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Entry version 75 (02 Dec 2020)
Sequence version 2 (26 Jun 2013)
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Protein

Low-density lipoprotein receptor-related protein

Gene

LRP6

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental proteinUniRule annotation, ReceptorUniRule annotationARBA annotation
Biological processEndocytosisARBA annotation, Wnt signaling pathwayUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Low-density lipoprotein receptor-related proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRP6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1375 – 1395HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19UniRule annotationAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501089792420 – 1614Low-density lipoprotein receptor-related proteinUniRule annotationAdd BLAST1595

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1271 ↔ 1286PROSITE-ProRule annotation
Disulfide bondi1289 ↔ 1301PROSITE-ProRule annotation
Disulfide bondi1296 ↔ 1314PROSITE-ProRule annotation
Disulfide bondi1308 ↔ 1323PROSITE-ProRule annotation
Disulfide bondi1327 ↔ 1339PROSITE-ProRule annotation
Disulfide bondi1334 ↔ 1352PROSITE-ProRule annotation
Disulfide bondi1346 ↔ 1361PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000004466, Expressed in embryonic post-anal tail and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.

UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000004540

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati63 – 106LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati107 – 149LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati150 – 193LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati194 – 236LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati237 – 277LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini285 – 324EGF-likeInterPro annotationAdd BLAST40
Repeati372 – 414LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati415 – 457LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati458 – 501LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati502 – 544LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati545 – 587LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Domaini591 – 628EGF-likeInterPro annotationAdd BLAST38
Repeati674 – 716LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati717 – 759LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati760 – 802LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati803 – 839LDL-receptor class BPROSITE-ProRule annotationAdd BLAST37
Repeati843 – 885LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Domaini892 – 930EGF-likeInterPro annotationAdd BLAST39
Repeati977 – 1025LDL-receptor class BPROSITE-ProRule annotationAdd BLAST49
Repeati1026 – 1068LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1069 – 1114LDL-receptor class BPROSITE-ProRule annotationAdd BLAST46
Repeati1115 – 1157LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1158 – 1199LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Domaini1207 – 1251EGF-likeInterPro annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1464 – 1489DisorderedSequence analysisAdd BLAST26
Regioni1554 – 1614DisorderedSequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1466 – 1482PolarSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LDLR family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1215, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158990

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002489_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KD13

Database of Orthologous Groups

More...
OrthoDBi
121310at2759

TreeFam database of animal gene trees

More...
TreeFami
TF315253

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112, LDLa, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 4 hits
4.10.400.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR000742, EGF-like_dom
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt
IPR017049, LRP5/6

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00057, Ldl_recept_a, 3 hits
PF00058, Ldl_recept_b, 12 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036314, LDL_recpt-rel_p5/6, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 4 hits
SM00192, LDLa, 3 hits
SM00135, LY, 20 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57424, SSF57424, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01209, LDLRA_1, 2 hits
PS50068, LDLRA_2, 3 hits
PS51120, LDLRB, 20 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KD13-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAVLRSLLV CGLCSLTRAS PLLLYANRRD LRLVDAAQVN ENATVVVSGL
60 70 80 90 100
EDAAAVDFIF IHGLIYWSDV SEEAIKRTEF NKTGNVQNVV ISGLLSPDGL
110 120 130 140 150
ACDWLGEKLY WTDSETNRIE VSNLDGSLRK VLFWQELDQP RAIALDPARG
160 170 180 190 200
FMYWTDWGEV PKIERAGMDG STRSIIITAD IYWPNGLTLD YEDQKLYWAD
210 220 230 240 250
AKLNFIHRSN LDGTHREAVI KGSLPHPFAL TLFGDTLYWT DWTTRAVLAC
260 270 280 290 300
NKYTGENLRE IHSNIFSPMD IHVFNQQRQP NATNPCGTNN GGCSHLCLMS
310 320 330 340 350
PVKPSYQCAC PTGVKLLENE KTCKDGAMEL LLLARRTDLR RISLDTPDFT
360 370 380 390 400
DIVLQLEDIR HAIAIDYDPV EGYIYWTDDE VRAIRRSFID GSASQFVVQA
410 420 430 440 450
QIAHPDGIAV DWIARNLYWT DTGTDRIEVT RLNGTMRKIL ISEELEEPRA
460 470 480 490 500
IVLDPMVGYM YWTDWGEIPK IERATLDGSD RVVLVNTSLG WPNGLALDYV
510 520 530 540 550
EHKIYWGDAK TDKIEVMNAD GTNRRVLVED KLPHIFGFTL LGDYIYWTDW
560 570 580 590 600
QRRSIERVHK RTAEREIIID QLPDLMGLKA TNVHQITGTN PCAELNGGCS
610 620 630 640 650
HLCLYRPQGL RCACPIGLEL INDMKTCIVP EAFLLFSRRA DIRRISLETN
660 670 680 690 700
NNNVAIPLTG VKEASALDFD VTDNRIYWTD ISLKTISRAF MNGSALEHVV
710 720 730 740 750
EFGLDYPEGM AVDWLGKNLY WADTGTNRIE VSKLDGQHRQ VLVWKDLDSP
760 770 780 790 800
RALALDPAEG FMYWTEWGGK PKIDRAAMDG SERSTLVPNV GRANGLTIDY
810 820 830 840 850
VKRRLYWTDL DTNLIESSNM LGLDRDVIAD DLPHPFGLTQ YQDYIYWTDW
860 870 880 890 900
SRRSIERANK TSGQNRTIIQ NHLDYVMDIL VFHSSRQAGW NECASSNGHC
910 920 930 940 950
SHLCLAVPVG GFVCGCPAHY SLNSDNKTCS APTSFLLFSQ KNAINRMVID
960 970 980 990 1000
ELQSPDIILP IHSLRNVRAI DYDPLDKQLY WIDSRQNVIR RSQEDGSQSF
1010 1020 1030 1040 1050
TVVMSPVPNQ NLDIQPYDLS IDIYSRYIYW TCEANNVINV TRLDGRPMGV
1060 1070 1080 1090 1100
VLKSDQDRPR AIVVNPEKGY MYFTNLQERS PPKIERAALD GTEREVLFSN
1110 1120 1130 1140 1150
GLSKPVALAV DSQLGKLFWA DSDLRRIESS DLSGANRIVL EDSNILQPIG
1160 1170 1180 1190 1200
LTVFENWLYW IDRHQQMIEK IDMTRQDRRT KVQARIAQLS DIHAVKELNM
1210 1220 1230 1240 1250
QEYKLHPCSQ DNGGCSHICI VKGDGTTRCS CPIHLVLLQD ELSCGEPPTC
1260 1270 1280 1290 1300
SPQHFTCFTG EIDCIPVAWR CDGFTECEDA SDEKNCPVCS ESQFQCDSGQ
1310 1320 1330 1340 1350
CIDSALQCNG EPNCQDSSDE KKCEVLCLTD QFRCSSGQCI GKNKKCDQNL
1360 1370 1380 1390 1400
DCSDNSDEQG CYTTEEPAPQ ASSTIGSVVG VILTLFVVTA MYFVCQRVLC
1410 1420 1430 1440 1450
PRMKGEGETM TNDYVVHGPA SVPLGYVPHP SSLSGSLPGM PRGKSVISSL
1460 1470 1480 1490 1500
SIMGGSSGPP YDRAHVTGAS SSSSSSTKGT YFPPILNPPP SPATERSHYT
1510 1520 1530 1540 1550
MEFGYSSNSP STHRSYSYRP YSYRHFAPPT TPCSTDVCDS DYAPSRRVMT
1560 1570 1580 1590 1600
TTVGKGYTSD LNYDSEPVPP PPTPRSQYLS AEENYESCPP SPFTERSYSH
1610
HLYPPPPSPC TDSS
Length:1,614
Mass (Da):181,031
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC0B59D88D2957866
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_008109576.1, XM_008111369.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000004645; ENSACAP00000004540; ENSACAG00000004466

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100554684

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
acs:100554684

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_008109576.1, XM_008111369.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000004540

Genome annotation databases

EnsembliENSACAT00000004645; ENSACAP00000004540; ENSACAG00000004466
GeneIDi100554684
KEGGiacs:100554684

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4040

Phylogenomic databases

eggNOGiKOG1215, Eukaryota
GeneTreeiENSGT00940000158990
HOGENOMiCLU_002489_0_0_1
InParanoidiG1KD13
OrthoDBi121310at2759
TreeFamiTF315253

Gene expression databases

BgeeiENSACAG00000004466, Expressed in embryonic post-anal tail and 14 other tissues

Family and domain databases

CDDicd00112, LDLa, 3 hits
Gene3Di2.120.10.30, 4 hits
4.10.400.10, 3 hits
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR000742, EGF-like_dom
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt
IPR017049, LRP5/6
PfamiView protein in Pfam
PF00057, Ldl_recept_a, 3 hits
PF00058, Ldl_recept_b, 12 hits
PIRSFiPIRSF036314, LDL_recpt-rel_p5/6, 1 hit
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00181, EGF, 4 hits
SM00192, LDLa, 3 hits
SM00135, LY, 20 hits
SUPFAMiSSF57424, SSF57424, 3 hits
PROSITEiView protein in PROSITE
PS01209, LDLRA_1, 2 hits
PS50068, LDLRA_2, 3 hits
PS51120, LDLRB, 20 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KD13_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KD13
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: December 2, 2020
This is version 75 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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