UniProtKB - G1KCC2 (G1KCC2_ANOCA)
Protein
AXH domain-containing protein
Gene
ATXN1
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- identical protein binding Source: Ensembl
- poly(G) binding Source: Ensembl
- poly(U) RNA binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
- protein self-association Source: Ensembl
GO - Biological processi
- anatomical structure development Source: GO_Central
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- nervous system development Source: GO_Central
- nuclear export Source: Ensembl
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: AXH domain-containing proteinInterPro annotation |
Gene namesi | Name:ATXN1Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Cytosol
- cytosol Source: Ensembl
Nucleus
- nuclear inclusion body Source: Ensembl
- nuclear matrix Source: Ensembl
- nucleolus Source: Ensembl
- nucleoplasm Source: Ensembl
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000003919, Expressed in testis and 14 other tissues |
Interactioni
GO - Molecular functioni
- identical protein binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
- protein self-association Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000003810 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 535 – 666 | AXHInterPro annotationAdd BLAST | 132 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 68 | DisorderedSequence analysisAdd BLAST | 68 | |
Regioni | 698 – 772 | DisorderedSequence analysisAdd BLAST | 75 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 40 – 67 | PolarSequence analysisAdd BLAST | 28 | |
Compositional biasi | 738 – 763 | PolyampholyteSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the ATXN1 family.ARBA annotation
Phylogenomic databases
eggNOGi | KOG4053, Eukaryota |
GeneTreei | ENSGT00390000005939 |
HOGENOMi | CLU_019983_0_0_1 |
InParanoidi | G1KCC2 |
OMAi | ELPCTKL |
TreeFami | TF350643 |
Family and domain databases
InterProi | View protein in InterPro IPR043404, ATAXIN1-like IPR003652, Ataxin_AXH_dom IPR036096, Ataxin_AXH_dom_sf IPR040172, ATXN1 |
PANTHERi | PTHR13392, PTHR13392, 1 hit PTHR13392:SF5, PTHR13392:SF5, 1 hit |
Pfami | View protein in Pfam PF08517, AXH, 1 hit |
SMARTi | View protein in SMART SM00536, AXH, 1 hit |
SUPFAMi | SSF102031, SSF102031, 1 hit |
PROSITEi | View protein in PROSITE PS51148, AXH, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KCC2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKSNQERSNE SLPPKKREIP ATSLPSDVKP LVLASENHRA DNLTWLSSTT
60 70 80 90 100
SSQSSVSGRS RSGGTLVEAG SHQGIGLHKS LSTGMDYSPP SAPRSVPATA
110 120 130 140 150
TLPTVYPSAL SQAGTPVSPV QYTHLQHTFQ FVGPQYSGPY AGFIPSPLIS
160 170 180 190 200
PTASSATSTA ASATAVATTP SQRSQLEAYS TLLANMSNLS QQGHKVEPHL
210 220 230 240 250
VRTPGLITAG SPPPTQQNQY VHISSSQSAV RNVSPPAIPV HLHPHQTVIP
260 270 280 290 300
HAFALGPSSQ VVVQYTDSGG HFVTRESTKK SESSRLQAMQ AKEILNGEIE
310 320 330 340 350
KGRRYGLSPS SEVNLVKSGN KPSPHHYEAR HVVVHSGPTD YITRDSSSVR
360 370 380 390 400
SSIMVVPNNN TTTADMEIQH GSNRETPPSV LNEKGSLHLG KTAHRSYALS
410 420 430 440 450
PPHTVIQTTH SASEHLPVGL PAAAFYTGTQ PPVIGYLSSQ QQAFGYPGSL
460 470 480 490 500
PQHLVIPGTQ PLLIPVGNAD IDSSGVPPSM ATSSPQLAAV PHTFVTTTIP
510 520 530 540 550
KSENFNAESL ASQQAYQAAV VQAQIHLPLV QSVPSSATAP PTLPPYFMKG
560 570 580 590 600
SIIQLANGEL KKVEDLKTED FIQSAEISCD LKIDSSTVER IDDSHNPGIA
610 620 630 640 650
MIQFAVGEHR AQVSVEVLVE YPFFVFGQGW SSCCPERTSQ LFDLPCSKLS
660 670 680 690 700
VGDVCISLTL KNLKNGSIKK GQSMDSASIL LKHSKNDSLT SSRHRYAEQE
710 720 730 740 750
NGIDQGSAKM SSENGELKFP DKIGLPAASL LTKSEPSKPT ATRKRRWSAP
760 770 780
ESRKLEKSEE EPPLTLPKPS FIPQEVKICI EGRSNVGK
Genome annotation databases
Ensembli | ENSACAT00000003902; ENSACAP00000003810; ENSACAG00000003919 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000003810 |
Genome annotation databases
Ensembli | ENSACAT00000003902; ENSACAP00000003810; ENSACAG00000003919 |
Phylogenomic databases
eggNOGi | KOG4053, Eukaryota |
GeneTreei | ENSGT00390000005939 |
HOGENOMi | CLU_019983_0_0_1 |
InParanoidi | G1KCC2 |
OMAi | ELPCTKL |
TreeFami | TF350643 |
Gene expression databases
Bgeei | ENSACAG00000003919, Expressed in testis and 14 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR043404, ATAXIN1-like IPR003652, Ataxin_AXH_dom IPR036096, Ataxin_AXH_dom_sf IPR040172, ATXN1 |
PANTHERi | PTHR13392, PTHR13392, 1 hit PTHR13392:SF5, PTHR13392:SF5, 1 hit |
Pfami | View protein in Pfam PF08517, AXH, 1 hit |
SMARTi | View protein in SMART SM00536, AXH, 1 hit |
SUPFAMi | SSF102031, SSF102031, 1 hit |
PROSITEi | View protein in PROSITE PS51148, AXH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KCC2_ANOCA | |
Accessioni | G1KCC2Primary (citable) accession number: G1KCC2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | October 19, 2011 | |
Last modified: | October 7, 2020 | |
This is version 49 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |