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Entry version 51 (29 Sep 2021)
Sequence version 1 (19 Oct 2011)
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Protein

DH domain-containing protein

Gene

CTHT_0073630

Organism
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DH domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CTHT_0073630Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiChaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri759272 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008066 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
209285.XP_006697619.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G0SHW7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini722 – 928DHInterPro annotationAdd BLAST207

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni336 – 359DisorderedSequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili220 – 261Sequence analysisAdd BLAST42
Coiled coili395 – 429Sequence analysisAdd BLAST35
Coiled coili472 – 522Sequence analysisAdd BLAST51
Coiled coili533 – 553Sequence analysisAdd BLAST21
Coiled coili589 – 637Sequence analysisAdd BLAST49
Coiled coili654 – 674Sequence analysisAdd BLAST21
Coiled coili748 – 823Sequence analysisAdd BLAST76
Coiled coili845 – 952Sequence analysisAdd BLAST108
Coiled coili979 – 1027Sequence analysisAdd BLAST49
Coiled coili1030 – 1069Sequence analysisAdd BLAST40
Coiled coili1088 – 1115Sequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0962, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006184_0_0_1

Database of Orthologous Groups

More...
OrthoDBi
179362at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.300, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003959, ATPase_AAA_core
IPR000219, DH-domain
IPR027417, P-loop_NTPase
IPR038729, Rad50/SbcC_AAA
IPR004584, Rad50_eukaryotes

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13304, AAA_21, 1 hit
PF13476, AAA_23, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00606, rad50, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010, DH_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G0SHW7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKIEKLSIL GVRSFGPHHP ETIAFNTPLT LIVGYNGSGK TTVIECLKYA
60 70 80 90 100
TTGELPPNST RNGAFIHDPD LVGEKEVRAQ VKLSFRSTIG ESYVVTRNIQ
110 120 130 140 150
LLVQRNNKRT QKTLEGSLLL RNNGERTVIS TRVAELDKLV SEKLGVPPAI
160 170 180 190 200
LDAVIFCHQD DSLWPMSEPA ALKKRFDEIF EAQKYTKVIE NIRLLKKKKG
210 220 230 240 250
DELKILKERE VQDKANKERA EKVDRLMAQL TREILEAREK CNELSKQMEE
260 270 280 290 300
ESAKIKDKYE QANSFLKIMN DLQTKTEKLE YKKDAIVELR SRIEELPDPD
310 320 330 340 350
EVLRNTLDEY EQTINRIVAD RDHKAAQFHD LQAELKSARD QHTAKAAEQG
360 370 380 390 400
KHQSDKEKYE RQLVARERMI REAAERHEIR GYNGDLDDRR IAIFNERIQK
410 420 430 440 450
ILNDKRRELE RLQRENQEEL DRKTAVIAER ESRKQSVIRD RKAAKDRIIS
460 470 480 490 500
LGKDMASIQG ELSSIDIDEG TEEMLRAEMK ELQARIEAAK ADEQNANLDA
510 520 530 540 550
QIKEVNEEIW KLESLSAKLA RELVECTRLA SERAQLDLRR KQLAERKREL
560 570 580 590 600
EIMTNTWNEQ FSTLLGEGWR PETLERDFSD VLKQQQLLVG EHRKKKDATQ
610 620 630 640 650
QELKQAEYQL SNARNLHNKL TNEMEACMRA VQTAMKEARD LDSAPPVDEY
660 670 680 690 700
ITMLETDEKE LAEVETALKL YDELKKHYST IKDRALRFNK CYICDRDFTN
710 720 730 740 750
QEAAKTRLLE KVAKRLGDEE KKELLEDQAA FMKSLDILRA VRVKYDTYQR
760 770 780 790 800
LSSELPQLSR EIDSETNRRE DLVRRLEDQD LAFREADNKL QEMETLNKHV
810 820 830 840 850
MKITQLLKDI SDAEKQVERS QQLSNIETRS ADEINEEQTT CAEQTRAAQA
860 870 880 890 900
KLTKLTAEKQ RLKDLVRQLE VERLQLENKI SSAVQQLERK KRLQESIARH
910 920 930 940 950
KEDQNQARNA VQEADEELER LEPEIAGARA ALDEARQACR AKEQKVAAER
960 970 980 990 1000
DAIAQTVSEL NMINSEIQEY LDRGGPSSLA ANQRAIANLE TQMANLEGEM
1010 1020 1030 1040 1050
RELTVQINKL NKEIDNSDAK KRNIADNLTY RKNLREKDAL EREIAELEAR
1060 1070 1080 1090 1100
NAQEDYDRLI KEAHYLEAHR SKLNADRERL MGMMSTKDEE FRRLNEEYEL
1110 1120 1130 1140 1150
DLKDAKAKYK ETHIKVETTK AAIEDLGRGM AAVDHAIMQY HSKMMEQINR
1160 1170 1180 1190 1200
TIAELWQSTY QGTDIDTIQI RSDVESTTSS DSGTRRNYNY RVSMVKGDTE
1210 1220 1230 1240 1250
MDMRGRCSAG QKVLASIIIR LALAESFCAN CGLIALDEPT TNLDSDNIRS
1260 1270 1280 1290 1300
LAESLHGIIK ARQAQGNLQL IVITHDEEFL KYMQCSDFCD DFYRVKRDEK
1310
QNSVIVRESI TRITE
Length:1,315
Mass (Da):151,984
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE888632EDFFFE57E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GL988048 Genomic DNA Translation: EGS17037.1

NCBI Reference Sequences

More...
RefSeqi
XP_006697619.1, XM_006697556.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EGS17037; EGS17037; CTHT_0073630

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
18261401

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cthr:CTHT_0073630

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL988048 Genomic DNA Translation: EGS17037.1
RefSeqiXP_006697619.1, XM_006697556.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DA9X-ray3.00A/B1-224[»]
A/B233-1315[»]
5DACX-ray2.50A/B1-224[»]
A/B233-1315[»]
SMRiG0SHW7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi209285.XP_006697619.1

Genome annotation databases

EnsemblFungiiEGS17037; EGS17037; CTHT_0073630
GeneIDi18261401
KEGGicthr:CTHT_0073630

Phylogenomic databases

eggNOGiKOG0962, Eukaryota
HOGENOMiCLU_006184_0_0_1
OrthoDBi179362at2759

Family and domain databases

Gene3Di3.40.50.300, 2 hits
InterProiView protein in InterPro
IPR003959, ATPase_AAA_core
IPR000219, DH-domain
IPR027417, P-loop_NTPase
IPR038729, Rad50/SbcC_AAA
IPR004584, Rad50_eukaryotes
PfamiView protein in Pfam
PF13304, AAA_21, 1 hit
PF13476, AAA_23, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits
TIGRFAMsiTIGR00606, rad50, 1 hit
PROSITEiView protein in PROSITE
PS50010, DH_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG0SHW7_CHATD
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G0SHW7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: September 29, 2021
This is version 51 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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