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Entry version 74 (12 Aug 2020)
Sequence version 2 (26 Jun 2013)
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Protein

HECT-type E3 ubiquitin transferase

Gene

HERC2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.ARBA annotation EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4767Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathwayPROSITE-ProRule annotationARBA annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HECT-type E3 ubiquitin transferaseARBA annotation (EC:2.3.2.26ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HERC2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000005186, Expressed in testis and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000005145

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati515 – 570RCC1PROSITE-ProRule annotationAdd BLAST56
Repeati571 – 622RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati625 – 676RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati677 – 728RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati729 – 780RCC1PROSITE-ProRule annotationAdd BLAST52
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1208 – 1284Cytochrome b5 heme-bindingInterPro annotationAdd BLAST77
Domaini1861 – 1934MIB/HERC2InterPro annotationAdd BLAST74
Domaini2706 – 2753ZZ-typeInterPro annotationAdd BLAST48
Domaini2763 – 2940DOCInterPro annotationAdd BLAST178
Repeati2963 – 3014RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati3015 – 3069RCC1PROSITE-ProRule annotationAdd BLAST55
Repeati3070 – 3121RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati3122 – 3173RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati3176 – 3227RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati3228 – 3279RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati3280 – 3331RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati3957 – 4008RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati4009 – 4062RCC1PROSITE-ProRule annotationAdd BLAST54
Repeati4063 – 4114RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati4115 – 4166RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati4169 – 4220RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati4221 – 4272RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati4273 – 4324RCC1PROSITE-ProRule annotationAdd BLAST52
Domaini4462 – 4799HECTInterPro annotationAdd BLAST338

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni51 – 92DisorderedSequence analysisAdd BLAST42
Regioni1558 – 1580DisorderedSequence analysisAdd BLAST23
Regioni1928 – 1960DisorderedSequence analysisAdd BLAST33
Regioni2348 – 2375DisorderedSequence analysisAdd BLAST28
Regioni3464 – 3502DisorderedSequence analysisAdd BLAST39
Regioni3606 – 3633DisorderedSequence analysisAdd BLAST28
Regioni4807 – 4839DisorderedSequence analysisAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili950 – 985Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi57 – 91PolyampholyteSequence analysisAdd BLAST35
Compositional biasi1561 – 1580PolyampholyteSequence analysisAdd BLAST20
Compositional biasi3480 – 3500PolarSequence analysisAdd BLAST21
Compositional biasi4813 – 4827AcidicSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1426, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154975

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000101_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KDV1

Database of Orthologous Groups

More...
OrthoDBi
1062377at2759

TreeFam database of animal gene trees

More...
TreeFami
TF320636

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08664, APC10-HERC2, 1 hit
cd00078, HECTc, 1 hit
cd02344, ZZ_HERC2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.30, 3 hits
2.30.30.30, 1 hit
2.30.30.920, 1 hit
2.60.120.260, 1 hit
3.10.120.10, 1 hit
3.30.60.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004939, APC_su10/DOC_dom
IPR006624, Beta-propeller_rpt_TECPR
IPR021097, CPH_domain
IPR001199, Cyt_B5-like_heme/steroid-bd
IPR036400, Cyt_B5-like_heme/steroid_sf
IPR008979, Galactose-bd-like_sf
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR037976, HERC2_APC10
IPR010606, Mib_Herc2
IPR037252, Mib_Herc2_sf
IPR009091, RCC1/BLIP-II
IPR000408, Reg_chr_condens
IPR014722, Rib_L2_dom2
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
IPR041987, ZZ_HERC2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03256, ANAPC10, 1 hit
PF11515, Cul7, 1 hit
PF00173, Cyt-b5, 1 hit
PF00632, HECT, 1 hit
PF06701, MIB_HERC2, 1 hit
PF00415, RCC1, 16 hits
PF00569, ZZ, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00633, RCCNDNSATION

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01337, APC10, 1 hit
SM01117, Cyt-b5, 1 hit
SM00119, HECTc, 1 hit
SM00706, TECPR, 4 hits
SM00291, ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF159034, SSF159034, 1 hit
SSF49785, SSF49785, 1 hit
SSF50985, SSF50985, 3 hits
SSF55856, SSF55856, 1 hit
SSF56204, SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50255, CYTOCHROME_B5_2, 1 hit
PS51284, DOC, 1 hit
PS50237, HECT, 1 hit
PS51416, MIB_HERC2, 1 hit
PS00626, RCC1_2, 1 hit
PS50012, RCC1_3, 19 hits
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KDV1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSESFCLEA QTRFDSKWLK TDLQLAFTRD GLCGLWNEMV KDGEIVYTGT
60 70 80 90 100
ELSQNSEASP RKDDTTEGQT GSKKDDQNDK ERKDEEDTPS PTYRAKSIVE
110 120 130 140 150
SWVWGKQPDV SELKECLYVL VKEQQALAKK TATTTLSALR LKQRLAILER
160 170 180 190 200
YFIALNRTVL QENVKVKWKS SNFPLPAVDK KSPRPVGKGV EGLARVGSRA
210 220 230 240 250
ALSFAFAFLR RAWRSGEDAD LCSELLQESL DALRALPEAS LFDEGTVSSV
260 270 280 290 300
WLEVVERATK FLRSVVTGDI HGTPGSKGSG NIPLQDQHLA LAILLELAVQ
310 320 330 340 350
RGTLSQMLSA VILLLQLWDN GTRETDNERS AQGTSAPLLP LLQRFQNIIC
360 370 380 390 400
NKEMNNTEEE LQMLSYPLSP NENFLRYLIL PQDNELAIDL RQTAVVIMAH
410 420 430 440 450
LDRLATPCMP PHCSSPTSHK GSLQEVIAWG LIGWKYYANV SGPIQCEGLA
460 470 480 490 500
SLGVTQIACA EKRFLILSRN GRVYTQAYNS DILGPQLVQS LASRNIVKIA
510 520 530 540 550
AHSDGHHYLA LAATGEVFSW GCGDGGRLGH GDTVPLEEPK MISALSGKQA
560 570 580 590 600
GKHVVHIACG STYSAAITAE GELYTWGRGN YGRLGHGSSE DQTIPMLVTG
610 620 630 640 650
LKGLKVIDVS CGSGDAQTLA VTENGQVWSW GDGDYGKLGR GGSDGCKTPK
660 670 680 690 700
LIEKLQDLDI VKVSCGSQFS VALTKDGQVY SWGKGDNQRL GHGTEEHVRY
710 720 730 740 750
PKLLEGLQGE KVIDVVAGST HCLALTEDSE VYSWGSNDQC QHFDTLRITK
760 770 780 790 800
PDPTALPGLD SKHIVGIACG PAQSFAWSSC SEWSIGLRVP FVVDVCPMTF
810 820 830 840 850
EQLDLLLRQV TEGMDGTSDW PPPQEKECMA VATLNLLRLQ LHAAISHQVD
860 870 880 890 900
PECLGLGLGS VLLNSLKQTV VTLASNAGVL NTVQSAAQAV LQSGWSVLLP
910 920 930 940 950
TAEERARALS ALLPSAVSGN ETNVSPGRRF MIDLLVGSLM ADGGLESALN
960 970 980 990 1000
AAITAEIQDI EAKKEAQKEK EIDEQEANAS TLHRNRTPLD KDLINTGIYE
1010 1020 1030 1040 1050
SAGKQSLPLV QLIQQLLRNI ASQTIAKLKD VARRISSCLD HEHYSKERSA
1060 1070 1080 1090 1100
SLDLLLRFQR LLVSKLYPGD SAVQIPNTYS PELLGVGSLL KKYTALLCTH
1110 1120 1130 1140 1150
IGDILPVATS IASTSHRHFA EVTRIVDGDL TGVLLPEVVV SIVLLLSKNA
1160 1170 1180 1190 1200
GLIQEAGAIP LLAGLLEHLD RFNHLAPGKE RDDSEDLAWP GIMGSFFTGQ
1210 1220 1230 1240 1250
NCRNNEEVTL IRKADLENHN KDGGFWTVID GKVYDIKDFQ TQSLTGSSIL
1260 1270 1280 1290 1300
AQFAGEDPVV ALEAALQFED TRESMHAFCV GQYMEPDQEV ITTPDTGSLS
1310 1320 1330 1340 1350
SPLIDTERNL GLLLGLHASY LAMSTPLSPV EVECAKWLKS SIFSGGLQTS
1360 1370 1380 1390 1400
QIHYSYNEEK DEDHCSSPGN TTPNKSKLYS HRLTLSDHSQ PFLQAIADNN
1410 1420 1430 1440 1450
IQDHTVKDFL CQVERYCKQC HLTTPITFPP EHPVEEVGRL LLCCLLKHED
1460 1470 1480 1490 1500
LGHIALSLVH PAMLGVDQVK HRTLPKSVAD VCRVVYQAKC SLIRTHQEQG
1510 1520 1530 1540 1550
RSYKEVCAPV IERLRFLFNE LRPAVCNDLS IMSKLKSLSS LPRWRRVVQK
1560 1570 1580 1590 1600
IIRERRKKKV PKKSESSDVE ESKIGNEESD LEEPCVIPHS PVTADKRPLS
1610 1620 1630 1640 1650
VKSPKDKWQP LINTVTGVQK YKWLKQNVQG LYPQSALLST IVEFALKEEP
1660 1670 1680 1690 1700
VDVEKMRKCL LKQLERAEVR LEGIDTILKL ATKSFLLPSV QYAMFCGWQR
1710 1720 1730 1740 1750
LIPEGTNIGE PLTDCLKDVD LIPPFNRMLL EVTFGKLYSW AILNIRNILL
1760 1770 1780 1790 1800
DANSRFKELG IQPVPLQTIT NENPAGPSLG TIPQARFLLV MLNMLTLQHG
1810 1820 1830 1840 1850
ANTLNLLLNS GMLALTQTAL RLIGPSSDNV EEDMLASSHG ASATVLEESR
1860 1870 1880 1890 1900
KETTPVQLPV SGPELAAMMK IGTRVMRGVD WKWGDQDGPP PGLGRVIGEL
1910 1920 1930 1940 1950
GEDGWIRVQW DTGSTNSYRM GKEGKYDLKL AEPPPASQPA TEDSDTEDDS
1960 1970 1980 1990 2000
EGEQVERNLH PTTMMLTSTV NLLQTLCLSA GVHAEVMQNE ATRTLCGLLR
2010 2020 2030 2040 2050
MLVESGTIDK SASLPNTLVN KEQHRSWCTL GFIRSIALMP QMCSTLSTSQ
2060 2070 2080 2090 2100
WITLLMKIVE GHESFTAASL QRQILAVHLL KAVLPSWDKS ERSRDMKFLV
2110 2120 2130 2140 2150
EKLFGFLGSL LTTCSSDIPL LRESTLRRRK ARPQASLTAT HSSTLAEEIV
2160 2170 2180 2190 2200
ALLRTLHSLS QWNGLINKYI NSQLTSITHI FAGKQSEGAV LEDFFPDSES
2210 2220 2230 2240 2250
LEVGSLMAVL AVIGGIDSRL RLGGQVIHDE FGEGTVTRIT PKGKITVQFY
2260 2270 2280 2290 2300
DMRTCRICPL SQLKPLPVIP FNVNNLPFTE SMLSVWAQLV NLAGSKVEKH
2310 2320 2330 2340 2350
RMKTPNQGVS GQIDLDLLRC QQLKLYILKA GRALLSHQDK LRQILSQPAV
2360 2370 2380 2390 2400
QDSGSVPTDD GAVASPDVGD MSPEGPQPPM ILLQQLLTAA TQPSPVKAIF
2410 2420 2430 2440 2450
DKQELEAAAL AVCQYLAVES AHPSTPVFED CSSSEATTPI TVQHIKPAKV
2460 2470 2480 2490 2500
KKRKVSPIPP LPIVVQLMEM GFPRKNIEFA LKSLSGTSGS ASGLPGVEAL
2510 2520 2530 2540 2550
VGWLLDHPDV QITDLSDGDT VSDEYSDEEV TEDVEEAEAA YPVSTGAVVT
2560 2570 2580 2590 2600
ESQTYKKRAD FLSNDDYAVY VRENIQVGMM VRCCRTYEEV CEGDVGKVIK
2610 2620 2630 2640 2650
LDRDGLHDLN VQCDWQQKGG TYWVRYIHVE LIGFPPQSSP SHIKIGDKVR
2660 2670 2680 2690 2700
VKTSVTTPKY KWGSVTHRSV GVVKAFSANG KDVIVDFPQQ SHWTGLLSEM
2710 2720 2730 2740 2750
ELVPSIHPGV TCDGCQMFPI NGPRFKCRNC DDFDFCETCF KTRKHNTRHT
2760 2770 2780 2790 2800
FGRINEPGQS PVFCGRSGKQ LKRRHSSQRG MLLDDWSRIV KNLNVSSSVN
2810 2820 2830 2840 2850
QASRLIDGGE QCWQSSGSQG KHWIRLEICP DVLVHRLKMI VDPADSSYMP
2860 2870 2880 2890 2900
SLVVVSGGSS LNNLIELRTI TINPTDTTVL LLGDCIEYHR YIEVAIKQCR
2910 2920 2930 2940 2950
SSGIDCKIHG LSILGRIRAE DEDLAAVPFL ASDNEEEDDD KANTGSLVRK
2960 2970 2980 2990 3000
KTSGLESVAT IRTKVFVWGL NDKDQLGGLK GSKIKVPSFS ETLSALNVVQ
3010 3020 3030 3040 3050
VAGGSKSLFA VTVEGKVYAC GEATNGRLGL GLSSGTVPIP RQITALSNYV
3060 3070 3080 3090 3100
VKKVAVHSGG RHAMALTVDG KVFSWGEGDD GKLGHFSRMN CDKPRLIEAL
3110 3120 3130 3140 3150
KTKRIRDIAC GSSHSAAITS SGELYSWGLG EYGRLGHGDN TTQLKPKMVK
3160 3170 3180 3190 3200
VLLGHRVIQV ACGSRDAQTL ALTDEGLVFS WGDGDFGKLG RGGSEGCNIP
3210 3220 3230 3240 3250
QNIERLNGQG VCQIECGAQF SLALTKSGVV WTWGKGDYFR LGHGTDVHVR
3260 3270 3280 3290 3300
KPQVVEGLRG KKIIHVAVGA LHCLAVTDTG QVYAWGDNDH GQQGNGTTTV
3310 3320 3330 3340 3350
NRKPTLVQGL EGQKITRVAC GSSHSVSWTT MDVATPSVHE PVLFQTARDP
3360 3370 3380 3390 3400
LGASYLGVPS DADSSAASNK INGTNSSKPN RPSLAKILLS LDGNLAKQQA
3410 3420 3430 3440 3450
LSHILTSLQI MYARDAVVGA LMPASMIAPV ECLSSSPAPP PDLVSTGSAS
3460 3470 3480 3490 3500
NGDESMLAVD VEERLSPTPW QDRRVEVASS EDSVTPSAVT PSSTAASSRP
3510 3520 3530 3540 3550
FIPVTDDPGA ASIIAETMTK TKEDVESQSK VSGPEPQYLD EFTGLLVPDD
3560 3570 3580 3590 3600
TRVMVDLLKL AVSSRAGEKG KDVLSAVLSG MGTAYPQVAD MLLELCVTEL
3610 3620 3630 3640 3650
EDVATDSQSG RLSSQPVVVE SSHPYTDDTS TSGTVKIPGA EGLRVEFDRQ
3660 3670 3680 3690 3700
CSTERRHDPL TVMDGVNRIV SVRSGREWSD WSSELRIPGD ELKWKFISDG
3710 3720 3730 3740 3750
SVNGWGWRFT VYPIMPAAGP KDLLSDRCIL SCPSMDLVTC LLDFRLNFAS
3760 3770 3780 3790 3800
NRSIVPRLAA SLAACAQLSA LAASHRMWAL QRLRKLLTTE FGQSININRI
3810 3820 3830 3840 3850
LGENDGETRT MSFTGSALAA LVKGLPEALQ RQFDYEDPIV RGGKQLLHSP
3860 3870 3880 3890 3900
FFKVLVALAC DLELDTLPCC AETHKWAWFR RYCMASRVAV ALDKRTPMPR
3910 3920 3930 3940 3950
LFLDEVAKKI RELMADNENM DVLHESHDVF KREQDEQLVQ WMNRRPDDWT
3960 3970 3980 3990 4000
LSAGGSGTIY GWGHNHRGQL GGIEGAKVKV PTPCEALATL RPVQLIGGEQ
4010 4020 4030 4040 4050
TLFAVTADGK LYATGYGAGG RLGIGGTESV STPTLLESIQ HVFIKKVAVN
4060 4070 4080 4090 4100
SGGKHCLALS SEGEVYSWGE AEDGKLGHGN RSPCDRPRVI ESLRGIEVVD
4110 4120 4130 4140 4150
IAAGGAHSAC ITAAGDLYTW GKGRYGRLGH GDSEDQLKPK LVEALQGYRV
4160 4170 4180 4190 4200
IDIACGSGDA QTLCLTDDDT VWSWGDGDYG KLGRGGSDGC KVPMKIDSLT
4210 4220 4230 4240 4250
GVGVVKVECG SQFSVALTKS GAVYTWGKGD YHRLGHGSDD HVRRPRQVQG
4260 4270 4280 4290 4300
LQGKKVIAIA TGSLHCVCCT EDGEVYTWGD NDEGQLGDGT TNAIQRPRLV
4310 4320 4330 4340 4350
AALQGKKINR VACGSAHTLA WSTSKPANAG KLPTQVPMEY NHLQEIPIIA
4360 4370 4380 4390 4400
LRNRLLLLHH ISELFCPCIP MFDLEGRLEE TGQGPSVGFD TLRGILISQG
4410 4420 4430 4440 4450
KEAAFRKVVQ ATMVRDRQHG PVVELNRIQV KRSRSKGGLA GPDGTKSVFG
4460 4470 4480 4490 4500
QMCAKMCSFS PDSLLLPHRV WKVKFVGESV DDCGGGYSES IAEMCEELQN
4510 4520 4530 4540 4550
GLTPLLIVTP NGRDESGANR DCFLLNPAAK SLLHMNMFRF LGVLLGIAIR
4560 4570 4580 4590 4600
TGSPLSLNLA EPVWKQLAGM NLTIADLSEV DKDFIPGLMY IRDNEATSEE
4610 4620 4630 4640 4650
FEAMSLPFTV PNASGQDIQL SSKYAHITLD NRAEYVRLAI NYRLHEFDEQ
4660 4670 4680 4690 4700
VAAVREGMAR VVPVPLLSLF TGYELETMVC GSPDIPLHLL KSVATYKGIE
4710 4720 4730 4740 4750
PTASLIQWFW EVMESFSNTE RSLFLRFVWG RTRLPRTIAD FRGRDFVIQV
4760 4770 4780 4790 4800
LDKYNPPDHF LPESYTCFFL LKLPRYSCKQ VLEEKLKYAI HFCKSIDTDD
4810 4820 4830
YARIALTGEP TADDSSDDSD NEDADSFASD STQDYLTGH
Length:4,839
Mass (Da):529,211
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iADC9D8BCB597A59B
GO

Sequence databases

NCBI Reference Sequences

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RefSeqi
XP_016847835.1, XM_016992346.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSACAT00000005262; ENSACAP00000005145; ENSACAG00000005186

Database of genes from NCBI RefSeq genomes

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GeneIDi
100566865

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_016847835.1, XM_016992346.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000005145

Genome annotation databases

EnsembliENSACAT00000005262; ENSACAP00000005145; ENSACAG00000005186
GeneIDi100566865

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8924

Phylogenomic databases

eggNOGiKOG1426, Eukaryota
GeneTreeiENSGT00940000154975
HOGENOMiCLU_000101_0_0_1
InParanoidiG1KDV1
OrthoDBi1062377at2759
TreeFamiTF320636

Enzyme and pathway databases

UniPathwayiUPA00143

Gene expression databases

BgeeiENSACAG00000005186, Expressed in testis and 14 other tissues

Family and domain databases

CDDicd08664, APC10-HERC2, 1 hit
cd00078, HECTc, 1 hit
cd02344, ZZ_HERC2, 1 hit
Gene3Di2.130.10.30, 3 hits
2.30.30.30, 1 hit
2.30.30.920, 1 hit
2.60.120.260, 1 hit
3.10.120.10, 1 hit
3.30.60.90, 1 hit
InterProiView protein in InterPro
IPR004939, APC_su10/DOC_dom
IPR006624, Beta-propeller_rpt_TECPR
IPR021097, CPH_domain
IPR001199, Cyt_B5-like_heme/steroid-bd
IPR036400, Cyt_B5-like_heme/steroid_sf
IPR008979, Galactose-bd-like_sf
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR037976, HERC2_APC10
IPR010606, Mib_Herc2
IPR037252, Mib_Herc2_sf
IPR009091, RCC1/BLIP-II
IPR000408, Reg_chr_condens
IPR014722, Rib_L2_dom2
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
IPR041987, ZZ_HERC2
PfamiView protein in Pfam
PF03256, ANAPC10, 1 hit
PF11515, Cul7, 1 hit
PF00173, Cyt-b5, 1 hit
PF00632, HECT, 1 hit
PF06701, MIB_HERC2, 1 hit
PF00415, RCC1, 16 hits
PF00569, ZZ, 1 hit
PRINTSiPR00633, RCCNDNSATION
SMARTiView protein in SMART
SM01337, APC10, 1 hit
SM01117, Cyt-b5, 1 hit
SM00119, HECTc, 1 hit
SM00706, TECPR, 4 hits
SM00291, ZnF_ZZ, 1 hit
SUPFAMiSSF159034, SSF159034, 1 hit
SSF49785, SSF49785, 1 hit
SSF50985, SSF50985, 3 hits
SSF55856, SSF55856, 1 hit
SSF56204, SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50255, CYTOCHROME_B5_2, 1 hit
PS51284, DOC, 1 hit
PS50237, HECT, 1 hit
PS51416, MIB_HERC2, 1 hit
PS00626, RCC1_2, 1 hit
PS50012, RCC1_3, 19 hits
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KDV1_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KDV1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: August 12, 2020
This is version 74 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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