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Protein

RNA polymerase II transcription factor B subunit 2

Gene

NCAS0C01390

Organism
Naumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
Name:NCAS0C01390Imported
Ordered Locus Names:NCAS_0C01390Imported
OrganismiNaumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)Imported
Taxonomic identifieri1064592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNaumovozyma
Proteomesi
  • UP000001640 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi1064592.XP_003675496.1

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3471 Eukaryota
COG5144 LUCA
InParanoidiG0VCC0
KOiK03144
OrthoDBiEOG092C3703

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

G0VCC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSVLKNSV TQYLEEIPQQ VQTRLYESPA TCLAIYRLLP QLAKFFVMSM
60 70 80 90 100
VFNDKEVSLR DLDRWVKSNG KMQFQDAIKS MKSLHLIIPS KSNGGPLMIN
110 120 130 140 150
LNPTFRESFK NALTGGQVDN SFGIVADDDD DNGVVSLQLL DEYSANKWET
160 170 180 190 200
ILHFMVGTPM SSIPSASVLN LLKHTRLMEE VDHTSEFKIT NEGFQFLLQE
210 220 230 240 250
LNSQIWTLLL QYLKMSETLK MDSVDVLNFI FMLGALEVGK GYSIDGLSET
260 270 280 290 300
QKIMLKDMRD YGLVFQKYTN SNLFYPTNLA LMLTSDTKSI VRTASGALES
310 320 330 340 350
VLQNKREDSS KQANGEINKD LITNGDELDQ VGYNPQDIPD GSLIIETNFK
360 370 380 390 400
LYSYSNSPLQ IATLSLFVHL KSRFANMVTG QITRESIRRA LINGITADQI
410 420 430 440 450
IAYLETHAHP QMRRLAEERL EKKLELDPNS KDPLQVLPPT VVDQIKLWQL
460 470 480 490 500
ELDRVITYEG SLYSDFETIA EYTTLSKYAQ DIGVLLWKDD KKKKFFVSKE
510
GNSQVLDYAK RKLKKK
Length:516
Mass (Da):58,678
Last modified:October 19, 2011 - v1
Checksum:i7BD9A9B37393CBEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE576754 Genomic DNA Translation: CCC69129.1
RefSeqiXP_003675496.1, XM_003675448.1

Genome annotation databases

EnsemblFungiiCCC69129; CCC69129; NCAS_0C01390
GeneIDi11526399
KEGGincs:NCAS_0C01390

Similar proteinsi

Entry informationi

Entry nameiG0VCC0_NAUCC
AccessioniPrimary (citable) accession number: G0VCC0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: March 28, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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