UniProtKB - G1KDP7 (G1KDP7_ANOCA)
Protein
Submitted name:
Rho guanine nucleotide exchange factor 10
Gene
ARHGEF10
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: GO_Central
- kinesin binding Source: Ensembl
- Rho guanyl-nucleotide exchange factor activity Source: GO_Central
GO - Biological processi
- actin cytoskeleton organization Source: GO_Central
- activation of GTPase activity Source: Ensembl
- centrosome duplication Source: Ensembl
- mitotic spindle assembly Source: GO_Central
- myelination in peripheral nervous system Source: Ensembl
- positive regulation of stress fiber assembly Source: GO_Central
- regulation of Rho protein signal transduction Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Rho guanine nucleotide exchange factor 10Imported |
Gene namesi | Name:ARHGEF10Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Cytoskeleton
- centrosome Source: GO_Central
Cytosol
- cytosol Source: InterPro
Expressioni
Gene expression databases
Bgeei | ENSACAG00000005109, Expressed in testis and 14 other tissues |
Interactioni
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: GO_Central
- kinesin binding Source: Ensembl
- Rho guanyl-nucleotide exchange factor activity Source: GO_Central
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000005055 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 378 – 565 | DHInterPro annotationAdd BLAST | 188 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 64 | DisorderedSequence analysisAdd BLAST | 64 | |
Regioni | 77 – 103 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 147 – 175 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 188 – 263 | DisorderedSequence analysisAdd BLAST | 76 | |
Regioni | 1183 – 1219 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 1239 – 1259 | DisorderedSequence analysisAdd BLAST | 21 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 289 – 312 | Sequence analysisAdd BLAST | 24 | |
Coiled coili | 548 – 579 | Sequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 16 | AcidicSequence analysisAdd BLAST | 16 | |
Compositional biasi | 27 – 44 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 148 – 174 | PolarSequence analysisAdd BLAST | 27 | |
Compositional biasi | 191 – 207 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 245 – 259 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1184 – 1204 | PolyampholyteSequence analysisAdd BLAST | 21 | |
Compositional biasi | 1205 – 1219 | PolarSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG3522, Eukaryota |
GeneTreei | ENSGT00940000153798 |
HOGENOMi | CLU_001213_1_0_1 |
InParanoidi | G1KDP7 |
OMAi | CMVYIPV |
TreeFami | TF331430 |
Family and domain databases
CDDi | cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR030632, ARHGEF10 IPR039919, ARHGEF10/ARHGEF17 IPR035899, DBL_dom_sf IPR000219, DH-domain IPR011993, PH-like_dom_sf IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR12877, PTHR12877, 1 hit PTHR12877:SF14, PTHR12877:SF14, 1 hit |
Pfami | View protein in Pfam PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KDP7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
DDEEEEEGEQ FDFDSGDEIP EADRQTILLP NSESKNSAEQ EGNENLENGA
60 70 80 90 100
GAEKMEKTEA NVEGVLPRVN PYSVITISPM QEKEPSLSPE PSPKDGSISP
110 120 130 140 150
TVSIGYSVPV PCGYAVPSNL PLILPAYSSP VIIRSVSVDE EANIHVVPED
160 170 180 190 200
SHSNSQSSED PQNSEDNQGH NDDNVLTKWV ADPNTEWMEH PNEVIYDDVP
210 220 230 240 250
RENSDSEPEE MIYDDVENGE EGGNSSLEYG WSSSEFESYE EQSDSEGKNG
260 270 280 290 300
MPSSFLRGNH RRQLSHDITR LKEHYEKKMK DLMANTVGAV EIQQLKQKHE
310 320 330 340 350
LKVQKLMRAA REGTKDGLEK TKAAVKKGRC FIRTKSFINQ DHRSTCLEEE
360 370 380 390 400
ELFIDVDCMN TEAIMTPMPD GLSQQQVVRR YILGAVVDSE KNYVDALKRI
410 420 430 440 450
LEQYEKPLSE IEPKLLSERK LKMVFYRIKE ILQCHSLFQI ALASRVSEWD
460 470 480 490 500
SVEMIGDVFV ASFSKSMVLD AYSEYVNNFS TAVGILKKSC ATKPAFLEFL
510 520 530 540 550
KQCQESSPDR ITLYGLMMKP IQRFPQFILL LQDMLKNTTK GHPDRLPLQM
560 570 580 590 600
ALTELETLAE KLNERKRDAD QRCEVKQIAK AMNERYLNKL LSSGNRHLIR
610 620 630 640 650
SDDMLETVYN DKGEIVKTKE RRLFMLNDVL MCATVNIRSS HESSGVVSGQ
660 670 680 690 700
RYLLKWSVPL GHVDVIEYGS SENQDENCRF SSQHSSENIV VNAKPNKLYM
710 720 730 740 750
GPGQLYHDLQ NLLHDLNVVG QISQLIGSLK GNYQNLNQSV AHDWTSGLQK
760 770 780 790 800
LILRKEDEIR AADRCRIQLQ LPGKQDKSGR PTFFTAVFNT FTPAIKQSWI
810 820 830 840 850
KNLQMAKLAL AEENLLGWFC IDDDGNQIKK EKHPLLVKHM PVMMAKQQEF
860 870 880 890 900
KVECAAYNPE PYSCEEIDPD SLSIEHGFLW IGSCTNQMGQ IAIVSFQNSS
910 920 930 940 950
PKVIECFNVE SRILCMVYIP EEEKQKEPSV PLETEDTSTK HSSVPTICLG
960 970 980 990 1000
MEEGSISVYK SSQGSKKVRL QHFFTPEKST IMSLVYKTPH LFAGLVNGNI
1010 1020 1030 1040 1050
AIYTKLKDGS WNSEPQKVVK LGVLPVRSLL VMEETIWAAS GGQIFIINTE
1060 1070 1080 1090 1100
THVVECHFEA HQEEGMVISH MAVAGVGIWI KLTLLSSKTL LLVYHPNTFR
1110 1120 1130 1140 1150
NCSDTNKEVI LPFPNLAGQQ RVSVTSLLVC HGLLLVGTNL GIIVALPVPR
1160 1170 1180 1190 1200
LQGIPKVTGR GMVSYHAHNG PVKFLVMASV TSKRSKSKSR DPHSGLKDED
1210 1220 1230 1240 1250
QQNAVPSERP SSSLSNPNDS AIWLGGSIGS IAQKSDLSSS SGSLTLSHGS
1260 1270 1280 1290 1300
NTTEHRPEES AVYELLKEVS LNQGKKRRSR EGKAISVLVI SGGQGHRRVN
1310 1320
KKAKQQRPDE LVSSVMVWQI PLLKI
Genome annotation databases
Ensembli | ENSACAT00000005168; ENSACAP00000005055; ENSACAG00000005109 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000005055 |
Genome annotation databases
Ensembli | ENSACAT00000005168; ENSACAP00000005055; ENSACAG00000005109 |
Phylogenomic databases
eggNOGi | KOG3522, Eukaryota |
GeneTreei | ENSGT00940000153798 |
HOGENOMi | CLU_001213_1_0_1 |
InParanoidi | G1KDP7 |
OMAi | CMVYIPV |
TreeFami | TF331430 |
Gene expression databases
Bgeei | ENSACAG00000005109, Expressed in testis and 14 other tissues |
Family and domain databases
CDDi | cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR030632, ARHGEF10 IPR039919, ARHGEF10/ARHGEF17 IPR035899, DBL_dom_sf IPR000219, DH-domain IPR011993, PH-like_dom_sf IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR12877, PTHR12877, 1 hit PTHR12877:SF14, PTHR12877:SF14, 1 hit |
Pfami | View protein in Pfam PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KDP7_ANOCA | |
Accessioni | G1KDP7Primary (citable) accession number: G1KDP7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | October 19, 2011 | |
Last modified: | August 12, 2020 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |