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Protein

Lysophospholipase NTE1

Gene

NDAI0D04780

Organism
Naumovozyma dairenensis (strain ATCC 10597 / BCRC 20456 / CBS 421 / NBRC 0211 / NRRL Y-12639) (Saccharomyces dairenensis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis.UniRule annotation

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1336NucleophilePROSITE-ProRule annotation1
Active sitei1454Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolasePROSITE-ProRule annotation
Biological processLipid degradationPROSITE-ProRule annotation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1UniRule annotation (EC:3.1.1.5UniRule annotation)
Alternative name(s):
Intracellular phospholipase BUniRule annotation
Gene namesi
Name:NDAI0D04780Imported
Ordered Locus Names:NDAI_0D04780Imported
OrganismiNaumovozyma dairenensis (strain ATCC 10597 / BCRC 20456 / CBS 421 / NBRC 0211 / NRRL Y-12639) (Saccharomyces dairenensis)Imported
Taxonomic identifieri1071378 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNaumovozyma
Proteomesi
  • UP000000689 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei50 – 77HelicalUniRule annotationAdd BLAST28
Transmembranei89 – 109HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

Interactioni

Protein-protein interaction databases

STRINGi1071378.XP_003670034.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini754 – 855Cyclic nucleotide-bindingInterPro annotationAdd BLAST102
Domaini869 – 1013Cyclic nucleotide-bindingInterPro annotationAdd BLAST145
Domaini1303 – 1467PNPLAInterPro annotationAdd BLAST165

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili907 – 934Sequence analysisAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1307 – 1312GXGXXGPROSITE-ProRule annotation6
Motifi1334 – 1338GXSXGPROSITE-ProRule annotation5
Motifi1454 – 1456DGA/GPROSITE-ProRule annotation3

Sequence similaritiesi

Belongs to the NTE family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG2968 Eukaryota
COG0664 LUCA
COG1752 LUCA
KOiK14676
OrthoDBiEOG092C0BAH

Family and domain databases

CDDicd00038 CAP_ED, 2 hits
Gene3Di2.60.120.10, 2 hits
InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR001423 LysoPLipase_patatin_CS
IPR002641 PNPLA_dom
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF01734 Patatin, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 2 hits
SUPFAMiSSF51206 SSF51206, 4 hits
SSF52151 SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 2 hits
PS51635 PNPLA, 1 hit
PS01237 UPF0028, 1 hit

Sequencei

Sequence statusi: Complete.

G0WAI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNITQDKSTP SSSSSASPIS TSQERKGLPE QLIQAKHDWF LSSIGNFTWV
60 70 80 90 100
IIYFCTGSTM FVLKGISYIL TLFLLQIPGK IIHSANKMRF TISFTVILTV
110 120 130 140 150
IAILIYITYC IVKARVLSQY KKLTPDEDSL LMNQNIGAGT NREAGSTPLN
160 170 180 190 200
RSENMKNRNS NNINDDTFLS SYLDQFLSAI KIFGYLEKPV FHALTKNMKT
210 220 230 240 250
QKLDEGEILL LDNSIGFAIV VEGTLQVFHE VEQTADEIVR NEARDDITEH
260 270 280 290 300
ESVLRVEALT NNDNEDLTTY NSGISDSDSD SDFDSDDESS GYIRLKNGLG
310 320 330 340 350
KFQLLNTVKP GNPISSLVNI LNLFTSANPN ASPYNINGSR SDSNDRGNSN
360 370 380 390 400
NIDMQLQFGK FTLNSDNATS SCPTPSMDTT PPLQSSEHIP ALLSPYSIPK
410 420 430 440 450
VVARASTDCT IAIIPPQAFA RLTAKYPRSA SHMIQMILAK LYNVTFQTAH
460 470 480 490 500
NYLGLTREIM DIELSLNRSV KYELPYYLKE TVIRKSKASN SEIKHNDSNR
510 520 530 540 550
HARKSSFESS KPRLDSKTTS LSNDNLQAPI PAKPSRNSMV IGSRHVVLDS
560 570 580 590 600
RDHLNPGDLL SNVPLSRKEY NDDTPARDSK SPNQWTSKAN ASHDHIDTKK
610 620 630 640 650
HLKSYDRPKL KKNYQNGSSA SFIKTLKTKH GMNEDIKTRS FSAAQEETED
660 670 680 690 700
SSVRMAVTEA FFAFMGVSQS NMSAANPETS FTDSNTNLGR SVHRSSEISL
710 720 730 740 750
DPSIGSSVTH QTTLRILPSE YTITSRRQMK RNKKKKPYKE EISSNLDFDS
760 770 780 790 800
AKNEFAQGLQ LKFFKQGSNI VEANSDGKGM FYVISGKISV STSSDSDDHP
810 820 830 840 850
TNKKNHKIEH TLFSIGSGGI AGYLSGIVGY KSFVNLKAQT DVYVGFLPNK
860 870 880 890 900
VIERLCDKYF LIYLRIAETL SGLLSSRMLK LDHALEWVHL SASETLFSQD
910 920 930 940 950
DPANGIYVVL NGRLRQLQER KRNTTNDVNE AITHHDSKKD KMKNSTTYPV
960 970 980 990 1000
VVGELAQGES FGEVEVLTAM NRFTTIVAVR DSELARIPRT LFESIAMEHP
1010 1020 1030 1040 1050
SIMIRVSRLV AKKIMGNNYT QNNEDNNLAI PLTKSLNSLN SHYQTQNHSS
1060 1070 1080 1090 1100
GKITFRTITI LPIREGLPVE NFAMKLVQAF KQVGRNTIGL NQRTTLTHLG
1110 1120 1130 1140 1150
RHAFDRLAKL KQSGYFAELE EMYQTVVYIA DTPSKSSWTQ TCIAQGDCIL
1160 1170 1180 1190 1200
LLADATSLPD IGEYENLLLK SKTTARTELI LLHPERYVEP GLTQKWLRYR
1210 1220 1230 1240 1250
PWVHSHHHIQ LVVNPLEGIS ANKIHGFNGG ALALVDKFIQ TDFSKKTQQN
1260 1270 1280 1290 1300
ISKLLPDSLK TTVENFSSRF MKKRNAQFYT PTNPHKNDFL RLARILSGQA
1310 1320 1330 1340 1350
IGLVLGGGGA RGLSHLGVIQ AIEEQGIPID MIGGTSIGSF VGGLYAKDYD
1360 1370 1380 1390 1400
LVPIYGRVKK FAGRISSLWR TLLDLTWPVT SYTTGHEFNR GIWKTFGDTR
1410 1420 1430 1440 1450
IEDFWIQYYC NSTNITNSVQ EIHSFGYAWR YIRASMSLAG LLPPLEEHGS
1460 1470 1480 1490 1500
MLLDGGYLDN LPVLEMKARG CDTIFAVDVG SVDDRTPMKY GDSLNGFWIV
1510 1520 1530 1540 1550
FNRWNPFSSH PNVPNMAEIQ VRLGYVASVN ALEKAKNTAG VLYIRPPIEN
1560 1570 1580 1590 1600
YATLDFGKFE EIYAVGVDYG RIFFQELESE GKMPFLPGCQ AQVVASEVPE

FLLHRRHSI
Length:1,609
Mass (Da):179,932
Last modified:October 19, 2011 - v1
Checksum:i0D037F1EACCC5E9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE580270 Genomic DNA Translation: CCD24791.1
RefSeqiXP_003670034.1, XM_003669986.1

Genome annotation databases

EnsemblFungiiCCD24791; CCD24791; NDAI_0D04780
GeneIDi11495194
KEGGindi:NDAI_0D04780

Similar proteinsi

Entry informationi

Entry nameiG0WAI0_NAUDC
AccessioniPrimary (citable) accession number: G0WAI0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: May 23, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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