UniProtKB - G1KBV2 (G1KBV2_ANOCA)
Protein
Plasminogen
Gene
PLG
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.UniRule annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Catalytic activityi
- Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.UniRule annotationARBA annotation EC:3.4.21.7
Activity regulationi
Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 613 | Charge relay systemUniRule annotation | 1 | |
Active sitei | 656 | Charge relay systemUniRule annotation | 1 | |
Active sitei | 751 | Charge relay systemUniRule annotation | 1 |
GO - Molecular functioni
- apolipoprotein binding Source: Ensembl
- chaperone binding Source: Ensembl
- kinase binding Source: Ensembl
- protein antigen binding Source: Ensembl
- protein domain specific binding Source: Ensembl
- serine-type endopeptidase activity Source: GO_Central
- signaling receptor binding Source: Ensembl
GO - Biological processi
- blood coagulation Source: UniProtKB-UniRule
- extracellular matrix disassembly Source: Ensembl
- fibrinolysis Source: UniProtKB-UniRule
- interaction with symbiont Source: Ensembl
- mononuclear cell migration Source: Ensembl
- muscle cell cellular homeostasis Source: Ensembl
- myoblast differentiation Source: Ensembl
- negative regulation of cell-substrate adhesion Source: Ensembl
- negative regulation of fibrinolysis Source: Ensembl
- positive regulation of fibrinolysis Source: Ensembl
- tissue regeneration Source: Ensembl
- tissue remodeling Source: UniProtKB-UniRule
- trans-synaptic signaling by BDNF, modulating synaptic transmission Source: Ensembl
Keywordsi
Molecular function | Hydrolase, Protease, Serine proteaseUniRule annotation |
Biological process | Blood coagulation, FibrinolysisUniRule annotationARBA annotation, Hemostasis, Tissue remodelingUniRule annotationARBA annotation |
Protein family/group databases
MEROPSi | S01.233 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PLGImported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted UniRule annotationARBA annotation
Extracellular region or secreted
- extracellular space Source: Ensembl
Plasma Membrane
- extrinsic component of external side of plasma membrane Source: Ensembl
Other locations
- glutamatergic synapse Source: Ensembl
- Schaffer collateral - CA1 synapse Source: Ensembl
Keywords - Cellular componenti
SecretedUniRule annotationARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_5003413345 | 20 – 801 | PlasminogenSequence analysisAdd BLAST | 782 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 185 ↔ 262 | PROSITE-ProRule annotation | ||
Disulfide bondi | 206 ↔ 245 | PROSITE-ProRule annotation | ||
Disulfide bondi | 234 ↔ 257 | PROSITE-ProRule annotation | ||
Disulfide bondi | 275 ↔ 352 | PROSITE-ProRule annotation | ||
Disulfide bondi | 296 ↔ 335 | PROSITE-ProRule annotation | ||
Disulfide bondi | 324 ↔ 347 | PROSITE-ProRule annotation | ||
Disulfide bondi | 375 ↔ 452 | PROSITE-ProRule annotation | ||
Disulfide bondi | 396 ↔ 435 | PROSITE-ProRule annotation | ||
Disulfide bondi | 424 ↔ 447 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotation, PhosphoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000003225, Expressed in liver and 8 other tissues |
Interactioni
GO - Molecular functioni
- apolipoprotein binding Source: Ensembl
- chaperone binding Source: Ensembl
- kinase binding Source: Ensembl
- protein antigen binding Source: Ensembl
- protein domain specific binding Source: Ensembl
- signaling receptor binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000003302 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 98 | AppleInterPro annotationAdd BLAST | 84 | |
Domaini | 102 – 181 | KringleInterPro annotationAdd BLAST | 80 | |
Domaini | 184 – 262 | KringleInterPro annotationAdd BLAST | 79 | |
Domaini | 274 – 352 | KringleInterPro annotationAdd BLAST | 79 | |
Domaini | 374 – 452 | KringleInterPro annotationAdd BLAST | 79 | |
Domaini | 471 – 551 | KringleInterPro annotationAdd BLAST | 81 | |
Domaini | 572 – 799 | Peptidase S1InterPro annotationAdd BLAST | 228 |
Sequence similaritiesi
Keywords - Domaini
KringlePROSITE-ProRule annotationARBA annotation, SignalSequence analysisPhylogenomic databases
eggNOGi | ENOG502QVNP, Eukaryota |
GeneTreei | ENSGT00940000155208 |
HOGENOMi | CLU_017565_0_0_1 |
InParanoidi | G1KBV2 |
OrthoDBi | 164039at2759 |
TreeFami | TF329901 |
Family and domain databases
CDDi | cd00108, KR, 5 hits cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 2.40.20.10, 4 hits |
InterProi | View protein in InterPro IPR000001, Kringle IPR013806, Kringle-like IPR018056, Kringle_CS IPR038178, Kringle_sf IPR003609, Pan_app IPR023317, Pept_S1A_plasmin IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00051, Kringle, 5 hits PF00024, PAN_1, 1 hit PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF001150, Plasmin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00130, KR, 5 hits SM00473, PAN_AP, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF57440, SSF57440, 5 hits |
PROSITEi | View protein in PROSITE PS00021, KRINGLE_1, 5 hits PS50070, KRINGLE_2, 5 hits PS50948, PAN, 1 hit PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
i Sequence
Sequence statusi: Complete.
G1KBV2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSYKDICLL LLFFCTVQGD ILDSYVKTDG AWILGQNKKF YRTLNKEECA
60 70 80 90 100
AKCEAETTFT CRSFLFALKD QQCITLADNT KSTVVFRRAD VALFEKRIYL
110 120 130 140 150
LECRRGNGHD YRGTESKTQG GVACQKWADK NPHVPNFSPE SHPNESLEEN
160 170 180 190 200
YCRNPDDDEK GPWCYTTDPE KRYDYCSIPE CEEQCMYCSG ENYQGKISQT
210 220 230 240 250
ESGLQCQPWA SQEPHAHGYI PTNFPEKNLR SNYCRNPDGE PRPWCFTTSP
260 270 280 290 300
TKRWEFCNIP RCTTPAPVSI VERECLEGNG ENYRGKISVT VSGKACQSWS
310 320 330 340 350
AQTPHKHMRI PENYPCKGLE ENYCRNPDGE SRPWCYTTDS NTRWEYCDIA
360 370 380 390 400
NCNAPAVVTA AAPVLVPQAP AVEDCYEGTG TSYRGTMALT VSGKKCQAWS
410 420 430 440 450
SMRPHSHSKT PSQFPNADLR NNYCRNPDGD MAPWCYTTDP HTRWEFCNLQ
460 470 480 490 500
KCANLVQQRP QSTTPTNLGS DCRSGKGEDY RGHIASTASG KTCQEWRSQT
510 520 530 540 550
PHRHDSFTPQ THPRAGLEKN YCRNPDGDVN GPWCYTTDLS KAWDYCDVPK
560 570 580 590 600
CPPPEYECGK PKYKPLNCIG RIVGGCVSNP HSWPWQISLR TSFNMHFCGG
610 620 630 640 650
TLIDPEWVLT ATHCLERSSR PSSYRVAAGL HTERASEASA QHRNVQRLFK
660 670 680 690 700
EPSGADIALL KLSSPLLITD QVIPACLPPA NSMVAGGSEC YVTGWGETKG
710 720 730 740 750
TGGDGLLKET GFPVIENKVC NRPELLNGRV RNSELCAGNV DGGTDSCQGD
760 770 780 790 800
SGGPLVCSEQ GKYVLQGVTS WGLGCAQPMK PGVYVRVSRF IPWMERTMKE
N
Sequence databases
RefSeqi | XP_008121425.1, XM_008123218.2 |
Genome annotation databases
Ensembli | ENSACAT00000003385; ENSACAP00000003302; ENSACAG00000003225 |
GeneIDi | 100554661 |
KEGGi | acs:100554661 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_008121425.1, XM_008123218.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000003302 |
Protein family/group databases
MEROPSi | S01.233 |
Genome annotation databases
Ensembli | ENSACAT00000003385; ENSACAP00000003302; ENSACAG00000003225 |
GeneIDi | 100554661 |
KEGGi | acs:100554661 |
Organism-specific databases
CTDi | 5340 |
Phylogenomic databases
eggNOGi | ENOG502QVNP, Eukaryota |
GeneTreei | ENSGT00940000155208 |
HOGENOMi | CLU_017565_0_0_1 |
InParanoidi | G1KBV2 |
OrthoDBi | 164039at2759 |
TreeFami | TF329901 |
Gene expression databases
Bgeei | ENSACAG00000003225, Expressed in liver and 8 other tissues |
Family and domain databases
CDDi | cd00108, KR, 5 hits cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 2.40.20.10, 4 hits |
InterProi | View protein in InterPro IPR000001, Kringle IPR013806, Kringle-like IPR018056, Kringle_CS IPR038178, Kringle_sf IPR003609, Pan_app IPR023317, Pept_S1A_plasmin IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00051, Kringle, 5 hits PF00024, PAN_1, 1 hit PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF001150, Plasmin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00130, KR, 5 hits SM00473, PAN_AP, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF57440, SSF57440, 5 hits |
PROSITEi | View protein in PROSITE PS00021, KRINGLE_1, 5 hits PS50070, KRINGLE_2, 5 hits PS50948, PAN, 1 hit PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G1KBV2_ANOCA | |
Accessioni | G1KBV2Primary (citable) accession number: G1KBV2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 19, 2011 |
Last sequence update: | June 26, 2013 | |
Last modified: | February 10, 2021 | |
This is version 71 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |