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Entry version 58 (29 Sep 2021)
Sequence version 3 (29 Sep 2021)
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Protein
Submitted name:

BRCA2 DNA repair associated

Gene

BRCA2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation
Biological processDNA recombinationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
BRCA2 DNA repair associatedImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BRCA2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000004541, Expressed in embryo and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000004459

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4751, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003602

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008211_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KCX8

Identification of Orthologs from Complete Genome Data

More...
OMAi
WMERKPE

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04493, BRCA2DBD_OB1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015525, BRCA2
IPR015252, BRCA2_hlx
IPR036315, BRCA2_hlx_sf
IPR015187, BRCA2_OB_1
IPR015188, BRCA2_OB_3
IPR012340, NA-bd_OB-fold
IPR015205, Tower_dom

The PANTHER Classification System

More...
PANTHERi
PTHR11289, PTHR11289, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09169, BRCA-2_helical, 1 hit
PF09103, BRCA-2_OB1, 1 hit
PF09104, BRCA-2_OB3, 1 hit
PF09121, Tower, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002397, BRCA2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01341, Tower, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50249, SSF50249, 3 hits
SSF81872, SSF81872, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

G1KCX8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKENDAPTK KPSFFEIYKA RCDDSDLGPI SLNWFEELSS EAPPYDNKPE
60 70 80 90 100
YSDHKTNSLD QTIFKTPKVK LSTNNSAAST PMIFKEQNKA SLLCTPIKEF
110 120 130 140 150
CYSSTETGLN RSLLCTPKVF EEETPKGISV SLGAEADPDM SWSSSLATPP
160 170 180 190 200
TLSPTVIIGN HRIDKAFSYS LLGSISTPTT SNGIGLMKSS LKTMSSLSSL
210 220 230 240 250
KKRPKKFIYT INNTPANHGK VSCGDGTSTL FVPTSCVSEV SETTARYAGT
260 270 280 290 300
MSIFFLQVDF KIYKPFLTLK ELSTLRDSQN NLNRGQLIQP DLQKNENNSK
310 320 330 340 350
QRKLECKLYS EAKNLGGFKT ASNKEIRLSD NNIRQGKLLF GDIEEQYPED
360 370 380 390 400
LLSSQVQNTA NKNAHENATT SLIGRNVLSE NSCDLSHVSD SLMNLIQFTD
410 420 430 440 450
SQSSFQNKLK KQKIEGKQNL TASQEAEVAE LSNILEETGS QFDFTQFREH
460 470 480 490 500
KSVMYDNICE ESESYMNSEL WKDNDFEECF DNKVQRSDDP SSNNPSNSLP
510 520 530 540 550
MKSKTQTQNN EENTLIKSSS KKDIQHVVPV ISASLQSGLW DYSSAEGKNI
560 570 580 590 600
NISAEIINKI TKPVRDSATE MLSPHKTCQF NCSKSCNVMW ENINYNKERN
610 620 630 640 650
DLHQRAKEIN LEYMMRNNAK ERNFCIKENI QNKSKAIDLN KVVHITSTTE
660 670 680 690 700
VNLKIIKKYS VNVTENELSC TENHHSALGG HQFSGCGSTQ YNYNYQETMS
710 720 730 740 750
DLTCLAEIAK MEKDSPFNNA DRKENFNSSQ EGVTKNSGSS CLLQNVDSVA
760 770 780 790 800
DENIVAEKSK MLHFLTDSCS GKLDGTIAIG SIKEAITSVK RGTVSSQSDI
810 820 830 840 850
FGFHYPEIYE TRKMQMNAVG FQMASGKQIV ITDESLSKAR NLLSEETPFL
860 870 880 890 900
GKEDVAVYSV KPSIQTSIKE EQNVKITEVN KESGKETINH QDYMNPKSRF
910 920 930 940 950
KEPVDMVSNT ENLKAIKELS LDINSLESDL ICSQRKAMHT IDSLAKNRLA
960 970 980 990 1000
QILGKNDVLK TVSIDSATGQ DLYIEGLDTC AKQVLECLSS RTKSNAFIAG
1010 1020 1030 1040 1050
SKSHGSLDLT CNTTAEANYT DLISTHSALG HPQDSSNEKK SQELTGINEE
1060 1070 1080 1090 1100
AASSKILISE NISGEMSKNK SAIQRSDQKN LNANTFQKYS ASEEAASNVL
1110 1120 1130 1140 1150
KSRPVAFSTA SGKTVRISEK ALKKVKQLFD DDSCSSVKQN IKSQSKTSEH
1160 1170 1180 1190 1200
NLESCSNVLT SREQVSSSNY LSMEKVTLEK SVASQCLTAK EYHEDDQELQ
1210 1220 1230 1240 1250
HTASVPLNIV SESDCQTPCL QINNGPDTKA SNKLICSKSD FSINNCGFFS
1260 1270 1280 1290 1300
TASGKAVQLS EESLKKARQF FSEIEDDSLG CQTHVSGGGD HYWKASSVRN
1310 1320 1330 1340 1350
KATAKENKLL MSQGKILSNA EVDSNIPCGF STASGKQVQI SQKAVQSVME
1360 1370 1380 1390 1400
LFKEFSDDIN SNGFVAQQSL EQGDVSSVKD ADVKVKMEDT IVTQSKPQHR
1410 1420 1430 1440 1450
CNALSLATKN LEKRSSQNLL STKILTCVCD SEKSRNTETK HSTPCNIPRK
1460 1470 1480 1490 1500
GNLYSHCHTY SQTPENYLET EASESARAFM EDDDLTDSEA ERNKKAFASN
1510 1520 1530 1540 1550
SEINNSYSYA RAGKRCMEKE NTFGRYLFSF LFLTLHLFSS KCFYFFSFTK
1560 1570 1580 1590 1600
EVKKPNFTTP GRDLKGFKSD GPQQHVSKHS SSTSSCVFKQ FSNTSVREES
1610 1620 1630 1640 1650
KKTDNPTAKT TIKVFVPPFK TKPSASEDEI NSKESYFQNN NSVHGELSNT
1660 1670 1680 1690 1700
KTTVCSEASF CVWFLHFFTG LTNIASLHCA RNLQEMRILK KQKQVIGPQP
1710 1720 1730 1740 1750
GTLYLMKICA TSCRIPLKTA VDEKCPGSYF SEQLYAFGVS KQCLNVNSSN
1760 1770 1780 1790 1800
AEHFQFHIQD FFGRECFLDG NGIQLADGGY LIPTDDGKAG KEEFYRALCD
1810 1820 1830 1840 1850
TPGVDPKLIS KAWVYNHYKW IIWKLAAMEV AFPQEFASKC LTPERVLLQL
1860 1870 1880 1890 1900
KYRYDVEVDK SCRSAIKRIT ERDDVAAKTL VLCISRIISL SSNVSCISGN
1910 1920 1930 1940 1950
KSTTEENKKD VAVVEVTDGW YGIKAVLDPS LQSLLHKQKL TVGQKIVVHG
1960 1970 1980 1990 2000
AELMGPQDAC SPLDVPESLM LKISGNSTRR ARWYSTLGYY RDPRPFTLPL
2010 2020 2030 2040 2050
SSLFSDGGIV GCIDVVVQRI YPTQWMEKTS TGSYMFRNCR AEEREAAKHA
2060 2070 2080 2090 2100
ENKQKTLEAL LANIQAEFEK NEGEGKRVLR SRTLTRQQIR SLQDGAELYE
2110 2120 2130 2140 2150
AVLNAADPAY MEGYFSEEQL KALNSHRQMV NDKKRAQIEA EFKKAVESAE
2160 2170 2180 2190 2200
QDKSSSCSRD VTPVIKVRIV DYRKEEKGKV ILTIWRPSSH VCTLLKEGCP
2210 2220 2230 2240 2250
YRVFHVAASP SKGRAEPTNL QLTATKKTQY LQLPVSQEVL SQVYRPRECL
2260 2270 2280 2290 2300
MFSELLLESF RPACSEVDLV GYVVSLRKGT GFSTLVYLSD KDHNLIAVHI
2310 2320 2330 2340 2350
CTDLRQFAVE DIIIPSMLIS ATNLQWRPKF YSNIPSLFAG DLSTFSSKPK
2360 2370 2380 2390 2400
ETRLQEIFND LRNTVESDSC FQKDAERKLA TLLQTNVPQV MNLPKEHDFD
2410 2420 2430 2440 2450
PFPSPWRSDI STPNTELRLP SPLSIKRPNT KAPGSLCSTK VKADLQETPK
2460 2470 2480 2490 2500
NLEKRKAMDL LSQVPSPPPV KPICTFISPS LKRAFQPPRS SDPHHERFLK
2510 2520 2530 2540 2550
KTESTVREPG VKRPNETNFQ LENYFVADEE LAMINTQAFL SNSTEEKEAG
2560 2570 2580 2590
FTEKIAHTSH NDSSNSFSLR NNSSIVCSID VIQNREGRKT LNT
Length:2,593
Mass (Da):289,649
Last modified:September 29, 2021 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA297174F92EEE78F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A803SZT0A0A803SZT0_ANOCA
BRCA2 DNA repair associated
BRCA2
2,581Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A803T452A0A803T452_ANOCA
BRCA2 DNA repair associated
BRCA2
1,073Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A803T7B8A0A803T7B8_ANOCA
BRCA2 DNA repair associated
BRCA2
2,629Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000004560; ENSACAP00000004459; ENSACAG00000004541

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000004459

Genome annotation databases

EnsembliENSACAT00000004560; ENSACAP00000004459; ENSACAG00000004541

Phylogenomic databases

eggNOGiKOG4751, Eukaryota
GeneTreeiENSGT00390000003602
HOGENOMiCLU_008211_0_0_1
InParanoidiG1KCX8
OMAiWMERKPE

Gene expression databases

BgeeiENSACAG00000004541, Expressed in embryo and 14 other tissues

Family and domain databases

CDDicd04493, BRCA2DBD_OB1, 1 hit
InterProiView protein in InterPro
IPR015525, BRCA2
IPR015252, BRCA2_hlx
IPR036315, BRCA2_hlx_sf
IPR015187, BRCA2_OB_1
IPR015188, BRCA2_OB_3
IPR012340, NA-bd_OB-fold
IPR015205, Tower_dom
PANTHERiPTHR11289, PTHR11289, 1 hit
PfamiView protein in Pfam
PF09169, BRCA-2_helical, 1 hit
PF09103, BRCA-2_OB1, 1 hit
PF09104, BRCA-2_OB3, 1 hit
PF09121, Tower, 1 hit
PIRSFiPIRSF002397, BRCA2, 1 hit
SMARTiView protein in SMART
SM01341, Tower, 1 hit
SUPFAMiSSF50249, SSF50249, 3 hits
SSF81872, SSF81872, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KCX8_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KCX8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: September 29, 2021
Last modified: September 29, 2021
This is version 58 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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