UniProtKB - G1KBW8 (G1KBW8_ANOCA)
Protein
GPI mannosyltransferase 1
Gene
PIGM
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.UniRule annotation
: glycosylphosphatidylinositol-anchor biosynthesis Pathwayi
This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.UniRule annotationARBA annotationView all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.
GO - Molecular functioni
- alpha-1,4-mannosyltransferase activity Source: InterPro
- glycolipid mannosyltransferase activity Source: InterPro
- mannosyltransferase activity Source: GO_Central
GO - Biological processi
- GPI anchor biosynthetic process Source: GO_Central
Keywordsi
Molecular function | GlycosyltransferaseUniRule annotation, Transferase |
Biological process | GPI-anchor biosynthesisUniRule annotationARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00196 |
Names & Taxonomyi
Protein namesi | Recommended name: GPI mannosyltransferase 1UniRule annotationARBA annotation (EC:2.4.1.-UniRule annotation)Alternative name(s): GPI mannosyltransferase IUniRule annotation |
Gene namesi | Name:PIGMImported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
- glycosylphosphatidylinositol-mannosyltransferase I complex Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 20 – 38 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 93 – 114 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 221 – 248 | HelicalUniRule annotationAdd BLAST | 28 | |
Transmembranei | 285 – 309 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 316 – 336 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 356 – 377 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 384 – 407 | HelicalUniRule annotationAdd BLAST | 24 |
Keywords - Cellular componenti
Endoplasmic reticulumUniRule annotationARBA annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSACAG00000003466, Expressed in dewlap and 14 other tissues |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG3893, Eukaryota |
GeneTreei | ENSGT00390000017728 |
HOGENOMi | CLU_024220_3_1_1 |
InParanoidi | G1KBW8 |
OMAi | IQIISHY |
OrthoDBi | 1003258at2759 |
TreeFami | TF314752 |
Family and domain databases
InterProi | View protein in InterPro IPR007704, PIG-M |
PANTHERi | PTHR12886, PTHR12886, 1 hit |
Pfami | View protein in Pfam PF05007, Mannosyl_trans, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KBW8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASHQIQRKH IFTGFLQKDV LFSAAFMLRL ALVFYGIFQD RTMLVKYTDI
60 70 80 90 100
DYQVFTDAAR YITEGKSPFL RATYRYTPLL GWILTPNVYF TDLYGKILFV
110 120 130 140 150
VGDMVVAYLT YQILLLRGLD SRSACGYCAF WLLNPLPMTV SSRGNAESLV
160 170 180 190 200
AALVLGTMYY MEKRHFIKAA VFYGLSVHMK IYPVTYALPL VLHLQNKRDA
210 220 230 240 250
GHGKTGSVSS KGDFRELFFK LFSYDILIFG LVSGCTFAAL GLSFYLYYGW
260 270 280 290 300
EFLEHTYLYH LTRRDIRHNF SPYFYMLYLT AESEWSFVLG LAAFLPQLLL
310 320 330 340 350
LLVISFACYR DLIFCCFLHT AVFVSFNKVC TSQYFLWYLC LLPPVMPLLR
360 370 380 390 400
MSWQRAALLL LLWLSGQGLW LAPAYWLEFK GQNTFLLIWL AGLAFLFINC
410 420
MILVQIISHY SPLHTTRKIK QQ
Sequence databases
RefSeqi | XP_003215889.1, XM_003215841.3 XP_008122107.1, XM_008123900.2 |
Genome annotation databases
Ensembli | ENSACAT00000003432; ENSACAP00000003349; ENSACAG00000003466 |
GeneIDi | 100554927 |
KEGGi | acs:100554927 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_003215889.1, XM_003215841.3 XP_008122107.1, XM_008123900.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000003349 |
Genome annotation databases
Ensembli | ENSACAT00000003432; ENSACAP00000003349; ENSACAG00000003466 |
GeneIDi | 100554927 |
KEGGi | acs:100554927 |
Organism-specific databases
CTDi | 93183 |
Phylogenomic databases
eggNOGi | KOG3893, Eukaryota |
GeneTreei | ENSGT00390000017728 |
HOGENOMi | CLU_024220_3_1_1 |
InParanoidi | G1KBW8 |
OMAi | IQIISHY |
OrthoDBi | 1003258at2759 |
TreeFami | TF314752 |
Enzyme and pathway databases
UniPathwayi | UPA00196 |
Gene expression databases
Bgeei | ENSACAG00000003466, Expressed in dewlap and 14 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR007704, PIG-M |
PANTHERi | PTHR12886, PTHR12886, 1 hit |
Pfami | View protein in Pfam PF05007, Mannosyl_trans, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KBW8_ANOCA | |
Accessioni | G1KBW8Primary (citable) accession number: G1KBW8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | October 19, 2011 | |
Last modified: | December 2, 2020 | |
This is version 46 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |