UniProtKB - G1KDM7 (G1KDM7_ANOCA)
Protein
Lethal(3)malignant brain tumor-like protein 2
Gene
L3MBTL2
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- chromatin binding Source: GO_Central
- histone binding Source: GO_Central
- methylated histone binding Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- chromatin organization Source: UniProtKB-KW
- negative regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Chromatin regulatorARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Lethal(3)malignant brain tumor-like protein 2ARBA annotation |
Gene namesi | Name:L3MBTL2Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Keywords - Cellular componenti
NucleusARBA annotationPTM / Processingi
Keywords - PTMi
Isopeptide bondARBA annotation, PhosphoproteinARBA annotation, Ubl conjugationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000005056, Expressed in hindlimb bud and 14 other tissues |
Interactioni
Subunit structurei
Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.
ARBA annotationGO - Molecular functioni
- histone binding Source: GO_Central
- methylated histone binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000005013 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 68 – 103 | FCS-typeInterPro annotationAdd BLAST | 36 | |
Repeati | 166 – 270 | MBTPROSITE-ProRule annotationAdd BLAST | 105 | |
Repeati | 278 – 378 | MBTPROSITE-ProRule annotationAdd BLAST | 101 | |
Repeati | 388 – 491 | MBTPROSITE-ProRule annotationAdd BLAST | 104 | |
Repeati | 499 – 590 | MBTPROSITE-ProRule annotationAdd BLAST | 92 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 24 – 71 | DisorderedSequence analysisAdd BLAST | 48 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 24 – 39 | PolarSequence analysisAdd BLAST | 16 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG3766, Eukaryota |
GeneTreei | ENSGT00940000153840 |
HOGENOMi | CLU_005352_2_1_1 |
InParanoidi | G1KDM7 |
TreeFami | TF316498 |
Family and domain databases
Gene3Di | 3.30.60.160, 1 hit |
InterProi | View protein in InterPro IPR038038, L3MBTL2 IPR004092, Mbt IPR012313, Znf_FCS IPR038603, Znf_FCS_sf |
PANTHERi | PTHR12247:SF64, PTHR12247:SF64, 1 hit |
Pfami | View protein in Pfam PF02820, MBT, 3 hits |
SMARTi | View protein in SMART SM00561, MBT, 3 hits |
PROSITEi | View protein in PROSITE PS51079, MBT, 4 hits PS51024, ZF_FCS, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KDM7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
EQNEEEEEDD DLDLFGGYDS CRRYSTSADS ASTSYLEDSS ENEAGDREAG
60 70 80 90 100
EIPVSPSKSQ TPVPRVSDDN GSEPAICEMC GIVGTKDAFF SKTKRFCSVS
110 120 130 140 150
CSRSYSSNSK KASILARLQG KPPTKKAKVL HKASWSAKIG AFLHTQGTGQ
160 170 180 190 200
LADGTLTGQD AVISGFDWGT YLQDHGYKAA PVSCFKHVPL YDQWEDVIKG
210 220 230 240 250
MKVEVLNSDA VLPSRVYWIA SVIKIAGYKA LLRYEGFEND SSHDFWVNLG
260 270 280 290 300
TVDVHPIGWC AINSKILVPP QTIHSKFTNW REYLMKRLVG SRTIPVDFHI
310 320 330 340 350
KMTENMKYPF RQGMRVEIVD KALVSQTRVA VVDSVIGGRL RLLYEDGDSD
360 370 380 390 400
DDFWCHMWTP LIHPVGWSKR VGHCIKKTVL FKEKGSEMAN HPTFRKVYCD
410 420 430 440 450
AVPYLFRKVR SVYPEGSWFE VGMKLEAIDP LNLGNICVAT IHKILLDGYL
460 470 480 490 500
MIGIDGVASR DGSDWFCYHA SLHSIFPAGF CMKNNIELTF PKGYDANTFD
510 520 530 540 550
WESYLQDTSS EAAPARLFNM NFSNYLEMLV LSWFMLFCVL LSKHVLMKYF
560 570 580 590 600
NLSFSYWKPQ KQKDVLEFEC LRILVFIWRC ELIGFQLQPP VALVEPMSPV
610 620 630 640 650
PAKEVPKRRR KPFGKKLCQG KKVTPKARPV KQTTNKIAAP KAKEEMKAVS
660 670 680 690
KIELSKSNNE AVNKQVKEET LCAPISDFET SWFPVPVSIY LKDEDVD
Genome annotation databases
Ensembli | ENSACAT00000005126; ENSACAP00000005013; ENSACAG00000005056 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000005013 |
Genome annotation databases
Ensembli | ENSACAT00000005126; ENSACAP00000005013; ENSACAG00000005056 |
Phylogenomic databases
eggNOGi | KOG3766, Eukaryota |
GeneTreei | ENSGT00940000153840 |
HOGENOMi | CLU_005352_2_1_1 |
InParanoidi | G1KDM7 |
TreeFami | TF316498 |
Gene expression databases
Bgeei | ENSACAG00000005056, Expressed in hindlimb bud and 14 other tissues |
Family and domain databases
Gene3Di | 3.30.60.160, 1 hit |
InterProi | View protein in InterPro IPR038038, L3MBTL2 IPR004092, Mbt IPR012313, Znf_FCS IPR038603, Znf_FCS_sf |
PANTHERi | PTHR12247:SF64, PTHR12247:SF64, 1 hit |
Pfami | View protein in Pfam PF02820, MBT, 3 hits |
SMARTi | View protein in SMART SM00561, MBT, 3 hits |
PROSITEi | View protein in PROSITE PS51079, MBT, 4 hits PS51024, ZF_FCS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KDM7_ANOCA | |
Accessioni | G1KDM7Primary (citable) accession number: G1KDM7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | October 19, 2011 | |
Last modified: | December 2, 2020 | |
This is version 47 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |