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Entry version 65 (07 Oct 2020)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

LOC100555140

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphataseARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC100555140Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1087 – 1108HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

GlycoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000004413, Expressed in embryonic post-anal tail and 10 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 127Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini128 – 223Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini307 – 397Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini474 – 565Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini566 – 653Fibronectin type-IIIInterPro annotationAdd BLAST88
Domaini654 – 751Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini836 – 933Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini1157 – 1416Tyrosine-protein phosphataseInterPro annotationAdd BLAST260
Domaini1466 – 1709Tyrosine-protein phosphataseInterPro annotationAdd BLAST244
Domaini1626 – 1700TYR_PHOSPHATASE_2InterPro annotationAdd BLAST75

Keywords - Domaini

RepeatARBA annotation, SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0791, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164079

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002844_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KCS3

TreeFam database of animal gene trees

More...
TreeFami
TF351926

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 8 hits
3.90.190.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR029021, Prot-tyrosine_phosphatase-like
IPR000242, PTPase_domain
IPR041201, PTPRJ_TM
IPR003595, Tyr_Pase_cat
IPR000387, TYR_PHOSPHATASE_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041, fn3, 5 hits
PF18861, PTP_tm, 1 hit
PF00102, Y_phosphatase, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00700, PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060, FN3, 10 hits
SM00194, PTPc, 2 hits
SM00404, PTPc_motif, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 10 hits
SSF52799, SSF52799, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 7 hits
PS50056, TYR_PHOSPHATASE_2, 1 hit
PS50055, TYR_PHOSPHATASE_PTP, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KCS3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVWAPLPIHP QILVEDDRCN QTNWQRNPEG VPDKKSHLLN VSVSNQGRSN
60 70 80 90 100
SLFLTWEKLP RGVQNVSLAL YKFDTNTVLQ NGSAGLNATG FLFEGLLPGT
110 120 130 140 150
QYDIEVTVLL ICTQNSSRRV TGRTVPGPVR NVVLSHNSPS MLLASWSEAT
160 170 180 190 200
GGKDAYQLVL YHIKSQAPVK NVTIPRNATT YRFEKLLNGS EYALQITTLA
210 220 230 240 250
GSYKASTIAR HWTAPVVPET LAFQNSGSSS NLSASWSNAG GAEWFHFTLQ
260 270 280 290 300
NLHTVTEITT VSLKRGLTNY TFQHLKPGNP YRLEVSATAG PYRVEGPKVT
310 320 330 340 350
AYTYPLAPSG ITLVSSRWPS SLLASWEIPQ GDRDQFFLRF YSQERPLLQR
360 370 380 390 400
NVTIGPDKQN FTFEGLLPGT QYFLEVSALA GPYRASSQVV SAWTCEYSKL
410 420 430 440 450
YLKGVKASGR GREYWVQLYS EESLSFIQNV SVPHGTTQVT LNNLVPGTRY
460 470 480 490 500
RVEIVSRAGP HYISSQTAIG YTVPLMPLSL MVTSPISSVL SVQWKAPAGQ
510 520 530 540 550
RDKYMVSVSE EGATDTKWHM AIEKANTNTT ITGLAPGTCY FIAVWSLAGP
560 570 580 590 600
YSSASRNDTA CTPPAPPVNL TLKNLANASV LYTAWAKPPG GRDHYRMILY
610 620 630 640 650
SLLPPGMERV RDVGPDTQDF LWTGLPAGSQ FAVQVTAVKG QAEASSTIAV
660 670 680 690 700
AWTSPLPVTF VKTWNEKRPG RLSVSWVPTS GRLDSYELNL YPSEPIATAL
710 720 730 740 750
HTSLGKDATN FTFSGLLPGT KYLYEIISRA GPTRSSSGNF SAWTNPLVPR
760 770 780 790 800
KLAIKSDKRN PALLVTWAKP LSKPERCQLQ LWLSGNKTVL QRHTLVKWEI
810 820 830 840 850
QHVFQGLVPG RNYSVSLSCT AGPYENSSEM MAMPIEPSQV KELQCLPDAT
860 870 880 890 900
SMFLNWTISE GDIEAYELTV RKFSRGGLQK SKRLLAVSRA DTILTELTSN
910 920 930 940 950
TAYQISVSAV GKNGMKSPMV ALGCNTSVEV LPPPVQVDIP QFDDSSRVII
960 970 980 990 1000
SPDMFSEDNG LIEYYGVVVT TNESLLRPTQ DIISRTWYDH YYGHEDSYLA
1010 1020 1030 1040 1050
LLLPNPFHLN ESTSPKSWPV TVGAEECSQS RETCNGKLKT DAQYSIRFSI
1060 1070 1080 1090 1100
AAFTRYSQRT PRVSFTSFSA ADASTASAAS VNISAPLVSG IIVGFLATVT
1110 1120 1130 1140 1150
AIAGWICWRH LRARRMEKGN MPQEMITYSL RNTHRPIPLQ SFRQYYETRA
1160 1170 1180 1190 1200
ANSNNGFFQD FEELKEVGKD QPKTEAELPA NTSKNRYPHV LPYDYSRVKL
1210 1220 1230 1240 1250
SLVDEEPHSD YINANFVPGY NSPQEFIATQ GPLKKTLDDF WRLVWEQHIC
1260 1270 1280 1290 1300
TIVMLTVGME NGRVLCEYYW PSDSSPFCSG QIRIHLLAQN FADEWTTREF
1310 1320 1330 1340 1350
RIQHEGLNME RRVIHLHYTA WSNHGVPEST TSLNAFVELV RAHMQSASET
1360 1370 1380 1390 1400
GPTLVHAGPA PGPADHFAAV SPFILLNYLS LILTGLTTLQ LFTLKPPVSW
1410 1420 1430 1440 1450
LTHGQYIFLH SCILEKISEE PLLDQSGLEL SHPIPLKNFV QHHAKNCSKA
1460 1470 1480 1490 1500
NAGFLREYEV LLEAAKEEVN SVLPFSGSQP IGLESDDRSK VKFSPLDRDP
1510 1520 1530 1540 1550
FSDLSHVWFI PGCNSVKDYI AIEGPDKLAL EEFWGLIWEY GVHTIITLLP
1560 1570 1580 1590 1600
GQMNCPAPDN SCWPSESDPV CTERLTIQQG PKKVVSGWPC IQLRLKYEKK
1610 1620 1630 1640 1650
AKERLLQRFQ FPLAEGEELP DPEILVGFLT VIRQLVPYRK RTSPVVLHCS
1660 1670 1680 1690 1700
MGGLGQMGML IALDTLLQQL KEEKSVDVYG VVLRLVRSCC LMTPTLDRYI
1710
YLYDCIRDTI TQKQPNSRI
Length:1,719
Mass (Da):191,514
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B5E77D2608620D5
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000004372; ENSACAP00000004272; ENSACAG00000004413

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSACAT00000004372; ENSACAP00000004272; ENSACAG00000004413

Phylogenomic databases

eggNOGiKOG0791, Eukaryota
GeneTreeiENSGT00940000164079
HOGENOMiCLU_002844_0_0_1
InParanoidiG1KCS3
TreeFamiTF351926

Gene expression databases

BgeeiENSACAG00000004413, Expressed in embryonic post-anal tail and 10 other tissues

Family and domain databases

CDDicd00063, FN3, 6 hits
Gene3Di2.60.40.10, 8 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR029021, Prot-tyrosine_phosphatase-like
IPR000242, PTPase_domain
IPR041201, PTPRJ_TM
IPR003595, Tyr_Pase_cat
IPR000387, TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041, fn3, 5 hits
PF18861, PTP_tm, 1 hit
PF00102, Y_phosphatase, 2 hits
PRINTSiPR00700, PRTYPHPHTASE
SMARTiView protein in SMART
SM00060, FN3, 10 hits
SM00194, PTPc, 2 hits
SM00404, PTPc_motif, 2 hits
SUPFAMiSSF49265, SSF49265, 10 hits
SSF52799, SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 7 hits
PS50056, TYR_PHOSPHATASE_2, 1 hit
PS50055, TYR_PHOSPHATASE_PTP, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KCS3_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KCS3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: October 7, 2020
This is version 65 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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