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Protein

RNA polymerase II transcription factor B subunit 2

Gene

CTHT_0044720

Organism
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
ORF Names:CTHT_0044720Imported
OrganismiChaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)Imported
Taxonomic identifieri759272 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
Proteomesi
  • UP000008066 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

KOiK03144
OrthoDBiEOG092C3703

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

G0S965-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIPAVPQSY QLSDYLEKLP GTTFRKLYQQ PSSAFAIFRR MLPPLAKVFV
60 70 80 90 100
QALLYMPQPM LLSDLDVWVR PEAKMHRDRA LSILRSLHIV QITPPGKDRP
110 120 130 140 150
QEVQLTTNFR NSLRLALEGG AAHNSFGVPS SLPVDPRIDI AFLDNYARKK
160 170 180 190 200
WEDILHYVVS SVPVHGDAGP GGMGGGGPKA SVKDLLLAGR LVERRPDTKT
210 220 230 240 250
GIGITQAGFT FLLQEANAQV WTLLLLWLEA ADQAKAAAAA ASGVDPKNAP
260 270 280 290 300
PTKPDSIEML SFLFMLASLE LGRAYDTDAL SETRRNMLPA LVDFGLIYIP
310 320 330 340 350
REDTRQYFPT RLATTLTSSA SALRSVSSGF TAATNNTAND ASSLGGADPS
360 370 380 390 400
AHKGSIIIET NYRLYAYTSS PLQIAVLALF THLNMRFAGM VTGRLTRESI
410 420 430 440 450
RRAISFGITA DQIISYLASH AHEQMVRAAA AAGRPVLPPT VVDQIRLWQL
460 470 480 490 500
ENERMRTSPG FLFKDFENVE EYMALAGYAE EIGVLVWRSD RKRMFFASKF
510
EQLRDYLKSR KKEG
Length:514
Mass (Da):56,835
Last modified:October 19, 2011 - v1
Checksum:i4BDB0E70F4BE8A4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL988043 Genomic DNA Translation: EGS19976.1
RefSeqiXP_006694861.1, XM_006694798.1

Genome annotation databases

EnsemblFungiiEGS19976; EGS19976; CTHT_0044720
GeneIDi18258510
KEGGicthr:CTHT_0044720

Similar proteinsi

Entry informationi

Entry nameiG0S965_CHATD
AccessioniPrimary (citable) accession number: G0S965
Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: May 23, 2018
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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