Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 49 (12 Aug 2020)
Sequence version 2 (26 Jun 2013)
Previous versions | rss
Add a publicationFeedback
Protein

SH3 domain-containing protein

Gene

mia3

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SH3 domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mia3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000002254, Expressed in skeletal muscle tissue and 15 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000002216

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 61SH3InterPro annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni107 – 222DisorderedSequence analysisAdd BLAST116
Regioni261 – 336DisorderedSequence analysisAdd BLAST76
Regioni353 – 661DisorderedSequence analysisAdd BLAST309
Regioni690 – 746DisorderedSequence analysisAdd BLAST57
Regioni770 – 795DisorderedSequence analysisAdd BLAST26
Regioni852 – 871DisorderedSequence analysisAdd BLAST20
Regioni1003 – 1049DisorderedSequence analysisAdd BLAST47
Regioni1432 – 1458DisorderedSequence analysisAdd BLAST27
Regioni1657 – 1938DisorderedSequence analysisAdd BLAST282

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1220 – 1275Sequence analysisAdd BLAST56
Coiled coili1283 – 1317Sequence analysisAdd BLAST35
Coiled coili1332 – 1359Sequence analysisAdd BLAST28
Coiled coili1470 – 1511Sequence analysisAdd BLAST42
Coiled coili1519 – 1606Sequence analysisAdd BLAST88
Coiled coili1618 – 1645Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi110 – 134AcidicSequence analysisAdd BLAST25
Compositional biasi135 – 169PolyampholyteSequence analysisAdd BLAST35
Compositional biasi170 – 188PolarSequence analysisAdd BLAST19
Compositional biasi201 – 221PolarSequence analysisAdd BLAST21
Compositional biasi299 – 336PolyampholyteSequence analysisAdd BLAST38
Compositional biasi372 – 395AcidicSequence analysisAdd BLAST24
Compositional biasi417 – 448PolyampholyteSequence analysisAdd BLAST32
Compositional biasi449 – 475PolarSequence analysisAdd BLAST27
Compositional biasi480 – 539PolyampholyteSequence analysisAdd BLAST60
Compositional biasi563 – 580PolyampholyteSequence analysisAdd BLAST18
Compositional biasi581 – 614PolarSequence analysisAdd BLAST34
Compositional biasi629 – 645PolyampholyteSequence analysisAdd BLAST17
Compositional biasi646 – 660PolarSequence analysisAdd BLAST15
Compositional biasi690 – 708AcidicSequence analysisAdd BLAST19
Compositional biasi714 – 729PolyampholyteSequence analysisAdd BLAST16
Compositional biasi770 – 791PolyampholyteSequence analysisAdd BLAST22
Compositional biasi853 – 871PolyampholyteSequence analysisAdd BLAST19
Compositional biasi1003 – 1025PolarSequence analysisAdd BLAST23
Compositional biasi1026 – 1049PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1433 – 1458PolyampholyteSequence analysisAdd BLAST26
Compositional biasi1685 – 1699Pro-richSequence analysisAdd BLAST15
Compositional biasi1803 – 1895Pro-richSequence analysisAdd BLAST93
Compositional biasi1912 – 1926Pro-richSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QS87, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182767

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002106_1_0_1

TreeFam database of animal gene trees

More...
TreeFami
TF333137

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07653, SH3_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KAI6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCRGKAVKDF TAPDCRFLDF KEGESIYVYY KLTGRTNELW AGSVGNEFGY
60 70 80 90 100
FPKDLLEIKH IYTHDELELP TDETDFICFD GGKDDFDNYN VDELLKLSEN
110 120 130 140 150
ILAINDDENE LGTEKEEEPE GIDLESDGFE VSSEEESEDH AKMGEKDNVL
160 170 180 190 200
LDNKKNVEET LDSKSEDLIV NSDTDNSQGD QSAHQPFEEI LQETLKVPKH
210 220 230 240 250
ESAKNSNISQ GKPNQSVYGS KDDGAYTLLR QDVSADLKTT FGSTADAIVS
260 270 280 290 300
DDEATALVTS LDADLGEDMD TDSYETEKLE KPKQQPEVIP LLPFTEGEIK
310 320 330 340 350
SLEDTESKKM SSDSETSELD KTGKTATKLI HEKKDNSGLL THLGDKFFAI
360 370 380 390 400
VSGGERTVDE TENNKVDFKE QNGEEEEEEE EEEEEEEEDE LANSEFSSED
410 420 430 440 450
GPLMSEQDLI TKQKHNAYTE NSKEKKDTTQ DYEEDHAQTE EKPIMGEEVH
460 470 480 490 500
STSTHNFDAF SSYGDDQQSK ASVETNALKP LLDDIKDEPE GVSLHKVRKD
510 520 530 540 550
EKTEEERNVD DSLENDTKHK NLWEKTVKKD EEDKQPLNII PDLLEESRNG
560 570 580 590 600
SESDLDNDEI LEGEINSDSK QDEDFELKQI FGSKKQTNNS TVENTSIEKD
610 620 630 640 650
PEVPTRQSQQ ETVTQDSEDS EEEEEEDDPT GSKKSTKKEY VLKESKTATQ
660 670 680 690 700
HTNVTPQNIV KNEAEHLDKV PGMDMGIDKS PTEELLSLEL EEEEEEDFIE
710 720 730 740 750
EPEEELLQDE NAVSAKLSKE RHTDEQGFTL DAESSDPLPQ MPDDAISRAA
760 770 780 790 800
NPVDEMGEEA STTFEQAKKE VGTGDFNEEY EEEKQQEADK TAFSEVENSL
810 820 830 840 850
VEKSNEIKNN HDEIMPISLH ISKLEDKDDF NQTKKHLPKD FSQNSLEELQ
860 870 880 890 900
ISTEETEGEH SHGPKSDMEN TNEAIESKYS ESIRQLIIMK EFLDEKRIAR
910 920 930 940 950
IQKFVGEKHV FRIESLFHDM QLELQLTQKH GDNYENTDKA LDQILESSES
960 970 980 990 1000
DILDVLNKAL DEREAENKEE VIKEIDLFDE EAALMDDIQE LMYSLRQKYS
1010 1020 1030 1040 1050
PVSESTPLAS FPESKTDPSE STTANGRQID HDRQHVQSPD EGIDEKPPLD
1060 1070 1080 1090 1100
ADHMSIKEIL DQPKEDGNIL EGNGILDDTG IKDLFDNDKK EPNVDIPLQP
1110 1120 1130 1140 1150
AGSGTEKDFM AEDQLEVKEN IMEEVNSPPE RDSGAPYIHG SLVDAVQLAK
1160 1170 1180 1190 1200
ENIQPLTDIL MSTLPEDMQP GPDFHGLPWE PIIITALVGM ATLAIFFWRT
1210 1220 1230 1240 1250
CLSVKSRLYQ VTEKQLVEKI KTLLKEKTEI LEKMSEYEQK IKEAKESVKE
1260 1270 1280 1290 1300
AQKQNTNLSD EAAGLKDTVK GLQETNHLLD DRVKNLNTTI EMEREHNARK
1310 1320 1330 1340 1350
QEQIIEAQKS LEKLQETITL HSVELSEVQI ALNEAKLSEE KVKSDLRRVQ
1360 1370 1380 1390 1400
EENVRLKKSK EQVILLTATY GKIVPDQKLL QEAEGWSERH AELGEQIKLY
1410 1420 1430 1440 1450
QKSQKDIEEA LAYKENEIEV LTNCIMQLKQ LDADSESETK RDEGNDLANG
1460 1470 1480 1490 1500
EISDTRNEKM KSQIKQMMDV SRVKTTLSII EEERDNLRSK LNDEVSSRHE
1510 1520 1530 1540 1550
LEEQIKKLEH ESCSLQTVKS QLESECKTLQ QKVEILNELY QQKEMALQKK
1560 1570 1580 1590 1600
LTQEEYERQE KEQKLSAADE KAILAVEEVK VYKQRIQEME EELQKTERSY
1610 1620 1630 1640 1650
KNQIGTHEKK AHDNWLIARS AERALVEEKR EAANLRQKLI EVNQKIAALQ
1660 1670 1680 1690 1700
RPVIVKPTAG WPDHQGPPRR GPLSRDGSFG PSPVSGGAPS PPLMMEPPGR
1710 1720 1730 1740 1750
PLSANPRDGS RGELGAAIVD GPPVPRRHPE LSGRMSAPDL GPAVAALVNC
1760 1770 1780 1790 1800
GPRTSSPSTG LDGMQNPPKE FEAPCVSDAQ PSSAEATAVN IGPKGPSSFP
1810 1820 1830 1840 1850
GGPLMASPGP LPPPVRFGPP PRAPYGSRPP PLVRVGPPPP LPRDYPPGPP
1860 1870 1880 1890 1900
FGMRDFPPGP IPPPEQRGYL RGPPPFRPPP QRDFPPGPRL PPQGLRDYPP
1910 1920 1930
SSTRDLLPSG PSDYPGGPPC PPSPASSRDS AHPSEQKP
Length:1,938
Mass (Da):217,881
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF908D25F30FBEC31
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000002276; ENSACAP00000002216; ENSACAG00000002254

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000002216

Genome annotation databases

EnsembliENSACAT00000002276; ENSACAP00000002216; ENSACAG00000002254

Phylogenomic databases

eggNOGiENOG502QS87, Eukaryota
GeneTreeiENSGT00950000182767
HOGENOMiCLU_002106_1_0_1
TreeFamiTF333137

Gene expression databases

BgeeiENSACAG00000002254, Expressed in skeletal muscle tissue and 15 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PfamiView protein in Pfam
PF07653, SH3_2, 1 hit
SMARTiView protein in SMART
SM00326, SH3, 1 hit
SUPFAMiSSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KAI6_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KAI6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: August 12, 2020
This is version 49 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again