UniProtKB - G1KCJ7 (G1KCJ7_ANOCA)
Protein
Submitted name:
Uncharacterized protein
Gene
MDK
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- chondroitin sulfate binding Source: Ensembl
- growth factor activity Source: GO_Central
- heparan sulfate binding Source: Ensembl
- heparin binding Source: UniProtKB-KW
GO - Biological processi
- behavioral fear response Source: Ensembl
- cerebellar granular layer development Source: Ensembl
- cerebral cortex development Source: Ensembl
- cytoskeleton organization Source: Ensembl
- defecation Source: Ensembl
- dentate gyrus development Source: Ensembl
- glial cell projection elongation Source: Ensembl
- leukocyte chemotaxis involved in inflammatory response Source: Ensembl
- negative regulation of canonical Wnt signaling pathway Source: Ensembl
- negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
- negative regulation of epithelial cell apoptotic process Source: Ensembl
- negative regulation of inflammatory response to wounding Source: Ensembl
- negative regulation of neuron apoptotic process Source: Ensembl
- negative regulation of ossification Source: Ensembl
- negative regulation of regulatory T cell differentiation Source: Ensembl
- oogenesis Source: Ensembl
- positive regulation blood vessel branching Source: Ensembl
- positive regulation of artery morphogenesis Source: Ensembl
- positive regulation of cartilage development Source: Ensembl
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of epithelial to mesenchymal transition Source: Ensembl
- positive regulation of hepatocyte proliferation Source: Ensembl
- positive regulation of inflammatory response to wounding Source: Ensembl
- positive regulation of interleukin-12 production Source: Ensembl
- positive regulation of keratinocyte proliferation Source: Ensembl
- positive regulation of leukocyte adhesion to vascular endothelial cell Source: Ensembl
- positive regulation of macrophage chemotaxis Source: Ensembl
- positive regulation of neural precursor cell proliferation Source: Ensembl
- positive regulation of neuron migration Source: Ensembl
- positive regulation of neuron projection development Source: Ensembl
- positive regulation of neutrophil chemotaxis Source: Ensembl
- positive regulation of neutrophil extravasation Source: Ensembl
- positive regulation of oligodendrocyte differentiation Source: Ensembl
- positive regulation of smooth muscle cell chemotaxis Source: Ensembl
- positive regulation of substrate adhesion-dependent cell spreading Source: Ensembl
- positive regulation of T cell differentiation Source: Ensembl
- positive regulation of transcription, DNA-templated Source: Ensembl
- positive regulation of vascular endothelial cell proliferation Source: Ensembl
- regulation of actin cytoskeleton reorganization Source: Ensembl
- regulation of behavior Source: Ensembl
- regulation of bone remodeling Source: Ensembl
- regulation of chondrocyte differentiation Source: Ensembl
- response to auditory stimulus Source: Ensembl
- response to wounding Source: Ensembl
- short-term memory Source: Ensembl
- T cell activation involved in immune response Source: Ensembl
- tissue regeneration Source: Ensembl
Keywordsi
Molecular function | Heparin-bindingARBA annotation, MitogenARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Uncharacterized proteinImported |
Gene namesi | Name:MDKImported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- extracellular region Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5003413385 | 22 – 142 | Sequence analysisAdd BLAST | 121 |
Keywords - PTMi
Disulfide bondARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000004140, Expressed in hemipenis and 14 other tissues |
Interactioni
GO - Molecular functioni
- growth factor activity Source: GO_Central
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000004035 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 79 | PTN_MK_NInterPro annotationAdd BLAST | 57 | |
Domaini | 80 – 140 | PTN_MK_CInterPro annotationAdd BLAST | 61 |
Sequence similaritiesi
Belongs to the pleiotrophin family.ARBA annotation
Keywords - Domaini
SignalSequence analysisARBA annotationPhylogenomic databases
eggNOGi | ENOG502S022, Eukaryota |
GeneTreei | ENSGT00390000007640 |
HOGENOMi | CLU_136864_0_0_1 |
InParanoidi | G1KCJ7 |
OMAi | FETWGAC |
OrthoDBi | 1489280at2759 |
TreeFami | TF332376 |
Family and domain databases
Gene3Di | 2.20.60.10, 1 hit 2.30.90.10, 1 hit |
InterProi | View protein in InterPro IPR000762, Midkine_heparin-bd_GF IPR020090, PTN/MK_C_dom IPR038130, PTN/MK_C_dom_sf IPR020091, PTN/MK_diS_sf IPR020089, PTN/MK_N_dom IPR037122, PTN/MK_N_dom_sf IPR020092, PTN_MK_heparin-bd_GF_CS |
PANTHERi | PTHR13850, PTHR13850, 1 hit |
Pfami | View protein in Pfam PF01091, PTN_MK_C, 1 hit PF05196, PTN_MK_N, 1 hit |
PRINTSi | PR00269, PTNMIDKINE |
SMARTi | View protein in SMART SM00193, PTN, 1 hit |
SUPFAMi | SSF57288, SSF57288, 2 hits |
PROSITEi | View protein in PROSITE PS00619, PTN_MK_1, 1 hit PS00620, PTN_MK_2, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KCJ7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQVRGLFLLL VLVLLVAFSE AGKNKKDKVK KNGSDCEEWR WGPCVPNSKD
60 70 80 90 100
CGVGFREGTC NEETKKLKCK IPCNWKKEFG ADCKYKFESW GGCDSATGLK
110 120 130 140
ARSGTLKKAL YNAECQETIQ VTKPCSPKAK SKSKARKGKG KD
Sequence databases
RefSeqi | XP_016847653.1, XM_016992164.1 |
Genome annotation databases
Ensembli | ENSACAT00000004127; ENSACAP00000004035; ENSACAG00000004140 |
GeneIDi | 100565875 |
KEGGi | acs:100565875 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_016847653.1, XM_016992164.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000004035 |
Genome annotation databases
Ensembli | ENSACAT00000004127; ENSACAP00000004035; ENSACAG00000004140 |
GeneIDi | 100565875 |
KEGGi | acs:100565875 |
Organism-specific databases
CTDi | 4192 |
Phylogenomic databases
eggNOGi | ENOG502S022, Eukaryota |
GeneTreei | ENSGT00390000007640 |
HOGENOMi | CLU_136864_0_0_1 |
InParanoidi | G1KCJ7 |
OMAi | FETWGAC |
OrthoDBi | 1489280at2759 |
TreeFami | TF332376 |
Gene expression databases
Bgeei | ENSACAG00000004140, Expressed in hemipenis and 14 other tissues |
Family and domain databases
Gene3Di | 2.20.60.10, 1 hit 2.30.90.10, 1 hit |
InterProi | View protein in InterPro IPR000762, Midkine_heparin-bd_GF IPR020090, PTN/MK_C_dom IPR038130, PTN/MK_C_dom_sf IPR020091, PTN/MK_diS_sf IPR020089, PTN/MK_N_dom IPR037122, PTN/MK_N_dom_sf IPR020092, PTN_MK_heparin-bd_GF_CS |
PANTHERi | PTHR13850, PTHR13850, 1 hit |
Pfami | View protein in Pfam PF01091, PTN_MK_C, 1 hit PF05196, PTN_MK_N, 1 hit |
PRINTSi | PR00269, PTNMIDKINE |
SMARTi | View protein in SMART SM00193, PTN, 1 hit |
SUPFAMi | SSF57288, SSF57288, 2 hits |
PROSITEi | View protein in PROSITE PS00619, PTN_MK_1, 1 hit PS00620, PTN_MK_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KCJ7_ANOCA | |
Accessioni | G1KCJ7Primary (citable) accession number: G1KCJ7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | October 19, 2011 | |
Last modified: | December 2, 2020 | |
This is version 61 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |