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UniProtKB - G1KCX8 (G1KCX8_ANOCA)

Entry version 56 (07 Apr 2021)
Sequence version 2 (26 Jun 2013)
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Protein

Tower domain-containing protein

Gene

brca2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation
Biological processDNA recombinationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tower domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:brca2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSACAG00000004541, Expressed in embryo and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		28377.ENSACAP00000004459

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini679 – 720TowerInterPro annotationAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni149 – 169DisorderedSequence analysisAdd BLAST21
Regioni197 – 225DisorderedSequence analysisAdd BLAST29
Regioni1071 – 1096DisorderedSequence analysisAdd BLAST26
Regioni1144 – 1174DisorderedSequence analysisAdd BLAST31
Regioni1217 – 1241DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili693 – 727Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1148 – 1170PolyampholyteSequence analysisAdd BLAST23
Compositional biasi1217 – 1235PolarSequence analysisAdd BLAST19

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4751, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003602

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008211_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		G1KCX8

Identification of Orthologs from Complete Genome Data

More...OMAi		WMERKPE

Family and domain databases

Conserved Domains Database

More...CDDi		cd04493, BRCA2DBD_OB1, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015525, BRCA2
IPR015252, BRCA2_hlx
IPR036315, BRCA2_hlx_sf
IPR015187, BRCA2_OB_1
IPR015188, BRCA2_OB_3
IPR012340, NA-bd_OB-fold
IPR015205, Tower_dom

The PANTHER Classification System

More...PANTHERi		PTHR11289, PTHR11289, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09169, BRCA-2_helical, 1 hit
PF09103, BRCA-2_OB1, 1 hit
PF09104, BRCA-2_OB3, 1 hit
PF09121, Tower, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002397, BRCA2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01341, Tower, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50249, SSF50249, 3 hits
SSF81872, SSF81872, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KCX8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDTIVTQSK PQHRCNALSL ATKNLEKRSS QNLLSTKILT CVCDSEKSRN 
        60         70         80         90        100
TETKHSTPCN IPRKGNLYSH CHTYSQTPEN YLETEASESA RAFMEDDDLT 
       110        120        130        140        150
DSEAERNKKA FASNSEINNS YSYARAGKRC MEKENTFGEP PIKRKLLPEF 
       160        170        180        190        200
DQSERSSLKA SRSSLDGTMN DRKTNIYGIL LKPVNCDSLS FTKEVKKPNF 
       210        220        230        240        250
TTPGRDLKGF KSDGPQQHVS KHSSSTSSCV FKQFSNTSVR EESKKTDNPT 
       260        270        280        290        300
AKTTIKVFVP PFKTKPSASE DEINSKESYF QNNNSVHGEL SNTKVHETFL 
       310        320        330        340        350
QPEKEKYEKI SAVDSEIREI DLGLTNIASL HCARNLQEMR ILKKQKQVIG 
       360        370        380        390        400
PQPGTLYLMK ICATSCRIPL KTAVDEKCPG SYFSEQLYAF GVSKQCLNVN 
       410        420        430        440        450
SSNAEHFQFH IQDFFGRECF LDGNGIQLAD GGYLIPTDDG KAGKEEFYRA 
       460        470        480        490        500
LCDTPGVDPK LISKAWVYNH YKWIIWKLAA MEVAFPQEFA SKCLTPERVL 
       510        520        530        540        550
LQLKYRYDVE VDKSCRSAIK RITERDDVAA KTLVLCISRI ISLSSNVSCI 
       560        570        580        590        600
SGNKSTTEEN KKDVAVVEVT DGWYGIKAVL DPSLQSLLHK QKLTVGQKIV 
       610        620        630        640        650
VHGAELMGPQ DACSPLDVPE SLMLKISGNS TRRARWYSTL GYYRDPRPFT 
       660        670        680        690        700
LPLSSLFSDG GIVGCIDVVV QRIYPTQWME KTSTGSYMFR NCRAEEREAA 
       710        720        730        740        750
KHAENKQKTL EALLANIQAE FEKNEETGEG KRVLRSRTLT RQQIRSLQDG 
       760        770        780        790        800
AELYEAVLNA ADPAYMEGYF SEEQLKALNS HRQMVNDKKR AQIEAEFKKA 
       810        820        830        840        850
VESAEQDKSS SCSRDVTPVI KVRIVDYRKE EKEVILTIWR PSSHVCTLLK 
       860        870        880        890        900
EGCPYRVFHV AASPSKGRAE PTNLQLTATK KTQYLQLPVS QEVLSQVYRP 
       910        920        930        940        950
RECLMFSELL LESFRPACSE VDLVGYVVSL RKGTGFSTLV YLSDKDHNLI 
       960        970        980        990       1000
AVHICTDLRQ FAVEDIIIPS MLISATNLQW RPKFYSNIPS LFAGDLSTFS 
      1010       1020       1030       1040       1050
SKPKETRLQE IFNDLRNTVE SDSCFQKDAE RKLATLLQTN VPQVMNLPKE 
      1060       1070       1080       1090       1100
HDFDPFPSPW RSDAGNKHLI STPNTELRLP SPLSIKRPNT KAPGSLCSTK 
      1110       1120       1130       1140       1150
VKADLQETPK NLEKRKAMDL LSQVPSPPPV KPICTFISPS LKRAFQPPRS 
      1160       1170       1180       1190       1200
SDPHHERFLK KTESTVREPG VKRPNETNFQ LENYFVADEE LAMINTQAFL 
      1210       1220       1230       1240 
SNSTEEKEAG FTEKIAHTSH NDSSNSFSLR NNSCPSGKDK T
Length:1,241
Mass (Da):139,858
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i898CFE739F0C934B
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSACAT00000004560; ENSACAP00000004459; ENSACAG00000004541

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000004459

Genome annotation databases

EnsembliENSACAT00000004560; ENSACAP00000004459; ENSACAG00000004541

Phylogenomic databases

eggNOGiKOG4751, Eukaryota
GeneTreeiENSGT00390000003602
HOGENOMiCLU_008211_0_0_1
InParanoidiG1KCX8
OMAiWMERKPE

Gene expression databases

BgeeiENSACAG00000004541, Expressed in embryo and 14 other tissues

Family and domain databases

CDDicd04493, BRCA2DBD_OB1, 1 hit
InterProiView protein in InterPro
IPR015525, BRCA2
IPR015252, BRCA2_hlx
IPR036315, BRCA2_hlx_sf
IPR015187, BRCA2_OB_1
IPR015188, BRCA2_OB_3
IPR012340, NA-bd_OB-fold
IPR015205, Tower_dom
PANTHERiPTHR11289, PTHR11289, 1 hit
PfamiView protein in Pfam
PF09169, BRCA-2_helical, 1 hit
PF09103, BRCA-2_OB1, 1 hit
PF09104, BRCA-2_OB3, 1 hit
PF09121, Tower, 1 hit
PIRSFiPIRSF002397, BRCA2, 1 hit
SMARTiView protein in SMART
SM01341, Tower, 1 hit
SUPFAMiSSF50249, SSF50249, 3 hits
SSF81872, SSF81872, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KCX8_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KCX8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: April 7, 2021
This is version 56 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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