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Entry version 60 (07 Apr 2021)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

DOCK8

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factorARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DOCK8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 37Sequence analysisAdd BLAST37
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500341268438 – 2179Sequence analysisAdd BLAST2142

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000001924, Expressed in adrenal gland and 12 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000002146

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini634 – 803C2 DOCK-typeInterPro annotationAdd BLAST170
Domaini1712 – 2146DOCKERInterPro annotationAdd BLAST435

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1997, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155876

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000624_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1KAF3

Identification of Orthologs from Complete Genome Data

More...
OMAi
FVYPQRL

Database of Orthologous Groups

More...
OrthoDBi
20156at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313629

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08696, C2_Dock-C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.740, 1 hit
1.25.40.410, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR037808, C2_Dock-C
IPR035892, C2_domain_sf
IPR027007, DHR-1_domain
IPR027357, DHR-2
IPR026791, DOCK
IPR010703, DOCK_C
IPR021816, DOCK_C/D_N
IPR043161, DOCK_C_lobe_A
IPR043162, DOCK_C_lobe_C

The PANTHER Classification System

More...
PANTHERi
PTHR23317, PTHR23317, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06920, DHR-2, 1 hit
PF14429, DOCK-C2, 1 hit
PF11878, DUF3398, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51650, DHR_1, 1 hit
PS51651, DHR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1KAF3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPFPRRRRL RLPHVAAWSW SLPLAFGLLS TRKGAKAEAP ALLAALAGLH
60 70 80 90 100
ASAPPPFHAR SGQPGAGLGA DACMATLPAA DRRAFALKIN RHSSADIRKQ
110 120 130 140 150
FVNQLNLGQI PQRSISSPGF STVHLPQFYD AVEPVDFEGF LMMQLNNLDS
160 170 180 190 200
ELLQELGDFP EDDLEVAFTP KEHRTLQPSL PEEGAELDPH VRDCVQTYVR
210 220 230 240 250
DWLIVNRKNQ GNNEVYTFTK RGSRRDFHKT LQKQTFESEV LDYSNSNYQA
260 270 280 290 300
CPRHLKVLCD ESNRATLTSG DFDLRSLQPD PHLPSLLQPV SAENLKRQNE
310 320 330 340 350
EARQSNRPTE LFALYPSIDE EDAVEIRPVP ECPKEYLGNR LLVKIQTLKF
360 370 380 390 400
EIEIEPLFAS LALYDIKERK KISENFHCDL NSEQFKGFLR SHTPCVDSSS
410 420 430 440 450
LARSAVFSVT YPSPDIYLVI KIEKVLQQGE IGECAEPYMV LKESDGGKTK
460 470 480 490 500
EKVEKLKSQA ESFCHRLGAY RMPFAWVPIS LGSFFSISTL ERDIAELEVL
510 520 530 540 550
NGKGSTGDRK TMTMQTRRLS ERSLGIEDVS SMTNFKPTTL TVNTFFKQEG
560 570 580 590 600
DKLSDEDLFK FLADSKRSSS LQRRVKSIPG LLKLEISPAS EALTCCLSPE
610 620 630 640 650
LLPVKPFPEN RSRPHKEILE FPVREVYDPH TVYRNLLYVY PQRLNFANRL
660 670 680 690 700
ASGRNITIKI QFMCGEDPSC AMPIIFGKSS GPEFVKEVCT SVTYHNKSPD
710 720 730 740 750
FYEEVKIKLP AKLTERHHLL FTFCHISCQH KQGGCVETLL GYSWLPILLN
760 770 780 790 800
DRLQTGHYCL PVALDKLPAN YSMHSAEKVP PQSPPIKWVE GHKGVFNVEV
810 820 830 840 850
QAISSVHTQD NHLEKFFTLC HALESQVAFP IRVLNEKITE ATLEHELKLS
860 870 880 890 900
IICLNSSRLE PLVLFLHLVL DKLFQLAVQP MVIAGQTANF SQFAFESVVA
910 920 930 940 950
TVNSLHNSKD LSKDQHGRNC LLASYVYYVF RLPEIQREVV KLGTSGGVNL
960 970 980 990 1000
PESRYYTYGR TTAVSVGSRL LQSRATSCSN PDIAGTQTAT DEEVHNIMSS
1010 1020 1030 1040 1050
RIVDRSYNRM SYYSEPSSDM SSPCTSPRPS SKKHFHEELA LQMVVSAGMV
1060 1070 1080 1090 1100
RESVFKYSWF FFELLVKSMA QYVDNMEKRD TPRRSRFSSR FKDDITTIVN
1110 1120 1130 1140 1150
VVASEVAALL VKPQKESEQA EKMNISLAFF LYDLLSLMDR GFVFNLIKHY
1160 1170 1180 1190 1200
CNQLSNKLNT VPTLISMRLE FLRILCSHEH YLNLNLFFLT SSSAPTSPSP
1210 1220 1230 1240 1250
SLSSQNSSSC SSFQDQKLAN MFDLTADYRQ QHFLTGLLFT ELTAALDTEA
1260 1270 1280 1290 1300
EGISRVQRKA VSAIHSLLSS HDLDKSCLKP EVKVKVAALY LPLVGIILDA
1310 1320 1330 1340 1350
LPQLHDFTVS DGRNGKGRSG SPDEEQEAAS QINQNIALAI AGNQFNLLRS
1360 1370 1380 1390 1400
SGSSVSAVPY KYYNTLSPET TRHLLICFLW IMKNADQKLI QKWISDLPSM
1410 1420 1430 1440 1450
QLNKILDLLF ICVSAFEYKG KQSSDKVSTQ VLQKSRDVKA RLEEALLRGE
1460 1470 1480 1490 1500
GARGEMMKRC RMPVGNERFP GLNENLRWKK EQTHWRQANE RLDKTKAEID
1510 1520 1530 1540 1550
QEALVSGNLA TEANLIVLDM QENIIQATSA MDCRDNILGG VLKVLVNSLT
1560 1570 1580 1590 1600
CDQSTTYLMH CFATLRALIV KFGDLLFEEE VEQCADLCQR VLQHCSSSID
1610 1620 1630 1640 1650
ATRIQSCATL YLLMRYSFSS TSNFARVKMQ VTMSLASLVG KASDFNEEYL
1660 1670 1680 1690 1700
RKSLRTILAY AEEDTDMQPT LFPAQVEELL CNLNSILSDT VKMREFQEDP
1710 1720 1730 1740 1750
EMLMDLMYRI AKGYQTSPDL RLTWLQNMAE KHAKRKCYTE AAMCLVHAAA
1760 1770 1780 1790 1800
LVAEYLSMLE DHNYLPVGSV SFQNISSNVL EESAVSDDVL SPDEDGVCSG
1810 1820 1830 1840 1850
RYFSENGLVG LLEQAAELFS TGGLSETVNE VYKIVIPILE AHRDFRKLSS
1860 1870 1880 1890 1900
THSKLQKAFE NIINKGQKRM FGTYFRVGFY GAIFGDLDEQ EFVYKEPAIT
1910 1920 1930 1940 1950
KLPEISHRLE GFYGQCFGED RVTVIKDSTP VDKSKLDPSK AYIQITFVEP
1960 1970 1980 1990 2000
YFDDYEMKDR VTHFEKNFNL RRFMYTTPFT RDGRPRGELS EQYKRKTILT
2010 2020 2030 2040 2050
TMHAFPYIKT RINVIQKEEF VLMPIEVAIE DMQKKTLELA VATNQVPPDA
2060 2070 2080 2090 2100
KMLQMVLQGS VGATVNQGPL EVAQVFLAEI PEDSKLYRHH NKLRLCFKEF
2110 2120 2130 2140 2150
IMRCGEAVEK NKRLITVDQR EYQQELKKNY NKLKENLRPM IERKIPELYK
2160 2170
PIVKIDSISR DSFRNSSFRK TENLPPQSA
Length:2,179
Mass (Da):247,017
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4A0104D832BCFAEF
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_008101523.1, XM_008103316.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000002205; ENSACAP00000002146; ENSACAG00000001924

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100565160

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
acs:100565160

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_008101523.1, XM_008103316.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000002146

Genome annotation databases

EnsembliENSACAT00000002205; ENSACAP00000002146; ENSACAG00000001924
GeneIDi100565160
KEGGiacs:100565160

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
81704

Phylogenomic databases

eggNOGiKOG1997, Eukaryota
GeneTreeiENSGT00940000155876
HOGENOMiCLU_000624_0_0_1
InParanoidiG1KAF3
OMAiFVYPQRL
OrthoDBi20156at2759
TreeFamiTF313629

Gene expression databases

BgeeiENSACAG00000001924, Expressed in adrenal gland and 12 other tissues

Family and domain databases

CDDicd08696, C2_Dock-C, 1 hit
Gene3Di1.20.58.740, 1 hit
1.25.40.410, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR037808, C2_Dock-C
IPR035892, C2_domain_sf
IPR027007, DHR-1_domain
IPR027357, DHR-2
IPR026791, DOCK
IPR010703, DOCK_C
IPR021816, DOCK_C/D_N
IPR043161, DOCK_C_lobe_A
IPR043162, DOCK_C_lobe_C
PANTHERiPTHR23317, PTHR23317, 1 hit
PfamiView protein in Pfam
PF06920, DHR-2, 1 hit
PF14429, DOCK-C2, 1 hit
PF11878, DUF3398, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51650, DHR_1, 1 hit
PS51651, DHR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1KAF3_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1KAF3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: April 7, 2021
This is version 60 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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