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Protein

EEF1A lysine methyltransferase 1

Gene

EEF1AKMT1

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.UniRule annotation

Caution

Was originally thought to be an N6-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
EEF1A lysine methyltransferase 1UniRule annotation (EC:2.1.1.-UniRule annotation)
Alternative name(s):
N(6)-adenine-specific DNA methyltransferase 2UniRule annotation
Protein-lysine N-methyltransferase N6AMT2UniRule annotation
Gene namesi
Name:EEF1AKMT1UniRule annotationImported
Synonyms:N6AMT2UniRule annotation
OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
Taxonomic identifieri28377 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
Proteomesi
  • UP000001646 Componenti: Chromosome 3

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

Expressioni

Gene expression databases

BgeeiENSACAG00000002518 Expressed in 4 organ(s), highest expression level in heart

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3350 Eukaryota
ENOG4111GGY LUCA
GeneTreeiENSGT00390000016366
InParanoidiG1KAT8
OrthoDBiEOG091G0GA7
TreeFamiTF106153

Family and domain databases

HAMAPiMF_03187 Methyltr_EFM5, 1 hit
InterProiView protein in InterPro
IPR002052 DNA_methylase_N6_adenine_CS
IPR019369 Efm5/EEF1AKMT1
IPR029063 SAM-dependent_MTases
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS00092 N6_MTASE, 1 hit

Sequencei

Sequence statusi: Complete.

G1KAT8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDSDDDAPQ LSSEALAALQ EFYLEQQQRE DLEATEGANN CTLGSIEENW
60 70 80 90 100
QLSQFWYDTE TADHLAKEAI RAAGKGGRIA CVSAPSIYQK LKEQNNNDFS
110 120 130 140 150
TCILEYDQRF SVYGAEYIFY DYNDPLNLPA SLKEHSFDIV LADPPYLSEE
160 170 180 190 200
CLRKTAETIK YLTKGKVLLC TGSVMEEHAA KFLGVKMCKF IPKHTRNLAN
210
EFRCYVNYDS GLDFNSAS
Length:218
Mass (Da):24,639
Last modified:June 26, 2013 - v2
Checksum:i04651E258D53C768
GO

Sequence databases

RefSeqiXP_003219297.1, XM_003219249.3

Genome annotation databases

EnsembliENSACAT00000002467; ENSACAP00000002406; ENSACAG00000002518
GeneIDi100560575
KEGGiacs:100560575

Similar proteinsi

Entry informationi

Entry nameiG1KAT8_ANOCA
AccessioniPrimary (citable) accession number: G1KAT8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: September 12, 2018
This is version 39 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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