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Entry version 46 (13 Nov 2019)
Sequence version 1 (19 Oct 2011)
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Protein

CRM1_C domain-containing protein

Gene

CTHT_0002400

Organism
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CRM1_C domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CTHT_0002400Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiChaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri759272 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008066 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusSAAS annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

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DIPi
DIP-61562N

Protein interaction database and analysis system

More...
IntActi
G0RZB7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
209285.XP_006690787.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G0RZB7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini672 – 1001CRM1_CInterPro annotationAdd BLAST330

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili997 – 1026Sequence analysisAdd BLAST30

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KEGG Orthology (KO)

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KOi
K14290

Database of Orthologous Groups

More...
OrthoDBi
132850at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR041123 CRM1_repeat
IPR041235 Exp1_repeat_2
IPR013598 Exportin-1/Importin-b-like
IPR014877 XPO1_C_dom
IPR040485 XPO1_repeat_3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08767 CRM1_C, 1 hit
PF18777 CRM1_repeat, 1 hit
PF18784 CRM1_repeat_2, 1 hit
PF18787 CRM1_repeat_3, 1 hit
PF08389 Xpo1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01102 CRM1_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G0RZB7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVSVEELDA TVRAFYEGRG EQFKEDPDAW LMVDEILSRA TYEQTKCIRN
60 70 80 90 100
FVVQYILQCS SSEESLRTHR TLLNKLNLVL VSVLKQEWPH NWPTFINEIV
110 120 130 140 150
SACHSSLSVC ENNMIILRLL SEEVFDYSAD QMTSTKTRNL KSTMCAEFSM
160 170 180 190 200
IFQLCQEILN SATQPSLIKA TLETLLRFCN WIPLGYIFET PLIDTLRTRF
210 220 230 240 250
LEVPEFRNVT LQCLTEIGGL QTGGPGQPHT YDEQLIKMFT EVLTTISNII
260 270 280 290 300
PLQMDLKATY PNSNSRDQEF IQNLALFLTS FFTMHLPLIE NLPNRDFLTH
310 320 330 340 350
GHFYLIRISQ IDDREIFKIC LDYWLKLVQE LYEEMQSLPL NDMSSMGLGM
360 370 380 390 400
MSGGGAPNPA LLEHYPLRKH KYKEVLSNLR VVMIEKMVRP EEVLIVENDE
410 420 430 440 450
GEIVREFVKD TDSVQLYKTI RECLVYLTHL DVVDMEQIMT EKLARQVDGS
460 470 480 490 500
EWSWHNCNVL CWAIGSISMA MNEETEKRFL VTVIKDLLGL TEMKRGKDNK
510 520 530 540 550
AVVASNIMYI VGQYPRFLKA HWKFLKTVVN KLFEFMHESH EGVQDMACDT
560 570 580 590 600
FIKIAKQCRR HFVALQPSEN EPFIEEIIRN IGKITCDLTP QQVHTFYEAC
610 620 630 640 650
GYMVSAQGNR NQQERLLAEL MAIPNAAWDE IIKAATMNPG ILHEPDTIKI
660 670 680 690 700
IGNIMKTNVS ACSSIGPYFF PQIGRLYNDM LQMYAATSQL ISEAVARDGE
710 720 730 740 750
IATKMPKVRG LRTIKKEILK LVETFVEKAE DLQAVRSQMI PGLLDSVLVD
760 770 780 790 800
YNRNVPGARD AEVLKAMTVI ITRLQGLMED QVPAIMENVF ECTLDMINKD
810 820 830 840 850
FAEYPEHRVE FFNLLRAINL YCFPALLKLD NRQFKFVIDS CMWASKHDNR
860 870 880 890 900
DVETAGLNMC LELINNIAEK TDVQTCNAFF NQFFIRILQD VFFVLTDTDH
910 920 930 940 950
KAGFKTQSML LMRLFYFVHP ADGSAPKIQG PIYQPDQAQP GTGNREFLAN
960 970 980 990 1000
FVGTLLQNAF ANLTPLQITT FVKDCFELNT QYDKFRVVLR DFLISLREFA
1010 1020 1030 1040
GDNAELYQVE KEQQEREARA ADLERRSKVG GLLKPSELED EEL
Length:1,043
Mass (Da):119,873
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i408152251E3FA51A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GL988032 Genomic DNA Translation: EGS23545.1

NCBI Reference Sequences

More...
RefSeqi
XP_006690787.1, XM_006690724.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EGS23545; EGS23545; CTHT_0002400

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
18254278

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cthr:CTHT_0002400

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL988032 Genomic DNA Translation: EGS23545.1
RefSeqiXP_006690787.1, XM_006690724.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FGVX-ray2.94A1-1043[»]
4HZKX-ray3.10A/B1-1043[»]
SMRiG0RZB7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-61562N
IntActiG0RZB7, 1 interactor
STRINGi209285.XP_006690787.1

Genome annotation databases

EnsemblFungiiEGS23545; EGS23545; CTHT_0002400
GeneIDi18254278
KEGGicthr:CTHT_0002400

Phylogenomic databases

KOiK14290
OrthoDBi132850at2759

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR041123 CRM1_repeat
IPR041235 Exp1_repeat_2
IPR013598 Exportin-1/Importin-b-like
IPR014877 XPO1_C_dom
IPR040485 XPO1_repeat_3
PfamiView protein in Pfam
PF08767 CRM1_C, 1 hit
PF18777 CRM1_repeat, 1 hit
PF18784 CRM1_repeat_2, 1 hit
PF18787 CRM1_repeat_3, 1 hit
PF08389 Xpo1, 1 hit
SMARTiView protein in SMART
SM01102 CRM1_C, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG0RZB7_CHATD
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G0RZB7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: November 13, 2019
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
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