UniProtKB - G1KCX8 (G1KCX8_ANOCA)
Protein
Tower domain-containing protein
Gene
brca2
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
GO - Biological processi
- double-strand break repair via homologous recombination Source: GO_Central
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Biological process | DNA recombinationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Tower domain-containing proteinInterPro annotation |
Gene namesi | Name:brca2Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Expressioni
Gene expression databases
Bgeei | ENSACAG00000004541, Expressed in embryo and 14 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 679 – 720 | TowerInterPro annotationAdd BLAST | 42 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 149 – 169 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 197 – 225 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 1071 – 1096 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 1144 – 1174 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 1217 – 1241 | DisorderedSequence analysisAdd BLAST | 25 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 693 – 727 | Sequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1148 – 1170 | PolyampholyteSequence analysisAdd BLAST | 23 | |
Compositional biasi | 1217 – 1235 | PolarSequence analysisAdd BLAST | 19 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG4751, Eukaryota |
GeneTreei | ENSGT00390000003602 |
HOGENOMi | CLU_008211_0_0_1 |
InParanoidi | G1KCX8 |
OMAi | WMERKPE |
Family and domain databases
CDDi | cd04493, BRCA2DBD_OB1, 1 hit |
InterProi | View protein in InterPro IPR015525, BRCA2 IPR015252, BRCA2_hlx IPR036315, BRCA2_hlx_sf IPR015187, BRCA2_OB_1 IPR015188, BRCA2_OB_3 IPR012340, NA-bd_OB-fold IPR015205, Tower_dom |
PANTHERi | PTHR11289, PTHR11289, 1 hit |
Pfami | View protein in Pfam PF09169, BRCA-2_helical, 1 hit PF09103, BRCA-2_OB1, 1 hit PF09104, BRCA-2_OB3, 1 hit PF09121, Tower, 1 hit |
PIRSFi | PIRSF002397, BRCA2, 1 hit |
SMARTi | View protein in SMART SM01341, Tower, 1 hit |
SUPFAMi | SSF50249, SSF50249, 3 hits SSF81872, SSF81872, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KCX8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEDTIVTQSK PQHRCNALSL ATKNLEKRSS QNLLSTKILT CVCDSEKSRN
60 70 80 90 100
TETKHSTPCN IPRKGNLYSH CHTYSQTPEN YLETEASESA RAFMEDDDLT
110 120 130 140 150
DSEAERNKKA FASNSEINNS YSYARAGKRC MEKENTFGEP PIKRKLLPEF
160 170 180 190 200
DQSERSSLKA SRSSLDGTMN DRKTNIYGIL LKPVNCDSLS FTKEVKKPNF
210 220 230 240 250
TTPGRDLKGF KSDGPQQHVS KHSSSTSSCV FKQFSNTSVR EESKKTDNPT
260 270 280 290 300
AKTTIKVFVP PFKTKPSASE DEINSKESYF QNNNSVHGEL SNTKVHETFL
310 320 330 340 350
QPEKEKYEKI SAVDSEIREI DLGLTNIASL HCARNLQEMR ILKKQKQVIG
360 370 380 390 400
PQPGTLYLMK ICATSCRIPL KTAVDEKCPG SYFSEQLYAF GVSKQCLNVN
410 420 430 440 450
SSNAEHFQFH IQDFFGRECF LDGNGIQLAD GGYLIPTDDG KAGKEEFYRA
460 470 480 490 500
LCDTPGVDPK LISKAWVYNH YKWIIWKLAA MEVAFPQEFA SKCLTPERVL
510 520 530 540 550
LQLKYRYDVE VDKSCRSAIK RITERDDVAA KTLVLCISRI ISLSSNVSCI
560 570 580 590 600
SGNKSTTEEN KKDVAVVEVT DGWYGIKAVL DPSLQSLLHK QKLTVGQKIV
610 620 630 640 650
VHGAELMGPQ DACSPLDVPE SLMLKISGNS TRRARWYSTL GYYRDPRPFT
660 670 680 690 700
LPLSSLFSDG GIVGCIDVVV QRIYPTQWME KTSTGSYMFR NCRAEEREAA
710 720 730 740 750
KHAENKQKTL EALLANIQAE FEKNEETGEG KRVLRSRTLT RQQIRSLQDG
760 770 780 790 800
AELYEAVLNA ADPAYMEGYF SEEQLKALNS HRQMVNDKKR AQIEAEFKKA
810 820 830 840 850
VESAEQDKSS SCSRDVTPVI KVRIVDYRKE EKEVILTIWR PSSHVCTLLK
860 870 880 890 900
EGCPYRVFHV AASPSKGRAE PTNLQLTATK KTQYLQLPVS QEVLSQVYRP
910 920 930 940 950
RECLMFSELL LESFRPACSE VDLVGYVVSL RKGTGFSTLV YLSDKDHNLI
960 970 980 990 1000
AVHICTDLRQ FAVEDIIIPS MLISATNLQW RPKFYSNIPS LFAGDLSTFS
1010 1020 1030 1040 1050
SKPKETRLQE IFNDLRNTVE SDSCFQKDAE RKLATLLQTN VPQVMNLPKE
1060 1070 1080 1090 1100
HDFDPFPSPW RSDAGNKHLI STPNTELRLP SPLSIKRPNT KAPGSLCSTK
1110 1120 1130 1140 1150
VKADLQETPK NLEKRKAMDL LSQVPSPPPV KPICTFISPS LKRAFQPPRS
1160 1170 1180 1190 1200
SDPHHERFLK KTESTVREPG VKRPNETNFQ LENYFVADEE LAMINTQAFL
1210 1220 1230 1240
SNSTEEKEAG FTEKIAHTSH NDSSNSFSLR NNSCPSGKDK T
Genome annotation databases
Ensembli | ENSACAT00000004560; ENSACAP00000004459; ENSACAG00000004541 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000004459 |
Genome annotation databases
Ensembli | ENSACAT00000004560; ENSACAP00000004459; ENSACAG00000004541 |
Phylogenomic databases
eggNOGi | KOG4751, Eukaryota |
GeneTreei | ENSGT00390000003602 |
HOGENOMi | CLU_008211_0_0_1 |
InParanoidi | G1KCX8 |
OMAi | WMERKPE |
Gene expression databases
Bgeei | ENSACAG00000004541, Expressed in embryo and 14 other tissues |
Family and domain databases
CDDi | cd04493, BRCA2DBD_OB1, 1 hit |
InterProi | View protein in InterPro IPR015525, BRCA2 IPR015252, BRCA2_hlx IPR036315, BRCA2_hlx_sf IPR015187, BRCA2_OB_1 IPR015188, BRCA2_OB_3 IPR012340, NA-bd_OB-fold IPR015205, Tower_dom |
PANTHERi | PTHR11289, PTHR11289, 1 hit |
Pfami | View protein in Pfam PF09169, BRCA-2_helical, 1 hit PF09103, BRCA-2_OB1, 1 hit PF09104, BRCA-2_OB3, 1 hit PF09121, Tower, 1 hit |
PIRSFi | PIRSF002397, BRCA2, 1 hit |
SMARTi | View protein in SMART SM01341, Tower, 1 hit |
SUPFAMi | SSF50249, SSF50249, 3 hits SSF81872, SSF81872, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KCX8_ANOCA | |
Accessioni | G1KCX8Primary (citable) accession number: G1KCX8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | April 7, 2021 | |
This is version 56 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |