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Entry version 56 (07 Oct 2020)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene
N/A
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, CiliumARBA annotation, CytoplasmARBA annotation, DyneinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000003111, Expressed in brain and 7 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000003010

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini599 – 998DHC_N2InterPro annotationAdd BLAST400
Domaini1127 – 1453AAA_6InterPro annotationAdd BLAST327
Domaini1620 – 1755Dynein_AAA_lidInterPro annotationAdd BLAST136
Domaini1975 – 2070AAA_lid_1InterPro annotationAdd BLAST96
Domaini2135 – 2259AAA_8InterPro annotationAdd BLAST125

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili558 – 585Sequence analysisAdd BLAST28
Coiled coili654 – 674Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3595, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154280

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000038_5_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KBI6

TreeFam database of animal gene trees

More...
TreeFami
TF316836

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.710, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035699, AAA_6
IPR026983, DHC_fam
IPR041589, DNAH3_AAA_lid_1
IPR042228, Dynein_2_C
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041466, Dynein_AAA5_ext
IPR024317, Dynein_heavy_chain_D4_dom
IPR013602, Dynein_heavy_dom-2
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR10676, PTHR10676, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF17857, AAA_lid_1, 1 hit
PF08393, DHC_N2, 1 hit
PF17852, Dynein_AAA_lid, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KBI6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSEQKQIRT NYLFLKKCVE SNPVVPIQME WLESMLTLIP QKLMEGKDRE
60 70 80 90 100
KLVEELLAEV KEDYEKSMKR YMVQMAIQDL HNNNTKSKGF WFPPHSHNRE
110 120 130 140 150
NLLQRPWHQS FLQARKQIFQ NLHILHPTLR ILLDIGYKTF SDLLIADISG
160 170 180 190 200
FRSKGPIEYE TLQNDVSINC LKTEEKILNT WYPRVINLFT RKEALEGVKP
210 220 230 240 250
DKVDSFYNCV ATLMSNQLKE LLKRTVEAYV QLFDVDDQRW LPLFKMDLTF
260 270 280 290 300
DDEKMDFYPS FQDLQDTILC VYELLPQRNL VSLANHVQTI HSWLGGTTAI
310 320 330 340 350
STLDTELPEH VIAWASSILK KAVQENLKGA KAQFDYYVEK YGWLVDGAAD
360 370 380 390 400
DRINQFVEEE HSFDEYAEFI DEFFTLAKEI MNLPMVAHFP MVRLDCEDLK
410 420 430 440 450
QGLSEKAKSF AYQLLNIIAQ NHKRENESIC DEFETIKVRA LKVPQTTEEM
460 470 480 490 500
MESIVYIDKA KTIGIQQLYE RIKECRQRMS YLLDVYFFDA EDLALNAAVL
510 520 530 540 550
LWPQNINPIF DENDDIIEQS KRKSESELLA KREKLIMEIE RQTRRMQEFT
560 570 580 590 600
EFSDLDRMQQ YVTDMRTLQK RIQDADEAVA FINKEEKLLN WELTEYPDLE
610 620 630 640 650
TLKVNIDPYQ KLFVFILKWQ RTEKRWMDGA FSDLNGEKME TEVDEFFREI
660 670 680 690 700
YKTLRFFQQK LKKVMEQIKD FKENIPLVTI LCNPGIRTRH WKQMSEIVGY
710 720 730 740 750
DLTPDSGTTL RKVLKQNLTP YLEQFETISM GASKEFSLEK AMHTMMEVWE
760 770 780 790 800
SISFQISLYR ETGVNILCAV DEIQTILDDQ IVKTQTMKGS PFIKPFEKQI
810 820 830 840 850
TEWEERLVRI QDTIDEWLKV QAQWLYLEPI FSSEDIMQQM PEEGRQFQTV
860 870 880 890 900
DRYWKDIMRY CAKDPKVLAA TSLTGLLEKL QNCNELLDKI MKGLNAYLEK
910 920 930 940 950
KRLFFPRFFF LSNDEMLEIL SETKDPLRVQ PHLKKCFEGI AKLEFLSNLD
960 970 980 990 1000
IKAMYSTEGE RVEFISTIST SEARGAVEKW LIQVEDLMLK SIHDVITRSR
1010 1020 1030 1040 1050
IAYPVGERKV WVREWPGQVV LCVSQMFWTS EVHEAIGSGS EGLRNYYKNL
1060 1070 1080 1090 1100
QLQLNDIVEL VRGKLSKQTR TTLGALVTID VHARDVVMEM IESGVLRETD
1110 1120 1130 1140 1150
FQWLAQLRYY WEHENVRVRI INCNVKYAYE YLGNSPRLVI TPLTDRCYRT
1160 1170 1180 1190 1200
LIGAFYLNLG GAPEGPAGTG KTETTKDLAK ALAVQCVVFN CSDGLDYLAM
1210 1220 1230 1240 1250
GKFFKGLASS GAWACFDEFN RIELEVLSVV AQQILCIQRA IQLKLETFNF
1260 1270 1280 1290 1300
EGTELKLNPN CFVAITMNPG YAGRSELPDN LKVLFRTVAM MVPNYALIAE
1310 1320 1330 1340 1350
ISLYSYGFLN AKPLSVKIVM TYRLCSEQLS SQFHYDYGMR AVKAVLIAAG
1360 1370 1380 1390 1400
NLKLKFPEEN EDILLLRSIE DVNEPKFLSH DIPLFKGITS DLFPGVQLPQ
1410 1420 1430 1440 1450
ADYNEFLECA HECCKEHNVQ PVKVFLEKMI QTYEMMIVRH GFMLVGEPFA
1460 1470 1480 1490 1500
GKTKVLHVLA DTLSLMNQRG YGDEEKVVHR TVNPKSITMG QLFGRFDPVS
1510 1520 1530 1540 1550
HESVSSTIQI VGYGLCGCDT AKHRDYAFYN TRIHTTFFGN QAKHSSSLEM
1560 1570 1580 1590 1600
HMFTIEPVLI WNQPPLFTQP SHFFQARPAT VSRCGMIYLE PLQLGWMPLV
1610 1620 1630 1640 1650
TSWLNTLPEP LNQKENQELL EDLFNWLIPP ALRIRQKKCK ELVTTNNSNN
1660 1670 1680 1690 1700
VVSLTRLLEM LLCATVQKDP SNKNIQKWIT GGFAFSLIWS IGGTCDSDGR
1710 1720 1730 1740 1750
TVFDNFMKDI VTGKLEEHPV PASVGKWDHP FEEKGLVYDY MFEMKGKGRW
1760 1770 1780 1790 1800
AHWNEFLKTV QYSDKNTKIQ DIIVPTMDTV RYTYLMDLCI KYGIPLLFIG
1810 1820 1830 1840 1850
PTGTGKSVYV KDKLMHHVEK DLYFPFFVNF SARTSANQTQ NIIMARLDKR
1860 1870 1880 1890 1900
RKGIFGPPMG KKCIIFVDDM NMPSLEQYGA QPPIELLRQF FDHGIWYDLK
1910 1920 1930 1940 1950
DTNKITLVDI QLMAAMGPPG GGRNPVTPRF LRHFNICTIN TFSDETMVRI
1960 1970 1980 1990 2000
FSTVVSFYLR ANEFLPEYFT IGNQIVSGTM EVYKKAMLHL LPTPAKSHYT
2010 2020 2030 2040 2050
FNLRDFSRVI LGCLLIKKDS VVSKHTMVRL FVHEVFRVFY DRLVDDTDRA
2060 2070 2080 2090 2100
WLFKLTKEIL REHFKEAFDS VFAHLRKENA PVTEEDLRNL LFGDYMNPDL
2110 2120 2130 2140 2150
EGDERIYFEI PDIQMFNDIV DLCLDEYNQT HKTRMNLVIF RYVLEHLSRI
2160 2170 2180 2190 2200
CRVLKQSGGN ALLVGMGGSG RQSMTRLATS MAKMSIFQPE ISKSYGMNEW
2210 2220 2230 2240 2250
REDVKTLFRS AGVKGLKTVF LITDTQIKDE GFLEDVDSVL NTGEVPNLFA

ADEKQEVME
Length:2,259
Mass (Da):262,082
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC9A169FDDB872BA
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000003087; ENSACAP00000003010; ENSACAG00000003111

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000003010

Genome annotation databases

EnsembliENSACAT00000003087; ENSACAP00000003010; ENSACAG00000003111

Phylogenomic databases

eggNOGiKOG3595, Eukaryota
GeneTreeiENSGT00940000154280
HOGENOMiCLU_000038_5_3_1
InParanoidiG1KBI6
TreeFamiTF316836

Gene expression databases

BgeeiENSACAG00000003111, Expressed in brain and 7 other tissues

Family and domain databases

Gene3Di1.10.8.710, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR035699, AAA_6
IPR026983, DHC_fam
IPR041589, DNAH3_AAA_lid_1
IPR042228, Dynein_2_C
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041466, Dynein_AAA5_ext
IPR024317, Dynein_heavy_chain_D4_dom
IPR013602, Dynein_heavy_dom-2
IPR027417, P-loop_NTPase
PANTHERiPTHR10676, PTHR10676, 2 hits
PfamiView protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF17857, AAA_lid_1, 1 hit
PF08393, DHC_N2, 1 hit
PF17852, Dynein_AAA_lid, 1 hit
SUPFAMiSSF52540, SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KBI6_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KBI6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: October 7, 2020
This is version 56 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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