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Entry version 37 (02 Jun 2021)
Sequence version 1 (19 Oct 2011)
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Protein

MIF4G domain-containing protein

Gene

CTHT_0071550

Organism
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MIF4G domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CTHT_0071550Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiChaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri759272 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008066 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
209285.XP_006697423.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G0SFP0

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1193 – 1429MIF4GInterPro annotationAdd BLAST237

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 103DisorderedSequence analysisAdd BLAST103
Regioni144 – 298DisorderedSequence analysisAdd BLAST155
Regioni365 – 404DisorderedSequence analysisAdd BLAST40
Regioni480 – 567DisorderedSequence analysisAdd BLAST88
Regioni582 – 957DisorderedSequence analysisAdd BLAST376
Regioni1028 – 1147DisorderedSequence analysisAdd BLAST120
Regioni1450 – 1608DisorderedSequence analysisAdd BLAST159

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 76Polar residuesSequence analysisAdd BLAST76
Compositional biasi89 – 103Polar residuesSequence analysisAdd BLAST15
Compositional biasi164 – 186Polar residuesSequence analysisAdd BLAST23
Compositional biasi238 – 264Polar residuesSequence analysisAdd BLAST27
Compositional biasi380 – 402Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi480 – 498Pro residuesSequence analysisAdd BLAST19
Compositional biasi510 – 562Polar residuesSequence analysisAdd BLAST53
Compositional biasi607 – 639Polar residuesSequence analysisAdd BLAST33
Compositional biasi640 – 921Basic and acidic residuesSequence analysisAdd BLAST282
Compositional biasi1028 – 1043Polar residuesSequence analysisAdd BLAST16
Compositional biasi1070 – 1084Polar residuesSequence analysisAdd BLAST15
Compositional biasi1106 – 1122Polar residuesSequence analysisAdd BLAST17
Compositional biasi1480 – 1496Polar residuesSequence analysisAdd BLAST17
Compositional biasi1506 – 1531Polar residuesSequence analysisAdd BLAST26
Compositional biasi1546 – 1562Polar residuesSequence analysisAdd BLAST17

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0401, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003998_0_0_1

Database of Orthologous Groups

More...
OrthoDBi
594395at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.970.30, 1 hit
1.25.40.180, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR022745, eIF4G1_eIF4E-bd
IPR036211, eIF4G_eIF4E-bd_sf
IPR016021, MIF4-like_sf
IPR003890, MIF4G-like_typ-3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12152, eIF_4G1, 1 hit
PF02854, MIF4G, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00543, MIF4G, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101489, SSF101489, 1 hit
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G0SFP0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSTASTTNQ NPATTTNAPA ASYASAAGAN TKPTSPLIAT GSQTPVVVGS
60 70 80 90 100
TSTSQNASQQ QPLNGGGTTT VTVTPAVPSA APPVARGSSI VNGGSNHGHT
110 120 130 140 150
SSVTISAPAS HIANGGPVGN HKNIQFGFPS PQGTPHMAGA VPIPITGSGN
160 170 180 190 200
HRIPSPAHSP SPIPQVPQQS GGQRAPNMSQ VPPPTFGSFP GDNDRHLRQH
210 220 230 240 250
PGANQAPHLR HDSPASGHGD GVSHGGHGRG GYQGQGRGRG GFNTSQFNAP
260 270 280 290 300
PMGGYAQSRN FSGANAGRGG MYHPQGRGGM QQYPSSPQPP RASPAGTPTM
310 320 330 340 350
AHGTPVIPPA TIPTPHAQPF YPPLYSQVKS PFHFNNQSTL QQFTKSKPGR
360 370 380 390 400
RDSEKVAHRL RVPTAPLPKH TGMDQPLAPR SRRSSKRWDP AGENHRDFHS
410 420 430 440 450
GMQMPEYSDG PIPTYGFKAG RPVPVLAPHM MGTTIDLSPE SGTFEKLLTS
460 470 480 490 500
NKMQVPNPYA IGPMDGYRMN YPAYGPPQPM NPYLGQPPQF PPAGPQPFVA
510 520 530 540 550
PYASAQPAAP PMSRNASQVS GQPATTPQAQ PPVIASSTPL QRSTQPAQPA
560 570 580 590 600
IVSSTSNFSR PPKKSAAVVI KNPDGSVLDF SQVKGQTQAK TPPVVSSTPT
610 620 630 640 650
PPPKASTPSH ARTESVTTSG KTAEQVRNEF KNAVQTKVES SEAKAKEEEA
660 670 680 690 700
AKAAAEKAAA EKAAAEEAAA EEAAKKAAEE QAKAQAEAKA QEEAEAKAKA
710 720 730 740 750
EAEAKAKAEA EARAREEAEA KAKAEAEAKA QAEAEAKAQA EAEARAKAEA
760 770 780 790 800
EAEARAKEEA EAKAREEAES KAKAEAEVKA KAEDDEKTEA RKPAGALKDP
810 820 830 840 850
NEMTEEELER MIREMEEEDA RREREQEEIS ARKKKEAEEA KRREEEEKAK
860 870 880 890 900
KAAEMDRKLR EMEREMERLE EEKERRRKEA EAKGEVVSVR ELLGKTKNAE
910 920 930 940 950
ESKVSSEKDK GAAEKASSSI PDEPEKASTS KPGARKPAAL NLAPLKTASV
960 970 980 990 1000
EAPQPSAALQ SLRSARFLPG IVQDIYPPGI KSPNPALNEA VQKKGRIFKY
1010 1020 1030 1040 1050
DVQFLLQFQN VFTEKPSPDF DQQVKALIGD SDSSRSGSAR TPGGAGRQGS
1060 1070 1080 1090 1100
RGPSSAFPPG GAMGQFGAKT LPPGTTSEQR FAMSQGSLPR PGMGTMGGAF
1110 1120 1130 1140 1150
NRPSAFPGNL SRTPSSGPGG LPSPRTGSRR GGSRAKVSEA QAAKTMPLTQ
1160 1170 1180 1190 1200
GQEIKPITIS ATGWKPMSIG NKTVQNPTAV INAGGHLDPE MVQRKVKAAL
1210 1220 1230 1240 1250
NKMTPENFDR ISEQILTIAS QSKDESDGRT LRQVIQLTFE KACDEAHWAS
1260 1270 1280 1290 1300
MYAKFCKRML DSMSPEIRDE NLLDKNGNVV CGGALFRKYL LNRCQEEFER
1310 1320 1330 1340 1350
GWKVDLPKNG KGEVDLMSDE YYAAAAAKRK GLGLVQFIGE LYKLTMLTER
1360 1370 1380 1390 1400
IMHECVRKLL EFQDMPDEAE IESLCKLLRT IGGNLDAHER GKQLMDAYFT
1410 1420 1430 1440 1450
RINAIIELPG LPSRLKFMLM DIVDLRKANW VSKDANKGPK TLEEVRAEHM
1460 1470 1480 1490 1500
QAEAQAAQKA AETARNASRS GPGGRPAGGR SDSRNTSYSN TATNVGMDDL
1510 1520 1530 1540 1550
RRLKGSSSRT GSNNPSFGPT SMFNSRSNSG RRMGGPGGAF GRAGEDSGTS
1560 1570 1580 1590 1600
SRTGTPPVSN RESVAHANAF GLLADTGDHP ASPPSTHASP ALSKATLDTV

AAGDVKKE
Length:1,608
Mass (Da):170,961
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i54CD748ACD45DE96
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GL988047 Genomic DNA Translation: EGS17805.1

NCBI Reference Sequences

More...
RefSeqi
XP_006697423.1, XM_006697360.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EGS17805; EGS17805; CTHT_0071550

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
18261193

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cthr:CTHT_0071550

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL988047 Genomic DNA Translation: EGS17805.1
RefSeqiXP_006697423.1, XM_006697360.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6FBZX-ray1.50B954-1030[»]
6FC0X-ray1.29B954-1030[»]
SMRiG0SFP0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi209285.XP_006697423.1

Genome annotation databases

EnsemblFungiiEGS17805; EGS17805; CTHT_0071550
GeneIDi18261193
KEGGicthr:CTHT_0071550

Phylogenomic databases

eggNOGiKOG0401, Eukaryota
HOGENOMiCLU_003998_0_0_1
OrthoDBi594395at2759

Family and domain databases

Gene3Di1.20.970.30, 1 hit
1.25.40.180, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR022745, eIF4G1_eIF4E-bd
IPR036211, eIF4G_eIF4E-bd_sf
IPR016021, MIF4-like_sf
IPR003890, MIF4G-like_typ-3
PfamiView protein in Pfam
PF12152, eIF_4G1, 1 hit
PF02854, MIF4G, 1 hit
SMARTiView protein in SMART
SM00543, MIF4G, 1 hit
SUPFAMiSSF101489, SSF101489, 1 hit
SSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG0SFP0_CHATD
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G0SFP0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: June 2, 2021
This is version 37 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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