UniProtKB - G1KC46 (G1KC46_ANOCA)
Protein
Aspartate aminotransferase
Gene
GOT1
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Miscellaneous
In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.UniRule annotation
Catalytic activityi
- EC:2.6.1.1UniRule annotationARBA annotation
Cofactori
pyridoxal 5'-phosphateARBA annotation
GO - Molecular functioni
- L-aspartate:2-oxoglutarate aminotransferase activity Source: GO_Central
- phosphatidylserine decarboxylase activity Source: Ensembl
- pyridoxal phosphate binding Source: InterPro
GO - Biological processi
- aspartate biosynthetic process Source: GO_Central
- aspartate catabolic process Source: Ensembl
- cellular response to insulin stimulus Source: Ensembl
- fatty acid homeostasis Source: Ensembl
- glutamate catabolic process to 2-oxoglutarate Source: Ensembl
- glutamate catabolic process to aspartate Source: Ensembl
- glycerol biosynthetic process Source: Ensembl
- Notch signaling pathway Source: Ensembl
- oxaloacetate metabolic process Source: Ensembl
- response to glucocorticoid Source: Ensembl
Keywordsi
Molecular function | AminotransferaseUniRule annotationARBA annotation, Transferase |
Ligand | Pyridoxal phosphateARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:GOT1Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Nucleus
- nucleoplasm Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSACAG00000003583, Expressed in heart and 14 other tissues |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationARBA annotationProtein-protein interaction databases
STRINGi | 28377.ENSACAP00000003569 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 407 | Aminotran_1_2InterPro annotationAdd BLAST | 374 |
Sequence similaritiesi
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.ARBA annotation
Phylogenomic databases
eggNOGi | KOG1412, Eukaryota |
GeneTreei | ENSGT00950000183082 |
HOGENOMi | CLU_032440_1_2_1 |
InParanoidi | G1KC46 |
OrthoDBi | 1104596at2759 |
TreeFami | TF314089 |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR004839, Aminotransferase_I/II IPR000796, Asp_trans IPR004838, NHTrfase_class1_PyrdxlP-BS IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
PANTHERi | PTHR11879, PTHR11879, 1 hit |
Pfami | View protein in Pfam PF00155, Aminotran_1_2, 1 hit |
PRINTSi | PR00799, TRANSAMINASE |
SUPFAMi | SSF53383, SSF53383, 1 hit |
PROSITEi | View protein in PROSITE PS00105, AA_TRANSFER_CLASS_1, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KC46-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPGGKSVFA AVPQALPVAV FQLTADFRAD ADPRKVNLGV GAYRTDEGQP
60 70 80 90 100
WVLPVVRKVE TMITKDTSLN HEYLPILGLP EFRANSSRIA LGDDSPAIKE
110 120 130 140 150
NRVGGVQSLG GTGALRIGAE FLRRWYNGTN NTATPVYISS PTWENHNSVF
160 170 180 190 200
TDAGFKDIRS YRYWDAAKRG LDIQGFLEDL EKAPEFSIFI LHACAHNPTG
210 220 230 240 250
TDPTQEQWKQ IAAVMKRRFL FPFFDSAYQG FASGSLDRDA WAVRYFVSEG
260 270 280 290 300
FELFCAQSFS KNFGLYNERV GNLTVVAKDG ENVQRVLSQM EKIVRTTWSN
310 320 330 340 350
PPSQGARIVA TTLTTPELFA EWKGNVKTMA DRVLLMRAEL RSRLEALHTP
360 370 380 390 400
GTWNHITEQI GMFSFTGLNP KQVLFLIKEK HIYLMASGRI NMCGLTAKNL
410
DYVAASIHEA VTKIQ
Sequence databases
RefSeqi | XP_003218453.1, XM_003218405.3 |
Genome annotation databases
Ensembli | ENSACAT00000003657; ENSACAP00000003569; ENSACAG00000003583 |
GeneIDi | 100554156 |
KEGGi | acs:100554156 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_003218453.1, XM_003218405.3 |
3D structure databases
SMRi | G1KC46 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000003569 |
Genome annotation databases
Ensembli | ENSACAT00000003657; ENSACAP00000003569; ENSACAG00000003583 |
GeneIDi | 100554156 |
KEGGi | acs:100554156 |
Organism-specific databases
CTDi | 2805 |
Phylogenomic databases
eggNOGi | KOG1412, Eukaryota |
GeneTreei | ENSGT00950000183082 |
HOGENOMi | CLU_032440_1_2_1 |
InParanoidi | G1KC46 |
OrthoDBi | 1104596at2759 |
TreeFami | TF314089 |
Gene expression databases
Bgeei | ENSACAG00000003583, Expressed in heart and 14 other tissues |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR004839, Aminotransferase_I/II IPR000796, Asp_trans IPR004838, NHTrfase_class1_PyrdxlP-BS IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
PANTHERi | PTHR11879, PTHR11879, 1 hit |
Pfami | View protein in Pfam PF00155, Aminotran_1_2, 1 hit |
PRINTSi | PR00799, TRANSAMINASE |
SUPFAMi | SSF53383, SSF53383, 1 hit |
PROSITEi | View protein in PROSITE PS00105, AA_TRANSFER_CLASS_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KC46_ANOCA | |
Accessioni | G1KC46Primary (citable) accession number: G1KC46 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | December 2, 2020 | |
This is version 51 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |