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Entry version 52 (02 Jun 2021)
Sequence version 2 (26 Jun 2013)
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Protein

Rho-GAP domain-containing protein

Gene

ARHGAP31

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho-GAP domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGAP31Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000004634, Expressed in forelimb bud and 11 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000004525

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 216Rho-GAPInterPro annotationAdd BLAST196

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni385 – 423DisorderedSequence analysisAdd BLAST39
Regioni507 – 526DisorderedSequence analysisAdd BLAST20
Regioni537 – 643DisorderedSequence analysisAdd BLAST107
Regioni801 – 841DisorderedSequence analysisAdd BLAST41
Regioni880 – 902DisorderedSequence analysisAdd BLAST23
Regioni991 – 1011DisorderedSequence analysisAdd BLAST21
Regioni1114 – 1140DisorderedSequence analysisAdd BLAST27
Regioni1265 – 1420DisorderedSequence analysisAdd BLAST156

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi392 – 415Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi545 – 563Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi585 – 615Polar residuesSequence analysisAdd BLAST31
Compositional biasi617 – 633Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi818 – 841Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi888 – 902Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1280 – 1333Polar residuesSequence analysisAdd BLAST54
Compositional biasi1347 – 1361Polar residuesSequence analysisAdd BLAST15
Compositional biasi1395 – 1420Polar residuesSequence analysisAdd BLAST26

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1449, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159458

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006917_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KD09

Database of Orthologous Groups

More...
OrthoDBi
1300981at2759

TreeFam database of animal gene trees

More...
TreeFami
TF351451

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00620, RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00324, RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350, SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50238, RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KD09-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNKGGKPKL KRKGATNVFG CDLTEYLENS GQDVPPVLKS CAEFIETHGI
60 70 80 90 100
VDGIYRLSGV TSNIQKLRQE FGSDSCPDLT REVYLQDIHC VGSLCKLYFR
110 120 130 140 150
ELPNPLLTYE LYKKFTGAIS CFPEEQQLVQ IQNAIQELPP SHYRTLEYLS
160 170 180 190 200
KHLTLLASFS SMTNMHTRNL ALVWAPNLLR SKEIEAVGCN GDAAFLEVRV
210 220 230 240 250
QQLVIEFILN HVDEIFSDNA TARPKEDEEN KPIMRSLTLP PSASLPMKLV
260 270 280 290 300
SLEEAQARSL SACHPARKER RENSLPEIVP VTGSFFHTVL DLPDSKRKLS
310 320 330 340 350
TKSKKWKSIF NLGRSGSEAK TKLSRNGSVF VRGQKLSEKV TIRPAKSMDS
360 370 380 390 400
LCSIPVEEDE KGNFKRTVMA GGFFVPMMKP RMGGLSNSPD VRKQEAEWDP
410 420 430 440 450
KEDVKGAEGG TEDTEENNIS RPSQVRPLPE QLKVFRAIED PESEQTSPKM
460 470 480 490 500
CRMFYTSNDG TAKSGFHGTL FPLEASPRHQ RKALNISEPF AVSVPLRVSA
510 520 530 540 550
VISINSTPCR SPAKDKPAFP SLQESPLLGQ DSAISAATEG DDNSRLEQPT
560 570 580 590 600
VKEEKKPESK VVAPDTTAEE PAIPKKPEPI DDAQPATKTQ ETKSGWGHGS
610 620 630 640 650
QAPQLKQSLE QRQLVKIPGD QQEEDEARHG QLGVKDQPEQ GCQQQELLRD
660 670 680 690 700
KVEDTLLLKE LASEENSSAA LESPWQDVQQ ELKIVESEEE LPFTATAPEK
710 720 730 740 750
VKLQESESSL IIISPSEANS VVCGSVLPLT RLKEESIVGT TSTMSHFPLF
760 770 780 790 800
GISSKGSKDS MVCNPELFRK QGGASFILPK LENIPYGIPC TKDCLKDEDT
810 820 830 840 850
KSDISLPQEQ KLPSKPLERP TLLRDELSSH PKEKDLDDPE WKSNSWILQK
860 870 880 890 900
KKQGTTVTKA EESDKEFSKR EDLANSKILT GVGSHQLKES RLSDKAQDPL
910 920 930 940 950
DQQDEDSCLN HVQNLELVEP WEEHQWVTSP LHSPTFKGTQ EKALPEFEPQ
960 970 980 990 1000
NQGKAQSHFK KPFFSRSFSL DSKDFVKRHW GTPVPSISAN DEHLCNNTRS
1010 1020 1030 1040 1050
GAREHSATQE REAGRVEAWL NLSNESSKLV GRIQKPLCQE TDFAAIELPL
1060 1070 1080 1090 1100
PQFIGYQESA EKEVHEGKEN QDLMNHMESS LSQFSTGDSL FNSSGPLKDT
1110 1120 1130 1140 1150
TFVQQADTSA TAVMKGSVGE LQGSKNEDIP RRERPRPSSL NLDSVLPAAS
1160 1170 1180 1190 1200
FFNFESLSVP TPPRHFLCGQ KEVKTSDSVP SLPVACPSKS KADLWGSHFD
1210 1220 1230 1240 1250
PQELDYIMMA HATTGRRNSA PVSVSAVRTS FMVKMCQARA VPVIPPKIQY
1260 1270 1280 1290 1300
TQVPLPLQTQ NSNCRTQVTP EDKEVEATVS QCKSNKNAQG QMQSPKSPSV
1310 1320 1330 1340 1350
DRKGKENNTA TFVDSPATRK VESSFSNHNS TQDAPVLRRK RTSEGETTGD
1360 1370 1380 1390 1400
NPQSSKMERP SGVSKPSYRS RPGRPQSLIL FSPPFPIMDH PSSSADSRVL
1410 1420 1430 1440 1450
LSPIRSPSQS PSTSPISSDL SGTVAEGVML RNKMTIPKNG QRLETSTSCF
1460
YQPQRRSVIL DGRSGRQIE
Length:1,469
Mass (Da):162,892
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i69D01B9DBA7AC657
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_008106095.1, XM_008107888.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000004629; ENSACAP00000004525; ENSACAG00000004634

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100553371

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
acs:100553371

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_008106095.1, XM_008107888.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000004525

Genome annotation databases

EnsembliENSACAT00000004629; ENSACAP00000004525; ENSACAG00000004634
GeneIDi100553371
KEGGiacs:100553371

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57514

Phylogenomic databases

eggNOGiKOG1449, Eukaryota
GeneTreeiENSGT00940000159458
HOGENOMiCLU_006917_0_0_1
InParanoidiG1KD09
OrthoDBi1300981at2759
TreeFamiTF351451

Gene expression databases

BgeeiENSACAG00000004634, Expressed in forelimb bud and 11 other tissues

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
PfamiView protein in Pfam
PF00620, RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324, RhoGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238, RHOGAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KD09_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KD09
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: June 2, 2021
This is version 52 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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