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Protein

Acyl-CoA desaturase

Gene

NCAS0D03250

Organism
Naumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Stearyl-CoA desaturase that utilizes O2 and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.UniRule annotation

Catalytic activityi

Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Expected to bind 2 Fe2+ ions per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processElectron transportUniRule annotation, Fatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transport
LigandHemeUniRule annotationSAAS annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA desaturaseUniRule annotation (EC:1.14.19.1UniRule annotation)
Gene namesi
Name:NCAS0D03250Imported
Ordered Locus Names:NCAS_0D03250Imported
OrganismiNaumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)Imported
Taxonomic identifieri1064592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNaumovozyma
Proteomesi
  • UP000001640 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei96 – 114HelicalSequence analysisAdd BLAST19
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Transmembranei241 – 258HelicalSequence analysisAdd BLAST18
Transmembranei270 – 295HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi1064592.XP_003676267.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini396 – 474Cytochrome b5 heme-bindingInterPro annotationAdd BLAST79

Sequence similaritiesi

Belongs to the fatty acid desaturase type 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0537 Eukaryota
KOG1600 Eukaryota
COG1398 LUCA
COG5274 LUCA
InParanoidiG0VEB5
KOiK00507
OrthoDBiEOG092C2CE8

Family and domain databases

CDDicd03505 Delta9-FADS-like, 1 hit
Gene3Di3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR009160 Acyl-CoA_deSatase_haem/ster-bd
IPR015876 Acyl-CoA_DS
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR018506 Cyt_B5_heme-BS
IPR005804 FA_desaturase_dom
IPR001522 FADS-1_CS
PANTHERiPTHR11351 PTHR11351, 1 hit
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
PF00487 FA_desaturase, 1 hit
PIRSFiPIRSF000345 OLE1, 1 hit
PRINTSiPR00075 FACDDSATRASE
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit
PROSITEiView protein in PROSITE
PS00191 CYTOCHROME_B5_1, 1 hit
PS50255 CYTOCHROME_B5_2, 1 hit
PS00476 FATTY_ACID_DESATUR_1, 1 hit

Sequencei

Sequence statusi: Complete.

G0VEB5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPQITTRSS VEVATTPVLS NDIETVDLIE ANIVASGANK KTVRVVNGLG
60 70 80 90 100
SLMGSKEITQ LDDSITAKVQ PSTTTSGEKL HISEQPWTLN NWHQHINWLN
110 120 130 140 150
MVLTVFIPAI GFYFALSGKV PVRKNVVLFA LFYYVASGIT ITAGYHRLWS
160 170 180 190 200
HRAFEARWPL RLFFAILGAA NVQGSIKWWG HSHRIHHRYT DTPRDPYDAR
210 220 230 240 250
RGLWYSHMGW MLMKPNPKYK ARADISDLND DWIVRFQHRH YIPIMILTAF
260 270 280 290 300
VFPTWVVGKY ISPGDYMAGF IYAGILRVFA IQQATFCINS LAHFLGDQPF
310 320 330 340 350
DDKRTPRDNW ITALVTFGEG YHNFHHEFPT DYRNAIKWYQ YDPTKLFIYA
360 370 380 390 400
TSILGLALNL KTFDANVIQQ GIVQQQEKKV NKMKNKLHWG PTLDELPVWD
410 420 430 440 450
KKEFVEQAQL NKNLVVISGI IHDISNYIPE HPGGESLIKQ ALGKDATRAF
460 470 480 490
QGGVYRHSTA AQNVLSELRV AVLKENGNAA MNFVKRRGEQ FDKNKFE
Length:497
Mass (Da):56,733
Last modified:October 19, 2011 - v1
Checksum:i7812313D5C93FD2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE576755 Genomic DNA Translation: CCC69906.1
RefSeqiXP_003676267.1, XM_003676219.1

Genome annotation databases

EnsemblFungiiCCC69906; CCC69906; NCAS_0D03250
GeneIDi11528327
KEGGincs:NCAS_0D03250

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE576755 Genomic DNA Translation: CCC69906.1
RefSeqiXP_003676267.1, XM_003676219.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1064592.XP_003676267.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCCC69906; CCC69906; NCAS_0D03250
GeneIDi11528327
KEGGincs:NCAS_0D03250

Phylogenomic databases

eggNOGiKOG0537 Eukaryota
KOG1600 Eukaryota
COG1398 LUCA
COG5274 LUCA
InParanoidiG0VEB5
KOiK00507
OrthoDBiEOG092C2CE8

Family and domain databases

CDDicd03505 Delta9-FADS-like, 1 hit
Gene3Di3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR009160 Acyl-CoA_deSatase_haem/ster-bd
IPR015876 Acyl-CoA_DS
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR018506 Cyt_B5_heme-BS
IPR005804 FA_desaturase_dom
IPR001522 FADS-1_CS
PANTHERiPTHR11351 PTHR11351, 1 hit
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
PF00487 FA_desaturase, 1 hit
PIRSFiPIRSF000345 OLE1, 1 hit
PRINTSiPR00075 FACDDSATRASE
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit
PROSITEiView protein in PROSITE
PS00191 CYTOCHROME_B5_1, 1 hit
PS50255 CYTOCHROME_B5_2, 1 hit
PS00476 FATTY_ACID_DESATUR_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG0VEB5_NAUCC
AccessioniPrimary (citable) accession number: G0VEB5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: December 20, 2017
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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