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Entry version 46 (10 Feb 2021)
Sequence version 2 (11 Jul 2012)
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Protein

Phosphatase and actin regulator

Gene

phactr4a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatase and actin regulatorUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:phactr4aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-051030-69, phactr4a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
G1K2M1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000015552, Expressed in heart and 24 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
G1K2M1, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds PPP1CA and actin.

UniRule annotationARBA annotation

Binds ppp1ca and actin.

ARBA annotation

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati59 – 84RPELPROSITE-ProRule annotationAdd BLAST26
Repeati879 – 904RPELPROSITE-ProRule annotationAdd BLAST26
Repeati917 – 942RPELPROSITE-ProRule annotationAdd BLAST26

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 870DisorderedSequence analysisAdd BLAST870

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi49 – 89PolyampholyteSequence analysisAdd BLAST41
Compositional biasi133 – 147PolyampholyteSequence analysisAdd BLAST15
Compositional biasi162 – 328PolyampholyteSequence analysisAdd BLAST167
Compositional biasi360 – 374PolarSequence analysisAdd BLAST15
Compositional biasi430 – 452PolarSequence analysisAdd BLAST23
Compositional biasi493 – 507PolarSequence analysisAdd BLAST15
Compositional biasi530 – 567Pro-richSequence analysisAdd BLAST38
Compositional biasi611 – 631Pro-richSequence analysisAdd BLAST21
Compositional biasi632 – 650PolarSequence analysisAdd BLAST19
Compositional biasi651 – 665Pro-richSequence analysisAdd BLAST15
Compositional biasi676 – 690Pro-richSequence analysisAdd BLAST15
Compositional biasi757 – 782PolyampholyteSequence analysisAdd BLAST26
Compositional biasi829 – 865PolyampholyteSequence analysisAdd BLAST37

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the phosphatase and actin regulator family.UniRule annotationARBA annotation

Keywords - Domaini

RepeatUniRule annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157582

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015753_1_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
REQWMAV

TreeFam database of animal gene trees

More...
TreeFami
TF316316

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029984, Phactr4
IPR004018, RPEL_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR12751:SF20, PTHR12751:SF20, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02755, RPEL, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00707, RPEL, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51073, RPEL, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

G1K2M1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENRDDEVDH SMPESDGANP GAGNPSAKSK GKFPSLGKIF KPWKWRKKKT
60 70 80 90 100
SDKFKETSEV LERKMSVRKP REELIERGLL KDIPENESND VNHKAPPVKN
110 120 130 140 150
GHTGPVPGDR KSDSGSEVKA PSSRPQGEDQ RNSCAPEAER RSRVPSDVSR
160 170 180 190 200
NRQPLDVDAQ TRIPTEPDRR SRLESDYEKR TGSLPLDRPG QEDGRYRREE
210 220 230 240 250
REEKANREKE RRDRKDDRDV RGERRDDRDK HDKRPDKENW QGRDDREKER
260 270 280 290 300
RNDREKREEK DWRDNRDRKQ PRDRKEEHER RDEPERVDDR ERKEQIERRE
310 320 330 340 350
ERDKREERDR REEKGRRDVR RPEPAKQVSD GKLTRPQSEM DMRPVLSKSI
360 370 380 390 400
SDNGLKVRPV SEALQSSTLL RYTSGEEETR TRKGSVGVQF VPEPKPASTS
410 420 430 440 450
TKESQPPPKQ AILPPKRVIA APSSAEPAPV PPSFSSLSSS SSSSSSSSSS
460 470 480 490 500
SAPPIAKPPP RTVSLNVDDS SRTILIPSLI AGDREVPPTV PAHTTPATVS
510 520 530 540 550
THKTLPTVPA HMTPPTVPAH VTTPAAPAHS NPPAVLPHST PPTVPKHPTP
560 570 580 590 600
AAPVPLKQPP MPPPKPVHHS SNTALQVDPS QVPVPVKRSP PIPPKRNTPV
610 620 630 640 650
TKRNSGDSSA NLPEPPPPAP TSVPIPAAAP ISAPPSTQSD DSKNSNSGGF
660 670 680 690 700
SPPPPHIPPS PPRAHQPHEV IRVDPPSPTT EPPSQPPPLP LHIRIQRALN
710 720 730 740 750
SPGPVHPNPE GSQRAHSLLF ETPPDLINEA LGGGRYSLPV TIEPLRLPED
760 770 780 790 800
DDFDMEEELQ KLRAGPRPTQ KPELEPRSRR GLVEDPQVAV IPEDAGSESS
810 820 830 840 850
EEEEDESDSD QSIKYRDDNE EDDDEEDVPK SGLASRVKRK DTLALKLERQ
860 870 880 890 900
QEKEKSQEED SSTWNNKEQW EAVRNKIGTA LTRRLSQRPT AQELEQRNIL
910 920 930 940 950
LAKNEEVRRA ERSEIKRRLT RKLSQRPTIA DLQARKILRF HEYVESTHAQ
960 970 980 990
DYDRRADKPW TKLTPADKAA IRKELNEFKS SEMEVHEESR IFTRFHRP
Length:998
Mass (Da):112,527
Last modified:July 11, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7434FEA1D5F292AE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QIC4PHR4A_DANRE
Phosphatase and actin regulator 4A
phactr4a
725Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3ITL9I3ITL9_DANRE
Phosphatase and actin regulator
phactr4a
321Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IPH0A0A0R4IPH0_DANRE
Phosphatase and actin regulator 4A
phactr4a
1,011Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1QFA2F1QFA2_DANRE
Phosphatase and actin regulator 4A
phactr4a
260Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL954687 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000055619; ENSDARP00000055618; ENSDARG00000015552

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954687 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiG1K2M1

Genome annotation databases

EnsembliENSDART00000055619; ENSDARP00000055618; ENSDARG00000015552

Organism-specific databases

ZFINiZDB-GENE-051030-69, phactr4a

Phylogenomic databases

GeneTreeiENSGT00940000157582
HOGENOMiCLU_015753_1_0_1
OMAiREQWMAV
TreeFamiTF316316

Gene expression databases

BgeeiENSDARG00000015552, Expressed in heart and 24 other tissues
ExpressionAtlasiG1K2M1, baseline

Family and domain databases

InterProiView protein in InterPro
IPR029984, Phactr4
IPR004018, RPEL_repeat
PANTHERiPTHR12751:SF20, PTHR12751:SF20, 4 hits
PfamiView protein in Pfam
PF02755, RPEL, 3 hits
SMARTiView protein in SMART
SM00707, RPEL, 3 hits
PROSITEiView protein in PROSITE
PS51073, RPEL, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG1K2M1_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G1K2M1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: July 11, 2012
Last modified: February 10, 2021
This is version 46 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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