Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 52 (29 Sep 2021)
Sequence version 2 (29 Sep 2021)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

FRAS1 related extracellular matrix 3

Gene

FREM3

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
FRAS1 related extracellular matrix 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FREM3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

GlycoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000003206, Expressed in embryonic post-anal tail and 11 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000003195

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FRAS1 family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation, SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1306, Eukaryota
KOG2090, Eukaryota
KOG3597, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162501

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000394_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KBR1

Identification of Orthologs from Complete Genome Data

More...
OMAi
VITEFTQ

TreeFam database of animal gene trees

More...
TreeFami
TF316876

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.2030, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038081, CalX-like_sf
IPR003644, Calx_beta
IPR039005, CSPG_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03160, Calx-beta, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00237, Calx_beta, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF141072, SSF141072, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51854, CSPG, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G1KBR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEAARLGLL VGALLRLLCS LPAPVASHPM PEPSLLLLPG EALLVSNRGV
60 70 80 90 100
RVPFGRSVWL DPARDLSIRV RDGERCFLRA LESGPAPHRP GALSPSRFPC
110 120 130 140 150
AFGPRQVSYT HFGARSPGRH RLSLQLRYDT PERTLVAPFS LEVEVLAQQL
160 170 180 190 200
RLLSRNLPLS VETLRGRSPP LDAKVLAFAD VGELPCRLTA LPHPQSYLPA
210 220 230 240 250
YGRLVDSEGR PLPAGYSNDC QQFLLDGIRY EHTALTASPN RDYIPMLVQV
260 270 280 290 300
GPQDGQALSS SFEESQGEQE YFQVVVRIRE GAENTPPKPS FVALLMMEVD
310 320 330 340 350
QFVLTAITPD MLAAEDLESP SDLLLFNLTS PWPATEEEGE RGQQGYLIST
360 370 380 390 400
DDPGRPLTSF TQQEVRELKI AYQPPTLDSD QERLFQLEME VLDLEGASSE
410 420 430 440 450
PFAFVVVVKP MNTLAPVAVF NRVAGPQMML FEGQSRPLSG NLEISDEDNL
460 470 480 490 500
DEVKVWVTRG LKHGELRVLG ALPGRQFFTP AELKAGQVIY QHDGSEHSYS
510 520 530 540 550
DNIVFRMGDG RHQVEFLYPI TIAPEDDQPP LLNANTGLVL SEHQVVQISP
560 570 580 590 600
FVLSATDIDS EDATIRFVLK EIEGSADQRL GVLLLRQAET PSSYEKEDVE
610 620 630 640 650
EDLVASSIWR FLASEEVYEK EVTEWLQQDI LDGKLFYRHT GPHSTKLVVD
660 670 680 690 700
EFTFYLQDDN DPPNQSGEQV FLIKIQPVDN LPPELYPGTT LQMTVLEYQV
710 720 730 740 750
THFRKHYLRY TDLDTEDREL RYTVLTPPTD TDENHPVVAG QIVLTDNPLV
760 770 780 790 800
AITQFTQAQI NHHKVAYKPP DQELGITPRV VQFTYSVEDT GGNSALGIFT
810 820 830 840 850
LFLQPVDNQP PQITNAGFTV FEGGSFLLTN SQLDATDKDT DSDRIVFTLM
860 870 880 890 900
EAPQHGHLRY LEEGVMVQGE SFLLDDIVNG RLSYQHSGDE FTSDSFQLEV
910 920 930 940 950
SDGVHQVPIT VKIAVQPVDD ERPSITIPGR NGLLGAFIDV LENSATEITN
960 970 980 990 1000
SLIQGTDEDT DELALTFIVE DPPKLGDILV DGVPSRKFTQ QDLISGTVVY
1010 1020 1030 1040 1050
SDFFNLTISD LSSDWVVGGS SVEGVRVTVT ILPVDNIAPE VMVGEEPFTA
1060 1070 1080 1090 1100
YEGGKSVLNL NLLDVEDVDT PRDDILCTIV VQSTSGYLEN ISPAPGSEKS
1110 1120 1130 1140 1150
RAGTAISAFS IKDVRLGHIN YVQSIHKGVE PVEDRFTFQC SDGINISPHH
1160 1170 1180 1190 1200
FFPIVIIPTN DEKPDLYVRE FVVLEGMSLV IDTPILNGAD ADIPPDELHF
1210 1220 1230 1240 1250
FITVPPKHGQ IVNQLPTGTV LVRNFTLEEI REASSIVYEH DDSETKEDTF
1260 1270 1280 1290 1300
RIQLTDGLHT VEQEVLIMVI LVDDETPRLS INDGLDVEVG ESKIITNREL
1310 1320 1330 1340 1350
KATDIDSEDK TLMYIIRFVP RQGLLQRINK EGEVLGNITL GMNFTQNDID
1360 1370 1380 1390 1400
QGFIHYIHTG RQGVRDLVKF DVTDGINPLI DRYFYITISG IDMVFPEVIN
1410 1420 1430 1440 1450
KGVTLKEGGK VTLTTDLLST SDINSPDELL QFSITRAPIR GHLENSDRPG
1460 1470 1480 1490 1500
VPVTTFTQLQ LAGNKIYYIH TADDEVKMDS FEFEVTDGYN PVFRTFRVSI
1510 1520 1530 1540 1550
TDVDNKKPIL TIHDLTIQEG DTKLITPFEL NVEDRDTPDH LLRFIITQVP
1560 1570 1580 1590 1600
VHGQIIYNNS YSVTSFTKQD LNENMINYRH DGTETNQDSF SFTITDGTHS
1610 1620 1630 1640 1650
DFYVFPDTIL ETHQPQTMKI QIHSLDNGVP QIVVNKGTVT LRNIPTGHLG
1660 1670 1680 1690 1700
FLITSKYLKA EDRDSPYKVL KFKITDGPRH GLIINTALGN GSIKAFTQAE
1710 1720 1730 1740 1750
IDDMKICYVL KQGENATSDI FHFSVEDSGG NKLKSQPFRL NWAWISLEKE
1760 1770 1780 1790 1800
YYIVDEDSRV LEVTLKRRGY LGETSFISIG TKDGTAEKDK DFKGKAQKQV
1810 1820 1830 1840 1850
QFNPGQTMAT WKVRIIVDNE YEESEVFQII LSDPVMAALE FPDRATVEIV
1860 1870 1880 1890 1900
DPGDESTVYI PGSEYRIEED VGELLIPIRR SGDVSHELMV ICSTHQGSAT
1910 1920 1930 1940 1950
GTVPSTVLSY SDYISRPEDH TSLIRFDKDE TEKSCRVIII DDSLYEEDET
1960 1970 1980 1990 2000
FNVTLSMAMG GQIGTEFPTT KVTILADTDD EPAFYFGDTE YHVAESAGYV
2010 2020 2030 2040 2050
EVHVWRTGTD LSKAATVTVR SRKTEPLSAE AGVDYVGISR NLDFAPGVNM
2060 2070 2080 2090 2100
QTFRVTILDD LGQPVLEGPE KFELVLRMPM NAVLGEPSKT TIFINDTITD
2110 2120 2130 2140 2150
LPKVQFKEPL YTVNEKDGLV SAIIYRSGDV NHKSTVRCYT RQGSAQVMMD
2160 2170 2180 2190 2200
YEERPNTDDS VVVFLSGDTE KSCKVVLEDD AIYEEEEEFR LVLGTPKGSS
2210 2220 2230 2240 2250
VFGASLGEQK ETLVKIKDEE DRPVIKFSEI KYSIQEPQEP GEIAVVKIPV
2260 2270 2280 2290 2300
FRLGDSSKVS IVRIHTKDGS ATSGEDYNPM SDDIEFKEGE TEHFIEVEVL
2310 2320 2330 2340 2350
YDGVREMREA FTVHLKPDEN MVAETQTNKA IVYIEEMDSV ADVTFPAVPQ
2360 2370 2380 2390 2400
VVSLLLYDDT AKSKANPQPP TGYPVMCVTA CNPKYSDYDK TGSICAAENI
2410 2420 2430 2440 2450
NDTLTLYRWL VSAPSGSDGV TSPMREVDSN TFFTNTKSIA LDSIYFQAGS
2460 2470 2480 2490 2500
RVQCAARAVN ANGDMGLELQ SPIYTVNRDE GLCQPRIPGT VGAEPFSAKI
2510 2520 2530 2540 2550
RYTGPDDPDY PNLIKLIVTM PHMDGMLPVV STRPLSNFEL TLSPDGTRVG
2560 2570 2580 2590 2600
NHKCSNLLDY NEIETKYGFI TDNVKNPEVI GETSPYQYSS ALRTAKTLRF
2610 2620 2630 2640 2650
YRNLNLDACL WEFNSYYDMS ELLTDCSGSI GTDGQVLNLV QSYVTLRVPL
2660 2670 2680 2690 2700
YVSYVFHSPA AVGGWQHFDL QSELKLTFVY DTAILWKDGI GSPPEAELQG
2710 2720 2730 2740 2750
SLYPTSMQIN EEGRLVVYFR TEIRFRGQFV MSHPGTSLSS MVMSADHPGL
2760 2770 2780 2790 2800
TFTLSLSQNE RTFHQPMQQW KFVSDFAVRD YSGTYTVKLI PCIAAPSQEY
2810 2820 2830 2840 2850
TLPVICSPRE PITFDLDIRF QQVSDPVAAE FNLNTQMFLL SKKDLWLSDG
2860 2870 2880 2890 2900
SMGFGEGTDV AFTEDSEIYG RVMVDPVQNL GESFICNIEK VFLCTGADGY
2910 2920 2930 2940 2950
VPKYNPDNRE YGCLADSPSL LYRFKILDKA QPDTQAKVFG NMPFNAKLAA
2960 2970 2980 2990 3000
DHVDGFPLIK QSGSDGFSLL STPLFQVAAG REWYIHAIYM VRSRDNAHRG
3010 3020 3030 3040 3050
LGKRSAELHS VLSSVNRISG TPRVGRARRA ISDAPALAQD IGVDKNRGTN
3060 3070 3080 3090 3100
IQHIALDRSN KIVIRPNDKS QEGKPYEKPI LEITGSDAED KIVPIIGGAA
3110 3120 3130 3140 3150
GLLLLCCTVL IIILLLKRRG QSTDRKADSC INYSNSNETV TTQHSNGDSS

EV
Length:3,152
Mass (Da):350,859
Last modified:September 29, 2021 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i56CFFB7D17581ADD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A803SLY2A0A803SLY2_ANOCA
FRAS1 related extracellular matrix ...
FREM3
3,139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000003278; ENSACAP00000003195; ENSACAG00000003206

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000003195

Genome annotation databases

EnsembliENSACAT00000003278; ENSACAP00000003195; ENSACAG00000003206

Phylogenomic databases

eggNOGiKOG1306, Eukaryota
KOG2090, Eukaryota
KOG3597, Eukaryota
GeneTreeiENSGT00940000162501
HOGENOMiCLU_000394_0_0_1
InParanoidiG1KBR1
OMAiVITEFTQ
TreeFamiTF316876

Gene expression databases

BgeeiENSACAG00000003206, Expressed in embryonic post-anal tail and 11 other tissues

Family and domain databases

Gene3Di2.60.40.2030, 5 hits
InterProiView protein in InterPro
IPR038081, CalX-like_sf
IPR003644, Calx_beta
IPR039005, CSPG_rpt
PfamiView protein in Pfam
PF03160, Calx-beta, 5 hits
SMARTiView protein in SMART
SM00237, Calx_beta, 5 hits
SUPFAMiSSF141072, SSF141072, 5 hits
PROSITEiView protein in PROSITE
PS51854, CSPG, 12 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KBR1_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KBR1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: September 29, 2021
Last modified: September 29, 2021
This is version 52 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again