UniProtKB - G1KCN4 (G1KCN4_ANOCA)
Protein
Submitted name:
Uncharacterized protein
Gene
SOCS5
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotationView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Molecular functioni
- 1-phosphatidylinositol-3-kinase regulator activity Source: GO_Central
- epidermal growth factor receptor binding Source: Ensembl
- receptor tyrosine kinase binding Source: Ensembl
GO - Biological processi
- cellular response to low-density lipoprotein particle stimulus Source: Ensembl
- cytokine-mediated signaling pathway Source: Ensembl
- epidermal growth factor receptor signaling pathway Source: Ensembl
- intracellular signal transduction Source: InterPro
- negative regulation of epidermal growth factor-activated receptor activity Source: Ensembl
- negative regulation of inflammatory response Source: Ensembl
- negative regulation of interleukin-6 production Source: Ensembl
- negative regulation of monocyte chemotactic protein-1 production Source: Ensembl
- negative regulation of T-helper 2 cell differentiation Source: Ensembl
- phosphatidylinositol phosphorylation Source: GO_Central
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
- positive regulation of T-helper 1 cell differentiation Source: Ensembl
- protein ubiquitination Source: UniProtKB-UniPathway
- receptor signaling pathway via JAK-STAT Source: InterPro
- regulation of growth Source: UniProtKB-KW
- vascular endothelial cell response to fluid shear stress Source: Ensembl
Keywordsi
Molecular function | Signal transduction inhibitorARBA annotation |
Biological process | Growth regulationARBA annotation, Ubl conjugation pathwayARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Submitted name: Uncharacterized proteinImported |
Gene namesi | Name:SOCS5Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Other locations
- phosphatidylinositol 3-kinase complex Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSACAG00000004259, Expressed in brain and 14 other tissues |
Interactioni
GO - Molecular functioni
- epidermal growth factor receptor binding Source: Ensembl
- receptor tyrosine kinase binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000004120 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 377 – 472 | SH2InterPro annotationAdd BLAST | 96 | |
Domaini | 467 – 516 | SOCS boxInterPro annotationAdd BLAST | 50 |
Keywords - Domaini
SH2 domainPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG4566, Eukaryota |
GeneTreei | ENSGT00940000159000 |
HOGENOMi | CLU_035609_1_0_1 |
InParanoidi | G1KCN4 |
OMAi | CAAEIPQ |
OrthoDBi | 722019at2759 |
TreeFami | TF321368 |
Family and domain databases
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR000980, SH2 IPR036860, SH2_dom_sf IPR022252, SOCS4/SOCS5_dom IPR028420, SOCS5 IPR001496, SOCS_box IPR036036, SOCS_box-like_dom_sf |
PANTHERi | PTHR10155:SF15, PTHR10155:SF15, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF12610, SOCS, 1 hit PF07525, SOCS_box, 1 hit |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00253, SOCS, 1 hit SM00969, SOCS_box, 1 hit |
SUPFAMi | SSF158235, SSF158235, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit PS50225, SOCS, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KCN4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKVGKMWNS FKYRCQNLFN NESGNRNENL DVNSNNSSVR DKSVFVLDPV
60 70 80 90 100
DQRSSSPLRD VSLQLSLNPS KASSKKLQNC AAEIPQIVEI SIEKESDLGA
110 120 130 140 150
ATGARLARRD SYSRHAPWGG KKKHSCSTKT QSSLESNKRF GCCRLQRRER
160 170 180 190 200
RYGVSSVHDT DSVSSRTVGN RSLRQRLQDT VGLCFPVRTY CKQSKPLFSN
210 220 230 240 250
KRKIHLSELM LEKCPFPPGS DLAQKWHLIK QHTAPVSPHS TLFDAFDPSL
260 270 280 290 300
ASTEDEEDRL RERRRLSIEE GVDPPPNAQI HTFEATAQVN PLYKLGPKLA
310 320 330 340 350
PGMSELTGDC TSAPQGSSDL EEDTTTLCLQ SRRQKQRQMS GESHSHISRQ
360 370 380 390 400
GAWKVHTQID YIHCLVPDLL HITGNPCYWG VMDRYEAEAL LEGKPEGTFL
410 420 430 440 450
LRDSAQEDYL FSVSFRRYNR SLHARIEQWN HNFSFDAHDP CVFHSSTVTG
460 470 480 490 500
LLEHYKDPSS CMFFEPLLTV SLNRTFPFSL QYICRAVICR YTSYDGIDCL
510 520 530
PLPSMLQDFL KEYHYKQKVR VRWLEREPIK AK
Sequence databases
RefSeqi | XP_008103104.1, XM_008104897.2 XP_016847011.1, XM_016991522.1 |
Genome annotation databases
Ensembli | ENSACAT00000004217; ENSACAP00000004120; ENSACAG00000004259 |
GeneIDi | 100567705 |
KEGGi | acs:100567705 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_008103104.1, XM_008104897.2 XP_016847011.1, XM_016991522.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000004120 |
Genome annotation databases
Ensembli | ENSACAT00000004217; ENSACAP00000004120; ENSACAG00000004259 |
GeneIDi | 100567705 |
KEGGi | acs:100567705 |
Organism-specific databases
CTDi | 9655 |
Phylogenomic databases
eggNOGi | KOG4566, Eukaryota |
GeneTreei | ENSGT00940000159000 |
HOGENOMi | CLU_035609_1_0_1 |
InParanoidi | G1KCN4 |
OMAi | CAAEIPQ |
OrthoDBi | 722019at2759 |
TreeFami | TF321368 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Gene expression databases
Bgeei | ENSACAG00000004259, Expressed in brain and 14 other tissues |
Family and domain databases
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR000980, SH2 IPR036860, SH2_dom_sf IPR022252, SOCS4/SOCS5_dom IPR028420, SOCS5 IPR001496, SOCS_box IPR036036, SOCS_box-like_dom_sf |
PANTHERi | PTHR10155:SF15, PTHR10155:SF15, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF12610, SOCS, 1 hit PF07525, SOCS_box, 1 hit |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00253, SOCS, 1 hit SM00969, SOCS_box, 1 hit |
SUPFAMi | SSF158235, SSF158235, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit PS50225, SOCS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KCN4_ANOCA | |
Accessioni | G1KCN4Primary (citable) accession number: G1KCN4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | October 19, 2011 | |
Last modified: | December 2, 2020 | |
This is version 74 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |