UniProtKB - G1KDH8 (G1KDH8_ANOCA)
Protein
Ubiquitinyl hydrolase 1
Gene
USP11
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Catalytic activityi
- Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).ARBA annotation EC:3.4.19.12
GO - Molecular functioni
- cysteine-type peptidase activity Source: UniProtKB-KW
- RNA polymerase II transcription corepressor binding Source: Ensembl
- thiol-dependent ubiquitin-specific protease activity Source: UniProtKB-EC
GO - Biological processi
- protein deubiquitination Source: Ensembl
- ubiquitin-dependent protein catabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Thiol proteaseARBA annotation |
Biological process | Ubl conjugation pathwayARBA annotation |
Protein family/group databases
MEROPSi | C19.014 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:USP11Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: GO_Central
Keywords - Cellular componenti
CytoplasmARBA annotation, NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000004813, Expressed in hemipenis and 14 other tissues |
Interactioni
GO - Molecular functioni
- RNA polymerase II transcription corepressor binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000004936 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 119 | DUSPInterPro annotationAdd BLAST | 112 | |
Domaini | 243 – 865 | USPInterPro annotationAdd BLAST | 623 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 28 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 578 – 638 | DisorderedSequence analysisAdd BLAST | 61 | |
Regioni | 873 – 911 | DisorderedSequence analysisAdd BLAST | 39 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 583 – 622 | AcidicSequence analysisAdd BLAST | 40 |
Phylogenomic databases
eggNOGi | KOG1870, Eukaryota |
GeneTreei | ENSGT00940000160485 |
HOGENOMi | CLU_001060_7_1_1 |
InParanoidi | G1KDH8 |
TreeFami | TF106276 |
Family and domain databases
InterProi | View protein in InterPro IPR035927, DUSP-like_sf IPR038765, Papain-like_cys_pep_sf IPR006615, Pept_C19_DUSP IPR001394, Peptidase_C19_UCH IPR028135, Ub_USP-typ IPR018200, USP_CS IPR028889, USP_dom |
Pfami | View protein in Pfam PF06337, DUSP, 1 hit PF14836, Ubiquitin_3, 1 hit PF00443, UCH, 1 hit |
SMARTi | View protein in SMART SM00695, DUSP, 1 hit |
SUPFAMi | SSF143791, SSF143791, 1 hit SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS51283, DUSP, 1 hit PS00972, USP_1, 1 hit PS50235, USP_3, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KDH8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAERGLPGL EAQRRQVEGE GPAQPGLERP LRAGEKWYLL ENHWYKQWKA
60 70 80 90 100
YVESGNQNSS SFPGRINNAE LFEDLESYRL KDRLVEHEEY VLVPEEVWNK
110 120 130 140 150
LVSWYGTEHD QPAIERKVVD LPSMQKVEVY LVELYLCQHN DMDNFVISQF
160 170 180 190 200
SRMDVIDTVL KEARRQFCIP AEDETRLWVK NSDGSCERLR NLQTTVLDAC
210 220 230 240 250
LSSGQVVIME TRSKDGTWPS SRPHIMKNSI EEEELYRGQP GVCGLTNLGN
260 270 280 290 300
TCFMNSALQC LSNVPPLTEY FLNNCYLDEL NFSNPLGMKG EIAEAYADLI
310 320 330 340 350
KQQWSGHHRS IVPRMFKTKV GHFASQFLGY QQHDSQELLS FLLDGLHEDL
360 370 380 390 400
NRIKKKEYIE LKDAAGRPDE EVAEEAWRNH KRRNNSIIVD IFHGLFKSTL
410 420 430 440 450
VCPECGKVSV TFDPFCYLSA PLPVSKDRVM EVFFVSMDPS KKPEQHRLIV
460 470 480 490 500
PKAGKVLDLC LALSKHTEVP AERMMVADVF SHRFYKIYQM EESLSCILDR
510 520 530 540 550
DDIFIYEVSV SLLEDPSTAD AVVLPVYLRE HAQGRDYSDT YYGVVLFGHP
560 570 580 590 600
LLVSVPRDQL SWEAIYQLLL HRLSRYVTQP DSEEEEDQSE EGEDEEEEEE
610 620 630 640 650
EEEEEEEEEE EEEEEEEETA AEGSNSQEPS LEANQAKRKC RLPQKRQKLL
660 670 680 690 700
FTLHHVNSNG TSDRMASQDE IRSSQPYLAM DWDSDMKKRY YNEAEAEGYV
710 720 730 740 750
KHDCMGYMLK KNPVKLQECI ELFTTVETLE EENPWYCPTC KKHQLATKKL
760 770 780 790 800
DLWSLPEILI IHLKRFSYTK FSREKLDTLV EFPIQQDLNF SDFIGKPQKD
810 820 830 840 850
SLKASLVYQF IYASNLQISS GHVDTTFARN KDSGTWFYFD DSSVSAVSKS
860 870 880 890 900
QIESKAAYVL FYQRQDKIRH PVPPGAAVAT STAVGPDRED YGACCNPHPS
910
EQDSRDFMDV D
Genome annotation databases
Ensembli | ENSACAT00000005049; ENSACAP00000004936; ENSACAG00000004813 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000004936 |
Protein family/group databases
MEROPSi | C19.014 |
Genome annotation databases
Ensembli | ENSACAT00000005049; ENSACAP00000004936; ENSACAG00000004813 |
Phylogenomic databases
eggNOGi | KOG1870, Eukaryota |
GeneTreei | ENSGT00940000160485 |
HOGENOMi | CLU_001060_7_1_1 |
InParanoidi | G1KDH8 |
TreeFami | TF106276 |
Gene expression databases
Bgeei | ENSACAG00000004813, Expressed in hemipenis and 14 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR035927, DUSP-like_sf IPR038765, Papain-like_cys_pep_sf IPR006615, Pept_C19_DUSP IPR001394, Peptidase_C19_UCH IPR028135, Ub_USP-typ IPR018200, USP_CS IPR028889, USP_dom |
Pfami | View protein in Pfam PF06337, DUSP, 1 hit PF14836, Ubiquitin_3, 1 hit PF00443, UCH, 1 hit |
SMARTi | View protein in SMART SM00695, DUSP, 1 hit |
SUPFAMi | SSF143791, SSF143791, 1 hit SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS51283, DUSP, 1 hit PS00972, USP_1, 1 hit PS50235, USP_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KDH8_ANOCA | |
Accessioni | G1KDH8Primary (citable) accession number: G1KDH8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 54 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |