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UniProtKB - G1KEJ5 (G1KEJ5_ANOCA)
Protein
Submitted name:
Growth differentiation factor 5
Gene
GDF5
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- BMP binding Source: Ensembl
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- identical protein binding Source: Ensembl
GO - Biological processi
- BMP signaling pathway Source: GO_Central
- chondroblast differentiation Source: Ensembl
- embryonic limb morphogenesis Source: Ensembl
- forelimb morphogenesis Source: Ensembl
- hindlimb morphogenesis Source: Ensembl
- negative regulation of chondrocyte differentiation Source: Ensembl
- negative regulation of epithelial cell proliferation Source: Ensembl
- negative regulation of mesenchymal cell apoptotic process Source: Ensembl
- positive regulation of BMP signaling pathway Source: Ensembl
- positive regulation of chondrocyte differentiation Source: Ensembl
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
- regulation of multicellular organism growth Source: Ensembl
- regulation of SMAD protein signal transduction Source: Ensembl
- SMAD protein signal transduction Source: GO_Central
Keywordsi
Molecular function | Growth factorUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Growth differentiation factor 5Imported |
Gene namesi | Name:GDF5Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Sequence analysisAdd BLAST | 31 | |
ChainiPRO_5003412734 | 32 – 501 | Sequence analysisAdd BLAST | 470 |
Expressioni
Gene expression databases
Bgeei | ENSACAG00000005716, Expressed in lung and 5 other tissues |
Interactioni
GO - Molecular functioni
- BMP binding Source: Ensembl
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- identical protein binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000005591 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 378 – 501 | TGF_BETA_2InterPro annotationAdd BLAST | 124 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 30 – 162 | DisorderedSequence analysisAdd BLAST | 133 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 61 – 86 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 105 – 122 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 146 – 162 | Basic and acidic residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000160455 |
HOGENOMi | CLU_020515_0_0_1 |
InParanoidi | G1KEJ5 |
OMAi | QGKRPTK |
OrthoDBi | 749511at2759 |
TreeFami | TF316134 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KEJ5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKILHFLTLL LWYFGWFYLV LISLVLSPAE ASQGNPGAKL AVSKVDGKER
60 70 80 90 100
TPLPRAGTFR TGSHGYSTGN SKPRTKTNTA QAGTLLAKTD DSKKALPKAG
110 120 130 140 150
STDKKVGGHS SNRQTGVRTV SPKVQNFGPK APLKKTGTGN SDASSYKAKK
160 170 180 190 200
PKDSIAQRES KEALRHPAIT PHEYMLSLYR TLSDAERKGV NGSVKLETGL
210 220 230 240 250
ANTITSFIDK GQDDRAPTVK KQKYMFDISA LEKDGLLGAE LRILRKKPSD
260 270 280 290 300
TWKPHPHGKT CQVKLFSCST NRQASILLDS RTVNILDTAK WEVFDIWKLF
310 320 330 340 350
RNFKNSANLC FELEAFERGR PVDLRTVGFN RTGRQVNEKA LFLVFGRTKK
360 370 380 390 400
RDLFFNEIKA RSGQDDKTVY EYLFNQRRKR RAPLATRQGK RPNKNLKARC
410 420 430 440 450
SKKALHVNFK DMGWDDWIIA PLEYEAYHCE GLCEFPLRSH LEPTNHAVIQ
460 470 480 490 500
TLMNSMDPES TPPTCCVPTR LSPISILFID SANNVVYKQY EDMVVESCGC
R
Sequence databases
RefSeqi | XP_003220519.1, XM_003220471.3 |
Genome annotation databases
Ensembli | ENSACAT00000005713; ENSACAP00000005591; ENSACAG00000005716 |
GeneIDi | 100563147 |
KEGGi | acs:100563147 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_003220519.1, XM_003220471.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000005591 |
Genome annotation databases
Ensembli | ENSACAT00000005713; ENSACAP00000005591; ENSACAG00000005716 |
GeneIDi | 100563147 |
KEGGi | acs:100563147 |
Organism-specific databases
CTDi | 8200 |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000160455 |
HOGENOMi | CLU_020515_0_0_1 |
InParanoidi | G1KEJ5 |
OMAi | QGKRPTK |
OrthoDBi | 749511at2759 |
TreeFami | TF316134 |
Gene expression databases
Bgeei | ENSACAG00000005716, Expressed in lung and 5 other tissues |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KEJ5_ANOCA | |
Accessioni | G1KEJ5Primary (citable) accession number: G1KEJ5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | October 19, 2011 | |
Last modified: | May 25, 2022 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |