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Entry version 58 (02 Dec 2020)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

COL1A1

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL1A1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrixARBA annotation, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500341319025 – 1488Sequence analysisAdd BLAST1464

Keywords - PTMi

HydroxylationARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000005084, Expressed in skeletal muscle tissue and 15 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000005181

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 90VWFCInterPro annotationAdd BLAST59
Domaini1253 – 1488Fibrillar collagen NC1InterPro annotationAdd BLAST236

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni97 – 838DisorderedSequence analysisAdd BLAST742
Regioni883 – 1237DisorderedSequence analysisAdd BLAST355

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi124 – 143Pro-richSequence analysisAdd BLAST20
Compositional biasi169 – 189Pro-richSequence analysisAdd BLAST21
Compositional biasi1016 – 1030Pro-richSequence analysisAdd BLAST15
Compositional biasi1200 – 1219Pro-richSequence analysisAdd BLAST20

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156584

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001074_2_3_1

Database of Orthologous Groups

More...
OrthoDBi
337699at2759

TreeFam database of animal gene trees

More...
TreeFami
TF323987

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160, Collagen
IPR000885, Fib_collagen_C
IPR001007, VWF_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01410, COLFI, 1 hit
PF01391, Collagen, 8 hits
PF00093, VWC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00038, COLFI, 1 hit
SM00214, VWC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51461, NC1_FIB, 1 hit
PS01208, VWFC_1, 1 hit
PS50184, VWFC_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KDW3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSFVDSRLL LLIAATVLLT NGQGEEDIPS KGSCTQDGLR YNDKDVWKPE
60 70 80 90 100
PCQICVCDSG NILCDSMVCE EDLNCENPEI PFGECCPVCP ESGASVPYPE
110 120 130 140 150
TGVEGPKGEP GPRGDRGLPG PPGRDGIPGQ PGPPGPPGPP GLGGNFAPQL
160 170 180 190 200
SYGYDEKSGG LSLPGPMGPA GPRGLPGPPG APGPQGFQGP PGEPGEAGAS
210 220 230 240 250
GPMGPRGPAG PPGKNGDDGE AGKPGRPGER GAPGPQGARG LPGTAGLPGM
260 270 280 290 300
KGHRGFSGLD GAKGDAGPAG PKGEPGSPGE NGAPGQVGPR GLPGERGRPG
310 320 330 340 350
PAGPAGARGN DGAAGAAGPP GPTGPAGPPG FPGAAGPKGE TGAQGSRGSE
360 370 380 390 400
GPQGARGEPG PPGPAGSAGP SGNPGSDGQP GAKGATGAPG ISGAPGFPGA
410 420 430 440 450
RGPAGPQGPS GAPGPKGNSG EPGAQGNKGD AGAKGEPGPA GIQGPPGPPG
460 470 480 490 500
EEGKRGSRGE PGPAGLPGPA GERGAPGSRG FPGSDGIAGP KGPPGERGSP
510 520 530 540 550
GPAGAKGSPG ESGRPGEPGL PGVKGLTGSP GSPGPDGKTG PTGPAGQDGR
560 570 580 590 600
PGPAGPPGAR GQAGVMGFPG PKGAAGEPGK PGERGAPGAV GAVGAPGKDG
610 620 630 640 650
ETGAQGPPGP TGPAGERGEQ GPAGAPGFQG LPGPAGAPGE SGKPGEQGVP
660 670 680 690 700
GDVGAPGPSG ARGERGFPGE RGVQGPAGPA GPRGANGAPG NDGAKGDAGA
710 720 730 740 750
PGAPGNQGPP GLQGMPGERG AAGLPGAKGD RGDPGPKGVD GAPGKDGVRG
760 770 780 790 800
LTGPIGPPGP AGATGDKGEA GPSGPAGPTG ARGAPGDRGE PGPAGPAGFA
810 820 830 840 850
GPPGADGQPG AKGESGDAGA KGDAGAPGPA GATGPPGPAV SNPLLPTFPS
860 870 880 890 900
HSCKIPSFFC LTLTFFALML ISFYLLQGAV GAPGPKGSRG SAGPPGATGF
910 920 930 940 950
PGAAGRVGPP GPSGNIGLPG PPGPSGKEGA KGPRGETGPA GRAGEAGPVG
960 970 980 990 1000
PPGPPGEKGS PGGDGPAGAP GTPGPQGIAG QRGVVGLPGQ RGERGFPGLP
1010 1020 1030 1040 1050
GPSGEPGKQG PSGPNGERGP PGPMGPPGLA GPPGEAGREG SPGAEGAPGR
1060 1070 1080 1090 1100
DGAAGPKGDR GETGPAGPPG APGAPGAPGP IGPAGKNGDR GETGPAGPAG
1110 1120 1130 1140 1150
PAGPAGARGP NGPQGPRGDK GETGEQGDRG MKGHRGFSGL QGPPGPPGSP
1160 1170 1180 1190 1200
GEQGPSGSSG PAGPRGPPGS AGAAGKDGLN GLPGPIGPPG PRGRTGDVGP
1210 1220 1230 1240 1250
AGPPGPPGPP GPPGPPSGGF DFSFMPQPPQ EKAHDGGRYY RADDANVMRD
1260 1270 1280 1290 1300
RDLEVDTTLK SLSMQIENIR SPEGTRKNPA RTCRDLKMCH GDWKSGEYWI
1310 1320 1330 1340 1350
DPNQGCNLDA IKVYCNMETG QTCVHASQPN IAQKNWYISK NPKEMKHVWF
1360 1370 1380 1390 1400
GETMTDGFQF EYGSEGSNPA DVNIQLTFLR LMSTEASQNI TYHCKNSVAY
1410 1420 1430 1440 1450
MDQQSGNLKK ALTLQGSNEI EIRAEGNSRF TYGVIEDGCT SHTGSWGKTV
1460 1470 1480
IEYKTTKTSR LPIIDVAPMD VGAPDQEFGL EIGPACFL
Length:1,488
Mass (Da):141,893
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA58704778E91B6D
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_016850114.1, XM_016994625.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000005298; ENSACAP00000005181; ENSACAG00000005084

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100565711

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_016850114.1, XM_016994625.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000005181

Genome annotation databases

EnsembliENSACAT00000005298; ENSACAP00000005181; ENSACAG00000005084
GeneIDi100565711

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1277

Phylogenomic databases

eggNOGiKOG3544, Eukaryota
GeneTreeiENSGT00940000156584
HOGENOMiCLU_001074_2_3_1
OrthoDBi337699at2759
TreeFamiTF323987

Gene expression databases

BgeeiENSACAG00000005084, Expressed in skeletal muscle tissue and 15 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR008160, Collagen
IPR000885, Fib_collagen_C
IPR001007, VWF_dom
PfamiView protein in Pfam
PF01410, COLFI, 1 hit
PF01391, Collagen, 8 hits
PF00093, VWC, 1 hit
SMARTiView protein in SMART
SM00038, COLFI, 1 hit
SM00214, VWC, 1 hit
PROSITEiView protein in PROSITE
PS51461, NC1_FIB, 1 hit
PS01208, VWFC_1, 1 hit
PS50184, VWFC_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KDW3_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KDW3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: December 2, 2020
This is version 58 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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