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Entry version 57 (12 Aug 2020)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

ABCA4

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi961 – 968ATPPROSITE-ProRule annotation8
Nucleotide bindingi1966 – 1973ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCA4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei653 – 673HelicalSequence analysisAdd BLAST21
Transmembranei693 – 718HelicalSequence analysisAdd BLAST26
Transmembranei730 – 753HelicalSequence analysisAdd BLAST24
Transmembranei760 – 781HelicalSequence analysisAdd BLAST22
Transmembranei1674 – 1696HelicalSequence analysisAdd BLAST23
Transmembranei1726 – 1743HelicalSequence analysisAdd BLAST18
Transmembranei1755 – 1773HelicalSequence analysisAdd BLAST19
Transmembranei1785 – 1810HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000005200, Expressed in hindlimb bud and 2 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000005132

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini927 – 1160ABC transporterInterPro annotationAdd BLAST234
Domaini1932 – 2164ABC transporterInterPro annotationAdd BLAST233

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0059, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155624

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000604_19_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KDU0

TreeFam database of animal gene trees

More...
TreeFami
TF105191

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR003439, ABC_transporter-like
IPR026082, ABCA
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR19229, PTHR19229, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KDU0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFLRQVRLL LWKNWTLRKR QKLRLLVELL WPLSLFLALV WLRSINPVYR
60 70 80 90 100
QHECHFPNKA MPSAGTLPWL QGIFCNMNNP CFRSPTRGES PGVVSNYNNC
110 120 130 140 150
ILARVYQDAQ DLLLGSHGTE LGRLWEELQT LTHFVETIRT NPERIAGRGI
160 170 180 190 200
RVQDILKDGE NLTTFLFEDV GLSDLVVYNL MNAQVRPEQF AFGVPDLTLK
210 220 230 240 250
DIACSKTLLN RFIIFESSGG FQAVHSAMCA LSQEALQKVE DSLYANADFF
260 270 280 290 300
KLFQLLPTLL DSNAQGVDLH SWGRILSDLS QAVQKLVRRP SVQDLLTTLQ
310 320 330 340 350
PHLQDGESTS ARQLMGTLSD LLCGYPEGGG SRILSLNWYE DNNYKAFLVD
360 370 380 390 400
GTKKESIYFY DNTTTPFCNT LIQTMESNTL TKIAWRAVKP LLMGKILFAP
410 420 430 440 450
DSPAVRKILK NANSTFEELE RLQLFAKSWK EVGPQVWYFF QDSVQMNMIR
460 470 480 490 500
DTLQNPTVKG FLNEQLSSEG FTAEDVINFL SNGPAEERNK GTVNLNWRDI
510 520 530 540 550
FNVTNQVLHT VHQYLECLML DKFEGQADES EVADQALCLL EENKFWAAVI
560 570 580 590 600
FPDLDPTASQ LPPHVKYKIR MDIDAVEKTN KIKDRYWDPG PRADPVDDLR
610 620 630 640 650
YIWGGFAYLQ DMIEHGIIKA QTGVAVPPGI YLQQMPYPCF VDDVFMVTLT
660 670 680 690 700
RSFPIFMVLA WIYSISMIVK SIVLEKEMRL KEAMKNRGVT NGVIWFTWFL
710 720 730 740 750
DSFIMMAVST FLLTALIMHG DVLHYSNPHL LFLFLLTFTT ASIMEAFLLS
760 770 780 790 800
TFFSKANMAA ACSGVIYFTL YLPHIVCFAW QDRLTVNIKI MASFLSPVAF
810 820 830 840 850
GFGTEYLSRY EEQGLGLQWD NIRNSPLEGD QYSFLFSMEM MLLDAFIYGL
860 870 880 890 900
LAWYIDNVFP GDYGIPLPWY FPLQPSYWLG GECTLAFITR AIEKSEELSN
910 920 930 940 950
SFTLPASPED SANPYFEEEP SGLIPGVCIQ NLVKIFANSS RPAIDGMNIT
960 970 980 990 1000
FYEGQITAFL GHNGAGKTTT MSILTGLFPP TSGTIWVGGQ DIQTHMDSIR
1010 1020 1030 1040 1050
QNIGMCPQYN ILFNHLTVAE HIWFYSQLKG KSREKAVFEM EMMLADIGLP
1060 1070 1080 1090 1100
HKRNEEARNL SEIGGMQRKL SVAIAFVGEA KVIVLDEPTS GVDPYSRRSI
1110 1120 1130 1140 1150
WDLILKYRSG RTIILSTHHM DEADILGDRI AIISQGKLHC SGTPVFLKNS
1160 1170 1180 1190 1200
FGTGFYLTLV RKMKNTETVI LGSKCSCSCS SCAPTDGAAI LEQELDGNVN
1210 1220 1230 1240 1250
EINELVHHHV PEAQLIESIG QELIYLLPSK NFKQRSYASL FRELEETLAD
1260 1270 1280 1290 1300
LGLSSFGISD TPLEEVFLKV TADADPGTQN AEGTWNDYHN LRNSFLFPAL
1310 1320 1330 1340 1350
SGAHKTTELR MPQGANGISR RPVALKGDGS GGKGSWQNKG CQLFFQQMKA
1360 1370 1380 1390 1400
LLIKRFHHTS RSFKDFLAQI VLPSSFVLLA LILTIIIPPF GEYPGLTLQP
1410 1420 1430 1440 1450
WIYGQQFTFF SNERPGCEET ASLIDTFLNK PGFGNRCLKK TPLQNYSCIT
1460 1470 1480 1490 1500
SSTAWKTPPV PYNVSVLLQS STWSPENPSP SCKCSTRRKL TMLPECPLGA
1510 1520 1530 1540 1550
GGLPPPQRVQ RSTEILQDLT HRNISDFLVK TYPTLIRSSL KSKYWVNEQR
1560 1570 1580 1590 1600
YGGISVGGKL PVLDVTGEQI VAFLRDLGHM MNITGGEATK VVSKEMSNFL
1610 1620 1630 1640 1650
KYMETENNIK VWFNNKGWHA MVIFLNVANN AILRANLKQG KDPEEYGITA
1660 1670 1680 1690 1700
INHPLNLTKE QLSEVTVLTT SVDAVVSICV IFAMSFIPAS FVLFLIQERV
1710 1720 1730 1740 1750
TKAKHLQFVS GVSSFVYWFT NFLWDILNYT VSAGLVVAIF VVFKKKAYTS
1760 1770 1780 1790 1800
PSNLPALVTL LLLYGWAVIP MMYPASCFFS IPSTAYVALS CINLFIGINS
1810 1820 1830 1840 1850
SAITFILELF ENNPPLLKFN KTLKSILLVL PHFCLGRGLL DLAMNQAVTD
1860 1870 1880 1890 1900
VYARFGEEHL LNPFNWDFAG KNMVALAVQG VVFFVLNLLM QRNFLSTRWL
1910 1920 1930 1940 1950
PKNTLTPIID EDEDVAEERQ RIVNGGGKID ILNLQELTKF YTARRVPAVD
1960 1970 1980 1990 2000
RLCVGVRPGE CFGLLGVNGA GKTTTFKMLT GDTEVTSGDA IVAGHSVLTH
2010 2020 2030 2040 2050
ISDVHQNMGY CPQFDAIDDL LTGREHLRLY ARLRGVPAAE VEKVAEWGIQ
2060 2070 2080 2090 2100
KLGLLAYADQ LAGTYSGGNK RKLSTAIALI GCPPLVLLDE PTTGMDPQSR
2110 2120 2130 2140 2150
RFLWNSIVSV IRDGRAVVLT SHSMEECEAL CTRLAIMVKG TFKCLGTIQH
2160 2170 2180 2190 2200
LKYKYGDGYI VTMKMKAPKP GLPPDLSLAE HFIQVNFPGS VQREKHYNML
2210 2220 2230 2240 2250
QYQICSYSLA KIFRLILSNK DVLNIEEYSV TQTTLDQVFV NFAKQQMEDE
2260 2270
EIPLHPRAAG ANREVKVTPA FCQQATA
Length:2,277
Mass (Da):255,642
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8FDB316A9FCBAFAB
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000005249; ENSACAP00000005132; ENSACAG00000005200

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000005132

Genome annotation databases

EnsembliENSACAT00000005249; ENSACAP00000005132; ENSACAG00000005200

Phylogenomic databases

eggNOGiKOG0059, Eukaryota
GeneTreeiENSGT00940000155624
HOGENOMiCLU_000604_19_0_1
InParanoidiG1KDU0
TreeFamiTF105191

Gene expression databases

BgeeiENSACAG00000005200, Expressed in hindlimb bud and 2 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR003439, ABC_transporter-like
IPR026082, ABCA
IPR027417, P-loop_NTPase
PANTHERiPTHR19229, PTHR19229, 1 hit
PfamiView protein in Pfam
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50893, ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KDU0_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KDU0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: August 12, 2020
This is version 57 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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