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Entry version 45 (02 Jun 2021)
Sequence version 1 (19 Oct 2011)
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Protein
Submitted name:

Nuclease-like protein

Gene

CTHT_0007290

Organism
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi141MagnesiumCombined sources1
Metal bindingi143MagnesiumCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, NucleaseARBA annotation
LigandMagnesiumCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.22.4, 1279

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nuclease-like proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CTHT_0007290Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiChaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri759272 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008066 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi226InterchainCombined sources

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
209285.XP_006691260.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G0RYN2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 95XPGNInterPro annotationAdd BLAST95
Domaini108 – 183XPGIInterPro annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni416 – 437DisorderedSequence analysisAdd BLAST22
Regioni459 – 484DisorderedSequence analysisAdd BLAST26
Regioni507 – 889DisorderedSequence analysisAdd BLAST383

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi459 – 479Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi532 – 595Polar residuesSequence analysisAdd BLAST64
Compositional biasi605 – 619Polar residuesSequence analysisAdd BLAST15
Compositional biasi640 – 659Polar residuesSequence analysisAdd BLAST20
Compositional biasi695 – 727Basic and acidic residuesSequence analysisAdd BLAST33
Compositional biasi728 – 761Polar residuesSequence analysisAdd BLAST34
Compositional biasi809 – 839Polar residuesSequence analysisAdd BLAST31
Compositional biasi874 – 888Basic and acidic residuesSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2519, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007575_0_0_1

Database of Orthologous Groups

More...
OrthoDBi
1094524at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09906, H3TH_YEN1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036279, 5-3_exonuclease_C_sf
IPR041177, GEN1_C
IPR029060, PIN-like_dom_sf
IPR006086, XPG-I_dom
IPR006084, XPG/Rad2
IPR006085, XPG_DNA_repair_N
IPR037316, Yen1_H3TH

The PANTHER Classification System

More...
PANTHERi
PTHR11081, PTHR11081, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18380, GEN1_C, 1 hit
PF00867, XPG_I, 1 hit
PF00752, XPG_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00853, XPGRADSUPER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00484, XPGI, 1 hit
SM00485, XPGN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47807, SSF47807, 1 hit
SSF88723, SSF88723, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G0RYN2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGIKGIYKEI GSGERISLCK LAIDHLEQHN RPLRLAIDMA IWQFQIQAAR
60 70 80 90 100
GGSNPAIRTL FYRFVRLLSL GIHPIFVFDG PNKPIFKRNR RSGTGNGVST
110 120 130 140 150
AMAKRLIRLF GFTAHDAPGE AEAECAYLEQ QGIVDAVLSE DVDTIMFGSR
160 170 180 190 200
VTLRDWSSEG SKGGPPTHVT LHDAKKIAEG PSGLDREGMV LVALMSGGDY
210 220 230 240 250
LPDGIPGCGI KVACQAAKAG FGKELCRIKR ADKEAITEWK QRLLHELRTN
260 270 280 290 300
ESGFFRTKHK ALEIPENFPN MEVLRYYTHP VVSSPATIER LRQEFPPSST
310 320 330 340 350
VDIAGLREFT RETFDWTFRP GAIKLIKVLA PGLLVQRCLD RYVSGPRIDD
360 370 380 390 400
PDLKKKEEST LVKGISMRRE HFSTDATPEL RVSFIPAELV GLDPGQEPEV
410 420 430 440 450
QVEAFGRSGL ALNSDDEFDE DISSSQKAPK KPFDPWQPDL AWVPETILKL
460 470 480 490 500
GVPVTVEDWE EGQRSKGRAK EDKTAAKAKR KTKIIQSNMP AGALDKYVTV
510 520 530 540 550
TKNISDTTVK SKESAPITIP SSPPKPSSQP APPTLTRSKQ AKKPSTKLSK
560 570 580 590 600
QPTTRPSLDI NPWTIASSQC SPPRAGPSST LTADLLSTPT NDPPRSPAVS
610 620 630 640 650
HVAKTMPGGS TTSSDILPSH TAAAARDVEP ILIESSPVVP PPGTTASSTM
660 670 680 690 700
ANSSHPRQGT LVRGGVRGYG QKTPPKRQKR RVGQRALEEA EDSPALPTDE
710 720 730 740 750
AKPSEVHAES QLVRKDRTFK RVKSGTEDDL SSNTASTTTQ AVKQTTAPSS
760 770 780 790 800
TSTQTSIKSF GRVSKEPIKI SSEKVAAIET IVLSDSDSDS DDDDDLPLLF
810 820 830 840 850
PTKKAPPFLR SEQNPSSSST GSRSASSSTF VPASKSSTLV PDDDNHDEAD
860 870 880 890 900
PFGPIRPPSG DNGTQPIRSA SEIPQEPGDD DTKAEKKVLG RGVWGWNARE
910 920
WGKERRMWRV SEIEVVDLTG ED
Length:922
Mass (Da):100,404
Last modified:October 19, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5956606BC2625AB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GL988032 Genomic DNA Translation: EGS24018.1

NCBI Reference Sequences

More...
RefSeqi
XP_006691260.1, XM_006691197.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EGS24018; EGS24018; CTHT_0007290

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
18254767

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cthr:CTHT_0007290

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL988032 Genomic DNA Translation: EGS24018.1
RefSeqiXP_006691260.1, XM_006691197.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CNQX-ray2.60A2-465[»]
5CO8X-ray2.40A/C2-465[»]
6GRBX-ray2.40A1-530[»]
6GRCX-ray2.45A1-521[»]
6GRDX-ray2.66A1-530[»]
SMRiG0RYN2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi209285.XP_006691260.1

Genome annotation databases

EnsemblFungiiEGS24018; EGS24018; CTHT_0007290
GeneIDi18254767
KEGGicthr:CTHT_0007290

Phylogenomic databases

eggNOGiKOG2519, Eukaryota
HOGENOMiCLU_007575_0_0_1
OrthoDBi1094524at2759

Enzyme and pathway databases

BRENDAi3.1.22.4, 1279

Family and domain databases

CDDicd09906, H3TH_YEN1, 1 hit
InterProiView protein in InterPro
IPR036279, 5-3_exonuclease_C_sf
IPR041177, GEN1_C
IPR029060, PIN-like_dom_sf
IPR006086, XPG-I_dom
IPR006084, XPG/Rad2
IPR006085, XPG_DNA_repair_N
IPR037316, Yen1_H3TH
PANTHERiPTHR11081, PTHR11081, 1 hit
PfamiView protein in Pfam
PF18380, GEN1_C, 1 hit
PF00867, XPG_I, 1 hit
PF00752, XPG_N, 1 hit
PRINTSiPR00853, XPGRADSUPER
SMARTiView protein in SMART
SM00484, XPGI, 1 hit
SM00485, XPGN, 1 hit
SUPFAMiSSF47807, SSF47807, 1 hit
SSF88723, SSF88723, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG0RYN2_CHATD
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G0RYN2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 19, 2011
Last sequence update: October 19, 2011
Last modified: June 2, 2021
This is version 45 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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