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Protein

Phosphoglycerate kinase

Gene

TCIL3000_1_230

Organism
Trypanosoma congolense (strain IL3000)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (TCIL3000_10_5910), Glyceraldehyde-3-phosphate dehydrogenase (TCIL3000_0_05050)
  2. Phosphoglycerate kinase (TCIL3000_11_2180), Phosphoglycerate kinase (TCIL3000_1_230), Phosphoglycerate kinase (TCIL3000_1_240), Phosphoglycerate kinase (TCIL3000_0_37930), Phosphoglycerate kinase (TCIL3000_0_37920)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Pyruvate kinase (TCIL3000_10_12020)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39SubstrateUniRule annotation1
Binding sitei135SubstrateUniRule annotation1
Binding sitei172SubstrateUniRule annotation1
Binding sitei223ATPUniRule annotation1
Binding sitei345ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi375 – 378ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
ORF Names:TCIL3000_1_230Imported
OrganismiTrypanosoma congolense (strain IL3000)Imported
Taxonomic identifieri1068625 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaNannomonas

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingUniRule annotation3
Regioni62 – 65Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 2 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR027250 Pgk_euglenozoa
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PIRSF500126 Pgk_euglenozoa, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

G0UIR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLNEKKSIN ECDLKGKKTL VRVDFNVPVK GGVITNDYRI RSALPTIQKV
60 70 80 90 100
LNEGGSCILM SHLGRPKGIS ISEAAAVRSA GKVPGYEETA TLRPVAQRLG
110 120 130 140 150
ELLSKPVVFA PDCLDAADVV KKMSPGDVVL LENVRFYREE GSKKEEEREA
160 170 180 190 200
MAKVLASYGD IFVSDAFGTA HRDSATMTGI PKVLGHGAAG YLMEKEISYF
210 220 230 240 250
SKVLGNPPRP LVAIVGGSKV SDKIQLLDNM LQRIDYLLIG GAMAYTFLKA
260 270 280 290 300
QGHRIGTSMC EEDKLDLARS LLKKAEDRKV QVLLPVDHVC HTEFKAVDTP
310 320 330 340 350
VVTADADIPD GHMALDIGPK TIANYVETIG KCKSAIWNGP MGVFEMTPYS
360 370 380 390 400
KGTFAVAKAM GDCTQKNGLM SIIGGGDSAS AAEQSGEATR MSHVSTGGGA
410 420
SLELLEGKTL PGVAILDEKV
Length:420
Mass (Da):44,899
Last modified:October 19, 2011 - v1
Checksum:iC86B85FC771BF49F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE575314 Genomic DNA Translation: CCC89265.1

Similar proteinsi

Entry informationi

Entry nameiG0UIR5_TRYCI
AccessioniPrimary (citable) accession number: G0UIR5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: October 25, 2017
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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