Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - G1KDV1 (G1KDV1_ANOCA)

Entry version 74 (12 Aug 2020)
Sequence version 2 (26 Jun 2013)
Previous versions | rss
Add a publicationFeedback
Protein

HECT-type E3 ubiquitin transferase

Gene

HERC2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.ARBA annotation EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4767Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathwayPROSITE-ProRule annotationARBA annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HECT-type E3 ubiquitin transferaseARBA annotation (EC:2.3.2.26ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HERC2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSACAG00000005186, Expressed in testis and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		28377.ENSACAP00000005145

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati515 – 570RCC1PROSITE-ProRule annotationAdd BLAST56
Repeati571 – 622RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati625 – 676RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati677 – 728RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati729 – 780RCC1PROSITE-ProRule annotationAdd BLAST52
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1208 – 1284Cytochrome b5 heme-bindingInterPro annotationAdd BLAST77
Domaini1861 – 1934MIB/HERC2InterPro annotationAdd BLAST74
Domaini2706 – 2753ZZ-typeInterPro annotationAdd BLAST48
Domaini2763 – 2940DOCInterPro annotationAdd BLAST178
Repeati2963 – 3014RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati3015 – 3069RCC1PROSITE-ProRule annotationAdd BLAST55
Repeati3070 – 3121RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati3122 – 3173RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati3176 – 3227RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati3228 – 3279RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati3280 – 3331RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati3957 – 4008RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati4009 – 4062RCC1PROSITE-ProRule annotationAdd BLAST54
Repeati4063 – 4114RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati4115 – 4166RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati4169 – 4220RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati4221 – 4272RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati4273 – 4324RCC1PROSITE-ProRule annotationAdd BLAST52
Domaini4462 – 4799HECTInterPro annotationAdd BLAST338

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni51 – 92DisorderedSequence analysisAdd BLAST42
Regioni1558 – 1580DisorderedSequence analysisAdd BLAST23
Regioni1928 – 1960DisorderedSequence analysisAdd BLAST33
Regioni2348 – 2375DisorderedSequence analysisAdd BLAST28
Regioni3464 – 3502DisorderedSequence analysisAdd BLAST39
Regioni3606 – 3633DisorderedSequence analysisAdd BLAST28
Regioni4807 – 4839DisorderedSequence analysisAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili950 – 985Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi57 – 91PolyampholyteSequence analysisAdd BLAST35
Compositional biasi1561 – 1580PolyampholyteSequence analysisAdd BLAST20
Compositional biasi3480 – 3500PolarSequence analysisAdd BLAST21
Compositional biasi4813 – 4827AcidicSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1426, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154975

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000101_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		G1KDV1

Database of Orthologous Groups

More...OrthoDBi		1062377at2759

TreeFam database of animal gene trees

More...TreeFami		TF320636

Family and domain databases

Conserved Domains Database

More...CDDi		cd08664, APC10-HERC2, 1 hit
cd00078, HECTc, 1 hit
cd02344, ZZ_HERC2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.30, 3 hits
2.30.30.30, 1 hit
2.30.30.920, 1 hit
2.60.120.260, 1 hit
3.10.120.10, 1 hit
3.30.60.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004939, APC_su10/DOC_dom
IPR006624, Beta-propeller_rpt_TECPR
IPR021097, CPH_domain
IPR001199, Cyt_B5-like_heme/steroid-bd
IPR036400, Cyt_B5-like_heme/steroid_sf
IPR008979, Galactose-bd-like_sf
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR037976, HERC2_APC10
IPR010606, Mib_Herc2
IPR037252, Mib_Herc2_sf
IPR009091, RCC1/BLIP-II
IPR000408, Reg_chr_condens
IPR014722, Rib_L2_dom2
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
IPR041987, ZZ_HERC2

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03256, ANAPC10, 1 hit
PF11515, Cul7, 1 hit
PF00173, Cyt-b5, 1 hit
PF00632, HECT, 1 hit
PF06701, MIB_HERC2, 1 hit
PF00415, RCC1, 16 hits
PF00569, ZZ, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00633, RCCNDNSATION

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01337, APC10, 1 hit
SM01117, Cyt-b5, 1 hit
SM00119, HECTc, 1 hit
SM00706, TECPR, 4 hits
SM00291, ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF159034, SSF159034, 1 hit
SSF49785, SSF49785, 1 hit
SSF50985, SSF50985, 3 hits
SSF55856, SSF55856, 1 hit
SSF56204, SSF56204, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50255, CYTOCHROME_B5_2, 1 hit
PS51284, DOC, 1 hit
PS50237, HECT, 1 hit
PS51416, MIB_HERC2, 1 hit
PS00626, RCC1_2, 1 hit
PS50012, RCC1_3, 19 hits
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KDV1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSESFCLEA QTRFDSKWLK TDLQLAFTRD GLCGLWNEMV KDGEIVYTGT 
        60         70         80         90        100
ELSQNSEASP RKDDTTEGQT GSKKDDQNDK ERKDEEDTPS PTYRAKSIVE 
       110        120        130        140        150
SWVWGKQPDV SELKECLYVL VKEQQALAKK TATTTLSALR LKQRLAILER 
       160        170        180        190        200
YFIALNRTVL QENVKVKWKS SNFPLPAVDK KSPRPVGKGV EGLARVGSRA 
       210        220        230        240        250
ALSFAFAFLR RAWRSGEDAD LCSELLQESL DALRALPEAS LFDEGTVSSV 
       260        270        280        290        300
WLEVVERATK FLRSVVTGDI HGTPGSKGSG NIPLQDQHLA LAILLELAVQ 
       310        320        330        340        350
RGTLSQMLSA VILLLQLWDN GTRETDNERS AQGTSAPLLP LLQRFQNIIC 
       360        370        380        390        400
NKEMNNTEEE LQMLSYPLSP NENFLRYLIL PQDNELAIDL RQTAVVIMAH 
       410        420        430        440        450
LDRLATPCMP PHCSSPTSHK GSLQEVIAWG LIGWKYYANV SGPIQCEGLA 
       460        470        480        490        500
SLGVTQIACA EKRFLILSRN GRVYTQAYNS DILGPQLVQS LASRNIVKIA 
       510        520        530        540        550
AHSDGHHYLA LAATGEVFSW GCGDGGRLGH GDTVPLEEPK MISALSGKQA 
       560        570        580        590        600
GKHVVHIACG STYSAAITAE GELYTWGRGN YGRLGHGSSE DQTIPMLVTG 
       610        620        630        640        650
LKGLKVIDVS CGSGDAQTLA VTENGQVWSW GDGDYGKLGR GGSDGCKTPK 
       660        670        680        690        700
LIEKLQDLDI VKVSCGSQFS VALTKDGQVY SWGKGDNQRL GHGTEEHVRY 
       710        720        730        740        750
PKLLEGLQGE KVIDVVAGST HCLALTEDSE VYSWGSNDQC QHFDTLRITK 
       760        770        780        790        800
PDPTALPGLD SKHIVGIACG PAQSFAWSSC SEWSIGLRVP FVVDVCPMTF 
       810        820        830        840        850
EQLDLLLRQV TEGMDGTSDW PPPQEKECMA VATLNLLRLQ LHAAISHQVD 
       860        870        880        890        900
PECLGLGLGS VLLNSLKQTV VTLASNAGVL NTVQSAAQAV LQSGWSVLLP 
       910        920        930        940        950
TAEERARALS ALLPSAVSGN ETNVSPGRRF MIDLLVGSLM ADGGLESALN 
       960        970        980        990       1000
AAITAEIQDI EAKKEAQKEK EIDEQEANAS TLHRNRTPLD KDLINTGIYE 
      1010       1020       1030       1040       1050
SAGKQSLPLV QLIQQLLRNI ASQTIAKLKD VARRISSCLD HEHYSKERSA 
      1060       1070       1080       1090       1100
SLDLLLRFQR LLVSKLYPGD SAVQIPNTYS PELLGVGSLL KKYTALLCTH 
      1110       1120       1130       1140       1150
IGDILPVATS IASTSHRHFA EVTRIVDGDL TGVLLPEVVV SIVLLLSKNA 
      1160       1170       1180       1190       1200
GLIQEAGAIP LLAGLLEHLD RFNHLAPGKE RDDSEDLAWP GIMGSFFTGQ 
      1210       1220       1230       1240       1250
NCRNNEEVTL IRKADLENHN KDGGFWTVID GKVYDIKDFQ TQSLTGSSIL 
      1260       1270       1280       1290       1300
AQFAGEDPVV ALEAALQFED TRESMHAFCV GQYMEPDQEV ITTPDTGSLS 
      1310       1320       1330       1340       1350
SPLIDTERNL GLLLGLHASY LAMSTPLSPV EVECAKWLKS SIFSGGLQTS 
      1360       1370       1380       1390       1400
QIHYSYNEEK DEDHCSSPGN TTPNKSKLYS HRLTLSDHSQ PFLQAIADNN 
      1410       1420       1430       1440       1450
IQDHTVKDFL CQVERYCKQC HLTTPITFPP EHPVEEVGRL LLCCLLKHED 
      1460       1470       1480       1490       1500
LGHIALSLVH PAMLGVDQVK HRTLPKSVAD VCRVVYQAKC SLIRTHQEQG 
      1510       1520       1530       1540       1550
RSYKEVCAPV IERLRFLFNE LRPAVCNDLS IMSKLKSLSS LPRWRRVVQK 
      1560       1570       1580       1590       1600
IIRERRKKKV PKKSESSDVE ESKIGNEESD LEEPCVIPHS PVTADKRPLS 
      1610       1620       1630       1640       1650
VKSPKDKWQP LINTVTGVQK YKWLKQNVQG LYPQSALLST IVEFALKEEP 
      1660       1670       1680       1690       1700
VDVEKMRKCL LKQLERAEVR LEGIDTILKL ATKSFLLPSV QYAMFCGWQR 
      1710       1720       1730       1740       1750
LIPEGTNIGE PLTDCLKDVD LIPPFNRMLL EVTFGKLYSW AILNIRNILL 
      1760       1770       1780       1790       1800
DANSRFKELG IQPVPLQTIT NENPAGPSLG TIPQARFLLV MLNMLTLQHG 
      1810       1820       1830       1840       1850
ANTLNLLLNS GMLALTQTAL RLIGPSSDNV EEDMLASSHG ASATVLEESR 
      1860       1870       1880       1890       1900
KETTPVQLPV SGPELAAMMK IGTRVMRGVD WKWGDQDGPP PGLGRVIGEL 
      1910       1920       1930       1940       1950
GEDGWIRVQW DTGSTNSYRM GKEGKYDLKL AEPPPASQPA TEDSDTEDDS 
      1960       1970       1980       1990       2000
EGEQVERNLH PTTMMLTSTV NLLQTLCLSA GVHAEVMQNE ATRTLCGLLR 
      2010       2020       2030       2040       2050
MLVESGTIDK SASLPNTLVN KEQHRSWCTL GFIRSIALMP QMCSTLSTSQ 
      2060       2070       2080       2090       2100
WITLLMKIVE GHESFTAASL QRQILAVHLL KAVLPSWDKS ERSRDMKFLV 
      2110       2120       2130       2140       2150
EKLFGFLGSL LTTCSSDIPL LRESTLRRRK ARPQASLTAT HSSTLAEEIV 
      2160       2170       2180       2190       2200
ALLRTLHSLS QWNGLINKYI NSQLTSITHI FAGKQSEGAV LEDFFPDSES 
      2210       2220       2230       2240       2250
LEVGSLMAVL AVIGGIDSRL RLGGQVIHDE FGEGTVTRIT PKGKITVQFY 
      2260       2270       2280       2290       2300
DMRTCRICPL SQLKPLPVIP FNVNNLPFTE SMLSVWAQLV NLAGSKVEKH 
      2310       2320       2330       2340       2350
RMKTPNQGVS GQIDLDLLRC QQLKLYILKA GRALLSHQDK LRQILSQPAV 
      2360       2370       2380       2390       2400
QDSGSVPTDD GAVASPDVGD MSPEGPQPPM ILLQQLLTAA TQPSPVKAIF 
      2410       2420       2430       2440       2450
DKQELEAAAL AVCQYLAVES AHPSTPVFED CSSSEATTPI TVQHIKPAKV 
      2460       2470       2480       2490       2500
KKRKVSPIPP LPIVVQLMEM GFPRKNIEFA LKSLSGTSGS ASGLPGVEAL 
      2510       2520       2530       2540       2550
VGWLLDHPDV QITDLSDGDT VSDEYSDEEV TEDVEEAEAA YPVSTGAVVT 
      2560       2570       2580       2590       2600
ESQTYKKRAD FLSNDDYAVY VRENIQVGMM VRCCRTYEEV CEGDVGKVIK 
      2610       2620       2630       2640       2650
LDRDGLHDLN VQCDWQQKGG TYWVRYIHVE LIGFPPQSSP SHIKIGDKVR 
      2660       2670       2680       2690       2700
VKTSVTTPKY KWGSVTHRSV GVVKAFSANG KDVIVDFPQQ SHWTGLLSEM 
      2710       2720       2730       2740       2750
ELVPSIHPGV TCDGCQMFPI NGPRFKCRNC DDFDFCETCF KTRKHNTRHT 
      2760       2770       2780       2790       2800
FGRINEPGQS PVFCGRSGKQ LKRRHSSQRG MLLDDWSRIV KNLNVSSSVN 
      2810       2820       2830       2840       2850
QASRLIDGGE QCWQSSGSQG KHWIRLEICP DVLVHRLKMI VDPADSSYMP 
      2860       2870       2880       2890       2900
SLVVVSGGSS LNNLIELRTI TINPTDTTVL LLGDCIEYHR YIEVAIKQCR 
      2910       2920       2930       2940       2950
SSGIDCKIHG LSILGRIRAE DEDLAAVPFL ASDNEEEDDD KANTGSLVRK 
      2960       2970       2980       2990       3000
KTSGLESVAT IRTKVFVWGL NDKDQLGGLK GSKIKVPSFS ETLSALNVVQ 
      3010       3020       3030       3040       3050
VAGGSKSLFA VTVEGKVYAC GEATNGRLGL GLSSGTVPIP RQITALSNYV 
      3060       3070       3080       3090       3100
VKKVAVHSGG RHAMALTVDG KVFSWGEGDD GKLGHFSRMN CDKPRLIEAL 
      3110       3120       3130       3140       3150
KTKRIRDIAC GSSHSAAITS SGELYSWGLG EYGRLGHGDN TTQLKPKMVK 
      3160       3170       3180       3190       3200
VLLGHRVIQV ACGSRDAQTL ALTDEGLVFS WGDGDFGKLG RGGSEGCNIP 
      3210       3220       3230       3240       3250
QNIERLNGQG VCQIECGAQF SLALTKSGVV WTWGKGDYFR LGHGTDVHVR 
      3260       3270       3280       3290       3300
KPQVVEGLRG KKIIHVAVGA LHCLAVTDTG QVYAWGDNDH GQQGNGTTTV 
      3310       3320       3330       3340       3350
NRKPTLVQGL EGQKITRVAC GSSHSVSWTT MDVATPSVHE PVLFQTARDP 
      3360       3370       3380       3390       3400
LGASYLGVPS DADSSAASNK INGTNSSKPN RPSLAKILLS LDGNLAKQQA 
      3410       3420       3430       3440       3450
LSHILTSLQI MYARDAVVGA LMPASMIAPV ECLSSSPAPP PDLVSTGSAS 
      3460       3470       3480       3490       3500
NGDESMLAVD VEERLSPTPW QDRRVEVASS EDSVTPSAVT PSSTAASSRP 
      3510       3520       3530       3540       3550
FIPVTDDPGA ASIIAETMTK TKEDVESQSK VSGPEPQYLD EFTGLLVPDD 
      3560       3570       3580       3590       3600
TRVMVDLLKL AVSSRAGEKG KDVLSAVLSG MGTAYPQVAD MLLELCVTEL 
      3610       3620       3630       3640       3650
EDVATDSQSG RLSSQPVVVE SSHPYTDDTS TSGTVKIPGA EGLRVEFDRQ 
      3660       3670       3680       3690       3700
CSTERRHDPL TVMDGVNRIV SVRSGREWSD WSSELRIPGD ELKWKFISDG 
      3710       3720       3730       3740       3750
SVNGWGWRFT VYPIMPAAGP KDLLSDRCIL SCPSMDLVTC LLDFRLNFAS 
      3760       3770       3780       3790       3800
NRSIVPRLAA SLAACAQLSA LAASHRMWAL QRLRKLLTTE FGQSININRI 
      3810       3820       3830       3840       3850
LGENDGETRT MSFTGSALAA LVKGLPEALQ RQFDYEDPIV RGGKQLLHSP 
      3860       3870       3880       3890       3900
FFKVLVALAC DLELDTLPCC AETHKWAWFR RYCMASRVAV ALDKRTPMPR 
      3910       3920       3930       3940       3950
LFLDEVAKKI RELMADNENM DVLHESHDVF KREQDEQLVQ WMNRRPDDWT 
      3960       3970       3980       3990       4000
LSAGGSGTIY GWGHNHRGQL GGIEGAKVKV PTPCEALATL RPVQLIGGEQ 
      4010       4020       4030       4040       4050
TLFAVTADGK LYATGYGAGG RLGIGGTESV STPTLLESIQ HVFIKKVAVN 
      4060       4070       4080       4090       4100
SGGKHCLALS SEGEVYSWGE AEDGKLGHGN RSPCDRPRVI ESLRGIEVVD 
      4110       4120       4130       4140       4150
IAAGGAHSAC ITAAGDLYTW GKGRYGRLGH GDSEDQLKPK LVEALQGYRV 
      4160       4170       4180       4190       4200
IDIACGSGDA QTLCLTDDDT VWSWGDGDYG KLGRGGSDGC KVPMKIDSLT 
      4210       4220       4230       4240       4250
GVGVVKVECG SQFSVALTKS GAVYTWGKGD YHRLGHGSDD HVRRPRQVQG 
      4260       4270       4280       4290       4300
LQGKKVIAIA TGSLHCVCCT EDGEVYTWGD NDEGQLGDGT TNAIQRPRLV 
      4310       4320       4330       4340       4350
AALQGKKINR VACGSAHTLA WSTSKPANAG KLPTQVPMEY NHLQEIPIIA 
      4360       4370       4380       4390       4400
LRNRLLLLHH ISELFCPCIP MFDLEGRLEE TGQGPSVGFD TLRGILISQG 
      4410       4420       4430       4440       4450
KEAAFRKVVQ ATMVRDRQHG PVVELNRIQV KRSRSKGGLA GPDGTKSVFG 
      4460       4470       4480       4490       4500
QMCAKMCSFS PDSLLLPHRV WKVKFVGESV DDCGGGYSES IAEMCEELQN 
      4510       4520       4530       4540       4550
GLTPLLIVTP NGRDESGANR DCFLLNPAAK SLLHMNMFRF LGVLLGIAIR 
      4560       4570       4580       4590       4600
TGSPLSLNLA EPVWKQLAGM NLTIADLSEV DKDFIPGLMY IRDNEATSEE 
      4610       4620       4630       4640       4650
FEAMSLPFTV PNASGQDIQL SSKYAHITLD NRAEYVRLAI NYRLHEFDEQ 
      4660       4670       4680       4690       4700
VAAVREGMAR VVPVPLLSLF TGYELETMVC GSPDIPLHLL KSVATYKGIE 
      4710       4720       4730       4740       4750
PTASLIQWFW EVMESFSNTE RSLFLRFVWG RTRLPRTIAD FRGRDFVIQV 
      4760       4770       4780       4790       4800
LDKYNPPDHF LPESYTCFFL LKLPRYSCKQ VLEEKLKYAI HFCKSIDTDD 
      4810       4820       4830 
YARIALTGEP TADDSSDDSD NEDADSFASD STQDYLTGH
Length:4,839
Mass (Da):529,211
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iADC9D8BCB597A59B
GO

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_016847835.1, XM_016992346.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSACAT00000005262; ENSACAP00000005145; ENSACAG00000005186

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100566865

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_016847835.1, XM_016992346.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000005145

Genome annotation databases

EnsembliENSACAT00000005262; ENSACAP00000005145; ENSACAG00000005186
GeneIDi100566865

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8924

Phylogenomic databases

eggNOGiKOG1426, Eukaryota
GeneTreeiENSGT00940000154975
HOGENOMiCLU_000101_0_0_1
InParanoidiG1KDV1
OrthoDBi1062377at2759
TreeFamiTF320636

Enzyme and pathway databases

UniPathwayiUPA00143

Gene expression databases

BgeeiENSACAG00000005186, Expressed in testis and 14 other tissues

Family and domain databases

CDDicd08664, APC10-HERC2, 1 hit
cd00078, HECTc, 1 hit
cd02344, ZZ_HERC2, 1 hit
Gene3Di2.130.10.30, 3 hits
2.30.30.30, 1 hit
2.30.30.920, 1 hit
2.60.120.260, 1 hit
3.10.120.10, 1 hit
3.30.60.90, 1 hit
InterProiView protein in InterPro
IPR004939, APC_su10/DOC_dom
IPR006624, Beta-propeller_rpt_TECPR
IPR021097, CPH_domain
IPR001199, Cyt_B5-like_heme/steroid-bd
IPR036400, Cyt_B5-like_heme/steroid_sf
IPR008979, Galactose-bd-like_sf
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR037976, HERC2_APC10
IPR010606, Mib_Herc2
IPR037252, Mib_Herc2_sf
IPR009091, RCC1/BLIP-II
IPR000408, Reg_chr_condens
IPR014722, Rib_L2_dom2
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
IPR041987, ZZ_HERC2
PfamiView protein in Pfam
PF03256, ANAPC10, 1 hit
PF11515, Cul7, 1 hit
PF00173, Cyt-b5, 1 hit
PF00632, HECT, 1 hit
PF06701, MIB_HERC2, 1 hit
PF00415, RCC1, 16 hits
PF00569, ZZ, 1 hit
PRINTSiPR00633, RCCNDNSATION
SMARTiView protein in SMART
SM01337, APC10, 1 hit
SM01117, Cyt-b5, 1 hit
SM00119, HECTc, 1 hit
SM00706, TECPR, 4 hits
SM00291, ZnF_ZZ, 1 hit
SUPFAMiSSF159034, SSF159034, 1 hit
SSF49785, SSF49785, 1 hit
SSF50985, SSF50985, 3 hits
SSF55856, SSF55856, 1 hit
SSF56204, SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50255, CYTOCHROME_B5_2, 1 hit
PS51284, DOC, 1 hit
PS50237, HECT, 1 hit
PS51416, MIB_HERC2, 1 hit
PS00626, RCC1_2, 1 hit
PS50012, RCC1_3, 19 hits
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KDV1_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KDV1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: August 12, 2020
This is version 74 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again