orthologous Groups

More...
OrthoDBi
76868at2759

TreeFam database of animal gene trees

More...
TreeFami
TF101138

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KEL1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGDQAAHSM KMESAHLSDD QLVSVHQQMI ESQASYRNKL QNSQEAQHRQ
60 70 80 90 100
AILVQKLQGK VLQYRNWCRD LEQRLEASRA SYSLRQDNKK DHSLEKALIQ
110 120 130 140 150
LEEEQQRCQN LAGVNILLRD HLDKANEVNG ALREDVSKLT ADWTKARDEL
160 170 180 190 200
EYKESEWHKE RKFFESYMRA EHDRIIGIWR QVVTLHRYFL EMKTATDRDL
210 220 230 240 250
SELKVEQMRL SGSILISCFQ LSSDTRLLEM SNLESSVLKG SLQQQQQQLY
260 270 280 290 300
LKPEKTDMEK EIYQQTQAIM NLRVKGDLAR EDLQSRVIEL TALLEQSQKE
310 320 330 340 350
NEEKEKTVKT LRDTLEKSNH LELEYEQEQS RSKTVNEEIL SLRHVIKEIT
360 370 380 390 400
EAVLNGNDAT VGKPQVEQSA ELGHSLQLDP GGLDGTLLLV REALMKRSNE
410 420 430 440 450
VQHLRQQLLA SQNSITSLEK QQEQQEEHSR FQGQRLEQLE KERETFTSQI
460 470 480 490 500
QHQQSTIETY SRDYATLEKS RTELQQHLEV LEQEVWHLRQ NNTELQLKGD
510 520 530 540 550
MVNGEKEEQQ QELQRMMRER EYIQEDRNAL EERHSSLKNE LIALREALEK
560 570 580 590 600
SHLDGELMKQ EKYELASALE QTEQSLAQLT SAHNKLKAET ADLQGATAKM
610 620 630 640 650
SALNEALALD KVGLHQIILK MEQESQMLSD NVDRLEKMKS LSQKQLKQAE
660 670 680 690 700
QTNEELCTEK IRLEKLLQKA EELQEGLQDE LKMLKEEQKE TYEKLSQVHH
710 720 730 740 750
QHEKSISSLE QAHQESNRLG EMYAKVSKEK EKLMCEKATL EVRLGAVERE
760 770 780 790 800
KSALTEQVTE LRSVKDLLES SLFQAQQQVS QLEVAKGQLE MKVHAISQAK
810 820 830 840 850
EVIQGEVKCL RIELEAEKSR IEQENEERVQ LLSQAEQKHQ ETLSHRQIVH
860 870 880 890 900
KEEMNAVFQE LEGERERHRV ELEEALKRSA KEKEESESTC EQKLLELQKN
910 920 930 940 950
ITAIQTRMED ELFKAQNAKQ ELLFEKENER KSLLDELLQT KDKLTSTCQQ
960 970 980 990 1000
LEYFRQEIKK HQEEAQVTVQ GLEADLKDAQ HRMKTLEKKH KEEIKSLKEE
1010 1020 1030 1040 1050
INILLQQRDA LRSQVQELES QLLIAKDSCQ SISQEAQHHL REGQELSKQK
1060 1070 1080 1090 1100
ELEIAHLRKM LEAERKRCEE ISHQSIELQS QKEEMEHRNT ELQAMLQNQW
1110 1120 1130 1140 1150
EAEKHLNREL QRKQEEVQRQ CATLQALERE QNLWVEADRQ NSEQHNVLQR
1160 1170 1180 1190 1200
QLEEAKFQNK QLQTQKREAD LQNAKLLHQK EELECQNAQL KDALQSQREE
1210 1220 1230 1240 1250
AECESTILQS HWEEAQQRYS ELQNWKEKIE DENAELQALL SHQREKMESQ
1260 1270 1280 1290 1300
NMELQSKQKE IEHQNIVLQK MKEERSHWEE VEDQNSELKA ALQTMEQKRA
1310 1320 1330 1340 1350
SLALSLKETE DRAKKLQESD DAHKDEIAKL STALQLTEQL LAEYRKEMQE
1360 1370 1380 1390 1400
LNNEIQSLKQ KTAEKEAALV AQQEQLIQDV EESHTSEQRL KDSVQVLEAE
1410 1420 1430 1440 1450
VSTLRQSLRS TESRAEALAS ECQRACSARW EAQSQLSKLH SVLQYMLCNG
1460 1470 1480 1490 1500
LEVKVEHGGH GDNNIWNSLS LRTEQDKLIR PALSQSKDFS TELTVERVTE
1510 1520 1530 1540 1550
AIQKLRKDLW QSRLERDEVR NNMEKLKQQL IEKEGERDRI SAKAQELQKW
1560 1570 1580 1590 1600
FNESQEEKNK AEGKRGSLES ALKTEVIAFK EENVTLRRRL ITLEKTLEST
1610 1620 1630 1640 1650
EKQRKDMLDE RDSLQMAKDK LSWELDLLRE SIRASEIQTN AMEKINQSLE
1660 1670 1680 1690 1700
QELQTALSAL KTKNEELETQ QKKLATLHQE AEIGKTLQEN VDRLTASLEK
1710 1720 1730 1740 1750
KEEEIKFQLQ QIKDLERHRE VQKTTMEHLA ESLEKRTQET ECQKNQIEEV
1760 1770 1780 1790 1800
KKQEKMQKAD LERLNLELEK SLQIMQSQQE KIQKLEDLTQ TQSTILKSLT
1810 1820 1830 1840 1850
LDLEAKVKET QIKEEKIQIL EKNESSQIGS LLKELGDLKM QLTEKDWELA
1860 1870 1880 1890 1900
SQKQLLQECE EQGKKQEKCL HTRLEHMKAI LMDKEREVAS REEQIAGFQQ
1910 1920 1930 1940 1950
HEAQRDSHLC DLNEKVKELA FTVAQRDEEL ESQRQQIREM EGEMETELKT
1960 1970 1980 1990 2000
LRELTAKTQL SLKERNIELE FQRKHAEEVE RQIKILLGDV QISTAVLNLE
2010 2020 2030 2040 2050
DNNAEFQKDQ KEQLKKQTVL NMLEQLRVLL IRKEREIKSL KEQQDEHKEE
2060 2070 2080 2090 2100
NEKTVREMQT NLQQALENKE VQLQCLKEEN RQLHQLEEKA AAQTKSVMEN
2110 2120 2130 2140 2150
LEFTRTSLHD REKEIQSLKG HIREISRQKE VEQNKAVSLL NDLNKIKQSR
2160 2170 2180 2190 2200
TEKENELLRQ VEHIRTYQVK LEATQAELQA CQTRVNELQS VIKQKEEENE
2210 2220 2230 2240 2250
RDFKRLRHKH EPVQENDKHP GENEEYLEEK QRKKGEEMDA QNKQEKIKDE
2260 2270 2280 2290 2300
MKMLQENIQQ LQHLLKKKDD EVEWQKRKVE ELKERVKSKE KELLISSEHL
2310 2320 2330 2340 2350
KEIVSFLNLQ DNEDDNLQSH IQKLHMWKEL EIVRSKALQE KDQWLTRQKE
2360 2370 2380 2390 2400
KIQQLEDEKK VKKQELDHVT AILKKTESGE IEWREKAQRL DLSLAQSEEA
2410 2420 2430 2440 2450
LRALREEMTI MQNMVSERDR DRHNLQEQLD TAFRTLEEER TATKALVGDV
2460 2470 2480 2490 2500
DQFISEKHLP EILGKEGEEA MRKGGKLSWV DERRFLCRRL QLLQQAVARL
2510 2520 2530 2540 2550
ENDYRVLEQH NTQLREALKQ VEHERRRLKR SCGDLSLSFG LSQINAGPLK
2560 2570 2580 2590 2600
IPSIEKEETQ VLHKELEKLQ KQVFVLQKQL SLQKKQKQDY IDSCARTNHE
2610 2620 2630 2640 2650
LSGLHQELSD SLAAVAKEPE ATVLALETQK LDETLNYSLS LASGSCNGFF
2660
AGKHLISSTP KRLQQKDSK
Length:2,669
Mass (Da):313,359
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D6369FE7C61AA05
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_003220580.1, XM_003220532.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000005748; ENSACAP00000005625; ENSACAG00000005735

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100558279

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
acs:100558279

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_003220580.1, XM_003220532.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000005625

Genome annotation databases

EnsembliENSACAT00000005748; ENSACAP00000005625; ENSACAG00000005735
GeneIDi100558279
KEGGiacs:100558279

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11190

Phylogenomic databases

eggNOGiENOG502QTBY, Eukaryota
GeneTreeiENSGT00940000161056
HOGENOMiCLU_000920_0_0_1
InParanoidiG1KEL1
OrthoDBi76868at2759
TreeFamiTF101138

Gene expression databases

BgeeiENSACAG00000005735, Expressed in forelimb bud and 14 other tissues

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KEL1_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KEL1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: December 2, 2020
This is version 63 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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