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UniProtKB - G1KCX8 (G1KCX8_ANOCA)

Entry version 58 (29 Sep 2021)
Sequence version 3 (29 Sep 2021)
Previous versions | rss
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Protein
Submitted name:

BRCA2 DNA repair associated

Gene

BRCA2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation
Biological processDNA recombinationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
BRCA2 DNA repair associatedImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BRCA2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSACAG00000004541, Expressed in embryo and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		28377.ENSACAP00000004459

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4751, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003602

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008211_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		G1KCX8

Identification of Orthologs from Complete Genome Data

More...OMAi		WMERKPE

Family and domain databases

Conserved Domains Database

More...CDDi		cd04493, BRCA2DBD_OB1, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015525, BRCA2
IPR015252, BRCA2_hlx
IPR036315, BRCA2_hlx_sf
IPR015187, BRCA2_OB_1
IPR015188, BRCA2_OB_3
IPR012340, NA-bd_OB-fold
IPR015205, Tower_dom

The PANTHER Classification System

More...PANTHERi		PTHR11289, PTHR11289, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09169, BRCA-2_helical, 1 hit
PF09103, BRCA-2_OB1, 1 hit
PF09104, BRCA-2_OB3, 1 hit
PF09121, Tower, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002397, BRCA2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01341, Tower, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50249, SSF50249, 3 hits
SSF81872, SSF81872, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

G1KCX8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKENDAPTK KPSFFEIYKA RCDDSDLGPI SLNWFEELSS EAPPYDNKPE 
        60         70         80         90        100
YSDHKTNSLD QTIFKTPKVK LSTNNSAAST PMIFKEQNKA SLLCTPIKEF 
       110        120        130        140        150
CYSSTETGLN RSLLCTPKVF EEETPKGISV SLGAEADPDM SWSSSLATPP 
       160        170        180        190        200
TLSPTVIIGN HRIDKAFSYS LLGSISTPTT SNGIGLMKSS LKTMSSLSSL 
       210        220        230        240        250
KKRPKKFIYT INNTPANHGK VSCGDGTSTL FVPTSCVSEV SETTARYAGT 
       260        270        280        290        300
MSIFFLQVDF KIYKPFLTLK ELSTLRDSQN NLNRGQLIQP DLQKNENNSK 
       310        320        330        340        350
QRKLECKLYS EAKNLGGFKT ASNKEIRLSD NNIRQGKLLF GDIEEQYPED 
       360        370        380        390        400
LLSSQVQNTA NKNAHENATT SLIGRNVLSE NSCDLSHVSD SLMNLIQFTD 
       410        420        430        440        450
SQSSFQNKLK KQKIEGKQNL TASQEAEVAE LSNILEETGS QFDFTQFREH 
       460        470        480        490        500
KSVMYDNICE ESESYMNSEL WKDNDFEECF DNKVQRSDDP SSNNPSNSLP 
       510        520        530        540        550
MKSKTQTQNN EENTLIKSSS KKDIQHVVPV ISASLQSGLW DYSSAEGKNI 
       560        570        580        590        600
NISAEIINKI TKPVRDSATE MLSPHKTCQF NCSKSCNVMW ENINYNKERN 
       610        620        630        640        650
DLHQRAKEIN LEYMMRNNAK ERNFCIKENI QNKSKAIDLN KVVHITSTTE 
       660        670        680        690        700
VNLKIIKKYS VNVTENELSC TENHHSALGG HQFSGCGSTQ YNYNYQETMS 
       710        720        730        740        750
DLTCLAEIAK MEKDSPFNNA DRKENFNSSQ EGVTKNSGSS CLLQNVDSVA 
       760        770        780        790        800
DENIVAEKSK MLHFLTDSCS GKLDGTIAIG SIKEAITSVK RGTVSSQSDI 
       810        820        830        840        850
FGFHYPEIYE TRKMQMNAVG FQMASGKQIV ITDESLSKAR NLLSEETPFL 
       860        870        880        890        900
GKEDVAVYSV KPSIQTSIKE EQNVKITEVN KESGKETINH QDYMNPKSRF 
       910        920        930        940        950
KEPVDMVSNT ENLKAIKELS LDINSLESDL ICSQRKAMHT IDSLAKNRLA 
       960        970        980        990       1000
QILGKNDVLK TVSIDSATGQ DLYIEGLDTC AKQVLECLSS RTKSNAFIAG 
      1010       1020       1030       1040       1050
SKSHGSLDLT CNTTAEANYT DLISTHSALG HPQDSSNEKK SQELTGINEE 
      1060       1070       1080       1090       1100
AASSKILISE NISGEMSKNK SAIQRSDQKN LNANTFQKYS ASEEAASNVL 
      1110       1120       1130       1140       1150
KSRPVAFSTA SGKTVRISEK ALKKVKQLFD DDSCSSVKQN IKSQSKTSEH 
      1160       1170       1180       1190       1200
NLESCSNVLT SREQVSSSNY LSMEKVTLEK SVASQCLTAK EYHEDDQELQ 
      1210       1220       1230       1240       1250
HTASVPLNIV SESDCQTPCL QINNGPDTKA SNKLICSKSD FSINNCGFFS 
      1260       1270       1280       1290       1300
TASGKAVQLS EESLKKARQF FSEIEDDSLG CQTHVSGGGD HYWKASSVRN 
      1310       1320       1330       1340       1350
KATAKENKLL MSQGKILSNA EVDSNIPCGF STASGKQVQI SQKAVQSVME 
      1360       1370       1380       1390       1400
LFKEFSDDIN SNGFVAQQSL EQGDVSSVKD ADVKVKMEDT IVTQSKPQHR 
      1410       1420       1430       1440       1450
CNALSLATKN LEKRSSQNLL STKILTCVCD SEKSRNTETK HSTPCNIPRK 
      1460       1470       1480       1490       1500
GNLYSHCHTY SQTPENYLET EASESARAFM EDDDLTDSEA ERNKKAFASN 
      1510       1520       1530       1540       1550
SEINNSYSYA RAGKRCMEKE NTFGRYLFSF LFLTLHLFSS KCFYFFSFTK 
      1560       1570       1580       1590       1600
EVKKPNFTTP GRDLKGFKSD GPQQHVSKHS SSTSSCVFKQ FSNTSVREES 
      1610       1620       1630       1640       1650
KKTDNPTAKT TIKVFVPPFK TKPSASEDEI NSKESYFQNN NSVHGELSNT 
      1660       1670       1680       1690       1700
KTTVCSEASF CVWFLHFFTG LTNIASLHCA RNLQEMRILK KQKQVIGPQP 
      1710       1720       1730       1740       1750
GTLYLMKICA TSCRIPLKTA VDEKCPGSYF SEQLYAFGVS KQCLNVNSSN 
      1760       1770       1780       1790       1800
AEHFQFHIQD FFGRECFLDG NGIQLADGGY LIPTDDGKAG KEEFYRALCD 
      1810       1820       1830       1840       1850
TPGVDPKLIS KAWVYNHYKW IIWKLAAMEV AFPQEFASKC LTPERVLLQL 
      1860       1870       1880       1890       1900
KYRYDVEVDK SCRSAIKRIT ERDDVAAKTL VLCISRIISL SSNVSCISGN 
      1910       1920       1930       1940       1950
KSTTEENKKD VAVVEVTDGW YGIKAVLDPS LQSLLHKQKL TVGQKIVVHG 
      1960       1970       1980       1990       2000
AELMGPQDAC SPLDVPESLM LKISGNSTRR ARWYSTLGYY RDPRPFTLPL 
      2010       2020       2030       2040       2050
SSLFSDGGIV GCIDVVVQRI YPTQWMEKTS TGSYMFRNCR AEEREAAKHA 
      2060       2070       2080       2090       2100
ENKQKTLEAL LANIQAEFEK NEGEGKRVLR SRTLTRQQIR SLQDGAELYE 
      2110       2120       2130       2140       2150
AVLNAADPAY MEGYFSEEQL KALNSHRQMV NDKKRAQIEA EFKKAVESAE 
      2160       2170       2180       2190       2200
QDKSSSCSRD VTPVIKVRIV DYRKEEKGKV ILTIWRPSSH VCTLLKEGCP 
      2210       2220       2230       2240       2250
YRVFHVAASP SKGRAEPTNL QLTATKKTQY LQLPVSQEVL SQVYRPRECL 
      2260       2270       2280       2290       2300
MFSELLLESF RPACSEVDLV GYVVSLRKGT GFSTLVYLSD KDHNLIAVHI 
      2310       2320       2330       2340       2350
CTDLRQFAVE DIIIPSMLIS ATNLQWRPKF YSNIPSLFAG DLSTFSSKPK 
      2360       2370       2380       2390       2400
ETRLQEIFND LRNTVESDSC FQKDAERKLA TLLQTNVPQV MNLPKEHDFD 
      2410       2420       2430       2440       2450
PFPSPWRSDI STPNTELRLP SPLSIKRPNT KAPGSLCSTK VKADLQETPK 
      2460       2470       2480       2490       2500
NLEKRKAMDL LSQVPSPPPV KPICTFISPS LKRAFQPPRS SDPHHERFLK 
      2510       2520       2530       2540       2550
KTESTVREPG VKRPNETNFQ LENYFVADEE LAMINTQAFL SNSTEEKEAG 
      2560       2570       2580       2590 
FTEKIAHTSH NDSSNSFSLR NNSSIVCSID VIQNREGRKT LNT
Length:2,593
Mass (Da):289,649
Last modified:September 29, 2021 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA297174F92EEE78F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A803SZT0A0A803SZT0_ANOCA
BRCA2 DNA repair associated
BRCA2
2,581Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A803T452A0A803T452_ANOCA
BRCA2 DNA repair associated
BRCA2
1,073Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A803T7B8A0A803T7B8_ANOCA
BRCA2 DNA repair associated
BRCA2
2,629Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSACAT00000004560; ENSACAP00000004459; ENSACAG00000004541

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000004459

Genome annotation databases

EnsembliENSACAT00000004560; ENSACAP00000004459; ENSACAG00000004541

Phylogenomic databases

eggNOGiKOG4751, Eukaryota
GeneTreeiENSGT00390000003602
HOGENOMiCLU_008211_0_0_1
InParanoidiG1KCX8
OMAiWMERKPE

Gene expression databases

BgeeiENSACAG00000004541, Expressed in embryo and 14 other tissues

Family and domain databases

CDDicd04493, BRCA2DBD_OB1, 1 hit
InterProiView protein in InterPro
IPR015525, BRCA2
IPR015252, BRCA2_hlx
IPR036315, BRCA2_hlx_sf
IPR015187, BRCA2_OB_1
IPR015188, BRCA2_OB_3
IPR012340, NA-bd_OB-fold
IPR015205, Tower_dom
PANTHERiPTHR11289, PTHR11289, 1 hit
PfamiView protein in Pfam
PF09169, BRCA-2_helical, 1 hit
PF09103, BRCA-2_OB1, 1 hit
PF09104, BRCA-2_OB3, 1 hit
PF09121, Tower, 1 hit
PIRSFiPIRSF002397, BRCA2, 1 hit
SMARTiView protein in SMART
SM01341, Tower, 1 hit
SUPFAMiSSF50249, SSF50249, 3 hits
SSF81872, SSF81872, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KCX8_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KCX8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: September 29, 2021
Last modified: September 29, 2021
This is version 58 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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