Uncharacterized protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• 1-phosphatidylinositol-3-kinase regulator activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• epidermal growth factor receptor binding Source: Ensembl
• receptor tyrosine kinase binding Source: Ensembl

GO - Biological processⁱ

• cellular response to low-density lipoprotein particle stimulus Source: Ensembl
• cytokine-mediated signaling pathway Source: Ensembl
• epidermal growth factor receptor signaling pathway Source: Ensembl
• intracellular signal transduction Source: InterPro
• negative regulation of epidermal growth factor-activated receptor activity Source: Ensembl
• negative regulation of inflammatory response Source: Ensembl
• negative regulation of interleukin-6 production Source: Ensembl
• negative regulation of monocyte chemotactic protein-1 production Source: Ensembl
• negative regulation of T-helper 2 cell differentiation Source: Ensembl
• phosphatidylinositol phosphorylation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
• positive regulation of T-helper 1 cell differentiation Source: Ensembl
• protein ubiquitination Source: UniProtKB-UniPathway
• receptor signaling pathway via JAK-STAT Source: InterPro
• regulation of growth Source: UniProtKB-KW
• vascular endothelial cell response to fluid shear stress Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• epidermal growth factor receptor binding Source: Ensembl
• receptor tyrosine kinase binding Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MGKVGKMWNS FKYRCQNLFN NESGNRNENL DVNSNNSSVR DKSVFVLDPV 
        60         70         80         90        100
DQRSSSPLRD VSLQLSLNPS KASSKKLQNC AAEIPQIVEI SIEKESDLGA 
       110        120        130        140        150
ATGARLARRD SYSRHAPWGG KKKHSCSTKT QSSLESNKRF GCCRLQRRER 
       160        170        180        190        200
RYGVSSVHDT DSVSSRTVGN RSLRQRLQDT VGLCFPVRTY CKQSKPLFSN 
       210        220        230        240        250
KRKIHLSELM LEKCPFPPGS DLAQKWHLIK QHTAPVSPHS TLFDAFDPSL 
       260        270        280        290        300
ASTEDEEDRL RERRRLSIEE GVDPPPNAQI HTFEATAQVN PLYKLGPKLA 
       310        320        330        340        350
PGMSELTGDC TSAPQGSSDL EEDTTTLCLQ SRRQKQRQMS GESHSHISRQ 
       360        370        380        390        400
GAWKVHTQID YIHCLVPDLL HITGNPCYWG VMDRYEAEAL LEGKPEGTFL 
       410        420        430        440        450
LRDSAQEDYL FSVSFRRYNR SLHARIEQWN HNFSFDAHDP CVFHSSTVTG 
       460        470        480        490        500
LLEHYKDPSS CMFFEPLLTV SLNRTFPFSL QYICRAVICR YTSYDGIDCL 
       510        520        530 
PLPSMLQDFL KEYHYKQKVR VRWLEREPIK AK                    

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ