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Entry version 65 (02 Dec 2020)
Sequence version 1 (19 Oct 2011)
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Protein

ATP-dependent DNA helicase 2 subunit 1

Gene

XRCC6

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei30Schiff-base intermediate with DNA; for 5'-deoxyribose-5-phosphate lyase activityUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation, HelicaseARBA annotation, Hydrolase
Biological processDNA damage, DNA recombinationARBA annotation, DNA repairARBA annotation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-dependent DNA helicase 2 subunit 1ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:XRCC6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000004508, Expressed in forelimb bud and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000004463

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini310 – 456KuInterPro annotationAdd BLAST147

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 21DisorderedSequence analysisAdd BLAST21
Regioni534 – 559DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi539 – 559PolyampholyteSequence analysisAdd BLAST21

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2327, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153239

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014815_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KCX9

Identification of Orthologs from Complete Genome Data

More...
OMAi
PNDMMGI

Database of Orthologous Groups

More...
OrthoDBi
402798at2759

TreeFam database of animal gene trees

More...
TreeFami
TF315101

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.720.30, 1 hit
2.40.290.10, 1 hit
3.40.50.410, 1 hit
4.10.970.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006165, Ku70
IPR006164, Ku70/Ku80_beta-barrel_dom
IPR027388, Ku70_bridge/pillars_dom_sf
IPR005160, Ku_C
IPR005161, Ku_N
IPR036361, SAP_dom_sf
IPR016194, SPOC-like_C_dom_sf
IPR036465, vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02735, Ku, 1 hit
PF03730, Ku_C, 1 hit
PF03731, Ku_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF003033, Ku70, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00559, Ku78, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100939, SSF100939, 1 hit
SSF53300, SSF53300, 1 hit
SSF68906, SSF68906, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00578, ku70, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KCX9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNWVSYYKN EDEEEGEEQD EEVETIGEYK YSGRDTLLFL VDASKAMFDS
60 70 80 90 100
FDHDDDDDLT PFDMTIQCIQ NVYTNKIISH DRDLVGVVFY GTEQYKNSVD
110 120 130 140 150
FKHIYVLQDL DNPGAKRVLE LGKYKGEQGK ALFSKSFGHS TNYSLGEALW
160 170 180 190 200
VCSNLFSDVR LKMSHKRIML FTNEDNPHGQ DSSKAKFART KATDLRDTGI
210 220 230 240 250
YLDLMHLRKP GGFDISLFYR DIINTAEDED LGVHFDESSK LADLMKKVRS
260 270 280 290 300
KETRKRALGR LNLYLGKDVA LSVGIFNLVQ RAFKQPPVKL YRETNEPVKT
310 320 330 340 350
KTRTFNKETG SLLLPSDTKR AQIYGNRQIV LEKEEVEETK RFDSPGLYLV
360 370 380 390 400
GFKPLLMLKQ HHYIKPAQFI YPDESLISGS TALFRALLTK CLEKGVMAIC
410 420 430 440 450
RYTARRNIPP RFIALVPQEE ELDEQNVQIS PPGFHLIFLP YADDKRKIDF
460 470 480 490 500
TEKVPANQEQ VNKMKEIVQK LRFKYRSESF ENPVLQQHYM NLEALALDLM
510 520 530 540 550
EPEKAEDLTM PKVEVMDSRL DNLVEEFKQL VYPPGYDPDS KATKRKQAGD
560 570 580 590 600
GTEKPEKKAK IEISEEELRN HIKKGTLGKL TVPVLKEVCR IYKLTGGTKK
610
QELLDVVTNY FSKH
Length:614
Mass (Da):70,766
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC97FBCB2A6ACF8FB
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_003221047.1, XM_003220999.3
XP_008108956.1, XM_008110749.2
XP_008108957.1, XM_008110750.2
XP_008108958.1, XM_008110751.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000004564; ENSACAP00000004463; ENSACAG00000004508

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100552071

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
acs:100552071

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_003221047.1, XM_003220999.3
XP_008108956.1, XM_008110749.2
XP_008108957.1, XM_008110750.2
XP_008108958.1, XM_008110751.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000004463

Genome annotation databases

EnsembliENSACAT00000004564; ENSACAP00000004463; ENSACAG00000004508
GeneIDi100552071
KEGGiacs:100552071

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2547

Phylogenomic databases

eggNOGiKOG2327, Eukaryota
GeneTreeiENSGT00940000153239
HOGENOMiCLU_014815_2_0_1
InParanoidiG1KCX9
OMAiPNDMMGI
OrthoDBi402798at2759
TreeFamiTF315101

Gene expression databases

BgeeiENSACAG00000004508, Expressed in forelimb bud and 14 other tissues

Family and domain databases

Gene3Di1.10.720.30, 1 hit
2.40.290.10, 1 hit
3.40.50.410, 1 hit
4.10.970.10, 1 hit
InterProiView protein in InterPro
IPR006165, Ku70
IPR006164, Ku70/Ku80_beta-barrel_dom
IPR027388, Ku70_bridge/pillars_dom_sf
IPR005160, Ku_C
IPR005161, Ku_N
IPR036361, SAP_dom_sf
IPR016194, SPOC-like_C_dom_sf
IPR036465, vWFA_dom_sf
PfamiView protein in Pfam
PF02735, Ku, 1 hit
PF03730, Ku_C, 1 hit
PF03731, Ku_N, 1 hit
PIRSFiPIRSF003033, Ku70, 1 hit
SMARTiView protein in SMART
SM00559, Ku78, 1 hit
SUPFAMiSSF100939, SSF100939, 1 hit
SSF53300, SSF53300, 1 hit
SSF68906, SSF68906, 1 hit
TIGRFAMsiTIGR00578, ku70, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KCX9_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KCX9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: December 2, 2020
This is version 65 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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