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Protein
Submitted name:

Uncharacterized protein

Gene

THBS2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: InterPro
  • negative regulation of angiogenesis Source: GO_Central
  • positive regulation of synapse assembly Source: GO_Central

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:THBS2Imported
OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
Taxonomic identifieri28377 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
Proteomesi
  • UP000001646 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500341291023 – 1179Sequence analysisAdd BLAST1157

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi28377.ENSACAP00000002993

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini325 – 382VWFCInterPro annotationAdd BLAST58
Domaini556 – 596EGF-likeInterPro annotationAdd BLAST41
Domaini655 – 697EGF-likeInterPro annotationAdd BLAST43
Repeati700 – 735TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati736 – 771TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati772 – 794TSP type-3PROSITE-ProRule annotationAdd BLAST23
Repeati795 – 830TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati831 – 853TSP type-3PROSITE-ProRule annotationAdd BLAST23
Repeati854 – 891TSP type-3PROSITE-ProRule annotationAdd BLAST38
Repeati892 – 927TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati928 – 963TSP type-3PROSITE-ProRule annotationAdd BLAST36
Domaini967 – 1179TSP C-terminalInterPro annotationAdd BLAST213

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IFQQ Eukaryota
ENOG410XQKE LUCA
GeneTreeiENSGT00930000150838
InParanoidiG1KBH7
KOiK04659
OrthoDBiEOG091G00TV
TreeFamiTF324917

Family and domain databases

Gene3Di2.20.100.10, 3 hits
4.10.1080.10, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR000742 EGF-like_dom
IPR024731 EGF_dom
IPR001791 Laminin_G
IPR037349 Thrombospondin
IPR003367 Thrombospondin_3-like_rpt
IPR017897 Thrombospondin_3_rpt
IPR008859 Thrombospondin_C
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR015455 TSP2
IPR028974 TSP_type-3_rpt
IPR001007 VWF_dom
PANTHERiPTHR10199 PTHR10199, 2 hits
PTHR10199:SF10 PTHR10199:SF10, 2 hits
PfamiView protein in Pfam
PF12947 EGF_3, 1 hit
PF07645 EGF_CA, 1 hit
PF00090 TSP_1, 3 hits
PF02412 TSP_3, 7 hits
PF05735 TSP_C, 1 hit
PF00093 VWC, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 2 hits
SM00209 TSP1, 3 hits
SM00210 TSPN, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF103647 SSF103647, 3 hits
SSF49899 SSF49899, 2 hits
SSF82895 SSF82895, 3 hits
PROSITEiView protein in PROSITE
PS50026 EGF_3, 2 hits
PS50092 TSP1, 3 hits
PS51234 TSP3, 8 hits
PS51236 TSP_CTER, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

Sequencei

Sequence statusi: Complete.

G1KBH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLHRSWLLWL TILLTLWISS EAQDEDGGDE TTYDLMQISN INRKTIGAKA
60 70 80 90 100
FRGNISGVPA YRFIRFDHIP PLNSEKLKQI VKLIQQNEGF ILTATFRQDR
110 120 130 140 150
DSRGTIIALE GPGISQRQFE IISNGRDNTL ELSYWVDGSR KGYPLEDVDL
160 170 180 190 200
ADLQWKNITI QVLGENYSLY VGCDLIDSLS LEEPFYENLK AEKSRMYVVK
210 220 230 240 250
GSTRENHFRG LIQNIHLIFG TSVEDVLRNK GCQKSQSAEV NTINESTEIL
260 270 280 290 300
HLTPSVMTEY IGDNTEKKPE FCDRSCEELG SMFTELTGLR IVVNGLTEKL
310 320 330 340 350
EKVSEVNEKI VSELLGPNKT LKNQSACWQD GREFVNNSHW VVDSCTKCHC
360 370 380 390 400
QNSKTVCNKI TCPPVHCVSP AFIDGECCPV CSHSDDSEEG WSPWSEWTEC
410 420 430 440 450
SVTCGSGTQQ RGRSCDVTSN TCRGPSIQTR TCSLGKCDNR IRQDGGWSHW
460 470 480 490 500
SPWSSCSVTC GVGNITRIRL CNSPIPQMGG KGCKGSGRET KECEGPPCPV
510 520 530 540 550
NGRWSPWSPW SACTVTCGGG IHERSRLCNS PEPQYGGKPC VGDVIQRDMC
560 570 580 590 600
NKQDCPIDGC LSNPCFPGAD CNSYPDGSWS CGACPAGYLG NGTFCEDLNE
610 620 630 640 650
CAVVPDVCFK LNQNHRCVNT NPGFHCLPCP PRYKGTQPYG VGLEAARAEK
660 670 680 690 700
QVCEPANPCK DKTHNCHRSA ECIYLGHFSD PMYKCECRTG YAGDGFICGE
710 720 730 740 750
DSDLDGWPNN NLVCAANATY HCMKDNCPLL PNSGQEDFDK DGKGDACDED
760 770 780 790 800
DDNDGVEDDK DNCPLLFNPR QFDYDKDEVG DRCDNCPYVH NPAQIDTDNN
810 820 830 840 850
GEGDACAVDI DGDDVFNARD NCPYVYNTDQ IDTDGDGVGD QCDNCPLVHN
860 870 880 890 900
PEQTDVDNDL VGDQCDNNED IDEDGHQNNK DNCPYISNAN QADHDKDGKG
910 920 930 940 950
DACDPDDDND GIPDDRDNCR LTFNPDQKDS DGDGRGDICK DDFDNDKVPD
960 970 980 990 1000
IYDVCPENDA ISETDFRKFQ MVPLDPKGTT QIDPNWVIRH QGKELVQTAN
1010 1020 1030 1040 1050
SDPGIAVGYD EFSSVDFSGT FYVNTDRDDD YAGFVFAYQS SSRFYVLMWK
1060 1070 1080 1090 1100
QVTQTYWEDK PTRAYGYSGV SLKVVNSTTG TGEHLRNALW HTGNTAGQVR
1110 1120 1130 1140 1150
TLWHDPKNIG WKDYTAYRWH LIHRPKTGLI KVLVYEGKQI MADSGAIYDK
1160 1170
TYAGGRLGLF VFSQEMVYFS DLKYECRDA
Length:1,179
Mass (Da):131,380
Last modified:June 26, 2013 - v2
Checksum:i0D74AF86AAFF77AD
GO

Sequence databases

RefSeqiXP_008122806.1, XM_008124599.2

Genome annotation databases

EnsembliENSACAT00000003070; ENSACAP00000002993; ENSACAG00000002861
GeneIDi100563584
KEGGiacs:100563584

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_008122806.1, XM_008124599.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000002993

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSACAT00000003070; ENSACAP00000002993; ENSACAG00000002861
GeneIDi100563584
KEGGiacs:100563584

Organism-specific databases

CTDi7058

Phylogenomic databases

eggNOGiENOG410IFQQ Eukaryota
ENOG410XQKE LUCA
GeneTreeiENSGT00930000150838
InParanoidiG1KBH7
KOiK04659
OrthoDBiEOG091G00TV
TreeFamiTF324917

Family and domain databases

Gene3Di2.20.100.10, 3 hits
4.10.1080.10, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR000742 EGF-like_dom
IPR024731 EGF_dom
IPR001791 Laminin_G
IPR037349 Thrombospondin
IPR003367 Thrombospondin_3-like_rpt
IPR017897 Thrombospondin_3_rpt
IPR008859 Thrombospondin_C
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR015455 TSP2
IPR028974 TSP_type-3_rpt
IPR001007 VWF_dom
PANTHERiPTHR10199 PTHR10199, 2 hits
PTHR10199:SF10 PTHR10199:SF10, 2 hits
PfamiView protein in Pfam
PF12947 EGF_3, 1 hit
PF07645 EGF_CA, 1 hit
PF00090 TSP_1, 3 hits
PF02412 TSP_3, 7 hits
PF05735 TSP_C, 1 hit
PF00093 VWC, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 2 hits
SM00209 TSP1, 3 hits
SM00210 TSPN, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF103647 SSF103647, 3 hits
SSF49899 SSF49899, 2 hits
SSF82895 SSF82895, 3 hits
PROSITEiView protein in PROSITE
PS50026 EGF_3, 2 hits
PS50092 TSP1, 3 hits
PS51234 TSP3, 8 hits
PS51236 TSP_CTER, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG1KBH7_ANOCA
AccessioniPrimary (citable) accession number: G1KBH7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: November 7, 2018
This is version 54 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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