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Entry version 62 (16 Oct 2019)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

abcc3

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi665 – 672ATPPROSITE-ProRule annotation8
Nucleotide bindingi1324 – 1331ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:abcc3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei31 – 50HelicalSequence analysisAdd BLAST20
Transmembranei70 – 87HelicalSequence analysisAdd BLAST18
Transmembranei99 – 118HelicalSequence analysisAdd BLAST20
Transmembranei130 – 147HelicalSequence analysisAdd BLAST18
Transmembranei167 – 185HelicalSequence analysisAdd BLAST19
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Transmembranei430 – 449HelicalSequence analysisAdd BLAST20
Transmembranei455 – 473HelicalSequence analysisAdd BLAST19
Transmembranei541 – 561HelicalSequence analysisAdd BLAST21
Transmembranei970 – 993HelicalSequence analysisAdd BLAST24
Transmembranei1013 – 1035HelicalSequence analysisAdd BLAST23
Transmembranei1077 – 1096HelicalSequence analysisAdd BLAST20
Transmembranei1102 – 1126HelicalSequence analysisAdd BLAST25
Transmembranei1202 – 1218HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000001396 Expressed in 4 organ(s), highest expression level in heart

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28377.ENSACAP00000001445

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini316 – 598ABC transmembrane type-1InterPro annotationAdd BLAST283
Domaini633 – 855ABC transporterInterPro annotationAdd BLAST223
Domaini973 – 1253ABC transmembrane type-1InterPro annotationAdd BLAST281
Domaini1290 – 1524ABC transporterInterPro annotationAdd BLAST235

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni913 – 942DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi917 – 936PolyampholyteSequence analysisAdd BLAST20

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163867

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G1K9J3

KEGG Orthology (KO)

More...
KOi
K05667

Database of Orthologous Groups

More...
OrthoDBi
138195at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105199

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00957 MRP_assoc_pro, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G1K9J3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAFCNSSFW DPNLTLYTDN PDLTPCFQNT VLGWIPCFYL WCILPFYLFY
60 70 80 90 100
LKCNNRGYIV LSVLSRFKTV FAFLLWCVSW ANLFYSFHGI TQSRTPPSVY
110 120 130 140 150
FVTPLIVGIT MLLAMLLIQY ERLHGVQSSG ILIIFWFLCA LCAVGPLRSK
160 170 180 190 200
IIRTSAQDQM EDRFRITTFY IYFALILIEL ILACLKEKPP FFSPVNLDHN
210 220 230 240 250
PCPELNSGFL SKITFWWFTS MAVQGYKRPL EDKDLWSLNA EDKSDVVVKK
260 270 280 290 300
LQKEWNKQKH ERLQKKDVSY TKNPNNVMNH IADGPGETEI LLSSNTEQKE
310 320 330 340 350
PSFLKALIRT FGPYFLIGSF FKLIQDLLAF VNPQLLRILI GFIKDQSAPL
360 370 380 390 400
WWGYLIAALM FFSAVLQTII LHQHFQYCFV TGMRLRTGII GMIYRKSLVI
410 420 430 440 450
TNSAKRSSTV GEIVNLMSVD AQRFMDLTTF LNMLWSAPLQ ICLALYFLWQ
460 470 480 490 500
SLGPSVLAGV AVMVLLIPLN AVIAMKTRAF QVEQMRYKDS RIKLMNEILS
510 520 530 540 550
GIKVLKLYAW EPSFADKILE IRKNELRVLK KSAYLNSLST FTWVSAPFLV
560 570 580 590 600
ALTTFAVYAT VDENNILDAE KAFVSLSLFN LLRFPLNMLP QVISSIAQTS
610 620 630 640 650
VSLKRIQHFL SHDELDPSCV DTKLIAPGYS VTIRNGTFSW AKDLEPALKD
660 670 680 690 700
INWLVPNGSL VAVVGHVGCG KSSLVSALLG EMEKLHGEVA VKGSVAYVPQ
710 720 730 740 750
LAWIQNATLK DNILFGQPHN EQKYQMVLEA CALKQDLEML PGGDQTEIGE
760 770 780 790 800
KGINLSGGQR QRVSLARAVF SDTDVYLLDD PLSAVDSHVA KHIFDKVIGP
810 820 830 840 850
EGALRGKTRI LVTHGINFLP QVDHIVVVVD GMISEMGSYQ ELLQQNRSFA
860 870 880 890 900
EFLRNYAPDE DIEEDEPTIV EDEEVLLAED TLSNHIDLAD SEPVTNEARK
910 920 930 940 950
QFLRQLSVIS SDGECPSKMS TKRRVCEKKP PEPPLPKKGP PEKLIQAETA
960 970 980 990 1000
ETGTVKFTVF WQYMKAVGPI VSLFICFFYC CQNAAAVGAN VWLSDWTNEP
1010 1020 1030 1040 1050
VVNGTQHNVP MRVGVYGALG LLQGLFVLAS SFTLAMGGIR AARSLHAGLL
1060 1070 1080 1090 1100
ENKLHTPQSF YDTTPTGRII NRFSKDIYVI DEVIPPTILM FLGTFFTSLS
1110 1120 1130 1140 1150
TMLVIIASTP LFAVVIIPLA ILYFFAQRFY VATSRQLKRL ESVSRSPIYS
1160 1170 1180 1190 1200
HFSETVTGAS VIRAYRREKS FVYISDAKVN DNQKSYYPGI VANRWLGIRV
1210 1220 1230 1240 1250
EFVGNCVVFF AALFAVLSRN KLSAGVVGLS VSYALQVTMA LNWMVRMSSD
1260 1270 1280 1290 1300
LESNIVAVER VKEYSETETE APWIIEDKRP SENWPDQGEV QFANYSVRYR
1310 1320 1330 1340 1350
KGLDLVLKNL SLHVKGGEKV GIVGRTGAGK SSMTLCLFRI LEAVEGEIKI
1360 1370 1380 1390 1400
DGLRIADIGL HDLRSKLTII PQDPVLFSGT LRMNLDPFNK YSEEEIWNAL
1410 1420 1430 1440 1450
ELSHLKRFVS AQPAMLDYEC SEGGENLSVG QRQLVCLARA LLRKTRILVL
1460 1470 1480 1490 1500
DEATAAIDLE TDDLIQMTIR TQFEDCTVLT IAHRLNTIMD YTRVLVLDKG
1510 1520
AIAEFDTPSR LIESKGIFYG MAKDAGLA
Length:1,528
Mass (Da):171,827
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC965DD1ADD72C3D
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_003217355.1, XM_003217307.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000001480; ENSACAP00000001445; ENSACAG00000001396

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100566537

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
acs:100566537

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_003217355.1, XM_003217307.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000001445

Genome annotation databases

EnsembliENSACAT00000001480; ENSACAP00000001445; ENSACAG00000001396
GeneIDi100566537
KEGGiacs:100566537

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8714

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00940000163867
InParanoidiG1K9J3
KOiK05667
OrthoDBi138195at2759
TreeFamiTF105199

Gene expression databases

BgeeiENSACAG00000001396 Expressed in 4 organ(s), highest expression level in heart

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
TIGRFAMsiTIGR00957 MRP_assoc_pro, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1K9J3_ANOCA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1K9J3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: June 26, 2013
Last modified: October 16, 2019
This is version 62 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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