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Entry version 56 (07 Apr 2021)
Sequence version 2 (26 Jun 2013)
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Protein

Tower domain-containing protein

Gene

brca2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation
Biological processDNA recombinationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tower domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:brca2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000004541, Expressed in embryo and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000004459

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini679 – 720TowerInterPro annotationAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni149 – 169DisorderedSequence analysisAdd BLAST21
Regioni197 – 225DisorderedSequence analysisAdd BLAST29
Regioni1071 – 1096DisorderedSequence analysisAdd BLAST26
Regioni1144 – 1174DisorderedSequence analysisAdd BLAST31
Regioni1217 – 1241DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili693 – 727Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1148 – 1170PolyampholyteSequence analysisAdd BLAST23
Compositional biasi1217 – 1235PolarSequence analysisAdd BLAST19

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4751, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003602

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008211_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KCX8

Identification of Orthologs from Complete Genome Data

More...
OMAi
WMERKPE

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04493, BRCA2DBD_OB1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015525, BRCA2
IPR015252, BRCA2_hlx
IPR036315, BRCA2_hlx_sf
IPR015187, BRCA2_OB_1
IPR015188, BRCA2_OB_3
IPR012340, NA-bd_OB-fold
IPR015205, Tower_dom

The PANTHER Classification System

More...
PANTHERi
PTHR11289, PTHR11289, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09169, BRCA-2_helical, 1 hit
PF09103, BRCA-2_OB1, 1 hit
PF09104, BRCA-2_OB3, 1 hit
PF09121, Tower, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002397, BRCA2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01341, Tower, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50249, SSF50249, 3 hits
SSF81872, SSF81872, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KCX8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDTIVTQSK PQHRCNALSL ATKNLEKRSS QNLLSTKILT CVCDSEKSRN
60 70 80 90 100
TETKHSTPCN IPRKGNLYSH CHTYSQTPEN YLETEASESA RAFMEDDDLT
110 120 130 140 150
DSEAERNKKA FASNSEINNS YSYARAGKRC MEKENTFGEP PIKRKLLPEF
160 170 180 190 200
DQSERSSLKA SRSSLDGTMN DRKTNIYGIL LKPVNCDSLS FTKEVKKPNF
210 220 230 240 250
TTPGRDLKGF KSDGPQQHVS KHSSSTSSCV FKQFSNTSVR EESKKTDNPT
260 270 280 290 300
AKTTIKVFVP PFKTKPSASE DEINSKESYF QNNNSVHGEL SNTKVHETFL
310 320 330 340 350
QPEKEKYEKI SAVDSEIREI DLGLTNIASL HCARNLQEMR ILKKQKQVIG
360 370 380 390 400
PQPGTLYLMK ICATSCRIPL KTAVDEKCPG SYFSEQLYAF GVSKQCLNVN
410 420 430 440 450
SSNAEHFQFH IQDFFGRECF LDGNGIQLAD GGYLIPTDDG KAGKEEFYRA
460 470 480 490 500
LCDTPGVDPK LISKAWVYNH YKWIIWKLAA MEVAFPQEFA SKCLTPERVL
510 520 530 540 550
LQLKYRYDVE VDKSCRSAIK RITERDDVAA KTLVLCISRI ISLSSNVSCI
560 570 580 590 600
SGNKSTTEEN KKDVAVVEVT DGWYGIKAVL DPSLQSLLHK QKLTVGQKIV
610 620 630 640 650
VHGAELMGPQ DACSPLDVPE SLMLKISGNS TRRARWYSTL GYYRDPRPFT
660 670 680 690 700
LPLSSLFSDG GIVGCIDVVV QRIYPTQWME KTSTGSYMFR NCRAEEREAA
710 720 730 740 750
KHAENKQKTL EALLANIQAE FEKNEETGEG KRVLRSRTLT RQQIRSLQDG
760 770 780 790 800
AELYEAVLNA ADPAYMEGYF SEEQLKALNS HRQMVNDKKR AQIEAEFKKA
810 820 830 840 850
VESAEQDKSS SCSRDVTPVI KVRIVDYRKE EKEVILTIWR PSSHVCTLLK
860 870 880 890 900
EGCPYRVFHV AASPSKGRAE PTNLQLTATK KTQYLQLPVS QEVLSQVYRP
910 920 930 940 950
RECLMFSELL LESFRPACSE VDLVGYVVSL RKGTGFSTLV YLSDKDHNLI
960 970 980 990 1000
AVHICTDLRQ FAVEDIIIPS MLISATNLQW RPKFYSNIPS LFAGDLSTFS
1010 1020 1030 1040 1050
SKPKETRLQE IFNDLRNTVE SDSCFQKDAE RKLATLLQTN VPQVMNLPKE
1060 1070 1080 1090 1100
HDFDPFPSPW RSDAGNKHLI STPNTELRLP SPLSIKRPNT KAPGSLCSTK
1110 1120 1130 1140 1150
VKADLQETPK NLEKRKAMDL LSQVPSPPPV KPICTFISPS LKRAFQPPRS
1160 1170 1180 1190 1200
SDPHHERFLK KTESTVREPG VKRPNETNFQ LENYFVADEE LAMINTQAFL
1210 1220 1230 1240
SNSTEEKEAG FTEKIAHTSH NDSSNSFSLR NNSCPSGKDK T
Length:1,241
Mass (Da):139,858
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i898CFE739F0C934B
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000004560; ENSACAP00000004459; ENSACAG00000004541

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000004459

Genome annotation databases

EnsembliENSACAT00000004560; ENSACAP00000004459; ENSACAG00000004541

Phylogenomic databases

eggNOGiKOG4751, Eukaryota
GeneTreeiENSGT00390000003602
HOGENOMiCLU_008211_0_0_1
InParanoidiG1KCX8
OMAiWMERKPE

Gene expression databases

BgeeiENSACAG00000004541, Expressed in embryo and 14 other tissues

Family and domain databases

CDDicd04493, BRCA2DBD_OB1, 1 hit
InterProiView protein in InterPro
IPR015525, BRCA2
IPR015252, BRCA2_hlx
IPR036315, BRCA2_hlx_sf
IPR015187, BRCA2_OB_1
IPR015188, BRCA2_OB_3
IPR012340, NA-bd_OB-fold
IPR015205, Tower_dom
PANTHERiPTHR11289, PTHR11289, 1 hit
PfamiView protein in Pfam
PF09169, BRCA-2_helical, 1 hit
PF09103, BRCA-2_OB1, 1 hit
PF09104, BRCA-2_OB3, 1 hit
PF09121, Tower, 1 hit
PIRSFiPIRSF002397, BRCA2, 1 hit
SMARTiView protein in SMART
SM01341, Tower, 1 hit
SUPFAMiSSF50249, SSF50249, 3 hits
SSF81872, SSF81872, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KCX8_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KCX8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: April 7, 2021
This is version 56 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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