UniProtKB - G1KEG9 (G1KEG9_ANOCA)
Protein
Submitted name:
Uncharacterized protein
Gene
GLRA3
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 300 | Important for obstruction of the ion pore in the closed conformationUniRule annotation | 1 |
GO - Molecular functioni
- extracellularly glycine-gated chloride channel activity Source: Ensembl
- glycine binding Source: InterPro
- glycine-gated chloride ion channel activity Source: Ensembl
- neurotransmitter receptor activity Source: GO_Central
- transmembrane signaling receptor activity Source: InterPro
GO - Biological processi
- chemical synaptic transmission Source: GO_Central
- chloride transmembrane transport Source: GO_Central
- ion transmembrane transport Source: GO_Central
- nervous system process Source: GO_Central
- neuropeptide signaling pathway Source: GO_Central
- protein homooligomerization Source: Ensembl
- regulation of membrane potential Source: GO_Central
- response to amino acid Source: GO_Central
- signal transduction Source: GO_Central
- synaptic transmission, glycinergic Source: GO_Central
Keywordsi
Molecular function | Chloride channelARBA annotation, Ion channel |
Biological process | Ion transport, Transport |
Ligand | Chloride |
Names & Taxonomyi
Protein namesi | Submitted name: Uncharacterized proteinImported |
Gene namesi | Name:GLRA3Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- postsynaptic cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- glycine-gated chloride channel complex Source: Ensembl
- integral component of plasma membrane Source: GO_Central
- postsynaptic membrane Source: UniProtKB-SubCell
Other locations
- neuron projection Source: GO_Central
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 33 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 261 – 283 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 324 – 346 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 427 – 447 | HelicalUniRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Cell junction, Cell membraneARBA annotation, Cell projectionARBA annotation, Membrane, Postsynaptic cell membraneARBA annotation, SynapsePTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 177 ↔ 191 | UniRule annotation | ||
Disulfide bondi | 237 ↔ 248 | UniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotation, GlycoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000005650, Expressed in skeletal muscle tissue and 5 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 53 – 259 | Neur_chan_LBDInterPro annotationAdd BLAST | 207 | |
Domaini | 266 – 351 | Neur_chan_membInterPro annotationAdd BLAST | 86 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 388 – 408 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
SignalARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG3644, Eukaryota |
GeneTreei | ENSGT00940000158368 |
HOGENOMi | CLU_010920_1_4_1 |
InParanoidi | G1KEG9 |
OrthoDBi | 614790at2759 |
TreeFami | TF315453 |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR008127, Glycine_rcpt_A IPR008130, Glycine_rcpt_A3 IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00253, GABAARECEPTR PR01673, GLYRALPHA PR01676, GLYRALPHA3 PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KEG9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPPKTMARIQ YLRAAAVSGF YLWEAALLLS LVATKETDSA RSRSMPMSPS
60 70 80 90 100
DFLDKLMGRM SGYDARIRPN FKGPPVNVTC NIFINSFGSI AETTMDYRVN
110 120 130 140 150
IFLRQNWNDP RLAYSEYPDD SLDLDPSMLD SIWKPDLFFA NEKGANFHEV
160 170 180 190 200
TTDNKLLRIF KNGNVLYSIR LTLILSCPMD LKNFPMDVQT CIMQLESFGY
210 220 230 240 250
TMNDLIFEWQ ENGAVQVADG LTLPQFLLKE DKDLVYCTKH YNTGKFTCIE
260 270 280 290 300
VRFHLERQMG YYLIQMYIPS LLIVILSWVS FWINMDAAPA RVALGITTVL
310 320 330 340 350
TMTTQSSGSR ASLPKVSYVK AIDIWMAVCL LFVFSALLEY AAVNFVSRQH
360 370 380 390 400
KELLRFHRKR KKNKDDDMRE NRFSFTGYGM GPPCIPAKDG VAPKGPNNPT
410 420 430 440 450
QPAPKSHEEM RKVFIDRAKK IDTISRACFP LAFLIFNIFY WVIYKIVRHE
DIHQKQD
Sequence databases
RefSeqi | XP_008105778.1, XM_008107571.2 |
Genome annotation databases
Ensembli | ENSACAT00000005664; ENSACAP00000005543; ENSACAG00000005650 |
GeneIDi | 100566223 |
KEGGi | acs:100566223 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_008105778.1, XM_008107571.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000005543 |
Genome annotation databases
Ensembli | ENSACAT00000005664; ENSACAP00000005543; ENSACAG00000005650 |
GeneIDi | 100566223 |
KEGGi | acs:100566223 |
Organism-specific databases
CTDi | 8001 |
Phylogenomic databases
eggNOGi | KOG3644, Eukaryota |
GeneTreei | ENSGT00940000158368 |
HOGENOMi | CLU_010920_1_4_1 |
InParanoidi | G1KEG9 |
OrthoDBi | 614790at2759 |
TreeFami | TF315453 |
Gene expression databases
Bgeei | ENSACAG00000005650, Expressed in skeletal muscle tissue and 5 other tissues |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR008127, Glycine_rcpt_A IPR008130, Glycine_rcpt_A3 IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00253, GABAARECEPTR PR01673, GLYRALPHA PR01676, GLYRALPHA3 PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KEG9_ANOCA | |
Accessioni | G1KEG9Primary (citable) accession number: G1KEG9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 64 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |