UniProtKB - G1KCX9 (G1KCX9_ANOCA)
Protein
ATP-dependent DNA helicase 2 subunit 1
Gene
XRCC6
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 30 | Schiff-base intermediate with DNA; for 5'-deoxyribose-5-phosphate lyase activityUniRule annotation | 1 |
GO - Molecular functioni
- 5'-deoxyribose-5-phosphate lyase activity Source: Ensembl
- ATP binding Source: UniProtKB-KW
- cyclin binding Source: Ensembl
- damaged DNA binding Source: InterPro
- DNA helicase activity Source: InterPro
- double-stranded telomeric DNA binding Source: Ensembl
- protein-containing complex binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
- telomeric DNA binding Source: GO_Central
- transcription regulatory region sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- activation of innate immune response Source: Ensembl
- cellular response to gamma radiation Source: GO_Central
- cellular response to X-ray Source: GO_Central
- DNA recombination Source: UniProtKB-KW
- double-strand break repair via classical nonhomologous end joining Source: Ensembl
- double-strand break repair via nonhomologous end joining Source: GO_Central
- negative regulation of transcription, DNA-templated Source: Ensembl
- positive regulation of protein kinase activity Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- regulation of smooth muscle cell proliferation Source: Ensembl
- telomere maintenance Source: GO_Central
Keywordsi
Molecular function | DNA-bindingARBA annotation, HelicaseARBA annotation, Hydrolase |
Biological process | DNA damage, DNA recombinationARBA annotation, DNA repairARBA annotation |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: ATP-dependent DNA helicase 2 subunit 1ARBA annotation |
Gene namesi | Name:XRCC6Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- Ku70:Ku80 complex Source: GO_Central
- nuclear chromosome, telomeric region Source: GO_Central
- nucleolus Source: Ensembl
- nucleoplasm Source: Ensembl
Other locations
- nonhomologous end joining complex Source: Ensembl
- protein-DNA complex Source: Ensembl
- transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000004508, Expressed in forelimb bud and 14 other tissues |
Interactioni
GO - Molecular functioni
- cyclin binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000004463 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 310 – 456 | KuInterPro annotationAdd BLAST | 147 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 534 – 559 | DisorderedSequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 539 – 559 | PolyampholyteSequence analysisAdd BLAST | 21 |
Phylogenomic databases
eggNOGi | KOG2327, Eukaryota |
GeneTreei | ENSGT00940000153239 |
HOGENOMi | CLU_014815_2_0_1 |
InParanoidi | G1KCX9 |
OMAi | PNDMMGI |
OrthoDBi | 402798at2759 |
TreeFami | TF315101 |
Family and domain databases
Gene3Di | 1.10.720.30, 1 hit 2.40.290.10, 1 hit 3.40.50.410, 1 hit 4.10.970.10, 1 hit |
InterProi | View protein in InterPro IPR006165, Ku70 IPR006164, Ku70/Ku80_beta-barrel_dom IPR027388, Ku70_bridge/pillars_dom_sf IPR005160, Ku_C IPR005161, Ku_N IPR036361, SAP_dom_sf IPR016194, SPOC-like_C_dom_sf IPR036465, vWFA_dom_sf |
Pfami | View protein in Pfam PF02735, Ku, 1 hit PF03730, Ku_C, 1 hit PF03731, Ku_N, 1 hit |
PIRSFi | PIRSF003033, Ku70, 1 hit |
SMARTi | View protein in SMART SM00559, Ku78, 1 hit |
SUPFAMi | SSF100939, SSF100939, 1 hit SSF53300, SSF53300, 1 hit SSF68906, SSF68906, 1 hit |
TIGRFAMsi | TIGR00578, ku70, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KCX9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNWVSYYKN EDEEEGEEQD EEVETIGEYK YSGRDTLLFL VDASKAMFDS
60 70 80 90 100
FDHDDDDDLT PFDMTIQCIQ NVYTNKIISH DRDLVGVVFY GTEQYKNSVD
110 120 130 140 150
FKHIYVLQDL DNPGAKRVLE LGKYKGEQGK ALFSKSFGHS TNYSLGEALW
160 170 180 190 200
VCSNLFSDVR LKMSHKRIML FTNEDNPHGQ DSSKAKFART KATDLRDTGI
210 220 230 240 250
YLDLMHLRKP GGFDISLFYR DIINTAEDED LGVHFDESSK LADLMKKVRS
260 270 280 290 300
KETRKRALGR LNLYLGKDVA LSVGIFNLVQ RAFKQPPVKL YRETNEPVKT
310 320 330 340 350
KTRTFNKETG SLLLPSDTKR AQIYGNRQIV LEKEEVEETK RFDSPGLYLV
360 370 380 390 400
GFKPLLMLKQ HHYIKPAQFI YPDESLISGS TALFRALLTK CLEKGVMAIC
410 420 430 440 450
RYTARRNIPP RFIALVPQEE ELDEQNVQIS PPGFHLIFLP YADDKRKIDF
460 470 480 490 500
TEKVPANQEQ VNKMKEIVQK LRFKYRSESF ENPVLQQHYM NLEALALDLM
510 520 530 540 550
EPEKAEDLTM PKVEVMDSRL DNLVEEFKQL VYPPGYDPDS KATKRKQAGD
560 570 580 590 600
GTEKPEKKAK IEISEEELRN HIKKGTLGKL TVPVLKEVCR IYKLTGGTKK
610
QELLDVVTNY FSKH
Sequence databases
RefSeqi | XP_003221047.1, XM_003220999.3 XP_008108956.1, XM_008110749.2 XP_008108957.1, XM_008110750.2 XP_008108958.1, XM_008110751.1 |
Genome annotation databases
Ensembli | ENSACAT00000004564; ENSACAP00000004463; ENSACAG00000004508 |
GeneIDi | 100552071 |
KEGGi | acs:100552071 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_003221047.1, XM_003220999.3 XP_008108956.1, XM_008110749.2 XP_008108957.1, XM_008110750.2 XP_008108958.1, XM_008110751.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000004463 |
Genome annotation databases
Ensembli | ENSACAT00000004564; ENSACAP00000004463; ENSACAG00000004508 |
GeneIDi | 100552071 |
KEGGi | acs:100552071 |
Organism-specific databases
CTDi | 2547 |
Phylogenomic databases
eggNOGi | KOG2327, Eukaryota |
GeneTreei | ENSGT00940000153239 |
HOGENOMi | CLU_014815_2_0_1 |
InParanoidi | G1KCX9 |
OMAi | PNDMMGI |
OrthoDBi | 402798at2759 |
TreeFami | TF315101 |
Gene expression databases
Bgeei | ENSACAG00000004508, Expressed in forelimb bud and 14 other tissues |
Family and domain databases
Gene3Di | 1.10.720.30, 1 hit 2.40.290.10, 1 hit 3.40.50.410, 1 hit 4.10.970.10, 1 hit |
InterProi | View protein in InterPro IPR006165, Ku70 IPR006164, Ku70/Ku80_beta-barrel_dom IPR027388, Ku70_bridge/pillars_dom_sf IPR005160, Ku_C IPR005161, Ku_N IPR036361, SAP_dom_sf IPR016194, SPOC-like_C_dom_sf IPR036465, vWFA_dom_sf |
Pfami | View protein in Pfam PF02735, Ku, 1 hit PF03730, Ku_C, 1 hit PF03731, Ku_N, 1 hit |
PIRSFi | PIRSF003033, Ku70, 1 hit |
SMARTi | View protein in SMART SM00559, Ku78, 1 hit |
SUPFAMi | SSF100939, SSF100939, 1 hit SSF53300, SSF53300, 1 hit SSF68906, SSF68906, 1 hit |
TIGRFAMsi | TIGR00578, ku70, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KCX9_ANOCA | |
Accessioni | G1KCX9Primary (citable) accession number: G1KCX9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | October 19, 2011 | |
Last modified: | December 2, 2020 | |
This is version 65 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |