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UniProtKB - G1KBR1 (G1KBR1_ANOCA)

Entry version 52 (29 Sep 2021)
Sequence version 2 (29 Sep 2021)
Previous versions | rss
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Protein
Submitted name:

FRAS1 related extracellular matrix 3

Gene

FREM3

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
FRAS1 related extracellular matrix 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FREM3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

GlycoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSACAG00000003206, Expressed in embryonic post-anal tail and 11 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		28377.ENSACAP00000003195

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FRAS1 family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation, SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1306, Eukaryota
KOG2090, Eukaryota
KOG3597, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162501

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000394_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		G1KBR1

Identification of Orthologs from Complete Genome Data

More...OMAi		VITEFTQ

TreeFam database of animal gene trees

More...TreeFami		TF316876

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.2030, 5 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038081, CalX-like_sf
IPR003644, Calx_beta
IPR039005, CSPG_rpt

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03160, Calx-beta, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00237, Calx_beta, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF141072, SSF141072, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51854, CSPG, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G1KBR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEAARLGLL VGALLRLLCS LPAPVASHPM PEPSLLLLPG EALLVSNRGV 
        60         70         80         90        100
RVPFGRSVWL DPARDLSIRV RDGERCFLRA LESGPAPHRP GALSPSRFPC 
       110        120        130        140        150
AFGPRQVSYT HFGARSPGRH RLSLQLRYDT PERTLVAPFS LEVEVLAQQL 
       160        170        180        190        200
RLLSRNLPLS VETLRGRSPP LDAKVLAFAD VGELPCRLTA LPHPQSYLPA 
       210        220        230        240        250
YGRLVDSEGR PLPAGYSNDC QQFLLDGIRY EHTALTASPN RDYIPMLVQV 
       260        270        280        290        300
GPQDGQALSS SFEESQGEQE YFQVVVRIRE GAENTPPKPS FVALLMMEVD 
       310        320        330        340        350
QFVLTAITPD MLAAEDLESP SDLLLFNLTS PWPATEEEGE RGQQGYLIST 
       360        370        380        390        400
DDPGRPLTSF TQQEVRELKI AYQPPTLDSD QERLFQLEME VLDLEGASSE 
       410        420        430        440        450
PFAFVVVVKP MNTLAPVAVF NRVAGPQMML FEGQSRPLSG NLEISDEDNL 
       460        470        480        490        500
DEVKVWVTRG LKHGELRVLG ALPGRQFFTP AELKAGQVIY QHDGSEHSYS 
       510        520        530        540        550
DNIVFRMGDG RHQVEFLYPI TIAPEDDQPP LLNANTGLVL SEHQVVQISP 
       560        570        580        590        600
FVLSATDIDS EDATIRFVLK EIEGSADQRL GVLLLRQAET PSSYEKEDVE 
       610        620        630        640        650
EDLVASSIWR FLASEEVYEK EVTEWLQQDI LDGKLFYRHT GPHSTKLVVD 
       660        670        680        690        700
EFTFYLQDDN DPPNQSGEQV FLIKIQPVDN LPPELYPGTT LQMTVLEYQV 
       710        720        730        740        750
THFRKHYLRY TDLDTEDREL RYTVLTPPTD TDENHPVVAG QIVLTDNPLV 
       760        770        780        790        800
AITQFTQAQI NHHKVAYKPP DQELGITPRV VQFTYSVEDT GGNSALGIFT 
       810        820        830        840        850
LFLQPVDNQP PQITNAGFTV FEGGSFLLTN SQLDATDKDT DSDRIVFTLM 
       860        870        880        890        900
EAPQHGHLRY LEEGVMVQGE SFLLDDIVNG RLSYQHSGDE FTSDSFQLEV 
       910        920        930        940        950
SDGVHQVPIT VKIAVQPVDD ERPSITIPGR NGLLGAFIDV LENSATEITN 
       960        970        980        990       1000
SLIQGTDEDT DELALTFIVE DPPKLGDILV DGVPSRKFTQ QDLISGTVVY 
      1010       1020       1030       1040       1050
SDFFNLTISD LSSDWVVGGS SVEGVRVTVT ILPVDNIAPE VMVGEEPFTA 
      1060       1070       1080       1090       1100
YEGGKSVLNL NLLDVEDVDT PRDDILCTIV VQSTSGYLEN ISPAPGSEKS 
      1110       1120       1130       1140       1150
RAGTAISAFS IKDVRLGHIN YVQSIHKGVE PVEDRFTFQC SDGINISPHH 
      1160       1170       1180       1190       1200
FFPIVIIPTN DEKPDLYVRE FVVLEGMSLV IDTPILNGAD ADIPPDELHF 
      1210       1220       1230       1240       1250
FITVPPKHGQ IVNQLPTGTV LVRNFTLEEI REASSIVYEH DDSETKEDTF 
      1260       1270       1280       1290       1300
RIQLTDGLHT VEQEVLIMVI LVDDETPRLS INDGLDVEVG ESKIITNREL 
      1310       1320       1330       1340       1350
KATDIDSEDK TLMYIIRFVP RQGLLQRINK EGEVLGNITL GMNFTQNDID 
      1360       1370       1380       1390       1400
QGFIHYIHTG RQGVRDLVKF DVTDGINPLI DRYFYITISG IDMVFPEVIN 
      1410       1420       1430       1440       1450
KGVTLKEGGK VTLTTDLLST SDINSPDELL QFSITRAPIR GHLENSDRPG 
      1460       1470       1480       1490       1500
VPVTTFTQLQ LAGNKIYYIH TADDEVKMDS FEFEVTDGYN PVFRTFRVSI 
      1510       1520       1530       1540       1550
TDVDNKKPIL TIHDLTIQEG DTKLITPFEL NVEDRDTPDH LLRFIITQVP 
      1560       1570       1580       1590       1600
VHGQIIYNNS YSVTSFTKQD LNENMINYRH DGTETNQDSF SFTITDGTHS 
      1610       1620       1630       1640       1650
DFYVFPDTIL ETHQPQTMKI QIHSLDNGVP QIVVNKGTVT LRNIPTGHLG 
      1660       1670       1680       1690       1700
FLITSKYLKA EDRDSPYKVL KFKITDGPRH GLIINTALGN GSIKAFTQAE 
      1710       1720       1730       1740       1750
IDDMKICYVL KQGENATSDI FHFSVEDSGG NKLKSQPFRL NWAWISLEKE 
      1760       1770       1780       1790       1800
YYIVDEDSRV LEVTLKRRGY LGETSFISIG TKDGTAEKDK DFKGKAQKQV 
      1810       1820       1830       1840       1850
QFNPGQTMAT WKVRIIVDNE YEESEVFQII LSDPVMAALE FPDRATVEIV 
      1860       1870       1880       1890       1900
DPGDESTVYI PGSEYRIEED VGELLIPIRR SGDVSHELMV ICSTHQGSAT 
      1910       1920       1930       1940       1950
GTVPSTVLSY SDYISRPEDH TSLIRFDKDE TEKSCRVIII DDSLYEEDET 
      1960       1970       1980       1990       2000
FNVTLSMAMG GQIGTEFPTT KVTILADTDD EPAFYFGDTE YHVAESAGYV 
      2010       2020       2030       2040       2050
EVHVWRTGTD LSKAATVTVR SRKTEPLSAE AGVDYVGISR NLDFAPGVNM 
      2060       2070       2080       2090       2100
QTFRVTILDD LGQPVLEGPE KFELVLRMPM NAVLGEPSKT TIFINDTITD 
      2110       2120       2130       2140       2150
LPKVQFKEPL YTVNEKDGLV SAIIYRSGDV NHKSTVRCYT RQGSAQVMMD 
      2160       2170       2180       2190       2200
YEERPNTDDS VVVFLSGDTE KSCKVVLEDD AIYEEEEEFR LVLGTPKGSS 
      2210       2220       2230       2240       2250
VFGASLGEQK ETLVKIKDEE DRPVIKFSEI KYSIQEPQEP GEIAVVKIPV 
      2260       2270       2280       2290       2300
FRLGDSSKVS IVRIHTKDGS ATSGEDYNPM SDDIEFKEGE TEHFIEVEVL 
      2310       2320       2330       2340       2350
YDGVREMREA FTVHLKPDEN MVAETQTNKA IVYIEEMDSV ADVTFPAVPQ 
      2360       2370       2380       2390       2400
VVSLLLYDDT AKSKANPQPP TGYPVMCVTA CNPKYSDYDK TGSICAAENI 
      2410       2420       2430       2440       2450
NDTLTLYRWL VSAPSGSDGV TSPMREVDSN TFFTNTKSIA LDSIYFQAGS 
      2460       2470       2480       2490       2500
RVQCAARAVN ANGDMGLELQ SPIYTVNRDE GLCQPRIPGT VGAEPFSAKI 
      2510       2520       2530       2540       2550
RYTGPDDPDY PNLIKLIVTM PHMDGMLPVV STRPLSNFEL TLSPDGTRVG 
      2560       2570       2580       2590       2600
NHKCSNLLDY NEIETKYGFI TDNVKNPEVI GETSPYQYSS ALRTAKTLRF 
      2610       2620       2630       2640       2650
YRNLNLDACL WEFNSYYDMS ELLTDCSGSI GTDGQVLNLV QSYVTLRVPL 
      2660       2670       2680       2690       2700
YVSYVFHSPA AVGGWQHFDL QSELKLTFVY DTAILWKDGI GSPPEAELQG 
      2710       2720       2730       2740       2750
SLYPTSMQIN EEGRLVVYFR TEIRFRGQFV MSHPGTSLSS MVMSADHPGL 
      2760       2770       2780       2790       2800
TFTLSLSQNE RTFHQPMQQW KFVSDFAVRD YSGTYTVKLI PCIAAPSQEY 
      2810       2820       2830       2840       2850
TLPVICSPRE PITFDLDIRF QQVSDPVAAE FNLNTQMFLL SKKDLWLSDG 
      2860       2870       2880       2890       2900
SMGFGEGTDV AFTEDSEIYG RVMVDPVQNL GESFICNIEK VFLCTGADGY 
      2910       2920       2930       2940       2950
VPKYNPDNRE YGCLADSPSL LYRFKILDKA QPDTQAKVFG NMPFNAKLAA 
      2960       2970       2980       2990       3000
DHVDGFPLIK QSGSDGFSLL STPLFQVAAG REWYIHAIYM VRSRDNAHRG 
      3010       3020       3030       3040       3050
LGKRSAELHS VLSSVNRISG TPRVGRARRA ISDAPALAQD IGVDKNRGTN 
      3060       3070       3080       3090       3100
IQHIALDRSN KIVIRPNDKS QEGKPYEKPI LEITGSDAED KIVPIIGGAA 
      3110       3120       3130       3140       3150
GLLLLCCTVL IIILLLKRRG QSTDRKADSC INYSNSNETV TTQHSNGDSS 

EV
Length:3,152
Mass (Da):350,859
Last modified:September 29, 2021 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i56CFFB7D17581ADD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A803SLY2A0A803SLY2_ANOCA
FRAS1 related extracellular matrix ...
FREM3
3,139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSACAT00000003278; ENSACAP00000003195; ENSACAG00000003206

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000003195

Genome annotation databases

EnsembliENSACAT00000003278; ENSACAP00000003195; ENSACAG00000003206

Phylogenomic databases

eggNOGiKOG1306, Eukaryota
KOG2090, Eukaryota
KOG3597, Eukaryota
GeneTreeiENSGT00940000162501
HOGENOMiCLU_000394_0_0_1
InParanoidiG1KBR1
OMAiVITEFTQ
TreeFamiTF316876

Gene expression databases

BgeeiENSACAG00000003206, Expressed in embryonic post-anal tail and 11 other tissues

Family and domain databases

Gene3Di2.60.40.2030, 5 hits
InterProiView protein in InterPro
IPR038081, CalX-like_sf
IPR003644, Calx_beta
IPR039005, CSPG_rpt
PfamiView protein in Pfam
PF03160, Calx-beta, 5 hits
SMARTiView protein in SMART
SM00237, Calx_beta, 5 hits
SUPFAMiSSF141072, SSF141072, 5 hits
PROSITEiView protein in PROSITE
PS51854, CSPG, 12 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KBR1_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KBR1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: September 29, 2021
Last modified: September 29, 2021
This is version 52 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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