Uncharacterized protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chondroitin sulfate binding Source: Ensembl
• growth factor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• heparan sulfate binding Source: Ensembl
• heparin binding Source: UniProtKB-KW

GO - Biological processⁱ

• behavioral fear response Source: Ensembl
• cerebellar granular layer development Source: Ensembl
• cerebral cortex development Source: Ensembl
• cytoskeleton organization Source: Ensembl
• defecation Source: Ensembl
• dentate gyrus development Source: Ensembl
• glial cell projection elongation Source: Ensembl
• leukocyte chemotaxis involved in inflammatory response Source: Ensembl
• negative regulation of canonical Wnt signaling pathway Source: Ensembl
• negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
• negative regulation of epithelial cell apoptotic process Source: Ensembl
• negative regulation of inflammatory response to wounding Source: Ensembl
• negative regulation of neuron apoptotic process Source: Ensembl
• negative regulation of ossification Source: Ensembl
• negative regulation of regulatory T cell differentiation Source: Ensembl
• oogenesis Source: Ensembl
• positive regulation blood vessel branching Source: Ensembl
• positive regulation of artery morphogenesis Source: Ensembl
• positive regulation of cartilage development Source: Ensembl
• positive regulation of cell division Source: UniProtKB-KW
• positive regulation of epithelial to mesenchymal transition Source: Ensembl
• positive regulation of hepatocyte proliferation Source: Ensembl
• positive regulation of inflammatory response to wounding Source: Ensembl
• positive regulation of interleukin-12 production Source: Ensembl
• positive regulation of keratinocyte proliferation Source: Ensembl
• positive regulation of leukocyte adhesion to vascular endothelial cell Source: Ensembl
• positive regulation of macrophage chemotaxis Source: Ensembl
• positive regulation of neural precursor cell proliferation Source: Ensembl
• positive regulation of neuron migration Source: Ensembl
• positive regulation of neuron projection development Source: Ensembl
• positive regulation of neutrophil chemotaxis Source: Ensembl
• positive regulation of neutrophil extravasation Source: Ensembl
• positive regulation of oligodendrocyte differentiation Source: Ensembl
• positive regulation of smooth muscle cell chemotaxis Source: Ensembl
• positive regulation of substrate adhesion-dependent cell spreading Source: Ensembl
• positive regulation of T cell differentiation Source: Ensembl
• positive regulation of transcription, DNA-templated Source: Ensembl
• positive regulation of vascular endothelial cell proliferation Source: Ensembl
• regulation of actin cytoskeleton reorganization Source: Ensembl
• regulation of behavior Source: Ensembl
• regulation of bone remodeling Source: Ensembl
• regulation of chondrocyte differentiation Source: Ensembl
• response to auditory stimulus Source: Ensembl
• response to wounding Source: Ensembl
• short-term memory Source: Ensembl
• T cell activation involved in immune response Source: Ensembl
• tissue regeneration Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Keywords - PTMⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• growth factor activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MQVRGLFLLL VLVLLVAFSE AGKNKKDKVK KNGSDCEEWR WGPCVPNSKD 
        60         70         80         90        100
CGVGFREGTC NEETKKLKCK IPCNWKKEFG ADCKYKFESW GGCDSATGLK 
       110        120        130        140 
ARSGTLKKAL YNAECQETIQ VTKPCSPKAK SKSKARKGKG KD         

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ